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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JSFK (Jurnal Sains Farmasi & Klinis) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat JURNAL MEDIA KESEHATAN Jurnal Ilmiah Farmasi Farmasyifa Jurnal Pengabdian Masyarakat Bumi Raflesia Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharmacopoeia Indonesian Journal of Community Empowerment and Service Journal of Pharmaceutical and Sciences. BATOBO: Jurnal Pengabdian Kepada Masyarakat Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Bencoolen Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Abdimas Bencoolen
Dominica, Dwi
Program Studi S1 Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Bengkulu, Kota Bengkulu, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Sintesis Hijau Nanopartikel Perak Sebagai Antibakteri Nanda, Yogie Andika Tri; Dominica, Dwi; Haque, Aina Fatkhil; Rahmatullah, Febri
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 1 (2025): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i1.41356

Abstract

Nanopartikel perak adalah nanopartikel yang mengandung silver dalam molekulnya dan banyak digunakan sebagai agen antibakteri karena ukuran partikelnya yang kecil dan luas permukaan yang besar. Artikel ini bertujuan untuk menganalisis tentang sintesis hijau nanopartikel perak dan efektivitasnya sebagai antibakteri. Metode yang digunakan adalah studi literatur berbasis Systematic Literature Review (SLR) dengan mengumpulkan dan menganalisis artikel dari database Scopus, PubMed dan Elsevier. Hasil review menunjukkan bahwa sintesis hijau nanopartikel perak dapat dilakukan dengan menggunakan agen pereduksi alami dari ekstrak tumbuhan, yang menggantikan bahan kimia berbahaya dalam proses sintesis. Ekstrak tumbuhan mampu bermanfaat sebagai reduktor dalam proses sintesis nanopartikel perak. Karakterisasi nanopartikel perak dilakukan menggunakan berbagai teknik, seperti spektroskopi UV-Vis, spektroskopi FTIR, DLS, XRD, dan mikroskopi elektron (SEM, TEM). Efektivitas nanopartikel perak dipengaruhi oleh ukuran partikel, pH dan kondisi medium. Nanopartikel perak efektif melawan bakteri Gram-positif dan Gram-negatif melalui beberapa mekanisme, diantaranya perlekatan pada membran sel yang meningkatkan permeabilitas, pelepasan ion perak (Ag⁺) yang menghambat metabolisme dan replikasi bakteri, serta produksi spesies oksigen reaktif (ROS) yang menyebabkan stres oksidatif dan kerusakan sel bakteri. Dengan keunggulan ini, nanopartikel perak berpotensi besar dalam aplikasi medis sebagai agen antimikroba yang efektif dan berkelanjutan.
EVALUASI WAKTU HANCUR TABLET ASAM MEFENAMAT DENGAN VARIASI KONSENTRASI SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRAN MELALUI METODE GRANULASI BASAH Anjeliani, Cindy Choirina; Sari, Delia Komala; Sutanto, Teja Dwi; Dominica, Dwi; Ningrum, Karina Primatyas
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 2 (2025): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i2.43233

Abstract

Latarbelakang: Keberhasilan formulasi tablet sangat dipengaruhi oleh parameter mutu fisik, salah satunya adalah waktu hancur. Waktu hancur dapat memengaruhi bioavailabilitas obat, terutama pada zat aktif yang memiliki kelarutan rendah seperti asam mefenamat, sehingga pemilihan bahan penghancur seperti sodium starch glycolate (SSG) dan metode pembuatan yang tepat seperti granulasi basah sangat penting untuk memperbaiki kelarutan zat aktif. Metode: Penelitian ini merupakan studi eksperimental berupa formulasi tablet dengan granulasi basah menggunakan SSG 1–5%, lalu diuji waktu hancurnya. Hasil dan Pembahasan: Waktu hancur masing-masing formula, F1 (1%), F2 (2%), F3 (3%), F4 (4%), F5 (5%) berturut-turut adalah 3,52 menit, 2,72 menit, 2,56 menit, 1,52 menit, dan 1,31 menit, kelima formula memenuhi syarat uji waktu hancur yang baik. Kesimpulan: Semakin meningkat konsentrasi SSG, maka waktu hancur tablet menjadi semakin cepat, dan sebaliknya. Uji statistik one way ANOVA menunjukkan variasi konsentrasi SSG berpengaruh signifikan terhadap waktu disintegrasi tablet asam mefenamat.
Pengaruh Variasi Konsentrasi Minyak Atsiri Serai (Cymbopogon Flexuosus) Terhadap Stabilitas Sediaan Lotion dengan Kombinasi Emulgator TEA dan Asam Stearat Khairani, Marah; Sari, Delia Komala; Putranto, Agus M.H; Wulandari, Septi; Dominica, Dwi
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 2 (2025): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i2.43562

