Article Per Year (5 Year)
p-Index From 2021 - 2026
3.484
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Devotion: Journal of Research and Community Service Unram Journal of Community Service (UJCS) Biofaal Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Rumphius Pattimura Biological Journal Balobe: Jurnal Pengabdian Masyarakat Kalwedo Sains (KASA) BAKTI : Jurnal Pengabdian Kepada Masyarakat PENGAMATAN: Jurnal Pengabdian Masyarakat untuk Ilmu MIPA dan Terapannya Journal of Biomedical Sciences and Health
Martha Kaihena
Jurusan Biologi FMIPA dan Program Pendidikan Dokter Universitas Pattimura Ambon, Jl. Dr. Tamaela, Kampus Universitas Pattimura Ambon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Phytotherapy for Diabetes: A Preclinical Study of Ethanol Extract of Winged Bean (Psophocarpus tetragonolobus L.) Leaves in Diabetic Rat (Rattus norvegicus) Models Moniharapon, Mechiavel; Tahapary, Patrcik Indurian; Kaihena, Martha; Eddy, La
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp125-140

Abstract

The long-term use of synthetic hypoglycemic agents is known to cause adverse side effects and induce drug resistance. Winged bean (Psophocarpus tetragonolobus L.), a traditional medicinal plant from Maluku, contains secondary metabolites such as flavonoids, saponins, and tannins, which are believed to have potential in lowering blood glucose levels. This study aimed to investigate the effect of ethanolic extract of winged bean leaves on blood glucose reduction and β-cell regeneration in the pancreas of white rats (Rattus norvegicus) as a diabetic model. Thirty rats weighing between 150–200 g were divided into five groups: Group I (negative control), Group II (positive control), and Groups III, IV, and V (diabetic rats treated with ethanolic extract of winged bean leaves at doses of 2.52 mg/g BW, 5.04 mg/g BW, and 7.56 mg/g BW, respectively). Streptozotocin (STZ) was administered to Groups II–V to induce diabetes. Rats with blood glucose levels exceeding 200 mg/dL were subsequently treated with the designated doses of the extract in Groups III–V. On the final day, blood glucose levels were measured, and pancreatic organs were harvested for histological analysis. The results demonstrated that the ethanolic extract of winged bean leaves at a dose of 7.56 mg/g BW effectively reduced blood glucose levels in diabetic rats.
The Effect of Tongka Langit Banana Juice on Morphological Abnormalities Spermatozoa in Mice (Mus musculus) Infected by Plasmodium berghei Hitalesiakwane, Yesty E.; Kaihena, Martha; Samson, Efraim
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10727

Abstract

Malaria infection by Plasmodium is known to affect human reproduction. One of the reproductive organs affected by malaria infection is the testes. If there is a disorder in the testes, it will affect the spermatogenesis process, so that it can cause morphological abnormalities of the resulting spermatozoa. This study aims to determine the effect of administering Tongka Langit banana juice (Musa troglodytarum) on morphological abnormalities of spermatozoa in mice (Mus musculus) infected with Plasmodium berghei. The results of this study indicate that administering Tongka Langit banana juice can reduce spermatozoa abnormalities. Compared with the dose groups of 0.55g/mice/day and 0.65g/mice/day, administering Tongka Langit banana juice at a dose of 0.75g/mice/day is the most effective dose on reducing the average spermatozoa abnormalities in mice. The carotenoid content in Tongka Langit bananas is thought to ward off Plasmodium berghei infection, the cause of spermatozoa abnormalities in mice.
The Potential of Ethanol Extract from Langsat Leaves (Lansium Domesticum Var. Pubescent) In Controlling Aedes Aegypti Mosquitoes: A Study on The Effectiveness of Natural Substances as Mosquito Repellents Ukratalo, Abdul M; Ichsan, Muhammad Nurhidayat; Kaihena, Martha; Manery, Dodikrisno Ekaputra; Pangemanan, Victory Osvaldo; Moniharapon, Debby Dijola
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.1

Abstract

In recent decades, attention to the utilisation of natural materials as alternatives in vector control has increased. One potential source that needs to be explored is langsat leaves, which are known to have active compounds. Ethanol extracts of langsat leaves may contain compounds that can provide control effects against Aedes aegypti mosquito larvae. This study aims to assess the effectiveness of the ethanol extract of langsat leaves in controlling Aedes aegypti mosquitoes, the vector of Dengue Fever disease. The extraction method was carried out using the maceration technique with ethanol as the solvent. Bioactivity test was conducted through larvicidal bioassay against Aedes aegypti larvae. The results showed that the ethanol extract of langsat leaves has a larvicidal effect against Aedes aegypti mosquito larvae. The toxicity levels, both LC50 and LC90, indicate that the ethanol extract of langsat leaves has potential as a mosquito larva control agent.
Reproductive Health Optimization: Remarkable Benefits of Avocado Juice (Persea americana P. Mill) in Enhancing Production and Reducing Spermatozoal Abnormalities in Mice Exposed to Clove Cigarette Smoke Kaihena, Martha; Ukratalo, Abdul M; Pangemanan, Victory O; Manery, Dodikrisno E
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.2

