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All Journal Jurnal Bios Logos Indonesian Journal of Medicine Jurnal Pengabdian Pada Masyarakat METHABDI Majalah Ilmiah METHODA Jurnal Kedokteran Methodist
Hadyanto Lim
Departement Of Pharmacology, Faculty Of Medicine, Universitas Methodist Indonesia, Medan
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A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation : A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation lim, hadyanto; Hutasoit, Eka Samuel P; Endy Juli Anto
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Background Recurrent Bell’s palsy is a rare condition that can affect the ipsilateral or contralateral to the affected side of the primary attack. There is still no consensus on treatment guidelines for recurrent Bell’s palsy. Therefore, we report a case of idiopathic recurrent contralateral facial palsy treated with autologous peripheral blood stem cell (PBSC) transplantation. Case Presentation A 72-year-old man presented with the sudden onset of right facial weakness, which was contralateral to the affected side of the first episode of facial palsy. The weakness had progressed with difficulty in closing the right eye, drooling the water from the right side of the mouth, and chewing impairment which was consistent with House Brackmann grade IV or moderately severe facial nerve grading system. He had exposure to cold stimulation, and a history of hypertension. He was given G-CSF 10 ug/kg/day for 5 days to mobilize stem cells, followed by apheresis on the 5th day. He did not receive acupuncture treatment. He had a complete recovery in 3 weeks with House Brackmann grade I or normal function of facial nerve. Conclusion Peripheral blood stem cell transplantation had a beneficial effect on the complete recovery of this recurrent Bell’s palsy and provides a treatment strategy in patients with unilateral facial palsy.
Hubungan Kadar Kolesterol Total Dengan Kolesterol LDL Pada Pasien Hipertensi So Hanggrainy, Octavia; Lim, Hadyanto; Singh, Surjit
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1392

Abstract

The Background: Cholesterol is an essential structural component that forms the cell membrane and the external layer of plasma lipoproteins. The increase of total cholesterol is always accompanied by the increase in LDL cholesterol especially in hypertensive patients. The present study was conducted to find the correlation between total cholesterol and LDL cholesterol of the patients with hypertension Method: It is an observational analytic using cross sectional study in which the data were collected by clinical laboratory examination of Prodia Jl. S.Parman no. 17/223G Medan, North Sumatra Indonesia. The population included all patients with hypertension in which the samples were taken by consecutive sampling method so the total were 19 samples. Results: Majority of samples had normal total cholesterol of 8 persons (42.1%) and the majority of the study samples had high LDL cholesterol of 8 persons (42.1%). Conclusion: There is a significant correlation between total cholesterol and LDL cholesterol. It is indicated by the sig-p value = 0.004 (p <0.05). There is a significant correlation between total cholesterol and LDL cholesterol of the patients with hypertension. It is indicated by the correlation coefficient value r-count = 0.635 which is between 0.6 - 0.79
Hubungan Hipertensi Dengan Mikroalbumin Urin Pada Usia Diatas 40 Tahun Cristianto Sagala, Rudy; Lim, Hadyanto; Singh, Surjit
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1410

Abstract

Background : Hypertension is the risk factor for cardiovascular disease and it is related with endothelial dysfunction. The disease is marked by microalbuminuria. Microalbuminuria is related with the damage of endothelial glomerulus and predictor of chronic renal failure. Microalbuminuria increases albuminuria. This will manifest as endothelial damage of the glomerulus. This study is to assess the relation between hypertension and microalbuminuria in people over 40 years of age Methods : in 13 subjects of essential hypertension in Medan, basic data down and their blood pressure and microalbumin checked in Clinical Laboratory of Prodia on Jl. S. Parman No. 17/223 G Medan. This research use cross section study. Shapiro-Wilk test conducted to find out normal distribution data and Pearson correlation test conducted to find out the relation between the variables. The significant score is P<0.05. Results : 6 subjects in this research were in category of A2 (moderate): 3-30 mg/mmol creatinine.7 subject in this study were in category A3(Severe): >30 mg/mmol creatinine. There was correlation (r = 0.898, p = 0.000) between systolic hypertension and microalbuminuria and the correlation between diastolic and microalbuminuria was (r = 0.574, p = 0.040). Conclusion: Hypertension is related with the increase of microalbuminuria for both systolic hypertension and diastolic Hypertension.
A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation : A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation lim, hadyanto; Hutasoit, Eka Samuel P; Endy Juli Anto
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.2812

Abstract

Background Recurrent Bell’s palsy is a rare condition that can affect the ipsilateral or contralateral to the affected side of the primary attack. There is still no consensus on treatment guidelines for recurrent Bell’s palsy. Therefore, we report a case of idiopathic recurrent contralateral facial palsy treated with autologous peripheral blood stem cell (PBSC) transplantation. Case Presentation A 72-year-old man presented with the sudden onset of right facial weakness, which was contralateral to the affected side of the first episode of facial palsy. The weakness had progressed with difficulty in closing the right eye, drooling the water from the right side of the mouth, and chewing impairment which was consistent with House Brackmann grade IV or moderately severe facial nerve grading system. He had exposure to cold stimulation, and a history of hypertension. He was given G-CSF 10 ug/kg/day for 5 days to mobilize stem cells, followed by apheresis on the 5th day. He did not receive acupuncture treatment. He had a complete recovery in 3 weeks with House Brackmann grade I or normal function of facial nerve. Conclusion Peripheral blood stem cell transplantation had a beneficial effect on the complete recovery of this recurrent Bell’s palsy and provides a treatment strategy in patients with unilateral facial palsy.
. Pengaruh Teh Hijau Pada Epigenetik dan Antiaging: The Effect of Green Tea on Epigenetics and AntiAging Imelda, Imelda; Lim, Hadyanto
Jurnal Kedokteran Methodist Vol. 18 No. 1 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v20i1.4467

