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Antibacterial Activity of Sweet Orange (Citrus sinensis) Peel Tea against Enterobacteriaceae Isolated from a Water Depot Yumiko, Yumiko; Suhartomi, Suhartomi; Nasution, Sri Wahyuni; Syarifah, Siti; Simaremare, Ade Pryta R.
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.449-458

Most orange peels are not utilized and become useless waste that is thrown away. Orange peels contain many nutrients and compounds, such as flavonoids, terpenoids, alkaloids, and essential oils, which are secondary metabolites that act as antibacterial agents. This study intends to investigate the antibacterial activity of sweet orange peel tea against isolated Enterobacteriaceae from a random water depot sample around Universitas Prima Indonesia. This experiment used disc diffusion for antibacterial assay. Meanwhile, the sweet orange peel was brewed using two different methods, including infusion and decoction, in two different masses (3 grams and 5 grams). These sweet orange peel tea formulations were compared to standard (chloramphenicol) and control (distilled water). Enterobacteriaceae was isolated and identified from a random water depot sample around Universitas Prima Indonesia, which included colony identification in EMB agar and MacConkey agar, gram staining, and biochemical test. This study showed that a random water depot sample contaminated by Enterobacteriaceae had properties similar to Citrobacter sp. Sweet orange tea formulation inhibited this isolated Enterobacteriaceae growth (P-Value: 0.010). Antibacterial activity was observed in 3-gram infusion, 5-gram infusion, and 5-gram decoction. However, the antibacterial activity was not better than the standard (chloramphenicol). Overall, it can be concluded that the sweet orange peel tea as infusion or decoction has weak antibacterial activity against Enterobacteriaceae bacteria isolated from water depots, which had some properties similar to Citrobacter sp.

PERBANDINGAN OBAT ANTI JAMUR KETOCONAZOLE DAN SALEP 2-4 PADA KASUS TINEA PEDIS DI TEMPAT PEMBUANGAN AKHIR SAMPAH TERJUN KOTA MEDAN Ketaren, Divanya Regatha; Suhartomi, Suhartomi; Fadillah, Qori; Panjaitan, Joice Sonya Gani; Syarifah, Siti; Sihombing, Jenny Ria
Kieraha Medical Journal Vol 6, No 2 (2024): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v6i2.9100

Tinea Pedis merupakan salah satu infeksi jamur superfisial kulit yang paling umum di seluruh dunia yang bersifat menular dan berulang. Infeksi ini sering kali tertular secara kontak langsung dengan spora organisme penyebab atau bagian kulit yang terinfeksi. Prevalensi global tinea pedis diperkirakan sekitar 3% dengan risiko seumur hidup mencapai 70%. Prevalensi pada remaja dan dewasa lebih tinggi dibandingkan pada anak-anak. Kejadian tertinggi terjadi antara usia 16 dan 45 tahun saat aktivitas tinggi. Tujuan penelitian ini adalah untuk melihat perbandingan efektivitas antara obat anti jamur ketoconazole dengan Salep 2 - 4 yang mengandung salisilat dalam mengobati penyakit infeksi jamur di Tempat Pembuangan Akhir Sampah Terjun Kota Medan. Penelitian ini merupakan penelitian eksperimental uji klinis, yakni uji klinis acak terkontrol (Randomized Controlled Trial) yang dilakukan di Tempat Pembuangan Akhir Sampah Terjun Kota Medan sebanyak 32 pemulung dan petugas sampah, dibagi menjadi dua kelompok yaitu salep ketoconazole dan salep 2 - 4 dilakukan selama 14 hari dengan follow up pada hari ke - 4, 8, 14. Hasil pengobatan pada hari ke - 4 dengan angka kesembuhan salep ketoconazole (56.25%), salep 2-4 (18.75%) dengan nilai P = 0.028. Pada hari ke - 8 angka kesembuhan salep ketoconazole (68.75%) salep 2 - 4 (31.25%) dengan nilai P = 0.034. Pada hari ke â€“ 14 angka kesembuhan salep ketoconazole (93.75%) salep 2-4 (56.25%) dengan nilai P = 0.037. Kesimpulan dari terdapat perbandingan efektivitas antara obat anti jamur ketoconazole dan salep 2-4 dalam mengobati infeksi jamur tinea pedis.

