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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JCPS (Journal of Current Pharmaceutical Sciences) Dentin Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Odonto dental journal Jurnal Pengabdian Masyarakat Panacea Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Yusrinie Wasiaturrahmah
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KASTURI (Mangifera casturi) TERHADAP PERTUMBUHAN BAKTERI Aggregatibacter actinomycetemcomitans Luthfi Ridhwana; Fransiska Uli Arta Puspitasari; Yusrinie Wasiaturrahmah
Dentin Vol 4, No 2 (2020)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground: Prevalence of periodontitis in Indonesia is 74.1%, and periodontitis type that causes mayor periodontal damage with minimal microbiological factors is Aggressive Periodontitis. Microbiological factor in aggressive periodontitis is Aggregatibacter actinomycetemcomitans which producing toxins which stimulate the immune response and tissue damage. Many researchers today discover new antibiotic ingredients with a minimal side effect such as Kasturi plant. Kasturi leaf extract contains triterpenoids, flavonoids, tannins, and phenolic, which have the antibacterial effect. Objective: To Identifying and analyzing the effectiveness of antibacterial effect on Kasturi leaves extract against Aggregatibacter Actinomcetemcomitans growth. Methods: This study used true experimental post-test only with control group design by broth and agar dilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The result data analyzed with Kruskal-Wallis and Mann Whitney Post hoc test. Results: MIC was found at 20 mg/ml concentration and MBC at 40 mg/ml concentration. Conclusion: Kasturi leaf extract was effective in inhibited and stopped Aggregatibacter actinomycetemcomitans growth.Keywords :  Aggregatibacter actinomycetemcomitans, Aggressive Periodontitis, Kasturi leaf extract (Mangifera casturi), MBC, MIC.ABSTRAKLatar Belakang: Prevalensi periodontitis di Indonesia sebesar 74,1% dan periodontitis yang menimbulkan kerusakan besar dengan faktor mikrobiologi yang minimal yaitu periodontitis agresif. Faktor mikrobiologi berupa bakteri Aggregatibacter actinomycetemcomitans yang memproduksi toksin penyebab gangguan respons imun dan kerusakan jaringan. Penelitian mengenai bahan antibiotik dengan efek samping minimal telah banyak dilakukan salah satunya dengan tumbuhan Kasturi. Daun Kasturi mengandung senyawa berupa triterpenoid, flavonoid, tanin, dan fenol yang bersifat antibakteri. Tujuan: Mengetahui dan menganalisis efektivitas antibakteri ekstrak daun kasturi terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Metode: True experimental dengan desain post test only with control group dan mempunyai 6 kelompok perlakuan dengan 6 kali pengulangan. Penelitian ini menggunakan metode dilusi cair dan padat untuk mengetahui nilai Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM). Analisis data menggunakan metode Kruskal Wallis dan uji Post hoc Mann Whitney. Hasil: KHM pada ekstrak daun kasturi terdapat pada konsentrasi 20 mg/ml dan KBM pada konsentrasi 40 mg/ml. Kesimpulan: Ekstrak daun kasturi efektif dalam menghambat dan menghentikan pertumbuhan bakteri Aggregatibacter actinomycetemcomitans.Kata kunci :  Aggregatibacter actinomycetemcomitans, Ekstak Daun Kasturi (Mangifera casturi), KBM, KHM, Periodontitis Agresif,
FORMULASI DAN UJI STABLITAS FISIK GEL EKSTRAK BATANG PISANG MAULI (Musa acuminata) Maman Diki Wahyudi; Fitri Syahrina; Amy Nindia Carabelly; Dewi Puspitasari; Yusrinie Wasiaturrahmah
Dentin Vol 6, No 3 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v6i3.6824

