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All Journal Medula Juke Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Indonesian Tourism, Hospitality and Recreation Jurnal Kesehatan Medica Hospitalia JURNAL PIONIR JK Unila (Jurnal Kedokteran Universitas Lampung) JOURNAL LA MEDIHEALTICO Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Farmasetis Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Nurul Islamy
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Journal : Medica Hospitalia

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Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung Nurmayeni; Islamy, Nurul; Tjiptaningrum, Agustyas; Siregar, Bintang Abadi; Kusumaningtyas, Aditya; Windarti, Indri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.904

Abstract

BACKGROUND:Breast cancer is the most common cancer in Indonesia and is a leading cause of cancer-related deaths in the country. Metastases are responsible for most deaths among breast cancer patients. Breast cancer is typically classified into four subtypes based on immunohistochemistry: luminal A, luminal B, HER2+, and TNBC. OBJECTIVE:To determine the association between the metastatic pattern of breast cancer and their molecular subtypes at RSUD Dr. H. Abdul Moeloek Lampung. METHOD:This study was an observational analytic study with a cross-sectional design. The sample comprised 81 individuals who had suffered from breast cancer and were recorded in the medical records section of RSUD Dr. H. Abdul Moeloek Lampung between 2013 – 2021 and met the inclusion and exclusion criteria. The association between breast cancer subtypes and the incidence and metastase sites were tested using the Chi-Square test. RESULT:This study found a significant association between breast cancer subtypes and the incidence of metastases (p <0.05). The TNBC subtype had a more frequent rate of metastases (34.5%) than the other subtypes (31% luminal B, 20.7% luminal A, and HER2+ 13.8%). The study also revealed a relationship between ER status and the incidence of metastases (p < 0.05). The luminal A subtype tends to metastasize to the liver, luminal B tends to metastasize to the bone, HER2+ tends to metastasize to the lung and liver, and TNBC tends to metastasize to the lung. However, no significant association was found between breast cancer subtypes and metastatic sites. CONCLUSION:There was a significant association between breast cancer subtypes and the incidence of metastases, but not with the metastatic sites.  
Co-Authors Ade Yonata Ade Yonata, Ade Afrianza Dafi Ramadhan Agustyas Tjiptaningrum Ahmad Fauzi Akhmad Yogi Pramatirta, Akhmad Yogi Alandra Rizhaqi Vastra Amillia Siddiq Arli Suryawinata Aziz, M. Alamsyah Bahmid Bambang Eko Subakti Betta Kurniawan, Betta Dani Setiawan Dhea Mutiara Karmelita Edi Kurniawan Efriyan Imantika Ety Apriliana Fiana Deswita Firmansyah Basir Fukrapti Fukrapti Hamidi, Syahrul Haq, Rais Amaral Hasan Hasan Hermie Tendean Ikhlas Taufik Indri Windarti Javinka Fairuz Zahrani Julizar Mauttaqin Khaerunnisa P, Maya Khaerunnisa, Maya Khairun Nisa Khairun Nisa Kurniawaty, Evi Kusumaningtyas, Aditya Liana Sidharti Lukman Pura Lumentut, Anastasia M. Lumentut, Anastasia Mariane M Nico Hardianto M Tomy Iskandar M. Ricky Ramadhian Maelissa, Merlin Maelissa, Merlin M. Maelissa, Merlin Margreth Mahardika Putra Mallarangeng, Andi Nafisah Tendri Adjeng Marlon Brando Miftahul Husna Morfi, Chicy Widya Muhammad Caesario Liazmi Najoan, Rizki Nur Ayu Virginia Irawati Nurmayeni Nuswil Bernolian Prabowo, Arif Yudho Puspitasari, Maya Khaerunnisa Ratna Dewi Puspita Sari Restu Krisnanda Rezita Rahma Reza Rezita Rahma Reza Rinaldy, Dino Risdianto Risdianto Riska Putri Soraya Rizki Hanriko Rodiani - Rodiani, Rodiani Rudiyanto, Waluyo Sayuti, Marzuqi Selvi Rahmawaty Setyorini Irianti Siregar, Bintang Abadi Situmorang, Ephraim Matthew Sebastian Syahrul Hamidi Nasution Taruna, Achmad Theodorus Theodorus Ustami Panjaitan Waluyo Rudiyanto Wilda Ainia Silmi Kaffah Wirawan, Wahyudi Yuska, Salsa Nurfajri Zahra Dewi Hasna Difa