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All Journal bionature Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Pharmaceutical Reports Journal Microbiology Science MPSJ
Tadjuddin Naid
Laboratorium Kimia Farmasi, Fakultas Farmasi, Universitas Hasanuddin, Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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TLC Bioautography Analysis of Sappan (Caesalpinia sappan L.) Wood Extract Against Propionibacterium acnes and Staphylococcus epidermidis Bacteria Aisya, A. Henni; Naid, Tadjuddin; Amin, Asni; Kalsum T, Ummu; Ramlan, Pratiwi
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1102

Abstract

Sappan wood (Caesalpinia sappan L.) is one of the plants that is widely used in traditional medicine in Indonesia. Sappan wood is known to have several benefits, including its ability to treat several infectious diseases caused by bacteria. The aim of this research is to determine the class of active compounds that have antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis using TLC Bioautography analysis. The TLC results showed that the ethanol extract of Sappan wood contains alkaloid, flavonoid and phenol compounds. Bioautography TLC results show that the ethanol extract of Sappan wood has the potential for good antibacterial activity against the bacteria Propionibacterium acnes and Staphylococcus epidermidis with Rf values of 1: 0.92, Rf 2: 0.78, Rf 3: 0.65, Rf 4: 0.50, Rf 5: 0.38, Rf 6: 0.23 and Rf 7: 0.09 for Propinibacterium acnes. And the values of Rf 1: 0.65, Rf 2: 0.50, Rf 3: 0.38, Rf 4: 0.23 and Rf 5: 0.09 for Staphylococcus epidermidis.
Antioxidant Activity Test of Sappan (Caesalpinia sappan L.) and Chinese Teak (Senna alexandrina) Extract Combination Using DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radicals Scavenging Method Anisa, Rianti; Naid, Tadjuddin; Malik, Abd.; Nisaa, Nur Rezky Khairun
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1103

Abstract

Sappan (Caesalpinia sappan L.) is applied as food and traditional medicine. Chinese teak (Senna alexandrina) is a plant from the tropics that can be developed as an antioxidant. This study was conducted to determine the antioxidant activity of the combination of Sappan and Chinese Teak by the DPPH (1,1 Diphenyl 2 Picrylhydrazyl) Free Radical Scavenging method. The extraction method used was maceration with Ethanol 96% as solvent. Determination of antioxidant levels was done quantitatively using the UV-Vis Spectrophotometer instrument at a wavelength of 514 nm. From the results of the study, the regression value obtained for the comparison of Quercetin is y = 3.1303x + 0.2292 with R2 = 0.9974 and IC50 value of 15.899 μg/mL. For the antioxidant activity of Sappan, the regression value y=0.5769x + 18.543 with R2=0.9969 and IC50 value of 54.53 μg/mL, Chinese Teak obtained regression value y=0.1421x + 17.506 with R2=0.9989 and IC50 value of 228.67 μg/mL, and for the combination obtained regression value y=0.4304x + 36.622 with R2=0.9954 and IC50 value of 40.38 μg/mL. The results of this study indicate that the combination of Sappan and Chinese Teak extracts has a very strong antioxidant effect (<50 μg/mL).
AKTIVITAS ANTIBAKTERI EKSTRAK FERMENTAT ISOLAT FUNGI ENDOFIT DARI RIMPANG KUNYIT HITAM (Curcuma caesia Roxb.) TERHADAP BAKTERI INFEKSI MULUT DENGAN METODE DIFUSI AGAR Bantulu, Ananta Rahayu; Naid, Tadjuddin; Herwin, Herwin
As-Syifaa Jurnal Farmasi Vol 17, No 1 (2025): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v17i1.1350

Abstract

Black Turmeric (Curcuma caesia Roxb.) is a medicinal plant containing bioactive compounds such as flavonoids, alkaloids and phenols which have antibacterial activity. This study aims to determine the antibacterial activity of fermentate extract of endophytic fungi isolates derived from black turmeric rhizomes (Curcuma caesia Roxb.) against bacteria that cause oral infections such as Porphyromonas gingivalis and Streptococcus mutans by agar diffusion. Endophytic fungi isolates were obtained through isolation and purification processes using YGCA and PDA media. A total of 16 isolates were obtained, and 3 selected isolates (IFKH-8 and IFKH-9) showed antibacterial activity after screening tests (antagonistic tests). Macroscopic and microscopic morphological characterization tests were also carried out on selected isolates. Fermentation was carried out dynamically on MYB media for 3, 7, 14, and 21 days. The fermentate extract was evaluated for its antibacterial activity through the agar diffusion method against test bacteria. The results of the antibacterial activity test of ethyl acetate extract of endophytic fungi by diffusion to obtain the largest inhibition zone diameter in the IFKH-9 isolate of 7.27 mm at a concentration of 10% against Porphyromonas gingivalis bacteria and in the IFKH-9 isolate of 7.29 mm at a concentration of 10% against Streptococcus mutans bacteria
Aktivitas Antibakteri Fraksinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius) Terhadap Bakteri Escherichia coli Menggunakan Metode KLT-Bioautografi Latif, Safira Kartika Handayani; Naid, Tadjuddin; Fitriana, Fitriana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.93

