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All Journal International Journal of Public Health Science (IJPHS) Buletin Peternakan Majalah Kedokteran Bandung Jurnal Ilmu dan Teknologi Hasil Ternak Media Gizi Mikro Indonesia Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Jurnal Media Gizi Indonesia (MGI) GIZI INDONESIA Animal Production : Indonesian Journal of Animal Production Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Kesehatan Kusuma Husada Livestock and Animal Research Journal of Health and Nutrition Research Proceeding Muhammadiyah International Public Health and Medicine Conference Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)

Adi Magna Patriadi Nuhriawangsa

Animal Husbandry Study Program, Faculty Of Agriculture, Sebelas Maret University, Surakarta

Author-ID : 341099

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Antidiabetic effect of Centella asiatica extract (whole plant) in streptozotocin nicotinamide-induced diabetic rats Arwin Muhlishoh; Brian Wasita; Adi Magna Patriado Nuhriawangsa
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 6, ISSUE 1, 2018
Publisher : Alma Ata University Press

ABSTRAKLatar belakang: Pegagan (Centella asiatica) telah digunakan untuk pengobatan diabetes mellitus. Namun dosis efek anti diabetes ini belum diteliti.Tujuan: Untuk menguji pengaruh variasi dosis ekstrak pegagan (seluruh bagian tanaman) terhadap kadar gula darah, asupan makanan, dan berat badan pada tikus model diabetes mellitus yang diinduksi Streptozotocin Nicotinamide.Metode: Tiga puluh enam tikus Wistar jantan dibagi menjadi enam kelompok perlakuan berbeda: kontrol negatif, kontrol positif, kontrol obat (metformin 45 mg/KgBB/hari), ekstrak pegagan 300 mg/KgBB/hari, 600 mg/KgBB/hari, 1200 mg / KgBB / hari. Pemberian ekstrak pegagan (seluruh bagian tanaman) dan metformin dilakukan selama 28 hari. Kadar gula darah dianalisis menggunakan Glucose Oxidase Phenol Aminoantipyrina Peroxidase (GOD-PAP) sebelum dan sesudah perlakuan. Berat badan dan asupan makanan diukur setiap satu minggu. Data dianalisis menggunakan One Way ANOVA dengan tingkat kepercayaan 95%.Hasil: Pemberian variasi dosis ekstrak pegagan dan metformin secara signifikan menurunkan kadar gula darah, meningkatkan berat badan dan memperbaiki asupan makanan (p = 0,00). Kadar gula darah dan asupan makanan pada kelompok ekstrak pegagan (seluruh bagian tanaman) dosis tinggi (1200 mg / KgBB / hari) lebih baik dibanding kelompok dosis rendah (300 mg / KgBB / hari) dan kelompok dosis sedang (600 mg / hari), dan memiliki efek yang sama dengan tikus yang diobati dengan metformin 45 mg / KgBB / hari.Kesimpulan: Dosis tinggi ekstrak pegagan (1200 mg/KgBB/hari) memiliki efek anti-diabetes yang lebih baik dibanding dosis lain, dan memiliki efek yang sama dengan kontrol obat.KATA KUNCI: gula darah, diabetes, pegagan, Streptozotocin nicotinamideABSTRACT Background: Centella asiatica has been used for healing diabetes mellitus. The dosage of this anti diabetic effect was yet to be explored.Objectives: To examine the effect of the variation in the dosage of C. asiatica extract (whole plant) on blood glucose levels, food intake, and body weight in Streptozotocin Nicotinamide induced diabetic rats.Methods: Thirty-six male Wistar rat were divided into six different groups of treatments: negative control, positive control, medication control (metformin 45 mg/KgBW/day), extract of C. asiatica 300 mg/KgBW/day, 600 mg/KgBW/day, 1200 mg/KgBW/day. Treatments of C. asiatica extract (whole plant) and metformin was done for 28 days. Blood glucose was analyzed using the Glucose Oxidase Phenol Aminoantipyrina Peroxidase (GOD-PAP) before and after treatment. Body weight and food intake were measured every one week. The data were analyzed using One Way ANOVA with 95% confidence level.Results: The administration of the variation in the dosage of C. asiatica extract and metformin significantly decrease blood glucose levels, increase body weight and improve food intake (p =0.00). Blood glucose level and food intake among high dosage of C. asiatica extract (whole plant) group (1200 mg/KgBW/day) is better than the low dosage group (300 mg/KgBW/day) and moderate dosage group (600 mg/KgBW/ day), and have the same effect with the rats treated with metformin 45 mg/KgBW/day.Conclusion: High dosage of C. asiatica extract (1200 mg/KgBW/day) had a better anti-diabetic effe than other dosages, and had the same effect with the medication control.KEYWORDS: blood glucose, Centella asiatica, diabetes, nicotinamide, Streptozotocin

