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Efek Sinergis Vitamin C Dalam Meningkatkan Kinerja Antijamur Madu Apis dorsata Terhadap Biofilm Candida albicans Untuk Terapi Kandidiasis MASFUFATUN; ZAHRA, FATIMATUZ; AGUSTIN ANGRAENI, DWI PUTRI; NUZULA, FIRDAUSI
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.698

Abstract

Honey is a natural ingredient produced by bees from flower nectar that has antimicrobial, antioxidant, anti-inflammatory, good wound healing effects, and bacteriostatic. This study aims to determine the synergistic effect of vitamin C in improving the antifungal performance of Apis dorsata honey against Candida albicans biofilm for candidiasis therapy. This research design is true experimental with a post-test only control group design approach using the microtiter plate assay method to measure the Optical Density (OD) value of the biofilm matrix. The test of the synergistic effect of Vitamin C on Honey was carried out by adding vitamin C to honey concentrations of 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, and 50%. Furthermore, the MBIC50 value between honey and the combination of honey and vitamin C was compared. The results showed that both honey and the combination of honey and vitamin C were each able to decrease the growth of C. albicans biofilm matrix against A. dorsata honey at various concentrations. The results of the Minimum Biofilm Inhibitory Concentration 50% (MBIC50) value in A. dorsata honey and the combination of A. dorsata honey and vitamin C were 84.27% and 63.56% respectively. Based on this study, it can be concluded that vitamin C can increase the antifungal performance of A. dorsata by lowering the MBIC50 value. Thus, the combination of vitamin C and honey can be used as an alternative therapy for candidiasis.
PENGARUH PROJECT-BASED LEARNING BERBANTU MEDIA DIGITAL TEKA-TEKI SILANG TERHADAP KEMAMPUAN BERPIKIR KREATIF SISWA KELAS 5 SD Nuzula, Firdausi; Anggit Grahito Wicaksono; Sarafuddin
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 03 (2026): Volume 11 No. 03, September 2026 Processed
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i03.62550

Abstract

This study aimed to empirically examine the effect of implementing the Project-Based Learning (PjBL) model supported by digital crossword puzzle media on enhancing the creative thinking skills of fifth-grade students in Science and Social Studies (IPAS) at SD Negeri Gugus 2 R.A. Kartini Surakarta in the 2025/2026 academic year. A quantitative approach employing a quasi-experimental design with a Nonequivalent Control Group Design was used as the methodological framework. The population consisted of 165 fifth-grade students, with a sample of 53 students selected through purposive sampling, comprising 25 students in the experimental group and 28 students in the control group. Data were collected through observations, interviews, tests, and documentation. The research instrument, in the form of an essay test measuring creative thinking skills, was confirmed to be valid and reliable, with a Cronbach’s Alpha coefficient of 0.709. Prior to hypothesis testing, the data met the assumptions through the Shapiro–Wilk normality test and Levene’s Test of homogeneity, followed by comparative analysis using the Independent Samples t-Test. The findings revealed that the mean posttest score of the experimental group was higher than that of the control group, namely 71.56 and 58.25, respectively. The results of the independent samples t-test showed that the calculated t-value exceeded the critical t-value (5.061 > 2.008) with a significance value of 0.000 (< 0.05). Therefore, H₀ was rejected and Hₐ was accepted. These findings indicate that the implementation of Project-Based Learning assisted by digital crossword puzzle (Crossword Puzzle/CWP) media had a significant effect on students’ creative thinking skills in IPAS learning. This improvement was supported by the implementation of PjBL syntax integrated with digital crossword puzzle media at every stage of the learning process, encouraging students to actively participate in identifying problems, planning projects, engaging in discussions, developing ideas, and presenting project outcomes.