Abstract

ABSTRACTBackground: Mauli banana is a typical South Kalimantan banana. Mauli banana stems contain active substances, such as tannins, saponins, alkaloids, flavonoids, and lycopene. Several studies have shown that Mauli banana stem extract (BPM) has anti-inflammatory, antibacterial properties and reduces the viability of Streptococcus Mutans and Lactobacillus acidophilus in the formation of dual-species biofilms. Gel formulations must have physical stability to ensure the physical stability of the gel, gel quality, and meet the criteria parameters during storage. The physical stability test of the gel was investigated for 16 days at room temperature. Gel stability tests were homogeneity, dispersion, and pH tests. Objectives: to determine the formulation and physical stability including homogeneity, dispersibility, and pH test of BPM gel 25%; 37.5%; 50%, and 62.5%. Methods: Mauli banana stems were obtained from SMK-PP Banjarbaru, tested for determination, made extracts, and made BPM gel by adding propylene glycol, glycerin, Na-CMC, nipagin, and aquadest, then testing for homogeneity, spreadability, and pH. Results: BPM gel showed homogeneous results until the 16th day with even distribution of color and no coarse grains. The BPM gel dispersion test met the criteria of 3cm-5cm until the 16th day with the results of the BPM gel dispersive power being 3.7cm-4.6cm. In the pH test, the BPM gel also met the criteria until the 16th day with a physiological pH of the oral cavity of 5.5-7.9. Conclusion: BPM gel with a concentration of 25%; 37.5%; 50% and 62.5% have results that match the criteria based on homogeneity, dispersion, and pH. Keyword: Gel, Mauli Banana Stem Extract, Physical Stability ABSTRAK Latar Belakang: Pisang mauli merupakan pisang khas Kalimantan Selatan. Batang pisang mauli mengandung zat aktif, seperti tanin, saponin, alkaloid, flavonoid dan likopen. Beberapa penelitian ekstrak batang pisang mauli (BPM) memiliki khasiat sebagai antiinflamasi, antibakteri dan menurunkan viabilitas Streptococcus Mutans serta Lactobacillus achidophilus dalam pembentukan dual-spesisies biofilm. Pembuatan formulasi sebuah gel harus memiliki stabilitas fisik agar menjamin kestabilan fisik gel, kualitas gel dan memenuhi parameter kriteria selama penyimpanan. Uji stabilitas fisik gel diteliti selama 16 hari pada suhu ruangan. Pengujian stabilitas gel yang dilakukan ialah uji homogenitas, uji daya sebar dan uji pH. Tujuan: Mengetahui formulasi dan stabilitas fisik meliputi uji homogenitas, daya sebar dan pH gel ekstrak batang pisang mauli (Musa acuminata) konsentrasi 25%; 37,5%; 50% dan 62,5%. Metode: Batang pisang mauli diperoleh dari SMK-PP Banjarbaru, diuji determinasi, dilakukan pembuatan ekstrak dan pembuatan gel BPM dengan menambahkan propilen glikol, glycerin, Na-CMC, nipagin dan aquadest, selanjutnya gel dilakukan uji homogenitas, daya sebar dan pH. Hasil: Uji homogenitas menunjukan gel BPM semua konsentrasi homogen sampai hari ke-16 dengan meratanya penyebaran warna dan tidak terdapat butiran kasar. Uji daya sebar gel BPM memenuhi kriteria 3cm-5cm sampai hari ke-16 dengan hasil range daya sebar gel BPM 3,7cm-4,6cm. Pada uji pH gel BPM seluruh konsentrasi juga memenuhi kriteria sampai hari ke-16 dengan pH fisiologis rongga mulut 5,5-7,9. Kesimpulan: Gel ekstrak batang pisang mauli konsentrasi 25%; 37,5%; 50% dan 62,5% memiliki hasil yang sesuai dengan kriteria berdasarkan homogenitas, daya sebar dan pH. Kata kunci : Ekstrak Pisang Mauli, Gel, Stabilitas Fisik
ANTIBACTERIAL EFFECTIVENESS OF WATER HYACINTH (Eichhornia crassipes) LEAF EXTRACT ON THE GROWTH OF Porphyromonas gingivalis Laili Nurul Islami; Beta Widya Oktiani; Yusrinie Wasiaturrahmah
Dentin Vol 7, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i2.9716

Abstract

Background: The most common periodontal disease is periodontitis which is frequently found in the form of chronic periodontitis. Such disease is caused by the accumulation of the bacterium Porphyromonas gingivalis where supporting therapy such as chlorhexidine gluconate mouthwash 0.2% can be given. However, its use in the long term can have a negative effect on the oral cavity. There is a natural plant, namely water hyacinth (Eichhornia crassipes) which contains compounds that can be used as antibacterial, such as: tannins, phenols, flavonoids, alkaloids, saponins, terpenoids, and steroids. As a result of this, the water hyacinth plant can be used as an alternative herbal medicine. Purpose: To analyze the antibacterial effectiveness of water hyacinth leaf extract (Eichhornia crassipes) against the growth of Porphyromonas gingivalis bacteria. Methods: This study used True Experimental with posttest only with control group design. Antibacterial test was performed using liquid dilution method to determine MIC and solid dilution to determine MBC. Results: Based on the results and data analysis, it was found that the water hyacinth leaf extract had MIC at 1,56% and MBC at a concentration of 50%. Conclusion: Leaf extract of water hyacinth (Eichhornia crassipes) can inhibit and have antibacterial properties against the growth of Porphyromonas gingivalis bacteria. Keywords:      Chronic periodontitis, Leaf extract of Water Hyacinth, Porphyromonas gingivalis
GAMBARAN KESEIMBANGAN UKURAN GIGI DENGAN ANALISIS BOLTON PADA PELAJAR SUKU BANJAR (USIA 15-18 TAHUN) Kholish Atikah Azzam; Diana Wibowo; Alexander Sitepu; Rosihan Adhani; Yusrinie Wasiaturrahmah
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13110