Abstract

Minyak atsiri serai (Cymbopogon flexuosus) mengandung senyawa aktif seperti citral dan geraniol yang memiliki potensi sebagai pengawet alami dalam sediaan kosmetik. Penelitian ini bertujuan untuk mengevaluasi pengaruh variasi konsentrasi minyak atsiri seraiterhadap stabilitas fisik sediaan lotion yang diformulasikan dengan kombinasi emulgator asam stearat dan triethanolamine (TEA). Metode: Penelitian ini merupakan studi eksperimental berupa formulasi Lotion yang dibuat dalam lima formula dengan konsentrasi minyak atsiri 0%, 0,5%, 1%, 1,5%, dan 2%. Evaluasi dilakukan terhadap parameter organoleptik, pH, daya sebar, daya lekat, danviskositas selama penyimpanan 28 hari. Hasil dan pembahasan: Hasil menunjukkan bahwa peningkatan konsentrasi minyak atsiri cenderung menyebabkan peningkatan daya sebar dan penurunan viskositas serta daya lekat, yang mengindikasikan gangguan kestabilan sistem emulsi. Namun, penambahan minyak atsiri serai juga menunjukkan peran sebagai pengawet alami, terbuktidari kemampuannya mempertahankan warna, aroma, dan tekstur sediaan selama penyimpanan. Kesimpulan: Minyak atsiri serai berpotensi digunakan sebagai pengawet alami dalam lotion, namun penggunaannya harus disesuaikan agar tidak mengganggu kestabilan fisik sediaan.
POTENSI SEDIAAN PATCH TRANSDERMAL EKSTRAK DAUN KAYU MANIS (Cinnamomum Burmannii) SEBAGAI OBAT LUKA Anggraini, Dewi Febrina; Kasmadi, Fathnur Sani; Danuartha, Dhimas; Efendi, M. Rifqi; Dominica, Dwi
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 2 (2025): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i2.44809

Abstract

Luka merupakan kerusakan jaringan yang membutuhkan penanganan cepat untuk mencegah infeksi dan mempercepat proses penyembuhan. Daun kayu manis (Cinnamomum burmannii) diketahui mengandung senyawa bioaktif seperti sinamaldehid, flavonoid, tanin, terpenoid, dan saponin yang berperan sebagai antibakteri, antiinflamasi, serta stimulan angiogenesis. Penelitian ini bertujuan mengembangkan sediaan patch transdermal ekstrak daun kayu manis sebagai terapi luka secara in vivo. Ekstrak diperoleh melalui metode maserasi etanol 70%, dilanjutkan karakterisasi, skrining fitokimia, formulasi patch, uji mutu fisik, serta uji efektivitas pada tikus putih (Rattus norvegicus) dengan luka eksisi. Hasil penelitian menunjukkan bahwa patch transdermal formula 3 dengan konsentrasi ekstrak 7,5% mampu mempercepat penyembuhan luka dengan persentase kesembuhan 84,07%, mendekati kontrol positif (89,26%) dan lebih tinggi dibandingkan kontrol negatif (63,59%). Patch transdermal ekstrak daun kayu manis berpotensi dikembangkan sebagai alternatif terapi herbal untuk mempercepat proses penyembuhan luka.
Uji Efek Antihiperglikemik Seduhan Daun Sirih Cina (Peperomia Pellicida) Diberikan Secara Oral Pada Mencit Jantan (Mus Musculus) Ruri Ayu Agrace; Riana Versita; Muhamad Arifin; Dwi Kurnia Putri; Dwi Dominica; Dian Handayani; Ikhsan Ikhsan
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 3 (2024): May : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i3.401

