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Al Munawir
Department Of Pathology, Faculty Of Medicine, University Of Jember, Jember, 68121 Indonesia
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Journal : Neurona

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PEMANFAATAN ALPHA LIPOIC ACID SEBAGAI INHIBITOR DEGENERASI PROTEIN TAU UNTUK PENCEGAHAN CHRONIC TRAUMATIC ENCEPHALOPATHY Gunawan, Rudy; Utami, Nastiti Bekti; Putri, Gusfita Trisna Ayu; Romadhon, Nadia Jean; Muflikhatun, Khanif; Munawir, Al
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.36

Abstract

     THE USE OF ALPHA LIPOIC ACID AS TAU PROTEIN DEGENERATION INHIBITOR ON PREVENCE CHRONIC TRAUMATIC ENCEPHALOPATHYABSTRACTIntroduction: Chronic traumatic encephalopathy (CTE) is progressive neurodegenerative syndrome caused by repeated blunt object injury affects the head. This condition results in degeneration of tau, a protein that can help stabilize and support certain structures in brain’s cells, including internal transport system of the brain’s cell. Repeated injuries cause the degeneration of tau proteins that proteins misfold and change their form and then become free radicals cause neuron death. Alpha lipoic acid (ALA) is one of the antioxidant can bind free radicals and regenerate antioxidant vitamin C, vitamin E, and coenzyme Q10.Aim: To exam the effectiveness of alpha lipoic acid to inhibit the degeneration of tau protein in immunohistochemistry experimental animals’s brain.Methods: Experimental study in vivo of CTE model in rat by dropped 245g load on the head at 35cm height. 28 rats were randomly assigned to 7 groups; normal group without treatment, negative control group is given NaCl 0.9% 1.5mL, positive control group is given citicholine 6.75mg, group A is given ALA 1.0125mg, group B is given ALA 2.025mg, group C is given ALA 4.05mg, group D is given ALA 8.1mg and received 30 days CTE treatment. Experiment was conducted in May 2017 at Medical Faculty University of Jember. Tau protein degeneration were scored immunohistochemically.Results: Group D showed the closest to normal, while group A showed most tau protein degeneration (190.25±26.89) compared to normal group (53.25±43.39). Group D also showed lower tau protein score compared to positive control significantly.Discussion: Alpha lipoic acid is able to inhibit the progression of tau protein degeneration on immunohistochemistry staining of animal’s brains in CTE model.Keyword: Alpha lipoic acid, chronic traumatic encephalopathy, tau proteinABSTRAKPendahuluan: Chronic traumatic encephalopathy (CTE) adalah sindrom neurodegeneratif progresif akibat cedera berulang benda tumpul yang mengenai kepala. Cedera berulang tersebut menyebabkan degenerasi protein tau, yaitu protein yang dapat membantu menstabilkan dan mendukung struktur tertentu dalam sel otak, termasuk sel dari sistem transportasi internal. Akibatnya, protein tau gagal melipat dan mengubah bentuk, sehingga menjadi radikal bebas yang dapat menye- babkan kematian neuron. Alpha lipoic acid (ALA) adalah salah satu senyawa antioksidan yang mampu mengikat radikal bebas dan meregenerasi antioksidan vitamin C, vitamin E, dan koenzim Q 10.Tujuan: Mengetahui efektivitas pemberian alpha lipoic acid dalam menghambat progresivitas degenerasi protein tau pada gambaran imunohistokimia otak hewan coba.Metode: Studi eksperimental in vivo model CTE pada tikus dengan dijatuhi beban 245g di kepala pada ketinggian35cm. Terdapat 28 tikus yang dibagi menjadi 7 kelompok, yaitu: kelompok normal tanpa perlakuan, kelompok kontrol (-) diberikan NaCl 1,5mL, kontrol (+) diberikan sitikolin 6,75mg, kelompok A diberikan ALA 1,0125mg, kelompok B diberi- kan ALA 