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All Journal Jurnal Kesehatan Andalas Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kreativitas PKM Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Ina Kidney Human Care Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Eduvest - Journal of Universal Studies Oshada Proceeding International Health Conference
Harun Harnavi
Fakultas Kedokteran Universitas Andalas
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Global Medical and Health Communication

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Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Harun, Harnavi
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10964

Abstract

Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p<0.05. The average age of the subjects was 51.4±11.4 years, with 53% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/ml, range: 11–1,709 ng/ml) compared to the control group (6.028±1.829 ng/ml), with a significant difference (p<0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/ml (range: 29–1,709 ng/mL) in the impaired executive function group and 71.22 ng/ml (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.
Co-Authors Abdul Alim Rahimi Abdul Alim Rahimi Ade Asyari Ade Asyari Ade Sukma Ade Teti Vani Afdhol Falah Ajat Sudrajat Alexander Kam Alexander Kam Alexander Kam Alvarino Amelia Fitria Dewi Anandia Putriyuni Andikha Putra Annesa Fadella Arief Rinaldy Athif Abyaz Khalil Putra Avit Suchitra ayu pathya Dasman, Hardisman Deddy Canceria Suka Rahmatsyah Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Dela Hangri Jalmas Dessy Abdullah Dian Puspita Diana Melida Dional Setiawan Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Eryati Darwin Evelin Veronike Fauzar Fauzar Fauzar Fauzar Fauzar, Fauzar Febrianti Ika Kurnia Finny Fitry Yani Genta Pradana gina ariani Hannie Qalbina Syaiful Hannie Qalbina Syaiful Hardisman Dasman Husna Yetti Husna Yetti Ilmiawati Ilmiawati, Ilmiawati Indra, Syarif Indrapriyatna, Ahmad Syafruddin Irena Fathin Amelia Jalmas, Dela Hangri Jersivindo Ranazeri Jersivindo Ranazeri Kam Alexander Kam, Alexander Khairat AS Khairil Faiz Amir Khairil Faiz Amir Miftah Irramah Muhammad Iqbal Rivai Nadia Purnama D Nur Indrawaty Lipoeto Priyono, Drajad Putra, Mindy Pasuma Putri Lisna Radias Zasra Radias Zasra Rangga Lunesia Rapida Saragih Restu Susanti Rezki Sadeli Rini Yulia Rinita Amelia Rinita Amelia Rinita Amelia Rizkianto Imannual Rose Dinda Martini Roslaini Roslaini Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana Ruhsyahadati Ruhsyahadati Selfi Renita Rusjdi Sjaaf Fidiariani Sofiani, Dinda Putri Sri Puji Rahayuningsih Suratman, Rivani Sintia Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful Azmi Veronike, Evelin Vesri Yoga Vidiansyah, Achmad Viotra, Deka Yanuar Surya Saputra Poedjijo Yanuar Surya Saputra Poedjijo Yerizal Karani Yoga, Vesri Yudha E. Pratama Yudha Endra Pratama Yuliarni Syafrita Yulistia Asmi Yusti Siana Yusti Siana Zaki Mahmudi Dasril Zaki Mahmudi Dasril Zaki Mahmudi Dasril