Abstract

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.
Aktivitas antibateri sediaan hand and body lotion dari ekstrak etanol daun binahong (Anredera cordifolia (Ten.) Steenis) terhadap bakteri Staphylococcus aureus Dominica, Dwi; Anisah, Saskia; Wibowo, Risky Hadi; Shufyani, Fahma
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.405

Abstract

Background: Formulation is an activity to design the composition of the active ingredients and additional ingredients to make specific preparations. One of the herbal plants that can be formulated in hand and body lotion is binahong leaves (Anredera cordifolia (Ten.) Steenis), which contain secondary metabolites such as flavonoids, saponins, alkaloids, and tannins. These secondary metabolites function as antibacterials. Gram-positive bacteria often cause skin problems, such as Staphylococcus aureus. This study aimed to determine the antibacterial activity of 5%, 7.5%, 10%, 12.5%, and 15% binahong leaf extract hand and body lotion against S. aureus bacteria. This research was conducted experimentally, including an examination of the physical quality of the preparation (organoleptic, homogeneity, pH, spreadability, and adhesion). This Method research is an experimental study, including collecting samples, making kepok banana heart calyx juice with concentrations of 2%, 4% and 6%, ointment evaluation tests and cut wound healing activity tests on white mice which were grouped into five groups with each group consisting of of 5 mice. Statistical analysis included a one-way ANOVA test to see whether there was a significant difference between concentrations and wound healing in white male mice. The results showed that binahong leaf extract could be formulated into hand and body lotion preparations because it has a homogeneous composition, a pH range of 4.8-5.1, spreadability of 5.7-6.0 cm, and adhesion of 2.16-2.49 seconds. Hand and body lotion preparations with 10% binahong leaf extract have the best physical quality. All formulations of binahong leaf extract hand and body lotion in this study could inhibit the growth of S. aureus with weak inhibition, and the best formula for inhibiting the growth of S. aureus was 15% binahong leaf extract hand and body lotion having a diameter of inhibition zone 2.575 m.
Hubungan pengetahuan ibu dengan tindakan manajemen swamedikasi pada anak balita di Desa Ketapang Dua Aceh Timur. Shufyani, Fahma; Siregar, Syati Manaharawan; Dominica, Dwi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.727

Abstract

Introduction: Self-medication is something that is often practiced by the Indonesian community as a way to take care of themselves when they are sick. Taking and consuming medication without advice from a healthcare professional, whether for diagnosis, prescription, or health supervision, is called self-medication. Self-medication can provide significant benefits to the government in maintaining national health if done correctly. Self-medication can assist healthcare professionals, reduce the time spent waiting for a doctor's diagnosis, and save money, especially in developing countries, because healthcare professionals will be more focused on more serious and critical health conditions. Objective: This study aims to determine mothers' knowledge about self-medication for fever and to understand the self-medication actions taken by mothers, as well as to examine the relationship between mothers' knowledge and their self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh. Method: This study uses a quantitative method of a descriptive-analytical nature with a cross-sectional design. The sampling technique used purposive sampling. Data were analyzed using the Chi Square test. Data collection was conducted in July 2024. The research population is the knowledge of mothers regarding self-medication management for toddlers in Ketapang Dua Village, East Aceh. The sample of this study consists of 40 respondents. Results: from this study indicate that 35% of mothers have a fairly good level of knowledge about self-medication for fever. Self-medication for fever in toddlers shows that around 47.5% have taken appropriate actions. There is a significant relationship between maternal knowledge and self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh, with a p-value of 0.026 < 0.05. It can be concluded that the presence of maternal knowledge regarding self-medication for fever in toddlers in Ketapang Dua Village, East Aceh, is classified as quite good. The conclusion: of this study is that the frequency distribution of maternal knowledge shows that some have fairly good knowledge, with 14 respondents (35.0%) and respondents with less adequate knowledge amounting to 21 respondents (65.5%). The frequency distribution of fever self-medication actions shows that some mothers provided appropriate self-medication actions, with 19 respondents (47.5%) doing so, while 21 respondents (52.5%) provided less appropriate self-medication actions. There is a significant relationship between maternal knowledge and self-medication practices for fever in toddlers in Ketapang Dua village, East Aceh, with a p-value of 0.026 > 0.05.
Pengaruh penambahan ekstrak kental daun kelapa sawit (Elaeis Guineensis Jacq.) terhadap viskositas krim tabir surya antijerawat Dominica, Dwi; Putri , Yona Harianti; Versita , Riana; Shufyani , Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.729