Abstract

ABSTRACTBackground: South Kalimantan recorded having a high incidence of dental and oral health problems around 59.6% and malocclusion cases around 12%. The population of Banjar tribe in South Kalimantan is around 90%. Banjar’s genetic factors can influence the development of tooth size therefore influence result of normal occlusion. Bolton analysis is an index needed to determine balance of tooth size of upper and lower jaw. Objective: The aim of this research is to describe the discrepancy sizes using Bolton analysis in Banjar students (aged 15-18 years). Method: This research is an observasional descriptive study with cross-sectional approach. Results: The results showed that the average balance value for the size of the 6 anterior teeth (Anterior Ratio) was 79.51% ± 8.67. It was found that 97.6% of the samples were unbalanced with the highest frequency of jaw discrepancies in the mandible and the average value for balance size of the 12 teeth. overall (Overall Ratio) 91.32 ± 5.17, it was found that 98.8% of the sample numbers were unbalanced with the highest frequency of jaw discrepancy in the maxilla, namely 46 people (56.1%). Conclusion: The balance of tooth size in the Banjar tribe based on the anterior Bolton ratio was found to be predominantly unbalanced with the highest imbalance located in the lower jaw (mandible) and the overall Bolton ratio was found to be predominantly unbalanced with the highest imbalance located in the upper jaw (maxilla).Keywords : Tooth Size Discrepancy; Bolton Analysis; Banjar tribe  ABSTRAK Latar Belakang: Kalimantan Selatan tercatat memiliki angka kejadian permasalahan kesehatan gigi dan mulut yang tinggi yaitu sekitar 59,6% dan kasus maloklusi sekitar 12%. Penduduk terbesar di Kalimantan Selatan adalah suku Banjar sekitar 90% dari populasi. Faktor genetik Suku Banjar dapat mempengaruhi perkembangan ukuran gigi sehingga dapat menentukan hasil oklusi normal. Analisis Bolton merupakan indeks yang sering digunakan dan diperlukan untuk menentukan keseimbangan ukuran gigi rahang atas dan bawah. Tujuan: Tujuan penelitian ini untuk mengambarkan keseimbangan ukuran gigi dengan analisis Bolton pada pelajar Suku Banjar (Usia 15-18 Tahun). Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan pendekatan cross-sectional Hasil: Hasil penelitian menunjukan nilai rata-rata keseimbangan ukuran 6 gigi anterior (Anterior Rasio) 79,51% ± 8,67 didapati 97,6% jumlah sampel tidak seimbang dengan frekuensi rahang yang berdeskrepansi terbanyak pada mandibula dan nilai rata-rata keseimbangan ukuran 12 gigi keseluruhan (Overall Rasio) 91,32 ± 5,17 didapati 98,8% jumlah sampel tidak seimbang dengan frekuensi rahang yang berdeskrepansi terbanyak pada maksila yaitu 46 orang (56,1%). Kesimpulan: Keseimbangan ukuran gigi pada Suku Banjar berdasarkan rasio anterior Bolton didapati mayoritas tidak seimbang dengan letak ketidakseimbangan tertinggi pada rahang bawah (mandibula) dan rasio keseluruhan Bolton didapati mayoritas tidak seimbang dengan letak ketidakseimbangan tertinggi pada rahang atas (maksila). Kata kunci :  Analisis Bolton, Keseimbangan Ukuran Gigi, Suku Banjar 
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KECAPI (Sandoricum koetjape Merr) TERHADAP PERTUMBUHAN BAKTERI Aggregatibacter actinomycetemcomitans (Studi in Vitro) Dini Maulani; Yusrinie Wasiaturrahmah; Bayu Indra Sukmana; I Wayan Arya Krisnawan Firdaus; Irham Taufiqurrahman
Dentin Vol 9, No 1 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i1.16559

