Article Per Year (5 Year)
p-Index From 2020 - 2025
7.814
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan EQUILIBRIUM Majalah Kedokteran Gigi Indonesia Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Jurnal Ilmiah Kedokteran Wijaya Kusuma Health Notions INVOTEK: Jurnal Inovasi Vokasional dan Teknologi Multidiciplinary Journal Medical Technology and Public Health Journal Jurnal Mekanova : Mekanikal, Inovasi dan Teknologi Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Indonesian Journal of electronics, electromedical engineering, and medical informatics Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Journal of Telenursing (JOTING) Jurnal Surya Muda: Ilmu Keperawatan dan Ilmu Kesehatan Indonesian Journal of Anesthesiology and Reanimation (IJAR) AloHA International Journal of Health Advancement (AIJHA) Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) GANESHA MEDICINA Hang Tuah Medical Journal Jurnal Pengabdian Pada Masyarakat Journal for Quality in Public Health Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Manajemen dan Pendidikan Agama Islam Neurona Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics International Journal of Kita Kreatif Jurnal Inovasi Pendidikan Dasar dan Menengah
Al Munawir
Department Of Pathology, Faculty Of Medicine, University Of Jember, Jember, 68121 Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 72 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : UNEJ e-Proceeding

 1 
EFFECT OF POMELO (CITRUS GRANDIS) ETHANOLIC EXTRACT ON ATHEROSCLEROTIC PLAQUE FORMATION Mudzakkir Taufiqurrahman; Kiky Martha Ariesaka; Hilda Khairinnisa; Wahyu Dian Puspita; Azka Darajat; Al Munawir
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cardiovascular disease is a major health problem in developed and developing countries and still be the first rank causing death in the world, including Indonesia. Most of cardiovascular disease caused by atherosclerosis. Macrophage apoptosis can reduce the size of atherogenic lesions and the progression of atherosclerotic plaque formation. Proapopstosis effects on macrophages owned by flavonoids. This study aims to know the potential of flavonoids found in Citrus grandis extract which works by suppressing the phosphorylation of AKT Ser473 so that the formation of foam cells (foam call) can be minimized. The research sample is 38 male Wistar rats weighing 90-150 grams. Samples were divided into 5 groups. All groups except normal control group were induced atherosclerosis by utilizing the shear stress mechanism at the branch of the abdominal aorta. Shear stress created by injecting adrenaline i.v. followed by hyperlipidemic diet (egg yolk) for 3 weeks. Then, during the next two weeks, the positive control group treated with simvastatin, while the treatment group were treated with extracts of C. grandis (ECG) known to contains flavonoids. Macroscopic showed that ECG could reduce atherosclerotic lesions. of citrus grandis. The sample data captured in the form of mouse blood and abdominal aortic tissues. Based on the results of the TLC screening, Ethanolic Extrxct Meanwhile, the group given simvastatin as a positive control also showed fewer atherosclerotic lesions. ECG proven to lower cholesterol and triglyceride levels of rats that had been induced atherosclerosis. Award ECG doses of 500 and 1000 mg/kg showed a significant decrease in cholesterol (p <0.01) compared to the negative control group. ECG is proven to reduce atherosclerotic lesions, so that ECG can be used as an adjuvant for simvastatin to achieve maximal therapeutic effect against atherosclerosis.
Co-Authors . Zulfan Abd, Misswar Abd, Miswar Achmad, Fariz Ade Ananta Pratiwi Adelia Handoko Adinningtyas Intansari Adji, Novan K. Agung Sudrajat Agung_Sudrajat Agung Aini Hidayati Ali Santoso Alimas Jonsa Alloysius Vendhi Prasmoro, Alloysius Vendhi Anang Dwi Atmoko Ancah Caesarina Novi Marchianti Anhar Fazri Asti Nuris ASTUTI, IDA SRI SURANI WIJI Aulia Rahman Aulia, Tesya Ayik Nikmatul Laili Azka Darajat Bachtiar, Dandi Bagus Indra Kusuma Darmawan, Reza Dear F Sielma Desi Maulida Desy Tariustanti Desy Tariustanti Dewi Rokhmah dian febrianti Dika Pangestu, Yusufa Dori Yuvenda Edy Kurniawan Elfian Zulkarnain Elfian Zulkarnain, Elfian Erfan Efendi Erma Sulistyaningsih Farida Wahyu Ningtyias, Farida Wahyu Farida Wahyuningtiyas Farizal, Teuku Futri Syam Ghiza J.K. Barqly Hadi Prayitno Hartati, Rita Hasdi, Syaiful Hazmi Dwinanda Nurqistan Hendri, Afrizal Herdi Susanto Herri Darsan Hilda Khairinnisa I Gusti Ngurah Agung Darma Putra Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Ikmala, Riskita Isa Marufi ISLAMI, SHOFI IQDA Jalil, Muhammad Jauhar Firdaus Jayadi, Farid Jumanto Jumanto Kamarullah Kamarullah Kiky Martha Ariesaka kustin uds Laili, Ayik Nikmatul laili, Ayik Nikmatul Laksmi Indreswari Luluk Faridatul Mukaromah M. Yasep Setiawan Mahmuddin Marbun Maidi Saputra Masykur, Masykur Meylis Safriani Mirza Adia Nova Muazar, Muazar Mudzakkir Taufiqurrahman Muflikhatun, Khanif Muhammad Abrar Muhammad Aqib Husni Fadhli Muhammad Arif Nasution Muhammad Herizal Ihza Muhendra, Rifki Mulkan, Andi Murhaban Murhaban Murhaban Murtadho Ridwan Muzakir Muzakkir Muzakkir N. Nazaruddin Nabiel, Rifaldy Nadia Putri Yurianto Nafolion Nur Rahmat, Nafolion Nur Nanda Prima Natasya Febrilia Yulianti Novan K. Adji Pandan, Pandan wangi Pipiet Wulandari Pribadyo, Pribadyo Putri Erlinda Kusumaningarum Putri Kemala Sari Putri, Gusfita Trisna Ayu Raudhatun Nafisah Retno Widyastuti Riskita Ikmala Rita Fazlina Rizka N Wardani Rizki, Julia Roat Yeti Mustafida Romadhon, Nadia Jean Rosita Dewi Rudy Gunawan Sabrina M Pratama Safrirullah Safrirullah Saiful Bukhori Saiful Bukhori, Saiful Bukhori Salman Al Farisi samsunan Sarwendah Siswi Winasis Sayyidah Auliany Aminy Sekar Arum Srigati septa surya wahyudi, septa surya SHOFI IQDA ISLAMI Sihaan, Josua Cornel Roni Silvi Ahmada Chasya Solihin Solihin Solihin, Solihin Solihin Sri Wahyu Handayani Sugiyanta Sugiyanta Sukhairi, Teuku Ariessa Supangat Supangat Supangat Supangat Supangat Syahrul Fathi Syari, Zammiq Utami, Nastiti Bekti Vita Alfiatul Hasanah Wahyu Dian Puspita Widyantoro, Murwan Wiqodatul Ummah Y, Fadhil Yasrizal Yulianti, Natasya F. Yusnan, Muhammad Zahrah Febianti Zakir Husin Zarah Puspita Zarah Puspitaningtyas Zuhrizal Fadhly Zulfadhli Zulfadhli Zulfan Adi Putra