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All Journal Jurnal Kebijakan Kesehatan Indonesia Jurnal Kesehatan Andalas Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Kesehatan Medika Saintika Buletin Ilmiah Nagari Membangun Journal of Midwifery Majalah Kedokteran Andalas Contagion: Scientific Periodical Journal of Public Health and Coastal Health Indonesian Journal of Global Health research Nusantara Hasana Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Malahayati International Journal of Nursing and Health Science NERS Jurnal Keperawatan Indonesian Journal of Global Health Research
Nur Indrawaty Lipoeto
Andalas University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Determinants Influencing Elderly Utilization of Rumah Kasih: Social and Professional Support Analysis Basyariah Lubis; Nur Indrawaty Lipoeto; Rozi Sastra Purna; Rosfita Rasyid
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6557

Abstract

Indonesia’s aging population presents an increasing demand for accessible, community-based health services. However, the utilization of Rumah Kasih, a community health program for older adults, remains suboptimal. Objective to examine the reinforcing factors influencing its utilization, including support from healthcare workers, university students, community health workers (CHWs), village heads, family members, and peers. A quantitative, cross-sectional study was conducted involving 192 elderly respondents with total sampling. Data were collected using questionnaires and analyzed using chi-square tests and multivariate logistic regression. The bivariate analysis indicated that all support factors were significantly associated with service utilization (p < 0.05). Multivariate analysis identified healthcare worker support as the most influential predictor (OR = 48.346; p < 0.001), followed by student involvement (OR = 5.259; p = 0.005). Although family support was significant in the bivariate analysis, it was not retained in the multivariate model. CHW and peer support yielded high odds ratios but lacked statistical significance, possibly due to data variability or multicollinearity. These findings highlight the critical role of professional engagement and student participation in enhancing elderly involvement in community health programs. Strengthening these factors, along with targeted strategies to involve social actors, may improve the effectiveness and long-term sustainability of elderly care services.
Relationship Between Clean and Healthy Living Behavior and the Incidence of Stunting in Toddlers Winda Dwi Saputri; Desmawati Desmawati; Yuniar Lestari; Nur Indrawaty Lipoeto; Nelmi Silvia; Afdal Afdal
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6897

Abstract

Stunting is a condition of a short body based on the height-for-age index. Clean and healthy living behavior is an important behavior that can prevent stunting. The purpose of the study was to determine the relationship between clean and healthy living behavior and the incidence of stunting in toddlers at the Koto Panjang Ikua Koto Health Center. This study is an observational study with a cross sectional approach, he sampling technique used was proportional sampling with 82 respondents. Data were collected using a microtoise, the maternal and child health book and a questionnaire. The data were analyzed using chi-square and logistic regression test. The results showed a relationship between weighing toddlers and the incidence of stunting (p=0,003), exclusive breastfeeding is related to the incidence of stunting (p=0,009), the habit of washing hands with soap is related to the incidence of stunting (p=0,039), the use of healthy latrines is related to the incidence of stunting (p=0,017), eradication of mosquito larvae is related to the incidence of stunting (p=0,032). The results of the multivariate analysis showed that weighing toddlers had the most dominant relationship with the incidence of stunting (OR:6,376). Concluded that clean and healthy living behavior is significantly associated with the incidence of stunting.
The Effectiveness of Probiotic Administration as A Novel Therapeutic Target for Hypertension During Pregnancy Induced by Primary and Secondary Factors: A Systematic Literature Review of Preclinical Studies Budi Budi; Nur Indrawaty Lipoeto; Yanwirasti Yanwirasti; Donel Suheimi
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.307

Abstract

Hypertension during pregnancy, including preeclampsia, remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. The complex pathogenesis of pregnancy-related hypertension involves endothelial dysfunction, impaired angiogenesis, oxidative stress, and immune dysregulation. Conventional pharmacological therapies continue to face limitations in terms of efficacy and safety for pregnant women. Therefore, there is an urgent need for safer and more effective molecular-based therapeutic alternatives, one of which is the use of probiotics. The aim of this systematic review is to analyse the potential effectiveness of probiotic administration as a novel therapeutic target for pregnancy-induced hypertension driven by primary and secondary factors. This systematic review was conducted following the PRISMA guidelines. A comprehensive literature search was performed across databases including Google Scholar, PubMed, Taylor & Francis, and ScienceDirect, covering publications from 2015 to 2025. Inclusion criteria were applied based on the PICOS framework. A total of 14 preclinical in vivo studies met the inclusion criteria. Probiotics such as Akkermansia muciniphila, Bifidobacterium bifidum, Lactobacillus spp., Limosilactobacillus spp., and Lactiplantibacillus plantarum demonstrated significant effectiveness in reducing systolic and diastolic blood pressure, improving endothelial function, suppressing inflammation, and mitigating oxidative stress. These effects were mediated through mechanisms involving gut microbiota modulation and regulation of the renin-angiotensin system. Probiotics hold promise as a safe and effective alternative therapy for reducing hypertension during pregnancy and may support the development of future non-pharmacological, microbiota-based therapeutic strategies.
Literatur Review: The Role of Probiotics in Preventing Aging Prima Minerva; Nur Indrawaty Lipoeto; Jamsari Jamsari; Tofrizal Tofrizal
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.1391