Abstract

Background: Aggressive periodontitis is a disease that rapidly destroys the periodontal tissue caused by the dominance of Aggregatibacter actinomycetemcomitans bacteria by 90%. Aggressive periodontitis treatment can be in the form of antibiotics. One of the antibiotics that can be used is metronidazole gel 25%, but this drug can have side effects if used in the long term. There are herbal plants, namely kecapi leaves (Sandoricum koetjape Merr) which contain compounds that can be used as antibacterials including saponins, alkaloids, flavonoids, and triterpenoids. Objective: To determine the antibacterial effectiveness of kecapi leaves extract (Sandoricum koetjape Merr) concentrations of 10%, 20%, 30%, 40%, 50%, 60%, and 70% on the growth of Aggregatibacter actinomycetemcomitans bacteria. Methods: True experimental design with post test only with control group and there were 9 treatment groups with 3 repetitions. The treatment in this study was kecapi leaves extract concentration of 10%, 20%, 30%, 40%, 50%, 60%, and 70%, the positive control was metronidazole gel 25% and the negative control was aquadest. The antibacterial test used the liquid dilution method to determine the value of Minimum Inhibitory Content (MIC) and solid dilution to determine the value of Minimum Bactericidal Content (MBC). Results: Based on the results and data analysis, it was found that kecapi leaf extract had a Minimum Inhibitory Content (MIC) at a concentration of 10% and a Minimum Inhibitory Content (KBM) at a concentration of 30%. Conclusion: Kecapi leaves extract (Sandoricum koetjape Merr) concentration of 10%, 20%, 30%, 40%, 50%, 60%, and 70% has antibacterial effectiveness against the growth of Aggregatibacter actinomycetemcomitans.Keywords: Aggregatibacter actinomycetemcomitans, Aggressive Periodontitis, Kecapi leaves ABSTRAKLatar belakang: Periodontitis agresif merupakan penyakit yang merusak jaringan periodontal dengan cepat yang disebabkan oleh dominasi bakteri Aggregatibacter actinomycetemcomitans sebesar 90%. Perawatan periodontitis agresif dapat berupa antibiotik. Salah satu antibiotik yang dapat dipakai yaitu metronidazol gel 25%, namun obat ini dapat memberikan efek samping apabila digunakan dalam jangka panjang. Terdapat tumbuhan herbal yaitu daun kecapi (Sandoricum koetjape Merr) yang mengandung senyawa yang dapat digunakan sebagai antibakteri diantaranya saponin, alkaloid, flavonoid, dan triterpenoid. Tujuan: Mengetahui efektivitas antibakteri ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70% terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Metode: True experimental dengan desain post test only with control group dan terdapat 9 kelompok perlakuan dengan 3 kali pengulangan. Perlakuan pada penelitian ini yaitu ekstrak daun kecapi konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70%, kontrol positif berupa metronidazol gel 25% dan kontrol negatif berupa akuades. Uji antibakteri menggunakan metode dilusi cair untuk mengetahui nilai Kadar Hambat Minimum (KHM) dan dilusi padat untuk mengetahui nilai Kadar Bunuh Minimum (KBM). Hasil: Berdasarkan hasil dan analisis data didapatkan bahwa ekstrak daun kecapi memiliki Kadar Hambat Minimum (KHM) pada konsentrasi 10% dan Kadar Bunuh Minimum (KBM) pada konsentrasi 30%. Kesimpulan: Ekstrak daun kecapi (Sandoricum koetjape Merr) konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, dan 70% memiliki efektivitas antibakteri terhadap pertumbuhan bakteri Aggregatibacter actinomycetemcomitans.Kata Kunci : Aggregatibacter actinomycetemcomitans, Daun kecapi, Periodontitis Agresif
UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KALANGKALA (Litsea angulata) TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis (In vitro) Nor Rahman Sugiarto; Yusrinie Wasiaturrahmah; Tri Nurrahman; Muhammad Yanuar Ichrom Nahzi; Juliyatin Putri Utami; Bayu Indra Sukmana
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17742