Abstract

Introduction: ROS due to sun exposure can damage the skin. Skin structures that are damaged or thinned cause the risk of acne on the skin, one of which is that the skin can be infected with acne-causing bacteria. Palm leaf (Elaeis guineensis Jacq.) is one of the plants that has good antioxidants and antibacterial. The aim: This study aims to determine the effect of the addition of extracts on the viscosity of anti-acne sunscreen creams. Methods: This study was experimental by conducting a viscosity test of sunscreen preparations using a brokfield viscometer. The results of this study show that Formula F1 (1.5%) has the highest viscosity of 8,970 cPs, followed by F2 (3%) at 7890 cPs, and F3 (4.5%) at 7090 cPs which is included in the good viscosity range. Sunscreen creams have pseudoplastic flow properties. Conclusion: the higher the concentration of the extract, the greater the viscosity of the preparation.
UJI EFEKTIVITAS ANTIBAKTERI SABUN CUCI TANGAN YANG MENGANDUNG PERASAN JERUK KALIMANSI (Citrofotunella microcarpa) Dwi Dominica; Dian Handayani; Delia Komalasari; Buistu Arbaa Nuyuh Putri; Dinda Zulkarnain; Kurnia Hafidzah; Rizki Hadi Wibowo
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.437

Abstract

Kalamansi orange with the Latin name Citrofortunella microcarpa is an agricultural commodity that has been widely developed in Bengkulu Province. This study aims to determine the anti-bacterial activity of hand washing soap containing kalimansi orange juice against pathogenic bacteria, one of which is the bacteria S. aureus and E. Coli. The method used in this research is disc paper diffusion. The results of the antibacterial activity test were marked by the formation of a clear area around the disc paper on the media, the largest diameter of inhibition for S. aureus bacteria was given by F2, namely 30.595 mm and the largest diameter of inhibition for E. coli bacteria, which was given by F3, namely 28, 98mm so that it gets a very strong category. When compared to the comparator handsoap in the market HSFFLS @ the inhibitory power of hand washing soap from kalimansi orange juice was also greater both against S.aureus and E. Coli bacteria. The results of the inhibitory activity test between gram-positive and gram-negative bacteria showed that hand washing soap containing kalimansi orange juice had a greater potential for S. aureus gram-positive bacteria compared to Gram-negative bacteria E. Coli.
Pelatihan Pembuatan Permen Jelly Jeruk Kalamansi di Desa Panca Mukti Sebagai Imunomodulator Dominica, Dwi; Handayani, Dian; Yona Harianti Putri; Etriyanto Arman; Denty Safitri; Mutia Annisa Putri Pin Saadin; Susan Jaya Mutiara M Nur; Elsya Agustina; Lathifa Olivia Adeshi; Amanda Gusti Fatika
Indonesian Journal of Community Empowerment and Service (ICOMES) Vol. 5 No. 2 (2025): December 2025
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/icomes.v5i2.44735