Abstract

Aging is a complex biological process characterized by progressive functional decline of organs and tissues, largely driven by oxidative stress, chronic inflammation, and cellular senescence. Recent evidence suggests that age-related gut microbiota dysbiosis contributes significantly to inflammaging and oxidative damage, accelerating the aging process. Probiotics have emerged as potential gerobiotics due to their antioxidant, anti-inflammatory, and microbiota-modulating properties. This literature review aims to evaluate the role of probiotics in preventing and delaying the aging process through modulation of gut microbiota, oxidative stress reduction, and regulation of inflammatory. A narrative literature review was conducted using scientific publications from 2012 to 2023 obtained from NCBI (PubMed), ScienceDirect, and Google Scholar databases. Articles were selected based on relevance to probiotics, gut microbiota, oxidative stress, inflammation, and aging mechanisms. A total of 300 articles were identified from PubMed (n = 120), Science Direct (n = 95), and Google Scholar (n = 85). After removing duplicates, 235 articles were screened. 45 full text articles were assessed for eligibility, and 11 studies were included in the quantitative synthesis. The reviewed studies indicate that probiotics, particularly strains from the genera Lactobacillus, exert anti-aging effects by reducing reactive oxygen species (ROS), enhancing endogenous antioxidant enzymes (SOD, CAT, GPx), regulating inflammatory pathways (NF-κB, cytokines), activating Nrf2 signaling, maintaining intestinal barrier integrity, and restoring gut microbiota balance. Several probiotic strains were shown to delay telomere shortening, suppress cellular senescence markers, and improve metabolic. Probiotics play a significant role in preventing aging by modulating gut microbiota composition, reducing oxidative stress, and suppressing chronic inflammation. These findings support the potential application of probiotics as gerobiotics to promote healthy aging and extend health span.
EFEKTIFITAS PEMBERIAN SUSU KAMBING FERMENTASI TERHADAP ANTROPOMETRI BAYI BARU LAHIR Ira Suryanis; Hasmiwati Hasmiwati; Nur Indrawaty Lipoeto; Novirman Jamarun
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1834

Abstract

The balance of the gut microbiota during pregnancy is essential for maintaining maternal health and supporting optimal fetal development. Fermented goat’s milk contains naturally occurring probiotics that contribute to microbiota homeostasis and improved maternal nutritional status. This study aimed to evaluate the effect of fermented goat’s milk consumption on newborn anthropometric outcomes. Two group pretest posttest control was applied involving 15 third-trimester pregnant women who met the inclusion criteria. Participants consumed 75 mL of fermented goat’s milk daily for a period of 9–12 weeks. Maternal characteristics and neonatal anthropometric parameters were collected through structured observations and questionnaires. Data were analyzed using paired statistical tests. The findings demonstrated statistically significant improvements (p < 0.05) in neonatal birth weight, body length, and head circumference following the intervention. These results indicate that fermented goat’s milk may positively influence fetal growth without inducing gut microbiota dysbiosis. Further studies employing controlled designs and larger sample sizes are warranted to confirm these findings and elucidate the underlying mechanisms.
Co-Authors Adang Bachtiar Adrial Adrial Afdal, Afdal Afriwardi Afriwardi Amir, Arni Anggia Perdana Harmen Ariadi Ariadi Ariani, Peny Arif Sabta Aji Arifannisa Amril Asrawati Nurdin Badriul Hegar Bobby Indra Utama Budi Budi Chandra, Dian Novita Darmayanti Darmayanti Defrin Defrin Delmi Sulastri Desmawati Desmawati Donel Suheimi Efrida Efrida Eka Nofita Elmatris Sy Endrinaldi Erdanela Setiawati Eva Chundrayetti Eva Chundrayetti Fachrurrazi Al Ansori Fajar Aria Phitra Hafni Bachtiar Hasmiwati Hema Malini, Hema Husna Yetti Ika Nur Saputri Ilmiawati, Ilmiawati Ira Suryanis Jamsari Jamsari Lini Gustini Lubis, Basyariah Mayetti Mayetti Mohamad Reza Mudjiran Mudjiran Mudjiran Mudjiran Neherta, Meri Nelmi Silvia Netti Suharti Novirman Jamarun Nur Afrainin Syah Nur Mala Sari Nuzulia Irawati Prima Minerva Rahmi Novita Yusuf Rizanda Machmud Rosfita Rasyid Rozi Sastra Purna Safarina G Malik Sandy Setiawati Selfi Renita Rusjdi Silvi Zaimy Siti Nurhajjah Sukri Rahman Susmiati Susmiati Taufiqa, Zuhrah Tofrizal Tofrizal Vivin Puspasari Winda Dwi Saputri Yanwirasti Yanwirasti Yaumil Fauziah Yulia Fatma Nasution Yuliarni Syafrita Yulizawati . Yundelfa, Mandria Yuniar Lestari Yusrawati Yusrawati Zifrianthi Minanda Putri