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All Journal Majalah Kedokteran Bandung Journal of Biomedicine and Translational Research Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) Media Ilmu Kesehatan Majalah Kedokteran Andalas Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Nommensen Journal of Medicine Jurnal Inovasi Pendidikan dan Sains Kieraha Medical Journal Jurnal Impresi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) International Journal of Public Health Excellence (IJPHE) Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences. Jurnal Kedokteran Meditek Jurnal Kesehatan
Suhartomi
Departemen Farmakologi, Universitas Prima Indonesia, Sumatera Utara, Indonesia
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Evaluasi Formulasi Teh Celup dari Kombinasi Kulit Jeruk Manis (Citrus sinensis L.) dan Buah Ara (Ficus carica L.) sebagai Antibakteri terhadap Staphylococcus aureus M. Irgisyach Aqilla Husni; Marcelina Oktavia Mayang Sari Simat; Suhartomi Suhartomi; Hendrianto Hendrianto; Siti Syarifah; Maulinda Putri; Tri Widyawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1205

Abstract

The development of natural-based antibacterial agents is essential to reduce dependency on antibiotics and the risk of resistance. Sweet orange peel and fig fruit contain bioactive compounds with potential antibacterial effects. This study aimed to develop tea bag formulations made from sweet orange peel with the addition of fig fruit as an additive and to evaluate their in vitro antibacterial activity against Staphylococcus aureus. This experimental study employed two approaches, including disc diffusion and microdilution on several combination formulations of sweet orange peel and fig tea bags. The formulations consisted of F1 (1 g sweet orange peel and 1 g fig), F2 (1.5 g sweet orange peel and 0.5 g fig), and F3 (1.75 g sweet orange peel and 0.25 g fig). The disc diffusion assay showed that all formulations exhibited weak antibacterial activity against Staphylococcus aureus, producing inhibition zones of approximately 6–7 mm, except for F3 infusion, which demonstrated the widest inhibition zone with a mean diameter of about 8.21 mm (P-Value = 0.688). In the microdilution test, the MIC of F3 infusion was found to be 40 mg/mL, while the MBC was not detected at the tested concentrations. Overall, it can be concluded that the infusion of the tea bag formulation containing 1.75 g sweet orange peel and 0.25 g fig was the most promising combination; however, its antibacterial activity remained weak and was bacteriostatic rather than bactericidal.
Co-Authors Ade Pryta Romanauli Simaremare Andre Budi Anggi Sri Ananda Aipin Annisa, Elvia BRAWA TAMA UNSANDY Chrismis Novalinda Ginting Danni Frederiko Asido Sirait Dwi Putri Agita Sebayang Fadillah, Qori Felix Leonardi Gabriella M.C. Sipahutar Gabriella M.C. Sipahutar Gani Panjaitan, Joice Sonya Ginting, Audi Torry Ginting, Chrismis Novalinda Hanjaya Hendra Hendra Hendra Jirwanto Hendrianto Hendrianto Herlina Yani Herlina Yani Jenny Ria Sihombing Jenny Ria Sihombing Jenny Ria Sihombing JOICE SONYA GANI PANJAITAN Joice Sonya Gani Panjaitan Juliana Lina Ketaren, Divanya Regatha Linda Chiuman Linda Chiuman M. Irgisyach Aqilla Husni Marcelina Oktavia Mayang Sari Simat Marpaung, Okto Parningotan Elia Maulinda Putri Michelle Tandiono Mutia, Maya Sari Natasya Sabaria Aritonang Nathalia E.R. Sipahutar Nathalia E.R. Sipahutar Nathalia E.R. Sipahutar Panjaitan, Rudyn Raymond Putri, Maulinda Rizki Edmi Edison Rotua Chatarina Simanjuntak Rudy Rudy Runggu Retno Justiani Napitupulu Sadarita Sitepu Sefania Sagala Sembiring, Mediana Sherlyn Sherlyn Siti Syarifah Siti Syarifah Sitompul, Owen Sri Amelia Tandiono, Michelle Tarigan, Juliyanti Tarigan, Junita Theresia, Yohani Tri Widyawati Trirasetya, Mutiara Ulfa Veranyca Chiuman Wardhani, Fiska Maya Widya Yanti Sihotang Yolanda Eliza Putri Lubis Yulizal, Ok Yumiko, Yumiko