Abstract

Background: Cigarette smoke has the potential to disrupt hormonal balance, affect spermatogenesis processes, damage spermatozoa viability, and create the presence of toxic substances in spermatozoa. On the other hand, avocados contain protein and various vitamins, such as A, B, B1, B2, E, and C, as well as other substances, such as beta-carotene, linoleic acid, lecithin, calcium, iron, pantothenic acid, potassium, phosphorus, niacin, and natural plant oils. Vitamins C and E in avocados are believed to increase the number of Leydig cells and spermatozoa. Objective: This study aims to evaluate the potential of avocado juice to improve reproductive health in mice exposed to kretek cigarette smoke. Methods: Male mice (Mus musculus) aged 2 months, weighing ±20g each, were divided into 5 randomly assigned groups: K- (control without treatment), K+ (positive control exposed to cigarette smoke), P1 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.5 ml/20 g BW), P2 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.7 ml/20 g BW), and P3 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.9 ml/20 g BW). Cigarette smoke exposure was conducted for 14 days. Results: The results showed that regular avocado juice consumption could increase sperm production and reduce spermatozoa abnormalities in mice exposed to kretek cigarette smoke. Conclusion: The clinical implications of these findings may contribute to a better understanding of avocado juice's potential as a supplement to improve reproductive health, especially in the context of kretek cigarette smoke exposure.
Potential Bark Cinnamomum burmanii in Regenerating Damaged Liver Cells of Mice (Mus musculus) Diabetes Mellitus Model Ukratalo, Abdul M; Kaihena, Martha; Sirait, Dion P O; Pattimura, Nadira; Manery, Dodikrisno Ekaputra
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 02 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.864 KB) | DOI: 10.58549/pcjn.v2i01.58

Abstract

Diabetes mellitus is a chronic disease that can quickly increase the prevalence of complications in sufferers, such as liver damage. This study aims to examine the effect of methanol extract cinnamon bark (Cinnamomum burmanii Bl) in regenerating liver cell damage mice (Mus musculus) Diabetes Mellitus through the histological picture. 20 mice were divided into 5 groups which consisted of a negative control group, Positive control and a group of mice that were given methanol extract bark Cinnamomum burmannii dose of 125 mg/head/day, 250 mg/head/Day and 500 mg/head/day. In the positive control group and the group of mice that will be given extract streptozotocin injected dose of 0.2 ml and observed blood sugar levels if sugar levels have increased then given methanol extract bark Cinnamomum burmannii with a dose that has been determined and blood sugar levels were measured. On the last day, surgery is performed to remove the liver, after which histological preparations are made. The results showed that the administration of bark extract Cinnamomum burmanii can regenerate damaged liver cells of mice due to diabetes mellitus. This is due to the content of secondary metabolite compounds contained in the bark of Cinnamomum burmannii.
Co-Authors Adriana Hiariej, Adriana Adrien Jems Akiles Unitly Amos Killay Anneke Pesik Batlayeri, Sentia CECILIA ANNA SEUMAHU Efraim Samson, Efraim Handy Erwin Pier Leimena Henaulu, Adudin H Hermanus Nawaly Hitalesiakwane, Yesty E. Ichsan, Muhammad Nurhidayat Jotlely, Hery Kaliky, Arief Rahman Shabri Kaliky, Nunun Ainun Putri Sari Banun Kubela, Dormatina La Eddy Lapu, Petrus Luarwan, Welmince T. Mainassy, Meilissa C Manery, Dodikrisno E Manery, Dodikrisno Ekaputra Manurung, Brian Saputra Moniharapon, Debby Dijola Moniharapon, Mechiavel Nadira Pattimura Nindatu, Maria Nusaly, Windy Natalia Pagaya, Joseph Pangemanan, Victory O Pangemanan, Victory Osvaldo Patty, Kristi Lenci Pieter Agusthinus Riupassa Pieter Kakisina Ramadhany, Muhammad Reza Ratulewen, Desi Ellida Riupassa, Pieter A. Sahertian, Dece Elizabeth Sairudy, Albertus Salamena, Fuadiska Seumahu, Cecelia Anna Sirait, Dion P O Tahapary, Patrcik Indurian Tarangi, Filep Marfil Tetrapoik, Jenromp Ana Putri Moto Tuhumuri, Evelin Ukratalo, Abdul M Ukratalo, Abdul Mahid Umagapi, Muhammad Cesar