2,025mg, kelompok C diberikan ALA 4,05mg, serta kelompok D diberikan ALA 8,1mg dan mendapat perlakuan CTE selama 30 hari. Penelitian dilakukan pada bulan Mei 2017 di Fakultas Kedokteran Universitas Jember. Pemeriksaan skor degenerasi protein tau berdasarkan gambaran imunohistokimia.Hasil: Kelompok D dengan dosis tertinggi 8,1mg merupakan gambaran degenerasi protein tau paling sedikit mendekati normal, sedangkan kelompok A dengan dosis terendah 1,0125mg merupakan gambaran degenerasi protein tau paling banyak (190,25±26,89), jauh lebih tinggi dibandingkan kelompok normal (53,25±43,39). Demikian pula kelompok D dengan kontrol positif menunjukkan skor degenerasi protein tau kelompok D lebih rendah dibandingkan dengan kontrol positif secara bermakna.Diskusi: Pemberian ALA dosis tinggi mampu menghambat progresivitas degenerasi protein tau pada gambaran imunohistokimia otak hewan coba yang mengalami cedera kepala berulang.Kata kunci: Alpha lipoic acid, chronic traumatic encephalopathy, protein tau
Co-Authors . Zulfan Abd, Misswar Abd, Miswar Achmad, Fariz Ade Ananta Pratiwi Adelia Handoko Adinningtyas Intansari Adji, Novan K. Agung Sudrajat Agung_Sudrajat Agung Aini Hidayati Ali Santoso Alimas Jonsa Alloysius Vendhi Prasmoro, Alloysius Vendhi Anang Dwi Atmoko Ancah Caesarina Novi Marchianti Anhar Fazri Asti Nuris ASTUTI, IDA SRI SURANI WIJI Aulia, Tesya Ayik Nikmatul Laili Azka Darajat Bachtiar, Dandi Bagus Indra Kusuma Darmawan, Reza Dear F Sielma Desi Maulida Desy Tariustanti Desy Tariustanti Dewi Rokhmah dian febrianti Dika Pangestu, Yusufa Dori Yuvenda Edy Kurniawan Elfian Zulkarnain Elfian Zulkarnain, Elfian Erfan Efendi Erma Sulistyaningsih Farida Wahyu Ningtyias, Farida Wahyu Farida Wahyuningtiyas Farizal, Teuku Futri Syam Ghiza J.K. Barqly Hadi Prayitno Hartati, Rita Hasdi, Syaiful Hazmi Dwinanda Nurqistan Hendri, Afrizal Herdi Susanto Herri Darsan Hilda Khairinnisa I Gusti Ngurah Agung Darma Putra Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Ikmala, Riskita Isa Marufi ISLAMI, SHOFI IQDA Jalil, Muhammad Jauhar Firdaus Jayadi, Farid Jumanto Jumanto Kamarullah Kamarullah Kiky Martha Ariesaka kustin uds Laili, Ayik Nikmatul laili, Ayik Nikmatul Laksmi Indreswari Luluk Faridatul Mukaromah M. Yasep Setiawan Mahmuddin Marbun Maidi Saputra Masykur, Masykur Meylis Safriani Mirza Adia Nova Muazar, Muazar Mudzakkir Taufiqurrahman Muflikhatun, Khanif Muhammad Abrar Muhammad Aqib Husni Fadhli Muhammad Arif Nasution Muhammad Herizal Ihza Muhendra, Rifki Mulkan, Andi Murhaban Murhaban Murtadho Ridwan Muzakir Muzakkir Muzakkir N. Nazaruddin Nabiel, Rifaldy Nadia Putri Yurianto Nafolion Nur Rahmat, Nafolion Nur Nanda Prima Natasya Febrilia Yulianti Novan K. Adji Pandan, Pandan wangi Pipiet Wulandari Pribadyo, Pribadyo Putri Erlinda Kusumaningarum Putri Kemala Sari Putri, Gusfita Trisna Ayu Raudhatun Nafisah Retno Widyastuti Riskita Ikmala Rita Fazlina Rizka N Wardani Rizki, Julia Roat Yeti Mustafida Romadhon, Nadia Jean Rosita Dewi Rudy Gunawan Sabrina M Pratama Safrirullah Safrirullah Saiful Bukhori Saiful Bukhori, Saiful Bukhori Salman Al Farisi Sarwendah Siswi Winasis Sayyidah Auliany Aminy Sekar Arum Srigati septa surya wahyudi, septa surya SHOFI IQDA ISLAMI Sihaan, Josua Cornel Roni Silvi Ahmada Chasya Solihin Solihin Solihin, Solihin Solihin Sri Wahyu Handayani Sugiyanta Sugiyanta Sukhairi, Teuku Ariessa Supangat Supangat Supangat Supangat Supangat Syahrul Fathi Syari, Zammiq Utami, Nastiti Bekti Vita Alfiatul Hasanah Wahyu Dian Puspita Widyantoro, Murwan Wiqodatul Ummah Y, Fadhil Yasrizal Yulianti, Natasya F. Yusnan, Muhammad Zahrah Febianti Zakir Husin Zarah Puspita Zarah Puspitaningtyas Zuhrizal Fadhly Zulfadhli Zulfadhli Zulfan Adi Putra