Pengaruh chronotype dan tingkat stres terhadap status gizi dengan mediator perilaku makan pada mahasiswa perkuliahan daring Tesa Rafkhani; Mohammad Fanani; Adi Magna Patriadi Nuhriawangsa
Jurnal Gizi Klinik Indonesia Vol 18, No 2 (2021): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.70661

The effect of chronotype and stress levels on nutritional status mediated by eating behavior in college students with online lectureBackground: College students are a group at risk of experiencing changes in stress levels, changes in eating behavior, and sleep quality. Unhealthy eating behavior, if done continuously, will lead to weight gain.Objective: This study aims to analyze the effect of chronotype and stress levels on nutritional status mediated by the eating behavior of college students with online lectures.Methods: Cross-sectional survey with multistage cluster random sampling on 220 respondents. Chronotype data used by Morningness - Eveningness Questionnaire (MEQ). Stress level data using by Perceived Stress Scale (PSS-10) questionnaire. Eating behavior data was used by Dutch Eating Behavior Questionnaire (DEBQ). Nutritional status data is measured according to body mass index (BMI) by measuring weight (kg) and height (m2). Data were analyzed using Partial Least Square-Structural Equation Model (PLS-SEM) analysis using SmartPLS software.Results: The results showed that there was a significant indirect effect between chronotype (x1) on nutritional status (y2) mediated by eating behavior (p=0.037) with an impact of 0.085 or 8.5%. In comparison, the magnitude of the direct effect without a mediator was 0.193 or 19.3%. Furthermore, there is a significant indirect effect between stress level (x2) on nutritional status (y2) mediated by eating behavior (p=0.017) with an impact of 0.074 or 7.4%. The direct effect without a mediator is 0.217 or 21.7%.Conclusions: There is a significant indirect effect between chronotype and stress level on nutritional status mediated by eating behavior in students with online lectures. During the COVID-19 pandemic, college students should continue to pay attention to healthy eating behavior by preventing emotional eating, setting bedtime earlier, and avoiding stress by increasing physical activity.

HUBUNGAN BEBERAPA FAKTOR DENGAN STUNTING PADA BALITA BERAT BADAN LAHIR RENDAH Frienty Sherlla Mareta Lubis; Risya Cilmiaty; Adi Magna
Jurnal Kesehatan Kusuma Husada Vol. 9 No. 1, Januari 2018
Publisher : Universitas Kusuma Husada Surakarta

Stunting merupakan salah satu masalah gizi yang utama pada anak di Indonesia. Stunting menjadi masalah yang serius karena dikaitkan dengan kualitas sumberdaya manusia di kemudian hari. Anak dengan BBLR(Berat Badan Lahir Rendah) beresiko lebih tinggi menjadi stunting. Tujuan untuk mengetahui hubungan antara IMD (Inisiasi Menyusu Dini), dan BBLR dengan stunting pada anak usia 12-24 bulan dengan berat badan lahir rendah. Jenis penelitian adalah observasional analitik dengan menggunakan desain penelitian cross-sectional. Subjek penelitian ditentukan dengan purposive sampling. Subjek terdiri dari 82 balita yang berusia 12-24 bulan dengan BBLR di 2 kecamatan di Kota Surakarta. Pengumpulan data dilakukan dengan wawancara langsung dan pengukuran antropometri. Uji statistik Chi-square digunakan untuk menganalisis hubungan antara variabel IMD dengan stunting dan uji Anova digunakan untuk menganalisis hubungan antara variabel BBLR dengan stunting. Hasil: IMD tidak berhubungan signifikan dengan kejadian stunting (XÃ‚Â² = 0,286, p = 0,593), berat badan lahir rendah (BBLR) berhubungan signifikan dengan kejadian stunting pada ÃŽÂ± 10 % ( F = 1,561, p = 0,087). Kesimpulan: ada hubungan antara Berat Badan Lahir Rendah dengan Kejadian Stunting. Stunting is one of the main nutritional problems in children in Indonesia. Stunting becomes a serious problem because it is associated with the quality of human resources in the future. Children with LBW (Low Birth Weight) are at higher risk of becoming stunting. Objective: To know the relationship between IMD, and LBW with stunting in children aged 12-24 months with low birth weight. The type of research is observational analytic by using cross-sectional research design. Research subject is determined by purposive sampling. Subject consisted of 82 children aged 12-24 months with LBW in 2 districts in Surakarta. Data collection is done by direct interview and anthropometry measurement. Chi-square statistical test is used to analyze the relationship between IMD variable with stunting and Anova test is used to analyze the relationship between LBW variable with stunting. The result: IMD was not significantly associated with stunting incidence (XÃ‚Â² = 0.286, p = 0,593), low birth weight (LBW) was significantly associated with stunting incidence at ÃŽÂ± 10% (F = 1.561, p = 0.087). Conclusion: there is a relationship between Low Birth Weight with Stunting Event.

Ajwa Date (Phoenix dactylifera L.) Extract to Prevent Alzheimer’s Disease in Rat Model Rizka Muthia Nuruddin; Brian Wasita; Adi Magna Patriadi Nuhriawangsa
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2871

Alzheimer's disease (AD) is the most common disease of aging characterized by increased extracellular deposits of amyloid-β (Aβ) in the brain. Globally, the number of people affected by AD has increased from 35.6 million in 2010 to 46.8 million in 2015. Ajwa dates contain phenolic compounds that can protect against inflammation and oxidative stress in the brain. This study aimed to analyze the effect of the dose and duration of Ajwa date extract administration on IL-6 levels and SOD activity in rats induced with 400 mg/day homocysteine to trigger Alzheimer's Disease. This was a laboratory experimental study with a pretest-posttest group design conducted at the Laboratory of the Center for Food and Nutrition Studies (PSPG), Universitas Gadjah Mada, Yogyakarta, Indonesia from December 2020 - January 2021. A total of 48 rats were divided into one control group, one untreated group, and 4 treatment groups that received different doses of Ajwa Date Extract (ADE) for 21 and 28 days in rats. The results showed that the administration of ADE (Ajwa date extract) for 21 and 28 days could reduce IL-6 levels but did not have the same effectiveness as donepezil. The administration of 800 mg/kg BW ADE for 28 days can increase SOD activities with the same effectiveness as donepezil. Ajwa date extract can be proven to have beneficial effects to prevent Alzheimer's disease and can be used to prevent decreased antioxidant and increased inflammation. Thus, further studies to explore the potential clinical use of the extract to manage Alzheimer's Disease may be beneficial.

EFEK KOMBINASI BUBUK MENGKUDU DAN KELOR TERHADAP GLUKOSA DARAH PUASA TIKUS DMT2 DISLIPIDEMIA Alfian Abdul Rajab; Adi Magna Patriadi Nuhriawangsa; Setyo Sri Rahardjo
GIZI INDONESIA Vol 46, No 1 (2023): Maret 2023
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v46i1.765