Abstract

Fragrant pandan leaves (Pandanus amaryllifolius) have antibacterial abilities, which have secondary metabolites of alkaloids, flavonoids, tannins and saponins. The purpose of this study was to determine the antibacterial activity of extract fractionation from pandan leaves (Pandanus amaryllifolius) against Escherichia coli bacteria. This study used fragrant pandan leaf simplicia (Pandanus amaryllifolius) and extracted using the maceration method with 96% ethanol solvent and evaporated with a rotavapor, after which it was fractionated with ethyl acetate solvent and evaporated again using a rotavapor. The ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) was subjected to a screening test with a concentration of 2% against Escherichia coli bacteria, and a TLC-Bioautography test was carried out followed by identification of the chemical components. The result of the 2% concentration screening test on the ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) showed activity against Escherichia coli bacteria. TLC-Bioautography test result showed activity on Escherichia coli bacteria with Rf values of 0,94 and 0,65. The result of chemical identification of the ethyl acetate fraction of fragrant pandan leaves (Pandanus amaryllifolius) were positive for containing chemical compounds of flavonoids and tannins which can be used as antibacterials.
Aktivitas Antibakteri Ekstrak Metanol Daun Bidara (Ziziphus mauritiana Lam) Terhadap Bakteri Uji Penyebab Luka Infeksi Dengan Metode Difusi Agar Irfanitha, irfanitha; Naid, Tadjuddin; Nuryanti, Siska
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 1 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i1.199

Abstract

Bidara leaves (Ziziphus mauritiana Lam) have the ability as an antibacterial, because they contain chemical compounds such as alkaloids, flavanoids, saponins, tannins and phenols. The content of phytochemical substances in bidara leaves accelerates the wound healing process on the outer skin. This study aims to determine the antibacterial activity of the methanol extract of bidara leaves (Ziziphus mauritiana Lam) against test bacteria that cause infectious wounds using the agar diffusion method. This test began with a screening test using 4 test bacteria and the results were inhibiting the growth of Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis and Propionibacterium acnes at concentrations of 0.1% and 0.5%. Then tested the antibacterial activity of the methanol extract of bidara leaves (Ziziphus mauritiana Lam) using the agar diffusion method and the result was that the ethanol extract of bidara leaves Ziziphus mauritiana Lam) has strong potential as an antibacterial against the test bacteria with the largest diameter of the inhibition zone at a concentration of 4% of 15 .00mm.
UV-Visible Spectrophotometric Determination of Formalin Contamination in Tofu Circulated in Maros City - Indonesia Seniwati, Seniwati; Qawiy, Haqi Romadhona; Aminah, Aminah; Naid, Tadjuddin
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.538 KB) | DOI: 10.33096/pharmrep.v1i2.170

Abstract

Tofu is one of the healthiest foods because of its high protein content and the quality is equivalent to the quality of animal protein. Formaldehyde has a function as an antibacterial agent that can slow down the activity of bacteria in foods that contain a lot of protein, so formaldehyde reacts with proteins in food and makes food durable, but when it enters the human body, formaldehyde itself is mutagenic and carcinogenic which can trigger the growth of cancer cells. and gene defects in the body. Thus, in this study, we aim to determine the formalin contamination in tofu circulated in Maros City – Indonesia. This research was conducted from December 2014 to June 2015. The analysis of formalin contamination in tofu was conducted in qualitative and quantitative analysis. The qualitative analysis was performed using the specific reagent, and the quantitative analysis was measured by UV-Vis spectrophotometric method. The result showed that sample codes RMD1 and RMD2 with formalin contaminants because the color of the solution produced after the test was red correspond to the positive result. As for the tofu sample with sample code RMD3, the results were negative because it gave a yellow color after adding potassium permanganate reagent. In the quantitative analysis, samples were measured using a UV-Vis spectrophotometer at a wavelength of 571.5 nm. From the measurement process, the result exhibited that the samples RMD1 and RMD2 contain formalin of 5.92 and 3.34 g/gram, respectively.
Detection of Salmonella Bacteria In Soybean Tempeh Produced In Palekko Village, Takalar Regency Anggraeni, Nur Afni; Naid, Tadjuddin; Nuryanti, Siska
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1231