Effectiveness of Smoke-Free Campus Implementation on Smoking Behavior Control Trirasetya, Mutiara Ulfa; Leonardi, Felix; Suhartomi, Suhartomi; Sihotang, Widya Yanti; Edison, Rizki Edmi
Jurnal Kesehatan Vol 15 No 2 (2024): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v15i2.4538

The tobacco industry is a significant obstacle in the effort to control smoking behavior, especially since they are allowed to promote their products to the public, including students. To address this issue, the Ministry of Health developed a smoke-free zone that may be implemented in universities to reduce smoking rates among adolescents. To know the effectiveness of implementing a smoke-free campus policy on smoking behavior control at Universitas Prima Indonesia by assessing aspects of student knowledge and compliance levels. This research is a descriptive quantitative study with a cross-sectional design and uses purposive sampling techniques with the criteria of active smoker students, 74 people in the medical study program of the Faculty of Medicine, Dentistry, and Health Sciences at Universitas Prima Indonesia. Data was obtained in February-April by distributing questionnaires directly to student smokers. The results showed that smoking behavior control among students increased in 50 (67.6%) out of 74 respondents. This is supported by the relationship between the level of knowledge and students' attitudes toward smoking behavior control in the smoke-free campus area, as indicated by a p-value<0.05 (0.005<0.05 and 0.001<0.05). This study found that students’ knowledge and attitudes towards smoke-free campus areas are important aspects influencing the effectiveness of the smoke-free campus policy in controlling smoking behavior.

Systematic Review: Pengaruh Penggunaan Kosmetik Terhadap Kejadian Acne vulgaris Suhartomi, Suhartomi; Panjaitan, Joice Sonya Gani; Syarifah, Siti; Marpaung, Okto Parningotan Elia
Nommensen Journal of Medicine Vol 10 No 1 (2024): Nommensen Journal of Medicine: Edisi Agustus
Publisher : Universitas HKBP Nommensen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36655/njm.v10i1.1609

Background: Several factors reported to be associated with the incidence of acne vulgaris include genetics, race, stress, diet, cosmetics, drugs, and smoking habits. Many studies have been performed to look for the effect of cosmetic use on the incidence of acne vulgaris, but these studies are still limited to observational studies. Therefore, this study aimed to analyze the effect of cosmetic use on the incidence and severity of acne vulgaris through several studies in the 2018-2023 period. Methods: This systematic review was performed by systematically searching for some literatures on Google Scholar with the keywords Cosmetics and Acne vulgaris. The results of this systematic searching found 21 scientific articles in either English or Indonesian. Results: The most of literatures obtained reported that the use of cosmetics, in the form of compact powder, BB cream, and foundation affected the incidence of acne vulgaris. Meanwhile, patients suffered from acne vulgaris, who used compact powder and foundation consistently aggravated acne vulgaris. There is still limited study on other decorative cosmetics such as concealers and primers on the incidence of acne vulgaris. Conclusion: The use of cosmetics such as compact powder, BB cream, and foundation can cause acne vulgaris, furthermore compact powder and foundation can also aggravate acne vulgaris that has occurred.

Pengaruh Media Sosial, Persepsi Penyembuhan, dan Perilaku Self-Medication terhadap Terjadinya Akne Vulgaris Panjaitan, Joice Sonya Gani; Suhartomi, Suhartomi; Panjaitan, Rudyn Raymond
Nommensen Journal of Medicine Vol 11 No 1 (2025): Nommensen Journal of Medicine Edisi: Agustus 2025
Publisher : Universitas HKBP Nommensen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36655/njm.v11i1.1937

Latar belakang: Akne vulgaris sebagai suatu bentuk peradangan kronis pada kelanjar sebasea yang dapat terjadai pada kelompok usia produktif terutama mahasiswa. Pada era digitalisasi saat ini, aksestabilitas media sosial yang mudah dan cepat berkontribusi dalam peningkatan perilaku self medication. Tujuan: Untuk menganalisis hubungan paparan media sosial, perilaku swamedikasi, dan persepsi kesembuhan swamedikasi terhadap kejadian akne vulgaris. Metode: Penelitian obervasional ini menggunakan model case-control pada sekitar 190 orang mahasiswa maupun mahasiswi di Program Studi Pendidikan Dokter Umum Fakultas Kedokteran, Universitas HKBP Nommensen yang dipilih melalui simple random sampling. Variabel penelitian yang diukur dalam penelitian ini meliputi umur, jenis kelamin, paparan media sosial, Self-Medication, serta persepsi kesembuhan. Analisa data dalam penelitian ini diawali dengan analisa statistic deskriptid, kemudian diikuri dengan chi square dan data penelitian yang memiliki hubungan yang secara statistic signfikan pada chi square kemudian dimasukan dalam model regresi logistic. Hasil: Paparan sosial media (Nilai P: 0.020; Unadjusted OR [IK95%]:2.357 [1.132-4.909]; Adjusted OR [IK95%]: 0.577 [0.262-1.270]), perilaku self medication (Nilai P: 0.001; Unadjusted OR [IK95%]: 3.272 [1.630-6.569]; Adjusted OR [IK95%]: 0.497 [0.175-1.414]), dan persepsi kesembuhan swamedikasi (Nilai P: 0.001; Unadjusted OR [IK95%]: 2.773 [1.509-5.099]; Adjusted OR [IK95%]: 0.633 [0.246-1.629]) secara terpisah menunjukkan hubungan yang signifikan terhadap terjadinya akne vulgaris. Namun, ketiga faktor tersebut tidak menunjukkan hubungan yang signifikan terhadap terjadinya akne vulgaris pada model regresi logistic

ICU dan Non-ICU MRSA: Kejadian dan Faktor Risiko di Rumah Sakit Tersier Tarigan, Junita; Putri, Maulinda; Suhartomi, Suhartomi; Sitompul, Owen
Nommensen Journal of Medicine Vol 11 No 1 (2025): Nommensen Journal of Medicine Edisi: Agustus 2025
Publisher : Universitas HKBP Nommensen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36655/njm.v11i1.1939

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that is resistant to penicillin-class antibiotics and poses a serious threat to healthcare facilities. Its global prevalence reached 30% in 2020, while in Indonesia it ranges from 0.3% to 52%, with the highest rate reported in Jakarta. Objective: To compare the incidence and risk factors of MRSA among patients in the Intensive Care Unit (ICU) and general wards (non-ICU) at RSUP Haji Adam Malik Medan, during 2022–202. Methods: A cross-sectional study was performed on 569 patients in ICU and non-ICU wards with culture examinations performed from January 2022 to December 2023. Bivariate analysis was conducted for nine independent variables, followed by multivariate logistic regression for variables with p-values < 0.25. Results: From 18,121 culture examinations, 569 isolates of Staphylococcus aureus were identified. MRSA incidence was higher in non-ICU wards (246 of 441 isolates; 55.7%) than in the ICU (63 of 128 isolates; 49.2%). Statistically significant risk factors differed between the two groups: in ICU patients, only diabetes mellitus (OR 2.50; p = 0.017) was significant; while in non-ICU patients, chronic kidney disease (OR 0.644; p = 0.037) and a history of prior antibiotic use (OR 3.037; p = 0.011) were significant factors. Additionally, 4.21% of all isolates were confirmed as VRSA. Conclusion: MRSA incidence was higher among patients in non-ICU wards. The main risk factors differed between units: diabetes mellitus was prominent among ICU patients, whereas chronic kidney disease and previous antibiotic use played a role among non-ICU patients. These differences highlight the need for infection prevention and control strategies tailored to the specific risk profiles of each care unit.

PERBANDINGAN OBAT ANTI JAMUR KETOCONAZOLE DAN SALEP 2-4 PADA KASUS TINEA PEDIS DI TEMPAT PEMBUANGAN AKHIR SAMPAH TERJUN KOTA MEDAN Ketaren, Divanya Regatha; Suhartomi, Suhartomi; Fadillah, Qori; Panjaitan, Joice Sonya Gani; Syarifah, Siti; Sihombing, Jenny Ria
Kieraha Medical Journal Vol 6, No 2 (2024): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v6i2.9100

Tinea Pedis merupakan salah satu infeksi jamur superfisial kulit yang paling umum di seluruh dunia yang bersifat menular dan berulang. Infeksi ini sering kali tertular secara kontak langsung dengan spora organisme penyebab atau bagian kulit yang terinfeksi. Prevalensi global tinea pedis diperkirakan sekitar 3% dengan risiko seumur hidup mencapai 70%. Prevalensi pada remaja dan dewasa lebih tinggi dibandingkan pada anak-anak. Kejadian tertinggi terjadi antara usia 16 dan 45 tahun saat aktivitas tinggi. Tujuan penelitian ini adalah untuk melihat perbandingan efektivitas antara obat anti jamur ketoconazole dengan Salep 2 - 4 yang mengandung salisilat dalam mengobati penyakit infeksi jamur di Tempat Pembuangan Akhir Sampah Terjun Kota Medan. Penelitian ini merupakan penelitian eksperimental uji klinis, yakni uji klinis acak terkontrol (Randomized Controlled Trial) yang dilakukan di Tempat Pembuangan Akhir Sampah Terjun Kota Medan sebanyak 32 pemulung dan petugas sampah, dibagi menjadi dua kelompok yaitu salep ketoconazole dan salep 2 - 4 dilakukan selama 14 hari dengan follow up pada hari ke - 4, 8, 14. Hasil pengobatan pada hari ke - 4 dengan angka kesembuhan salep ketoconazole (56.25%), salep 2-4 (18.75%) dengan nilai P = 0.028. Pada hari ke - 8 angka kesembuhan salep ketoconazole (68.75%) salep 2 - 4 (31.25%) dengan nilai P = 0.034. Pada hari ke â€“ 14 angka kesembuhan salep ketoconazole (93.75%) salep 2-4 (56.25%) dengan nilai P = 0.037. Kesimpulan dari terdapat perbandingan efektivitas antara obat anti jamur ketoconazole dan salep 2-4 dalam mengobati infeksi jamur tinea pedis.

Anti-inflammatory Activity of Lemon Pepper Nanoemulsion on Carrageenan-Induced Male Wistar Rat Chiuman, Linda; Sebayang, Dwi Putri Agita; Chiuman, Veranyca; Suhartomi, Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6292

Lemon pepper does not only have a unique taste but also has some active compounds, which has anti-inflammatory activity. This study intended to investigate the anti-inflammatory effect of lemon pepper nanoemulsion on carrageenan-induced Wistar rats. This experimental study used Twenty-five male Wistar rats that were grouped into five different groups, including control, standard, lemon pepper nanoemulsion dose of 25, 50, and 75 mg/ kgBW. Initially, all rats received air injection in the back area for 5 days to form an air pouch. After that, all rats were injected with 1% carrageenan solution, and received treatment based on the groups for 48 hours via oral route. Then, it counted the number of white blood cells by Giemsa Stain that was expressed as a number of cells per High Power Field (HPF). The increasing of Lemon pepper nanoemulsion dose significantly decreased the number of leucocytes in the carrageenan aspiration after 48 hours of treatment (P-Value < 0.001). The lowest number of leucocytes was found in the Lemon Pepper Nanoemulsion dose of 75 mg/kgBW (2.40 leukocytes per HPF). Hence, it can be deducted that the lemon pepper nanoemulsion has an anti-inflammatory effect, especially at a dose of 50-75 mg/kgBW.

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