Abstract

Background: The global increase in aging population poses major public health challenges. Green tea, especially its bioactive compound epigallocatechin gallate (EGCG), has shown promising effects on healthspan and age-related diseases. Recent studies have explored its potential role in epigenetic regulation and antiaging mechanisms. Discussion: Green tea is rich in polyphenols, especially catechins like EGCG, which act as powerful antioxidants. EGCG modulates epigenetic mechanisms by inhibiting histone deacetylases (HDAC), altering DNA methylation, and regulating non-coding RNAs. These modifications support the expression of genes involved in cellular protection, stress resistance, and longevity. In addition to systemic benefits, green tea also demonstrates topical antiaging effects by reducing oxidative stress and improving collagen synthesis in the skin. Experimental models reveal EGCG’s capacity to delay aging through activation of key signaling pathways (e.g., AMPK, SIRT1, FOXO) and modulation of inflammatory and apoptotic mediators. Clinical studies further confirm that consistent green tea intake is associated with reduced epigenetic age and improved biological markers of aging Conclusion: Green tea, through its epigenetic influence and antioxidant properties, presents itself as a natural and effective antiaging agent. Regular consumption may contribute to the prevention of age- related diseases and the promotion of healthy aging.
Anti-inflammatory and Insulin-sensitizing Effects of Combined Pandanus amaryllifolius and Syzygium polyanthum Extracts in HFD-STZ Induced Diabetic Rats Meilinda, Selvia; Lim, Hadyanto; Anto, Endy Juli; Siahaan, Jekson M; Tarigan, Menang B
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.66731

Abstract

Type 2 Diabetes Mellitus (T2DM) is a global health crisis characterized by insulin resistance and pancreatic -cell failure, largely driven by chronic low-grade inflammation. Elevated pro-inflammatory markers, particularly TNF- and IL-6, disrupt insulin signaling. While conventional oral hypoglycemics are effective, their long-term use is often hindered by adverse effects. Pandanus amaryllifolius and Syzygium polyanthum are polyphenol-rich medicinal plants with significant antioxidant potential. This study evaluates the in vivo efficacy of a combined ethanolic extract of these plants in reducing TNF-, IL-6, and HOMA-IR levels, alongside in silico validation of their bioactive compounds. An experimental posttest-only control group design was employed using HFD-STZ-induced male Wistar rats. Key parameters included blood glucose, HOMA-IR, inflammatory cytokines, and pancreatic histopathology. Molecular docking was conducted to analyze the interaction between bioactive compounds and glucose metabolism receptors. The combined extracts significantly suppressed systemic inflammation, marked by a substantial reduction in TNF- and IL-6. This correlated with improved insulin sensitivity and lower HOMA-IR values. Histopathologically, the 200 mg/kg BW dose showed the most significant recovery of the islets of Langerhans. In silico analysis confirmed that flavonoids like quercetin exhibit strong binding affinities to target proteins. The combination of P. amaryllifolius and S. polyanthum acts as a potent anti-inflammatory and insulin sensitizer, offering a promising adjuvant therapy for T2DM management.
Co-Authors Ardinata, Dedi - Blondina Marpaung br. Sembiring, Rehulina Br. T. Tambun, Gita Sradha Brar, Dylan Amrirtraj Chalil, M. Jalaluddin A. Cristianto Sagala, Rudy Diani Nazma Dohude, Priscilla Putri Derlian Donny Nauphar Endy Juli Anto Endy Juli Anto Fadinie, Wulan Fransella, Kezia Gultom, Helmida Hakim, Enggrek Pelita Hamdi, Tasrif Hasni, Dita Henny Erina Saurmauli Ompusunggu Herlen, Aldo Hutagalung, Sanggam B. Hutasoit, Eka Samuel P Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Irfan Hamdani, Irfan Irina, Sinta Jaminsen Sinaga Jeffrey ., Jeffrey Juli Jamnasi Juwita -, Juwita Koswara, Caroline Lubis, Andriamuri P. Lumban Raja, Alex Maruli Tua Manullang, Frengky S. Mega, Juli Yosa Meilinda, Selvia Natalie S., Karen Ompusunggu, Henny E.S. Pakpahan, Edwin Anto Panggabean, Kristina Dameria Pardede, Sumondang M. Pasaribu, Sumihar Rimbun, Surjadi Sembiring, Budi Darmanta Siahaan, Dwi Lunarta D. S. Siahaan, Dwi Lunarta Docterina Sutanti Siahaan, Dwi Lunarta Doderina Siahaan, Jekson M Siahaan, Jekson Martiar Sihite, Fiorella Natalia Kinanti Silaen, Ester L. R. Silitonga, Hendrika Adriana Simanjuntak, Salomo Garda Utama Simbolon, Boyke M. Sinatra, Jadeny Singh, Surjit Sinurat, Suryati Siregar, Kamal B. Sitepu, John Frans So Hanggrainy, Octavia Stephanie S., Kezia Suryati Sinurat Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tanjung, Qodri F. Tarigan, Juliyanti Tarigan, Menang B Tarigan, Menang Bastanta Tiji, Widjaya Taufik Tobing, Paul S. M. L. Umar Zein Vivian Vivian Yahwardiah Siregar YUNAFRI, ANDRI Zainumi, Cut M.