Abstract

ABSTRACTBackground: Dental and oral health has not been a major focus due to the low level of public awareness regarding the importance of maintaining dental and oral health in Indonesia. Periodontitis is a disease with a prevalence of 74.1% in Indonesia. The main cause of chronic periodontitis is the bacterium  Porphyromonas gingivalis. Chlorhexidin  0.2% is gold standard that preventing periodontitis. However Chlorhexidin  0.2% has long-term side effects such as tooth discolouration. Therefore, an alternative mouthwash that has antibacterial properties is needed. Kalangkala leaf (Litsea angulata) is known to have the potential to inhibit the growth of  Porphyromonas gingivalis bacteria. Objective: To determine the antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against  Porphyromonas gingivalis bacteria with concentrations of 6.25%, 12.5%, 25%, and 50% based on the minimum inhibitory Concentration (MIC) and minimum bactericidal Concentration(MBC). Methods: True experimental research with posttest-only with control group design. The sample consisted of 6 groups with Chlorhexidin 0.2% as positive control and distilled water as negative control with 4 samples each. Data were analysed using normality, homogeneity, Krusskall wallis, and Mann-whitney tests. Results: From the test results, there was no minimum inhibition 6.25%, 12.5%, 25%, and 50%. The testing was not pursued for MBC. Conclusion: There is no antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against Porphyromonas gingivalis.Keywords: antibacteria, leaf extract, litsea angulata,  porphyromonas gingivalis ABSTRAK Latar Belakang: Kesehatan gigi dan mulut belum menjadi fokus utama karena tingkat kesadaran masyarakat yang rendah terkait pentingnya merawat kesehatan gigi dan mulut di Indonesia Periodontitis merupakan penyakit dengan prevalensi 74,1% di Indonesia. Penyebab utama periodontitis kronis yaitu bakteri Porphyromonas gingivalis. Chlorhexidin 0,2% merupakan gold standard dalam mencegah terjadinya periodontitis, tetapi Chlorhexidin  0,2% memiliki efek samping jangka panjang seperti perubahan warna pada gigi. Untuk mencegah terjadinya efek jangka panjang tersebut perlu obat kumur alternatif yang memiliki sifat antibakteri. Daun kalangkala (Litsea angulata) diketahui memiliki potensi untuk menghambat pertumbuhan bakteri Porphyromonas gingivalis. Tujuan: Mengetahui efektivitas antibakteri ekstrak daun kalangkala (Litsea angulata) terhadap bakteri Porphyromonas gingivalis dengan konsentrasi 6,25%, 12,5%, 25%, dan 50% berdasarkan Kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) Metode: Penelitian eksperimen murni (True Experimental) dengan rancangan percobaan menggunakan posttest-only with control group design. Sampel terdiri dari 6 kelompok dengan Chlorhexidin 0,2% sebagai kontrol positif dan akuades sebagai kontrol negatif dengan pengulangan masing-masing sebanyak 4 sampel. Data dianalisis dengan uji normalitas, homogenitas, Krusskall wallis, dan uji Mann-whitney. Hasil: Hasil uji tidak terdapat KHM pada semua konsentrasi ekstrak kalangkala yaitu konsentrasi 6,25%, 12,5%, 25%, dan 50%, sehingga tidak dilanjutkan untuk pengujian KBM. Kesimpulan: Tidak terdapat efektifitas antibakteri ekstrak daun kalangkala (Litsea angulata) konsentrasi 6,25%, 12,5%, 25%, dan 50% terhadap bakteri Porphyromonas gingivalis.Kata Kunci: antibakteri, ekstrak daun, litsea angulata porphyromonas gingivalis
PENGARUH PERENDAMAN GIGI DESIDUI PADA LARUTAN KITOSAN SISIK IKAN HARUAN (Channa striata) TERHADAP PELEPASAN ION KALSIUM Noval Ihza Maulana; Didit Aspriyanto; Deby Kania Tri Putri; Yusrinie Wasiaturrahmah; Sherli Diana
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13109