The prevalence of people with diabetes mellitus type 2 (DMT2) with dyslipidemia complications continues to increase. Hyperglycemia that occurs in DMT2 patients can cause oxidative stress that disrupts lipid metabolism. Combination of kelor and mengkudu powder has the potential to help lower blood glucose in T2DM with dyslipidemia because it contains flavonoids that can prevent oxidative stress and fiber that can slow the absorption of blood glucose. This study aims to determine the effect of giving a combination of kelor and mengkudu powder on changes in GDP levels in T2DM with dyslipidemia. This type of research is true-experimental with pretest-posttest with control group design. This study used 30 male Wistar rats aged 2-3 months, weighing 150-250 grams. The rats were divided into 6 groups, KN normal conditioned rats, K- T2DM rats without treatment, K+ T2DM rats given the drug atorvastatin and groups P1, P2, P3, T2DM rats given a combination powder of 600 mg/200 gBB /day in the ratio of P1 (0.5: 1.5), P2 (1: 1) and P3 (1.5: 0.5) for 14 days. GDP levels were examined using the GOD-PAP method, data analysis using the Wilcoxon test. After 14 days of intervention, the P2 group experienced the highest decrease in GDP levels of 176.20 ± 20.25 mg/dL (p=0.043) while in the control group there was no significant difference (p=0.416). Giving combination powder has an effect in reducing GDP levels. Combination powder can be considered to reduce glucose levels.Keywords: diabetes, GDP, kelor, mengkudu, powder ABSTRAK Prevelansi penyandang diabetes melitus tipe 2 (DMT2) dengan komplikasi dislipidemia terus mengalami peningkatan. Hiperglikemia yang terjadi pada pasien DMT2 dapat menimbulkan stress oksidatif sehingga mengganggu metabolisme lipid. Bubuk kombinasi kelor dan mengkudu berpotensi membantu menurunkan glukosa darah pada DMT2 dislipidemia karena mengandung flavonoid yang dapat mencegah stres oksidatif dan serat yang dapat memperlambat penyerapan glukosa darah. Penelitian ini bertujuan untuk mempelajari pengaruh pemberian bubuk kombinasi kelor dan mengkudu terhadap perubahan kadar GDP pada DMT2 dislipidemia. Jenis penelitian ini adalah true-experimental dengan pretest-posttest with co ntrol group design. Penelitian ini menggunakan 30 ekor tikus jantan Wistar usia 2-3 bulan dengan berat 150-250 gram. Tikus dibagi menjadi 6 kelompok yaitu KN tikus dikondisikan normal, K- tikus DMT2 tanpa perlakuan, K+ tikus DMT2 yang diberi obat atorvastatin dan kelompok P1, P2, P3 yaitu tikus DMT2 yang diberi bubuk kombinasi sebanyak 600 mg/200 gBB/Hari dengan perbandingan P1 (0,5:1,5), P2 (1:1) dan P3 (1,5:0,5) selama 14 hari. Kadar GDP diperiksa dengan metode GOD-PAP, analisis data menggunakan uji Wilcoxon. Setelah 14 hari intervensi kelompok P2 mengalami penurunan kadar GDP paling tinggi 176,20 ± 20,25 mg/dL (p=0,043) sedangkan pada kelompok kontrol tidak terdapat perbedaan yang bermakna (p=0,416). Pemberian bubuk kombinasi berpengaruh dalam menurunkan kadar GDP. Bubuk kombinasi dapat dipertimbangkan untuk menurunkan kadar glukosa.Kata kunci: bubuk, diabetes, GDP, kelor, mengkudu

PENGARUH PEMBERIAN SNACK CUP PISANG, KURMA, DAN MADU TERHADAP KADAR HEMOGLOBIN REMAJA PUTRI ANEMIA Vadira Rahma Sari; Adi Magna Patriadi Nuhriawangsa; Setyo Sri Rahardjo
GIZI INDONESIA Vol 46, No 1 (2023): Maret 2023
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v46i1.808

