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CRYPTOSPORIDIOSIS: EPIDEMIOLOGI, PATOGENESIS, MANIFESTASI KLINIS, DIAGNOSIS, DAN PENATALAKSANAAN: TINJAUAN LITERATUR Irawati, Nur Bebi Ulfah; Hermawati, Luluk; Nasution, Silvia Fitrina; Damayanti, Putri; Prameswari, Yuda Nabella; Zulfa, Hilizza Awalina
JURNAL BIOSENSE Vol 9 No 2 (2026): Edisi April 2026
Publisher : Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v9i2.7673

Abstract

Cryptosporidiosis is a parasitic infection caused by protozoa of the Cryptosporidium genus that infect humans and animals worldwide. The disease remains a significant public health concern, particularly in regions with limited access to clean water and adequate sanitation. This study aimed to review recent scientific evidence regarding the epidemiology, pathogenesis, clinical manifestations, diagnosis, and management of cryptosporidiosis. A literature review method was employed by analyzing scientific articles published between 2015 and 2025 retrieved from databases including PubMed, Scopus and Google Scholar. Relevant studies were selected based on predefined inclusion criteria and analyzed narratively. The review indicates that Cryptosporidium hominis and Cryptosporidium parvum are the most common species causing human infection and account for the majority of cases worldwide. Transmission primarily occurs through the fecal–oral route via contaminated water or food, as well as direct contact with infected hosts. Infection involves parasite attachment and invasion of intestinal epithelial cells, leading to mucosal damage, malabsorption, and diarrhea. Clinical manifestations vary depending on the host's immune status, ranging from mild self-limiting diarrhea in immunocompetent individuals to severe and chronic infection in immunocompromised patients. Diagnosis is commonly established through microscopic detection of oocysts, antigen-based assays, and molecular methods such as polymerase chain reaction (PCR). Current management mainly focuses on supportive therapy, while nitazoxanide remains the only antiparasitic drug approved by the FDA for the treatment of cryptosporidiosis. Therefore, improvements in sanitation, development of diagnostic methods, and effective prevention strategies are essential to reduce the global burden of cryptosporidiosis.
Clinical Interpretation of Urinalysis for Early Detection of Kidney Disorders: A Narrative Review Adinda Puspita Dewi; Selfie Selfie; Baety Adhayati; Yuda Nabella Prameswari; Lola Febriana Dewi; Luluk Hermawati
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.79

Abstract

Background: Chronic kidney disease (CKD) is a global health issue with a steadily increasing prevalence and often remains asymptomatic in its early stages. This silent progression contributes to delayed diagnosis and limited therapeutic options. Urinalysis is a simple, inexpensive, and noninvasive examination that remains relevant as an early screening tool to detect renal abnormalities before clinical manifestations appear. Methods: This narrative review summarizes the latest scientific evidence regarding the diagnostic value of urinalysis in the early detection of kidney disorders by highlighting the physical, chemical, and microscopic parameters of urine. Literature searches were conducted using PubMed, Scopus, and Google Scholar databases for studies published between 2020 and 2025 with the keywords urinalysis, kidney disease, early detection, uACR, and eGFR. Only English- or Indonesian-language articles relevant to the topic and containing empirical data were included. Results: Urinalysis has been shown to provide early indicators of proteinuria, hematuria, and pathological casts that reflect glomerular and tubular injury. Integration of urinalysis results with uACR and eGFR measurements, as recommended by KDIGO 2024, improves diagnostic accuracy and risk stratification. Additionally, automated digital microscopy and emerging biomarkers such as NGAL and KIM-1 show substantial potential in strengthening early detection capabilities. Discussion and Clinical Implications: Urinalysis not only serves as a screening tool but also holds prognostic value in guiding follow-up and clinical management of high-risk individuals. Proper interpretation of urinalysis findings can assist clinicians in determining the need for further assessment, initiating earlier interventions, and optimizing prevention of CKD progression. Conclusion: Urinalysis remains an essential basic examination for the early detection of kidney impairment. Its integrated application with modern laboratory parameters can enhance diagnostic effectiveness, accelerate clinical intervention, and reduce the global burden of chronic kidney disease.
Pendekatan Biopsikososial dalam Memahami Kesehatan Mental: Tinjauan Literatur Hermawati, Luluk; Prameswari, Yuda Nabella; Irawati, Nur Bebi Ulfah; Amelia, Rossa; Zulfa, Hilizza Awalina; Dwiyanti, Sophie
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 3 (2026): September: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i3.6738

Abstract

Mental health is a fundamental component of overall health that influences quality of life, productivity, and individuals’ social functioning. The development of mental disorders, such as depression and anxiety disorders, cannot be explained by a single factor; rather, it results from the interaction of multiple multidimensional determinants. This literature review aims to analyze the contribution of biological, psychological, and social factors to mental health based on current scientific evidence. This study employed a systematic narrative review approach. Literature searches were conducted in PubMed and Google Scholar databases using keywords related to mental health and biopsychosocial factors. The inclusion criteria comprised studies involving human populations published between 2015 and 2025 with observational, systematic review, or meta-analysis designs. Data were analyzed narratively to identify consistent patterns of findings. The results indicate that biological factors, such as genetic predisposition, neurotransmitter dysregulation, and medical comorbidities, increase vulnerability to mental disorders. Psychological factors, including coping strategies, emotion regulation, and exposure to stress and trauma, influence individuals’ psychological conditions. Social factors, such as social support, socioeconomic status, work or academic environment, and stigma, also play a significant role. In conclusion, mental health is the result of a dynamic interaction among biological, psychological, and social factors. Therefore, a comprehensive biopsychosocial approach is essential in promotive, preventive, and curative efforts.