Abstract

ABSTRACTBackground: Haruan fish (Channa striata) scale chitosan solution can maintain tooth structure by reducing the solubility rate of hydroxyapatite which makes up tooth enamel. Haruan fish (Channa striata) scale chitosan solution prevents tooth demineralization in an acidic environment. Objective: To analyze the effect of soaking deciduous teeth in chitosan solution from haruan fish scales (Channa striata) with concentrations of 1.25%, 2.5% and 5% on the release of calcium ions in an acidic environment. Method: Pure experimental research with a post-test only design with control group, consisting of 4 treatment groups. The negative control was immersion of deciduous teeth in lactic acid solution pH 5.2, and treatment groups with concentrations of 1.25%, 2.5% and 5%. All groups soaked deciduous teeth in lactic acid solution with a pH of 5.2 for each group. Measurement of calcium release levels in deciduous teeth using UV-Vis spectrophotometry instruments. Results: The results of this study are hypothesized to be acceptable or that there is an effect of soaking deciduous teeth in haruan fish scale chitosan (Channa striata) concentrations of 1.25%, 2.5% and 5% in inhibiting the release of calcium ions. This study showed that there were no significant differences between the 1.25%, 2.5% and 5% treatment groups, but there were significant differences between the control group and all treatment groups. Conclusion: Haruan fish (Channa striata) scale chitosan with concentrations of 1.25%, 2.5%, and 5% is able to inhibit the release of calcium in deciduous teeth and has potential as a demineralization inhibitor biomaterial.Keywords :  Caries, Calcium, Chitosan, Demineralization, Haruan.  ABSTRAK Latar Belakang: Larutan kitosan sisik ikan haruan (Channa striata) dapat menjaga struktur gigi melalui proses penurunan laju kelarutan hidroksiapatit penyusun enamel gigi. Larutan kitosan sisik ikan haruan (Channa striata) mencegah demineralisasi gigi dalam lingkungan asam. Tujuan: Menganalisis pengaruh perendaman gigi desidui pada larutan kitosan dari sisik ikan haruan (Channa striata) dengan konsentrasi 1,25%, 2,5%, dan 5% terhadap pelepasan ion kalsium dalam lingkungan asam. Metode: Penelitian eksperimental murni dengan desain post-test only with control group, terdiri dari 4 kelompok perlakuan. Kontrol negatif yaitu perendaman gigi desidui pada larutan asam laktat pH 5,2, dan kelompok perlakuan konsentrasi 1,25%, 2,5%, serta 5%. Semua kelompok perendaman gigi desidui dalam larutan asam laktat dengan pH 5,2 dilakukan pada setiap kelompok. Pengukuran kadar pelepasan kalsium gigi desidui menggunakan instrumen spektrofotometri UV-Vis. Hasil: Hasil penelitian ini hipotesis dapat diterima atau adanya pengaruh perendaman gigi desidui pada kitosan sisik ikan haruan (Channa striata) konsentrasi 1,25%, 2,5%, dan 5% dalam menghambat pelepasan ion kalsium. Pada penelitian ini menunjukkan tidak adanya perbedaan signifikan antar kelompok perlakuan 1,25%, 2,5%, dan 5%, namun terdapat perbedaan bermakna antara kelompok kontrol dengan semua kelompok perlakuan. Kesimpulan: Kitosan sisik ikan haruan (Channa striata) dengan konsentrasi 1,25%, 2,5%, dan 5% mampu menghambat pelepasan kalsium pada gigi desidui dan memiliki potensi sebagai biomaterial agen penghambat demineralisasi. Kata kunci : Demineralisasi, Haruan, Kalsium, Karies, Kitosan
Co-Authors Adhimas Rilo Pambudi Adhiya, Geyanina Melda Agung Satria Wardhana Alexander Sitepu Almadina Latanza Amy Nindia Carabelly Anna Khumaira Sari Arifin, Rahmad Asphia Rahmah Aspriyanto, Didit Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Cita Nursyaina Tasya Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Diana Wibowo Difa Intannia Dini Maulani Erida Wydiamala Firdaus, I Wayan Arya Krishnawan Fitri Syahrina Fransiska Uli Arta Puspitasari I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Isnaini, Nazhifah Jatmiko, Habibi Naufal Khoirunnisa Muslimawati Kholish Atikah Azzam Krisna Erlangga Putra Ramadhani Laili Nurul Islami Luthfi Ridhwana Maharani Laillyza Apriasari Maharani Laylliza Apriasari Maman Diki Wahyudi Mega Sari Mia Fitriana MUHAMMAD RAYHAN Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nahzi, Yanuar Ichrom Namira Aghnina, A.M. Della Namira Fathya Salsabila Nida Amalia Nor Kamalia Nor Rahman Sugiarto Noval Ihza Maulana Nugraha, Tyas Setia Nurrahman, Tri Okta Muthia Sari Okta Muthia Sari Pambudi, Adhimas Rilo Pramitha, Selviana Rizky Putra, Aditya Maulana Perdana Putra, Fedriko Gamaliel Rahmatullah, Satrio Wibowo Ramadhaniyah, Nur Raudhatul Jannah Reski Nurafia Rosihan Adhani, Rosihan Sandi, Dita Ayulia Dwi Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri