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All Journal Jurnal Studi Pemerintahan JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Pharmaciana: Jurnal Kefarmasian Sainteknol : Jurnal Sains dan Teknologi Gadjah Mada International Journal of Business agriTECH Jurnal Kebijakan dan Administrasi Publik Al-Kimia Jurnal Bioedukatika Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Biota Molekul: Jurnal Ilmiah Kimia Berkala Penelitian Hayati INSECTA: Integrative Science Education and Teaching Activity Journal Molekul: Jurnal Ilmiah Kimia Biodik: Jurnal Ilmiah Pendidikan Biologi Bioma : Jurnal Ilmiah Biologi
Sabirin Matsjeh
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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GREEN SYNTHESIS OF HALOGEN SUBSTITUTED CHALCONE AGAINST CERVICAL CANCER (HeLa) CELL LINES Fikroh, Retno Aliyatul; Matsjeh, Sabirin; Anwar, Chairil; Nurohmah, Beta Achromi
INSECTA: Integrative Science Education and Teaching Activity Journal Vol. 4 No. 1 (2023)
Publisher : Science Education, Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/insecta.v4i1.5876

Abstract

Cervical cancer is the second leading cause of death in women. Many cancer treatments currently provide toxic effects on normal cells. Therefore, alternative treatment using chalcone derivatives has potent anticancer properties that can help reduce cancer side effects. Chalcone derivatives with halogen and methoxy groups in ring B can potentially inhibit cancer cells. This research aimed to synthesize halogen-substituted chalcone by a green chemistry approach and determine activity against cervical cancer (HeLa) cell lines. The Claisen-Schmidt reaction was used to synthesize 2'-hydroxy-2-bromo-4,5-dimethoxychalcone using a grinding technique. The purity of the synthesized compound was determined using thin-layer chromatography and melting range. The compounds' structures were characterized using FTIR, MS 1H, and 13C-NMR. The result showed that the synthesized compound was yielded in 53% as a yellow solid. In vitro cytotoxicity of the synthesized chalcone was evaluated by the MTT assay method. The IC50 of the compound was 67,23 μg/mL as a moderate activity inhibiting cervical cancer (HeLa) cell lines. Based on the IC50 value, this compound can be a candidate for anticancer against Cervical cancer (HeLa) cell lines.
SINTESIS SENYAWA 4-(5-BROMO-4-HIDROKSI-3-METOKSIFENIL)-3-BUTEN-2-OL DAN UJI POTENSI SEBAGAI ATRAKTAN LALAT BUAH HAMA Pradika, Yuri; Pranowo, Deni; Matsjeh, Sabirin
Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Vol 7, No 2 (2024)
Publisher : Universitas Islam Kalimantan MAB Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/dl.v7i2.15291

Abstract

Sintesis senyawa 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol dan uji potensi sebagai atraktan lalat buah telah dilakukan. Penelitian ini bertujuan untuk mensintesis senyawa 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol dan uji potensi sebagai atraktan lalat buah hama yang baru. Sintesis senyawa 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol tersebut dilakukan melalui tiga tahap, tahap pertama yaitu reaksi brominasi terhadap vanilin dengan menggunakan KBrO3 dan HBr dalam kondisi asam. Tahap kedua yaitu reaksi kondensasi aldol terhadap 5-bromovanilin dengan aseton menggunakan katalis NaOH 20%. Tahap ketiga yaitu sintesis senyawa 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol melalui reaksi reduksi produk kondensasi aldol dengan NaBH4. Senyawa produk hasil reaksi dianalisis dengan GC-MS dan FT-IR.  Hasil sintesis 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol berupa cairan dengan rendemen 48,77%. Uji potensi sebagai atraktan lalat buah hama menunjukkan bahwa senyawa hasil 4-(5-bromo-4-hidroksi-3-metoksifenil)-3-buten-2-ol dapat berpotensi sebagai atraktan lalat buah (Bactrocera spp).
ACTIVITY OF NONI EXTRACT (Morinda citrifolia L.) AS A BIOFUNGICIDE AGAINST THE GROWTH OF THE FUNGUS Fusarium oxysporum IN VITRO Puspitasari, Etika Dyah; Matsjeh, Sabirin; Mardiah, Ainun; Juni Lestari, Tri Tunggal; Kumalasari, Dewi; Kartika Sari, Prita Anggraeni
BIOMA : Jurnal Ilmiah Biologi Vol. 14 No. 1 (2025): April 2025
Publisher : LPPM Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v14i1.1185

Abstract

Fusarium oxysporum is a fungus that attacks various plants and causes wilting. Several plants, including bananas, have experienced a decrease in productivity due to the Fusarium fungus. This research aims to determine the effect of the whole plant of noni plants (fruits, leaves, and twigs), methanol extract, and ethyl acetate on the growth of fusarium fungi. To determine the optimal extract concentration to inhibit fungal growth. This research is a factorial study with independent variables in the form of extract, ingredients (fruit, leaves, and twigs), and differences in concentration. The activity of the extract as a biofungicide was analyzed based on the fungal growth inhibition zone. The results were analyzed using Anava and continued with the Duncan test. The research results show that methanol extract and ethyl acetate extract of noni have the potential as bio fungicides for the fungus Fusarium oxysporum. Noni fruit ethyl acetate extract at a concentration of 80% is optimum for inhibiting the growth of Fusarium oxysporum
The Effect of Methanol and Ethyl Acetate Extracts of Kirinyuh Stem (Eupatorium odoratum L.) on Antifungal Activity of Fusarium oxysporum: Fika Pita Loka; Sabirin Matsjeh; Etika Dyah Puspitasari
JURNAL BIOEDUKATIKA Vol. 11 No. 2 (2023)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26555/bioedukatika.v11i2.30900

Abstract

Fusarium oxysporum is a fungus that has a negative role, namely causing moler disease or Fusarium wilt in shallot plants. The purpose of this study was to determine the effect of methanol and ethyl acetate extracts of kirinyuh stem (Eupatorium odoratum L.) on the antifungal activity of Fusarium oxysporum. This study used a complete randomized design (CRD) with 8 treatments, namely negative control, positive control, concentrations of 10%, 20%, 40%, 60%, 80%, 100% with 3 replicates. The activity test was conducted using the Kirby Bauer method. Data from the study were processed by analysis of variance (one way anova) and continued by Duncan's test. The results showed that methanol and ethyl acetate extracts of kirinyuh stems affect the antifungal activity of Fusarium oxysporum. Ethyl acetate extract is more active to inhibit Fusarium oxysporum fungi compared to methanol extract. The highest inhibition zone diameter in the methanol extract was at 100% concentration which was 7.5 mm and the lowest at 10% concentration which was 2.67 mm. The highest inhibition zone diameter in the ethyl acetate extract was at 100% concentration which was 12.33 mm and the lowest at 10% concentration which was 4.67 mm.
ACTIVITY OF NONI EXTRACT (Morinda citrifolia L.) AS A BIOFUNGICIDE AGAINST THE GROWTH OF THE FUNGUS Fusarium oxysporum IN VITRO Puspitasari, Etika Dyah; Matsjeh, Sabirin; Mardiah, Ainun; Juni Lestari, Tri Tunggal; Kumalasari, Dewi; Kartika Sari, Prita Anggraeni
BIOMA : Jurnal Ilmiah Biologi Vol. 14 No. 1 (2025): April 2025
Publisher : Prodi Pendidikan Biologi, FPMIPATI, Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v14i1.1185

Abstract

Fusarium oxysporum is a fungus that attacks various plants and causes wilting. Several plants, including bananas, have experienced a decrease in productivity due to the Fusarium fungus. This research aims to determine the effect of the whole plant of noni plants (fruits, leaves, and twigs), methanol extract, and ethyl acetate on the growth of fusarium fungi. To determine the optimal extract concentration to inhibit fungal growth. This research is a factorial study with independent variables in the form of extract, ingredients (fruit, leaves, and twigs), and differences in concentration. The activity of the extract as a biofungicide was analyzed based on the fungal growth inhibition zone. The results were analyzed using Anava and continued with the Duncan test. The research results show that methanol extract and ethyl acetate extract of noni have the potential as bio fungicides for the fungus Fusarium oxysporum. Noni fruit ethyl acetate extract at a concentration of 80% is optimum for inhibiting the growth of Fusarium oxysporum
Co-Authors Ainun Mardiah Andi Hairil Alimuddin Andi Hairil Alimuddin Andi Hairil Alimuddin Andi Hairil Alimuddin Chairil Anwar Chairil Anwar Chairil Anwar Chairil Anwar Chairil Anwar Chairil Anwar Chairil Anwar Chairil Anwar Damayanti Iskandar Daratu Kusuma Eviana Putri Deni Pranowo Dewi Kumalasari Dwi Siswanta Dwi Siswanta Elfi Susanti V. H. Eti Nurwening Sholikhah Etika Dyah Puspitasari Fika Pita Loka Fikroh, Retno Aliyatul Hanoch J Sohilait HAPSARI, MAHARANI Hardjono Sastrohamidjojo Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Iqna Yudiyanti Ismiyarto Ismitarto J Stuart Grossert Jefry Presson Jumina Jumina Jumina Jumina Juni Lestari, Tri Tunggal Kapelle, Imanuel B. D. Kartika Sari, Prita Anggraeni KRISDIYATMIKO, KRISDIYATMIKO kusmiyati kusmiyati Kusmiyati kusmiyati La Harimu Lukas Pardosi Meta Permata Putri Mudasir Mudasir Mudasir Mudasir Mudasir Muhammad Idham Darussalam Mardjan Muhammad Idham Darussalam Mardjan Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mutmainah Mutmainah Nanik Lestari, Nanik Novia Suryani Nuniek Herdyastuti Nuniek Herdyastuti Nurohmah, Beta Achromi Oedjijono Oedjijono Pambudi, Wisnu Puji Lestari Purwati Purwati Puspitasari, Etika Dyah Ratna Dewi Kusumaningtyas Respati Tri Swasono Retno Aliyatul Fikroh Retno Aliyatul Fikroh Retno Ambarwati Rokhima Rostiani S Mursiti Santi Nur Handayani Sari Edi Cahyaningrum Siti Nuryanti Siti Nuryanti Sri Juari Santosa Sri Juari Santosa Susilawati Susilawati Susilawati Susilawati Syarifah Asyura Tri Joko Raharjo Tri Joko Raharjo Tri Redjeki Tutik Dwi Wahyuningsih Winarto Haryadi Winarto Haryadi Yuri Pradika Zulfah Az Zahra