Approximately 50 percent of anemia in women is caused by iron deficiency. Using bananas, dates, and honey in a snack cup can be an alternative to fulfilling daily iron needs. This study aims to determine the effect of giving the snack cup on the hemoglobin levels of anemic adolescent girls. This study is a randomized control trial with a pretest-posttest with control groups design, which was conducted for two weeks with 32 anemic adolescent girls aged 13-18 years old and menstruating as subjects. Divided randomly into four groups Groups K- (regular food), K+ (iron tablets), P1 (snack cup containing 11,45 mg of iron), and P2 (snack cup containing 13,44 mg of iron). Hemoglobin levels were checked using the Autoanalyzer method. The paired-sample t-test showed that there were no significant differences before and after treatment in the four groups, as indicated by the values of p= 0.922 (K-), p= 0.619 (K+), p= 0.784 (P1) and p= 0.922 (P2). Kruskal Wallis test showed no difference in the mean change in hemoglobin between groups (p= 0.355). Consumption of SangKurMa F2 and F4 for two weeks did not affect the hemoglobin levels of anemic adolescent girls. It is necessary to balance the intake of other nutrients, such as protein which also plays a role in the process of hemoglobin synthesis. Keywords: anemia, hemoglobin, sangkurma snack cup, vitamin C, iron ABSTRAK Sekitar 50 persen kejadian anemia pada perempuan disebabkan defisiensi zat besi. Penggunaan pisang, kurma dan madu dalam pembuatan snack cup dapat menjadi alternatif pemenuhan kebutuhan zat besi harian remaja putri anemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian snack cup terhadap kadar hemoglobin remaja putri anemia. Penelitian ini merupakan randomized control trial dengan rancangan pretest posttest with control group. Penelitian dilakukan selama 2 minggu dengan subjek 32 remaja putri anemia berusia 13-18 tahun dan telah menstruasi yang kemudian dibagi secara random kedalam 4 kelompok. Kelompok K- (hanya mengonsumsi makanan biasa), K+ (diberikan TTD), P1 (diberikan snack cup mengandung 11,45 mg zat besi)) dan P2 (diberikan snack cup mengandung 13,44 mg zat besi). Kadar hemoglobin diperiksan menggunakan metode Autoanalyzer. Uji paired-sample t-test menunjukkan tidak terdapat perbedaan signifikan sebelum dan sesudah perlakuan pada keempat kelompok yang ditunjukkan dengan nilai p= 0,922 (K-), p= 0,619 (K+), p= 0,784 (P1) dan p= 0,922 (P2). Uji kruskal wallis menunjukkan tidak terdapat perbedaan perubahan rerata hemoglobin antar kelompok (p= 0,355). Konsumsi snack cup SangKurMa F2 dan F4 selama 2 minggu tidak berpengaruh terhadap kadar hemoglobin remaja putri anemia. Perlu adanya penyeimbangan asupan zat gizi lainnya seperti protein yang juga berperan dalam proses sintesis hemoglobin. Kata kunci: anemia, hemoglobin, snack cup sangkurma, vitamin C, zat besi

Evaluation of Food Hygienic Practices Training on Knowledge, Attitude, and Practice: A Study on Traditional Rambak Production in Berkah Enterprise Adi Magna Patriadi Nuhriawangsa; Lilik Retna Kartikasari; Winny Swastike; Aqni Hanifa; Bayu Setya Hertanto
Jurnal Ilmu dan Teknologi Hasil Ternak (JITEK) Vol. 18 No. 3 (2023)
Publisher : Faculty of Animal Science Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitek.2023.018.03.1

Rambak (hide’s cracker) produced by small and medium-scale local communities still relies on production processes that have been passed down from generation to generation, resulting in minimal application of information and technology related to food safety. Thus, training in food hygienic practices needs to be carried out on different food handlers in order to provide an overview of the level of success of a program. This research aims to evaluate the impact of food hygienic practices training on knowledge, perception, attitude, and practice of food handlers in producing rambak. Training activities were carried out at the rambak production site involving 14 workers. The training process included presentations of raw materials (hides), rambak qualities, and good hygienic practices, then it was followed by demonstrations of good hygiene practices. Furthermore, the workers put into practice the work method demonstrated by the team. The assessment of knowledge, attitudes, and practices using questionnaire were carried out before and after the training. After training, the majority of rambak workers understand how to use raw materials and food hygiene practices, but they lack knowledge about packaging aspects and good rambak quality, such as washing fresh ingredients with tap water. Worker attitudes show that they have positive attitudes toward good hygiene practices, with the exception of touching food with bare hands. Food hygiene practice demonstrates that they had good hygienic practices, but they did not separate raw materials from cooked rambak. The effect of food hygiene practices training on internal characteristics demonstrates that workers' attitudes improved significantly (p<0,05), but not their knowledge and practice of hygienic principles. In summary, several aspects of worker characteristics need to be improved includes knowledge, attitude, and practice of food hygiene. The training effect improved rambak workers' attitudes but did not improve their knowledge or practice of hygienic principles

Women osteoporosis prevention by protein, fat, vitamin D, phosphorus intake and chicken feet cookies consumption as source of calcium Rahma Ayu Ramadhania; Adi Magna Patriadi Nuhriawangsa; Lilik Wijayanti
AcTion: Aceh Nutrition Journal Vol 9, No 2 (2024): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v9i2.1699

