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All Journal BULETIN OSEANOGRAFI MARINA Jurnal Akuatika Jurnal Perikanan Kelautan Jurnal Kelautan : Indonesian Journal of Marine Science and Technology Jurnal Pengelolaan Sumberdaya Alam dan Lingkungan (Journal of Natural Resources and Environmental Management) Jurnal Akuatika Indonesia Jurnal Biodjati JFMR (Journal of Fisheries and Marine Research) ALCHEMY Jurnal Penelitian Kimia JURNAL CITRA KEPERAWATAN Indonesian Journal of Chemistry Journal of Aquaculture and Fish Health Journal Of Human And Education (JAHE) Makara Journal of Science Jurnal Perspektif Pembiayaan dan Pembangunan Daerah DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Masyarakat Jurnal Perikanan
Yeni Mulyani
Department Of Marine Science Faculty Of Fisheries And Marine Sciences Universitas Padjadjaran Jl. Raya Bandung Sumedang KM 21, Jatinangor West Java 45363, Indonesia
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Journal : Makara Journal of Science

 1 
Diketopiperazine Cyclo-(S-Pro-R-Leu) Produced by Periconia pseudobyssoides K5 Isolated from Toona sureni (Meliaceae) and its Heme Polymerization Inhibition Activity Azhari, Azmi; Harneti, Desi; Wulandari, Asri Peni; Mulyani, Yeni; Purbaya, Sari; Sari, Aprilia Permata; Pratama, Galih Bayu; Supratman, Unang; Shiono, Yoshihito
Makara Journal of Science Vol. 27, No. 1
Publisher : UI Scholars Hub

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Abstract

Fungi endophytes are living microorganisms colonizing inside the internal tissue of a plant and provide ecological benefits for their host. Endophytes provide various metabolites for plant adaptation toward biotic and abiotic stresses and have tremendous pharmacological activities. Toona sureni (T. sureni) (Meliaceae) belongs to the Toona genera and is reported to have antimalarial activity. To determine the compounds produced by the endophytic fungus from this plant, we isolated a compound from Periconia pseudobyssoides (P. pseudobyssoides) K5 endophytes from the stem bark of T. sureni. Diketopiperazine cyclo-(S-Pro-R-Leu), a non-ribosomal peptide, was isolated from brown rice fermented at 28 ± 2 ℃ for 30 days. The structure was determined by spectroscopic methods including fourier-transform infrared spectroscopy, mass spectrometry, and 1D and 2D nuclear magnetic resonance techniques. This compound was evaluated for heme polymerization inhibition activity (HPIA) with an IC50 value of 9.89 ± 0.24 mmol/L compared with positive control chloroquine phosphate with an IC50 value of 3.08 ± 0.58 mmol/L. This compound has been categorized as having low activity three times lower than positive control chloroquine phosphate. This information provides new leads about the compound diketopiperazine cyclo-(S-Pro-R-Leu) produced by P. pseudobyssoides K5 endophytes having low activity in inhibiting heme polymerization. In the future, to explore the potency of this compound as antimalarial agent, the other antimalarial test such as lactate dehydrogenase assay might be useful.
Co-Authors Agung Ramos Agung, M. Untung Kurnia Agung, Mochamad Untung Kurnia Aisyah Aisyah Aisyah Aisyah alfiah alfiah Ani Mardiastuti Ankiq Taofiqurohman Annisa Putri Fitrian Aprilia Permata Sari Ardhiansyah, Rasendriya Naufal Arief, Mochamad Candra Wirawan Asri Peni Wulandari Asri Peni Wulandari, Asri Peni Azmi Azhari Azmi Azhari, Azmi Bai'un, Nurul Hanifah Chandra, Vinoba Dede Supriatna Desi Harneti Putri Huspa Dewi Oktaviani Dhian Ririn Lestari, Dhian Ririn Donny Juliandri Prihadi Emma Rochima Eri Bachtiar Evi Liviawaty Fahrian, Hijrah Fajar Fauzi Abdullah Feby Arma Putra Fiddy Semba Prasetiya Fiddy Semba Prasetiya Galih Bayu Pratama Gustiani - Husnul Khotimah Ibnu Dwi Buwono Ibnu Faizal Iis Rostini Iklima Hasanah Indah Riyantini Indah Riyantini Indah Riyantini Jannah, Rodiatul Julaehah, Julaehah Kalysta Fellatami Karimah Syakirotin Kiki Haetami Kindi Farabi Lesta Krismawati Baeha Lestari, Indri Liawati, Liawati Lintang Permata Sari Yuliandi Madaniah AS, Ida Mahdalena Mahdalena Mala Septiani Manshur Awalludin Mega L. Syamsuddin Mochamad Rudyansyah Ismail Mochamad Untung Kurnia Agung Mochamad Untung Kurnia Agung Mochammad Agung Seno Pambudi Muhammad Andhika Pratama Muhammad Untung Kurnia Agung Muhammad Untung Kurnia Agung Mutaqin, Moh Fikri Tanzil Nilawati, Neli Noir P Purba Noir Primadona Purba Norsyehan Nuraini, Eviatun Nurfitriani, Evi Okliandi Saputra Pamungkas, Wahyuniar Pramunandya, Raka Aditya Pratama, Galih Bayu Purbaya, Sari Rega Permana Rizany, Ichsan Rohyati, Rohyati Rudy Kurniadi Sapari, Sapari Saptari, Muhammad Khairan Sari Purbaya Sari, Aprilia Permata Satrio Hadisnugroho Shiono, Yoshihito Siti Alfiah Solihat, Anisa Soraya, Afa Sulastri Arsad Sulehah, Sulehah sumarni, nini sunarto sunarto Syakirotin, Karimah Syawaludin Alisyahbana Harahap Tri Dewi K Pribadi Unang Supratman Vega K. Nurulita Wahyu Syafriansyah Wahyuniar Pamungkas Widyasthana, Ferdiansyah Naufal Yoshihito Shiono Yudi Nurul Ihsan Yuniar Mulyani Zahidah - Zallesa, Sheila Zendina, Luthfia