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All Journal AL KAUNIYAH Journal of Biomedicine and Translational Research Jurnal Sumberdaya Hayati Science and Technology Indonesia Jurnal Kreativitas PKM Jurnal Ilmiah RESPATI INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Indonesian Journal of Halal Research Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ners Jurnal EduHealth Jurnal Kesehatan Jurnal Sains dan Kesehatan Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Jekmal Malau
PT. Sciencewerke Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Literature Review : Study of molecular mechanism level of NSAID class of drugs as COX-2 inhibitors Zakiyah, Wildani; Sukma Wibowo, Sepvia Putri; Elyyana, Nina; Nur Darmawan, Shiyami Aulia; Lestari, Sepiyani Ayu; Sa'diyyah, Nur; Malau, Jekmal; Mulki, Munir Alinu
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.745 KB)

Abstract

NSAIDs (Non-Steroid Anti-Inflammatory Drugs) are drugs that can treat pain and inflammation. The therapeutic effect of NSAIDs as anti-inflammatory analgesics is that they have the ability to inhibit the biosynthesis of prostaglandins which are pain mediators. This prostaglandin has a major role in inhibiting the COX enzyme (cyclooxygenase) in which COX has two isoforms, namely COX1 isoenzyme (non-selective) and COX2 isoenzyme (selective). Tricyclic COX-2 selective inhibitors work by blocking COX-2. COX-2 binds to PD-L1 via the PGE2 pathway and affects macrophages in suppressing myeloid. COX-2 has functions including producing reactive oxygen species that are responsible for DNA damage, activating substances that deviate from intracellular pathways such as the MAPK and PI3 K/AKT pathways, activating STAT3, inducing Bcl-2, and producing growth factors including growth factors. epidermal (EGF)) and fibroblast growth factor (FGF).
DEVELOPMENT OF PLASMID-BASED FOR EXTERNAL CONTROL MATERIALS OF CYP2D6*10 (rs1065852) GENE PCR-BASED DETECTION Malau, Jekmal; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Rahmasari, Ratika; Raekiansyah, Muhareva; Rohmah, Siti; Meilani, Nanda Diva; Septi, Annisa Frastica; Zahro, Aurora Fatimatuz; Annajla, Fathina; Hermosaningtyas, Anastasia Aliesa; Hilmi, Indah Laily
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2557

Abstract

Reliable clinical diagnosis of Single Nucleotide Polymorphisms (SNPs) is necessary for personalizing tamoxifen medication according to CYP2D6*10 genetic variations. Our research aimed to create a recombinant plasmid for external control material with a molecular size of 3812 bp. The recombinant plasmid was achieved by cloning an 838 bp gene insert of CYP2D6*10 rs1065852 into a 2974 bp pJET1.2 plasmid into Escherichia coli DH10B and selection on ampicillin agar medium. Isolated E. coli recombinants provided the plasmid molecules for analysis. Bi-directional sequencing and Real-Time PCR confirmed the presence of wild-type and mutant rs1065852 DNA fragments in the plasmid, namely homozygote CC and TT. The conclusion is that we have successfully introduced a novel recombinant plasmid developed by cloning the SNP rs1065852, which carries the 100C>T mutation, using pJET 1.2/blunt system, which could significantly enhance the accuracy of clinical SNP diagnostics for personalized medicine in breast cancer treatment.
Co-Authors Abbas, Zuyyinna Alya Adrian Hartanto, Adrian Ahsanal Kasasiah Ainaputri, Aliza Salsabila Annajla, Fathina Astika, Eriyanti Atwita, Syelziva Yonda Damara, Dandy Satria Daniel Joko Wahyono Debora, Priscinya Christiana Dewijanti, Indah D. Edwin Yulian Elyyana, Nina Fikri, Al Mukhlas Hardiman, Imam Hasna, Vina Luthfiana Hermosaningtyas, Anastasia Aliesa Hitopik, Asman Imam Hardiman Imam Hardiman Indah Laily Hilmi Indratno, Saarah Hamidah Asmara Irwansyah, Silvana Lestari Lestari, Agatha Nabilla Lestari, Sepiyani Ayu Manalu, Rosario Trijuliamos Meilani, Nanda Diva Mierza, Vriezka Muhareva Raekiansyah Muhareva Raekiansyah Munir Alinu Mulki Nur Darmawan, Shiyami Aulia Permatasari, Vera Prastya, Muhammad Eka Primahana, Gian Rahma, Anisa Aula Rahmasari, Ratika Ratnasari, Devi Sa'diyyah, Nur Saryono Seagames Waluyo Seagames Waluyo, Seagames Septi, Annisa Frastica Septiani, Dia Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Siti Rohmah Sukma Wibowo, Sepvia Putri Sulistiawati Urbaningrum , Lestari Mahardika Urbaningrum, Lestari Mahardika Yulian, Edwin Yuswan, Apriza Zahra, Aliya Azkia Zahro, Aurora Fatimatuz Zakiyah, Wildani