Osteoporosis as a major health problem has four times risk in women than men. Protein, fat, vitamin D, and phosphorus are the main nutrients in bone development. Through this study, it can be known protein, fat, vitamin D, and phosphorus changes from the consumption of cookies chicken feet flour (Gallus domesticus), containing 130 mg calcium, equivalent to 15% of RDA to prevent osteoporosis due to low calcium intake with a quasi-experimental pre-test and post-test approach with control in women early adulthood for 14 days in Health Office of Tasikmalaya District in June 2022, with 102 people as sample based on Slovin's calculation with 10% of margin error through the multistage sampling method, which consists of cluster random sampling and simple random sampling. Observation of protein, fat, vitamin D, and phosphorus using the semi food frequency questionnaire. Data analysis used Post Hoc LSD. Based on data analysis, it is known that the difference in protein, vitamin D, and phosphorus intake significantly different with p> 0,05 of the three groups each other. While the difference in fat intake significantly different from the positive and negative control groups with p> 0,05. Consumption of cookies can increase protein, fat, vitamin D, and phosphorus intake.

Antihyperglycemic effect of patikan kebo in the rat models of diabetic Sherly Asri Widyaningrum; Brian Wasita; Adi Magna Patriadi Nuhriawangsa
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Diabetes mellitus is a heterogeneous metabolic disorder characterized by increased blood sugar levels due to insulin disorders. Current treatment for diabetes mellitus focuses on controlling and lowering blood glucose. However, long-term treatment for diabetes mellitus can have side effects that cause several medical problems. Medical therapy using natural ingredients as an alternative therapy is currently being considered because of its potential and minimal side effects. Patikan kebo is a natural ingredient containing the flavonoid quercetin group. However, the antihyperglycemic effect of the patikan kebo leaves is not known with certainty. This study aimed to determine the effect of patikan kebo leaf extract (EDPK) on the levels of GDP, insulin, HOMA-IR, and HOMA-B in male rats with diabetes mellitus induced by streptozotocin (STZ) and nicotinamide (NA). The design of this study was a pre-and post-test control group design. 42 male Wistar rats were divided into 7 groups: K (normal mice), KN (DMT2 mice without intervention), KP (DMT2 mice intervened with acarbose 1.8 mg/kg BW/day), P1 (DMT2 mice intervened with EDPK dose 75 mg/kg BW/day), P2 (DMT2 mice intervened with EDPK dose 150 mg/kg BW/day), and P3 (DMT2 rats intervened with EDPK dose 300 mg/kg BW/day). The intervention was given for 7 and 15 days. The data were statistically analyzed using the Two Way ANOVA test. EDPK was proven to decrease GDP and HOMA-IR levels and increase insulin and HOMA-B in the male Wistar rat model of diabetes mellitus induced by STZ+NA. EDPK with a dose of 300 mg/kg BW/day proved to have the strongest antihyperglycemic effect. Abstrak: Diabetes melitus merupakan penyakit kelainan metabolisme heterogen yang ditandai dengan adanya peningkatan kadar gula darah akibat gangguan sekresi insulin. Pengobatan diabetes melitus saat ini berfokus pada pengendalian dan penurunan kadar glukosa darah. Akan tetapi lama terapi pengobatan pada diabetes melitus dapat memberikan efek samping yang menyebabkan beberapa masalah medis. Terapi pengobatan menggunakan bahan alami sebagai terapi alternatif saat ini lebih dipertimbangkan karena potensi serta minimalnya efek samping yang diberikan. Patikan kebo merupakan bahan alami dengan kandungan flavonoid golongan quercetin. Namun saat ini belum diketahui secara pasti efek antihiperglikemik dari daun patikan kebo tersebut. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun patikan kebo (EDPK) terhadap kadar GDP, insulin, HOMA-IR, dan HOMA-B pada tikus jantan diabetes melitus yang diinduksi Streptozotocin (STZ) dan Nicotinamide (NA). Rancangan penelitian ini dengan pre and post test controlled group design. 42 ekor tikus jantan wistar dibagi menjadi 7 kelompok; K (tikus normal), KN (tikus DMT2 tanpa intervensi), KP (tikus DMT2 diintervensi dengan acarbose 1,8 mg/kgBB/hari), P1 (tikus DMT2 diintervensi EDPK dosis 75mg/kgBB/hari), P2 (tikus DMT2 diintervensi EDPK dosis 150mg/kgBB/hari), P3 (tikus DMT2 diintervensi EDPK dosis 300mg/kgBB/hari). Intervensi diberikan selama 7 dan 15 hari. Data dianalisis statistik menggunakan uji Two Way Annova. EDPK terbukti dapat menurunkan kadar GDP dan HOMA-IR, serta meningkatkan insulin dan HOMA-B pada tikus jantan wistar model diabetes melitus yang diinduksi STZ+NA . EDPK dengan dosis 300 mg/kg BB/hari intervensi terbukti memiliki efek antihipeglikemi paling kuat.

