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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Devotion: Journal of Research and Community Service Unram Journal of Community Service (UJCS) Biofaal Journal Rumphius Pattimura Biological Journal Balobe: Jurnal Pengabdian Masyarakat Kalwedo Sains (KASA) BAKTI : Jurnal Pengabdian Kepada Masyarakat PENGAMATAN: Jurnal Pengabdian Masyarakat untuk Ilmu MIPA dan Terapannya
Martha Kaihena
Jurusan Biologi FMIPA dan Program Pendidikan Dokter Universitas Pattimura Ambon, Jl. Dr. Tamaela, Kampus Universitas Pattimura Ambon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Phytotherapy for Diabetes: A Preclinical Study of Ethanol Extract of Winged Bean (Psophocarpus tetragonolobus L.) Leaves in Diabetic Rat (Rattus norvegicus) Models Moniharapon, Mechiavel; Tahapary, Patrcik Indurian; Kaihena, Martha; Eddy, La
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp125-140

Abstract

The long-term use of synthetic hypoglycemic agents is known to cause adverse side effects and induce drug resistance. Winged bean (Psophocarpus tetragonolobus L.), a traditional medicinal plant from Maluku, contains secondary metabolites such as flavonoids, saponins, and tannins, which are believed to have potential in lowering blood glucose levels. This study aimed to investigate the effect of ethanolic extract of winged bean leaves on blood glucose reduction and β-cell regeneration in the pancreas of white rats (Rattus norvegicus) as a diabetic model. Thirty rats weighing between 150–200 g were divided into five groups: Group I (negative control), Group II (positive control), and Groups III, IV, and V (diabetic rats treated with ethanolic extract of winged bean leaves at doses of 2.52 mg/g BW, 5.04 mg/g BW, and 7.56 mg/g BW, respectively). Streptozotocin (STZ) was administered to Groups II–V to induce diabetes. Rats with blood glucose levels exceeding 200 mg/dL were subsequently treated with the designated doses of the extract in Groups III–V. On the final day, blood glucose levels were measured, and pancreatic organs were harvested for histological analysis. The results demonstrated that the ethanolic extract of winged bean leaves at a dose of 7.56 mg/g BW effectively reduced blood glucose levels in diabetic rats.
The Effect of Tongka Langit Banana Juice on Morphological Abnormalities Spermatozoa in Mice (Mus musculus) Infected by Plasmodium berghei Hitalesiakwane, Yesty E.; Kaihena, Martha; Samson, Efraim
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10727

Abstract

Malaria infection by Plasmodium is known to affect human reproduction. One of the reproductive organs affected by malaria infection is the testes. If there is a disorder in the testes, it will affect the spermatogenesis process, so that it can cause morphological abnormalities of the resulting spermatozoa. This study aims to determine the effect of administering Tongka Langit banana juice (Musa troglodytarum) on morphological abnormalities of spermatozoa in mice (Mus musculus) infected with Plasmodium berghei. The results of this study indicate that administering Tongka Langit banana juice can reduce spermatozoa abnormalities. Compared with the dose groups of 0.55g/mice/day and 0.65g/mice/day, administering Tongka Langit banana juice at a dose of 0.75g/mice/day is the most effective dose on reducing the average spermatozoa abnormalities in mice. The carotenoid content in Tongka Langit bananas is thought to ward off Plasmodium berghei infection, the cause of spermatozoa abnormalities in mice.
Co-Authors Adriana Hiariej, Adriana Adrien Jems Akiles Unitly Amos Killay Anneke Pesik Batlayeri, Sentia CECILIA ANNA SEUMAHU Efraim Samson, Efraim Handy Erwin Pier Leimena Henaulu, Adudin H Hermanus Nawaly Hitalesiakwane, Yesty E. Jotlely, Hery Kaliky, Arief Rahman Shabri Kaliky, Nunun Ainun Putri Sari Banun Kubela, Dormatina La Eddy Lapu, Petrus Luarwan, Welmince T. Mainassy, Meilissa C Manurung, Brian Saputra Moniharapon, Debby Dijola Moniharapon, Mechiavel Nindatu, Maria Nusaly, Windy Natalia Pagaya, Joseph Patty, Kristi Lenci Pieter Agusthinus Riupassa Pieter Kakisina Ramadhany, Muhammad Reza Ratulewen, Desi Ellida Riupassa, Pieter A. Sahertian, Dece Elizabeth Sairudy, Albertus Salamena, Fuadiska Seumahu, Cecelia Anna Tahapary, Patrcik Indurian Tarangi, Filep Marfil Tetrapoik, Jenromp Ana Putri Moto Tuhumuri, Evelin Ukratalo, Abdul M Ukratalo, Abdul Mahid Umagapi, Muhammad Cesar