Abstract

Kegiatan pengabdian kepada masyarakat ini dilatarbelakangi oleh Desa Panca Mukti yang memiliki akses dekat terhadap perkebunan jeruk kalamansi tetapi pemanfaatannya masih terbatas, padahal buah ini kaya vitamin C dan berpotensi sebagai imunomodulator alami. Masyarakat setempat, khususnya ibu-ibu PKK, membutuhkan inovasi olahan berbasis bahan lokal yang tidak hanya meningkatkan kesehatan tetapi juga memiliki nilai ekonomi. Oleh karena itu, kegiatan ini bertujuan memperluas pengetahuan dan meningkatkan keterampilan masyarakat dalam mengolah jeruk kalamansi menjadi permen jelly herbal sebagai produk nutrasetikal peningkat daya tahan tubuh. Pelatihan dilaksanakan selama dua jam (10.00–12.00 WIB) dan diikuti oleh 26 peserta melalui penyampaian materi edukatif serta praktik langsung. Evaluasi dilakukan melalui pre-test dan post-test. Hasil evaluasi menunjukkan peningkatan signifikan pada tingkat pemahaman peserta dengan rata-rata skor pre-test sebesar 74,58% dan post-test meningkat menjadi 95,36%. Kegiatan ini memberikan dampak positif berupa peningkatan pengetahuan, keterampilan, serta munculnya peluang pemanfaatan potensi lokal menjadi produk fungsional dan bernilai ekonomis. Selain mendorong inovasi masyarakat, kegiatan ini juga berkontribusi pada upaya peningkatan kesehatan preventif melalui pemanfaatan bahan alam lokal yang bersifat imunomodulator.
Co-Authors Agung Giri Samudra Agus Martono Hadi Putranto Aina Fatkhil Haque, Aina Fatkhil Amanda Gusti Fatika Anggi Triphosa Simanjuntak Anggraini, Dewi Febrina Anisah, Saskia Anjeliani, Cindy Choirina Azhar, Afra Wafiqah Buistu Arbaa Nuyuh Putri Danuartha, Dhimas Dea Eka Rina Deddi Prima Putra Delia Komala Sari, Delia Komala Delia Komalasari Denty Safitri Dhea Ananda Dian Handayani Dian Handayani Dian Handayani Dian Handayani Dinah Khairunisah Dinda Zulkarnain Dinda Zulkarnain Dionni Ditya Perdana Dwi Kurnia Putri Dwita Oktiarni Elsya Agustina Etriyanto Arman Fadilla, Alena Fahma Shufyani Fahma Shufyani Feby R.A Putri Firza, Bunga Al I Ketut Suada Ikhsan Ikhsan Khairani, Marah Kurnia Hafidzah Lathifa Olivia Adeshi M. Rifqi Efendi Maharini, Indri Maulina, Tya Chalifatul Mayang Sari Muhamad Arifin Muhammad Andry Mutia Annisa Putri Pin Saadin Nanda, Yogie Andika Tri Ningrum, Karina Primatyas Okta, Fauzia Noprima Oktarini, Rizki Oktoviani Pratiwi, Reza Puspa Dwi Pratiwi Putri , Yona Harianti Putri, Fadilla Aliyah Putri, Yona Harianti Rahmatullah, Febri Rahmawati, Reza Reza Pertiwi Reza Rahmawati Riana Versita Rizki Hadi Wibowo Ruri Ayu Agrace SALPRIMA YUDHA S Sani K, Fathnur SEPTI WULANDARI Shufyani , Fahma Shufyani, Fahma Susan Jaya Mutiara M Nur Syati Manaharawan Siregar Teja Dwi Sutanto Tiara Feni Lestari Triawan, Deni Agus Tya Chalifatul Versita , Riana Versita, Riana Wibowo, Risky Hadi Yesika, Relin Yolanda, Sefty Yona Harianti Putri Yulihasri Yustisia, Nova