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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Tropical and Infectious Disease Global Medical and Health Communication ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Universa Medicina Paediatrica Indonesiana Chimica et Natura Acta Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia International Journal of Health Science and Technology Odonto dental journal
Ani Melani Maskoen
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Althea Medical Journal

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Durian Consumption Effect on the Plasma Malondialdehyde Level as Biomarker of Stress Oxidative in Rats Amri, Anugrah Aulia Ulil; Maskoen, Ani Melani; Hidayat, Syarief
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Excessive consumption of durian (Durio zibethinus Murray) in Indonesia is often connected with its effect on health. This study aims to understand the effect of durian consumption to malondialdehyde (MDA) in plasma as oxidative stress biomarker.Methods: The study used an experimental research design on animal models, in the Biochemistry and Molecular Biology Department, Faculty of Medicine, Universitas Indonesia, July–August 2012. Thirty two Sprague-Dawley rats were used, divided into four groups: control, treatment week 1, 2, and 3. Each treatment group was given 20 gram durian fruit diluted with water until 20 ml volume per oral, divided into two doses (10 ml each) with 4 hours interlude between doses for 1 week, 2 weeks, and 3 weeks. All groups got normal diet and water ad libitum. Plasma MDA level was measured by TBARS method, then analyzed using Kurskal-Wallis and Mann-Whitney tests.Results: Seventeen samples were successfully decapitated (5 for control; 6 for week 1; 3 for week 2; 3 for week 3). Average plasma MDA level for control treatment week 1, 2 and 3 groups were 0.707 nmol/ml, 0.432 nmol/ml, 0.312 nmol/ml, and 0.746 nmol/ml respectively. Data was significant (p<0.05) with p=0.02. Compared with control group, a significant increase occurred in week 1 and 2 groups with p=0.028 and p=0.025 respectively.Conclusions: Results of durian consumption show MDA level significantly decreases in week 1 and 2. However, MDA level dramatically increases exceeding control group level in week 3. [AMJ.2016;3(1):22–8] DOI: 10.15850/amj.v3n1.695
Co-Authors Afandi Charles, Afandi Agnes Rengga Indrati Alvinsyah Adhityo Pramono Anggraini Widjajakusuma Anugrah Aulia Ulil Amri, Anugrah Aulia Ulil Artilia, Ira Atia Nurul Sidiqa Attamimi, Fathimah Azzahra Bethy S. Hernowo Budi Setiabudiawan Choirunnisa, Tias Cissy B. Kartasasmita Cynthia Kurniawan Dany Hilmanto Darwis, Rudi Satria Dewantoro, Julius Broto Dias Aryani Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Efendi, Sjarief Hidajat Eky Setiawan Soeria Soemantri Eriska Riyanti Fitri Rahmi Fadhilah Florence Meliawaty Hardisiswo Soedjana Hendro Hendro Herman Susanto Herman Susanto Herry Garna I Made Joni Ida Parwati Indah Puti Rahmayani S. Kamisah, Yusof Khan, Muhammad Salman Lelani Reniarti Lelani Reniarti Maulia Putri, Maulia Mohammad Ghozali Muqdas, Faza Annisa Myrna Nurlatifah Zakaria, Myrna Nurlatifah Nasroen, Saskia Lenggogeni Nita Susanti Nurul Setia Rahayu Penggoam, Simeon Prasdiaz, Putri Indriani Prima Nanda Fauziah R. Agus Nurwiadh Rachman, Levina Azzahra Rahaju, Asih Rahayu, Nurul Setia Ramdan Panigoro Ratna Indriyanti, Ratna Ratu Safitri Reni Ghrahani Rovina Ruslami, Rovina Rusdianto Rusdianto, Rusdianto Samsudin Surialaga Sari Puspa Dewi Sarilita, Erli Saskia L. Nasroen, Saskia L. Simeon Penggoam Sulaksono, Haura Labibah Salsabil Sumantri, Nur Imaniati Syarief Hidayat Tichvy Tammama, Tichvy Tri Hanggono Achmad Ullah, Irfan Widiarsih, Erlina Widiarsih, Erlina Wijaya, Michelle Angelica Youngest, Racy Yuliati, Tri Yuliati, Tri Zannah, Putry Nurul