Abstract

Tempeh is a staple food in Indonesia, known for its nutritional benefits, including 25% protein, 5% fat, 4% carbohydrates, vitamin B12, and rich mineral content. Ensuring the safety and hygiene of tempeh is crucial, especially in preventing contamination by harmful bacteria like Salmonella, which poses serious health risks. This study aimed to detect the presence of Salmonella bacteria in tempeh produced in Palekko Village, Takalar Regency, using Salmonella Shigella Agar (SSA) medium. The method employed was experimental, involving the preparation and dilution of tempeh samples followed by incubation on SSA medium. The results is a no samples detected Salmonella met the Salmonella contamination limit requirements, which were negative/25g.
Antibacterial Activity of N-Hexane and Ethyl Acetate Fractions Of Pandanus Nut (P. Julianettii) Against Oral Pathogens Nur, Wardah Rafidah; Naid, Tadjuddin; Herwin, Herwin
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1333

Abstract

Oral infections caused by Streptococcus mutans and Porphyromonas gingivalis are common health problems. This in vitro study aimed to evaluate the antibacterial activity of Pandanus nut (Pandanus julianettii) with n-hexane and ethyl acetate fractions against these pathogens through agar diffusion assays. The n-hexane and ethyl acetate fractions were subjected to agar diffusion testing, with Minimum Inhibitory Concentration (MIC) values determined at 0.8% and 0.2% respectively against both bacterial strains. Subsequent Minimum Bactericidal Concentration (MBC) testing revealed values of 6.4-12.8% for n-hexane fraction and 3.2-6.4% for ethyl acetate fraction. In agar diffusion assays, the n-hexane fraction at 12.8% concentration produced inhibition zones of 15.54±0,20 mm on S. mutans and 15.46±0,35 mm on P. gingivalis. The ethyl acetate fraction showed significantly larger inhibition zones of 18.76±0,79 mm against S. mutans and 15.59±0,42 mm against P. gingivalis at the same concentration. These findings demonstrate that both n-hexane and ethyl acetate fractions of Pandanus nut possess substantial antibacterial activity against oral pathogens.
Antibacterial Activity of Ethanolic Extract of Pandanus Nut (Pandanus julianettii) Gastrointestinal Bacteria Using The Agar Diffusion Method Monika, Arum; Naid, Tadjuddin; Herwin, Herwin
Journal Microbiology Science Vol 5, No 2 (2025): Volume 5(2) 2025
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i2.1334

Abstract

Gastrointestinal infections are a major global health concern, often caused by pathogenic bacteria. This study aimed to evaluate the antibacterial activity of the ethanolic extract of Pandanus nut (Pandanus julianettii) against gastrointestinal pathogens using the agar diffusion method. The Minimum Inhibitory Concentration (MIC) of the extract was determined to be 6.4% for Shigella dysenteriae, Salmonella typhi, and Escherichia coli, and 3.2% for Vibrio cholerae. The Minimum Bactericidal Concentration (MBC) for all tested bacteria was 12.8%. Antibacterial activity analysis revealed that at the 12.8% concentration, the largest inhibition zones were observed: 22.68 mm for Salmonella typhi, 22.20 mm for Shigella dysenteriae, 21.26 mm for Escherichia coli, and 20.80 mm for Vibrio cholerae. These findings indicate that the ethanolic extract of Pandanus julianettii possesses strong antibacterial properties and holds potential as a natural therapeutic agent for managing gastrointestinal infections.
Co-Authors A Amaliah Dahlia ABD. MALIK Adelina, Nabila Aisya, A. Henni Alhijrah, Yayu Ambon, Nur Intan Aminah Aminah Andi Maulana Kamri Anggraeni, Nur Afni Anisa, Rianti Asni Amin Bantulu, Ananta Rahayu Dewi Yuliana Dharmawat, Dewi Tri Fitriana Fitriana Fitriani Mangerangi, Fitriani Gemini Alam Hanifah Almahdaly, Hanifah Hardiyanti, Vivi Herwin Herwin, Herwin Irfanitha, irfanitha Kalsum T, Ummu Kasim, Athia Kurnia Kus Haryono Latif, Safira Kartika Handayani Mamat Pratama, Mamat Marda, Marda Mas'ud, Ita Ayuningsih Maulidiyah, Zakiya Mirawati Mirawati Monika, Arum Muhammad Aswad Muldin, Nurul Insani Muzakkir Baits, Muzakkir Nasution, Annio Indah Lestari Nisaa, Nur Rezky Khairun Nur, Wardah Rafidah Nurung, Ayyub Harly Nuryadin, Yudhi Nuryadin, Yudhi Paduai, Muh. Harry Bagas Setiawan R. Palongko, Siska Oktavina S. Qawiy, Haqi Romadhona R. Rusli Rahmawati, Rahmawati Ramadhani, Nur Ramadini, Ristieyen Ramlan, Pratiwi Risfah Yulianty Rosdah, Rosdah Sadjidin, Sugiarto Saputri, Febrianti Ayu Seniwati Dali Seniwati Seniwati, Seniwati Septiyanti, Septiyanti Siska Nuryanti, Siska Umasangaji, Ria Fitriani Virsa Handayani Yenni Triana, Yenni Yoga Yuniadi Yusnita Rifai, Yusnita Zainal Abidin