Cava Smoothie As An Adjuvant in Iron Supplementation Can Increase Hemoglobin Levels and Erythrocyte Indices in Anemic Adolescent Girls Aryani, Vina Dinata Kamila; Muthmainah, Muthmainah; Nuhriawangsa, Adi Magna Patriadi
Media Gizi Indonesia Vol. 18 No. 3 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v18i3.188-200

Uncontrolled anemia leads to a decline in hemoglobin levels and erythrocyte blood indices, posing various health risks. To address this, a study aimed to assess the effectiveness of cava smoothies and iron supplementation in boosting hemoglobin levels and erythrocyte indices among anemic adolescent girls. The study involved 87 adolescent girls with moderate anemia, divided into three groups. The control group (C) received weekly iron tablets (60 mg), while two intervention groups (I1 and I2) were given the same iron tablets along with cava smoothies in increasing doses over 28 days. The results revealed significant improvements in hemoglobin levels. Group C showed an increase of 0.27 g/dL, while I1 and I2 demonstrated remarkable gains of 1.46 g/dL and 2.54 g/dL, respectively. Furthermore, erythrocyte indices (MCV, MCH, MCHC) exhibited positive changes. Group C saw increases of 0.35 fl, 0.34 pg, and 0.27 g/dL, I1 showed improvements of 0.69 fl, 0.61 pg, and 0.64 g/dL, and I2 experienced substantial enhancements of 1.97 fl, 1.61 pg, and 1.60 g/dL. In conclusion, the study confirmed that cava smoothies and iron supplementation effectively raise hemoglobin levels and improve erythrocyte indices in anemic adolescent girls, highlighting the potential benefits of this intervention for combating anemia.

Co-Authors Abd. Rasyid Syamsuri Abda Abda Adi Ratriyanto Adi Ratriyanto afifah, najla Agung Budiharjo Agustin Widiastuti Aji, Hutama Puranto Alfian Abdul Rajab Ananda Septi Dwi Pamungkas Aqni Hanifa Arwin Muhlishoh Aryani, Vina Dinata Kamila Astari Ratnaduhita Bayu Setya Hertanto Bayu Setya Hertanto Bayu Setya Hertanto Bayu Setya Hertanto Bayu Setya Hertanto Bayu Setya Hertanto Brian Wasita Brian Wasita Brian Wasita Brian Wasita Brian Wasita Brian Waskita Catur Suci Purwati Devi, Rhisma Mutiara Dhiah Putri Utami Diah Sekar Haruni Diffah Hanim Elita Marintan Farough Heidar Barido Fitria Dhenok Palupi Frienty Sherlla Mareta Lubis Harsono Salimo Haruni, Diah Sekar Indah Nur Lestarini Inna Siswanti Saputri Kinanthi Dewi Mutiek Krisna Rendi Awalludin Lies Mira Yusiati Lilik Kartikasari, Lilik Lilik Retna Kartikasari Lilik Retna Kartikasari Lilik Retna Kartikasari Lilik Retna Kartikasari Lilik Retna Kartikasari Lilik Wijayanti Mahra, Arifa Sofia Mohammad Fanani Mohammad Fanani Mohammad Fanani Muthmainah Muthmainah Novitasari Anggarawati Paramasari Dirgahayu Pratiwi Pratiwi Wulandari Pudjomartatmo Pudjomartatmo Pudjomartatmo Pudjomartatmo Rahardjo, Setyo Sri Rahardjo, Setyo Sri Rahma Ayu Ramadhania Ratih Dewanti Ratih Puspita Febrinasari Ratih Puspita Febrinasari Risya Cilmiaty Rizka Muthia Nuruddin Sajidan Sajidan (Sajidan) Septiana, Dian Setyo Sri Rahardjo Setyo Sri Rahardjo Sherly Asri Widyaningrum Sigit Yudhistira Soeparno Soeparno Tesa Rafkhani Tri Nugraha Susilawati USMAN, FAHMIL Vadira Rahma Sari Winny Swastike Winny Swastike Winny Swastike Winny Swastike Yanita Listianasari Yohan Fallo

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