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All Journal PHARMACON Jurnal Penelitian Farmasi Indonesia Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Pharmacoscript Jurnal Kefarmasian AKFARINDO Jurnal Inovasi Penelitian Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Michrun Nisa
Sekolah Tinggi Ilmu Farmasi Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : PHARMACON

 1 
FORMULASI GLIBENKLAMID DENGAN METODE SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) DAN UJI IN-VITRO DISOLUSI Nisa, Michrun
PHARMACON Vol 5, No 1 (2016): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.5.2016.11234

Abstract

FORMULASI GLIBENKLAMID DENGAN METODE SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) DAN UJI IN-VITRO DISOLUSI   Michrun Nisa1), Abdul Halim Umar1), Aisyah Fatmawati2) 1)Akademi Farmasi Kebangsaan Makassar 1)Fakultas Farmasi Universitas Hasanudin Makassar   ABSTRACT   Glibenclamide formulation has been research by the method of  Self Emulsifying Drug Delivery Systems  ( SEDDS ) and studies  in-  vitro  dissolution . This study aims to improve the dissolution rate of glibenclamide with  solid self-  emulsifying system  ( SSE ).  Solid self  -  emulsifying  process using the method of adsorption into the  solid carrier  . Glibenklamid  solid self emulsifying  ( SSE ) using a variation phase lipid of oleic acid and oleum  cocos , surfactant (  Tween 80) , and a variation of solid carrier (Avicel pH 101 , Lactose and Aerosil). Characterization results of glibenclamide  solid self-emulsifying  in-  vitro dissolution test using the medium of pH 7.4 phosphate buffer containing 8.5  % alcohol 96 % and 0.24 % tween 80 , sampling was conducted at 20, 40 , 60 , 80 , 100 and 120 minutes, were measured using a UV spectrophotometer at a wavelength 224 nm . The results showed that the formula 4 ( oleic acid  -  lactose ) release rate  62,628  %  at minute 120 , formula 5 ( oleic acid  -aerosil ) release rate  37,938 %,  formula 2 ( oleum cocos  -  lactose ) release rate 24,093 % , formula 3 (oleum cocos-avicel pH 101) release rate  23,689% , and the formula 1 (oleic acid - lactose ) release rate 21,977% . Key Words : Glibenclamide, SEDDS, Solid Carier, Dissolution. ABSTRAK   Penelitian formulasi glibenklamid dengan metode Self Emulsifying Drug Delivery Systems (SEDDS) dan  studi  in-vitro Disolusi bertujuan  untuk meningkatkan  laju disolusi glibenklamid dengan menggunakan sistem solid self emulsifying (SSE). Proses solid self-emulsifying dilakukan dengan metode adsorpsi ke dalam pembawa padatan (solid carrier). Formulasi Glibenklamid solid self emulsifying (SSE) menggunakan variasi minyak asam oleat dan oleum cocos, surfaktan (Tween 80), serta variasi solid carrier (Avicel pH 101, Laktosa dan Aerosil). Karakterisasi hasil glibenklamid solid self-emulsifying meliputi uji in-vitro disolusi menggunakan medium dapar posfat pH 7,4 mengandung 8,5 % alkohol 96% dan 0,24% tween 80, pengambilan sampel dilakukan pada menit ke- 20, 40, 60, 80, 100 dan 120 , kadarnya diukur menggunakan spektrofotometer UV pada panjang gelombang 224 nm. Dari hasil penelitian diketahui bahwa formula 4 (asam oleat-laktosa) terdisolusi hingga  62,628%  pada  menit  ke  120,  formula  5  (asam  oleat-aerosil)  terdisolusi 37,938%, formula 2 (oleum cocos-laktosa) terdisolusi 24,093%, formula 3 (asam oleat-avicel pH 101) terdisolusi 23,689%, dan formula 1 (oleum cocos-avicel pH 101) terdisolusi 21,977%.   Kata kunci : Glibenklamid, Sistem Solid Self Emulsifying (SSE), Solid carrier, Disolusi  
Co-Authors AA Sudharmawan, AA Abdul Halim Umar Agustina Ma'tang Parinding Aisyah Aisyah Aisyah F, Aisyah Aisyah Fatmawaty Alfrita Sarrin Sarrin Ali Djamhuri Andi Ardiansyah Arifin Andi Nur Aisyah Andi Paluseri Anugrawan, Muh Anugrawan, Muh Astrid, Astrid Astuti Amin Doa, Febi Rofina Doa, Febi Rofina Dwi Anggara Putri Usman Fahimah, Nurul Fajriansyah Fajriansyah Fajriansyah, Fajriansyah Fatima Fatima Febi Rofina Doa Hapiwaty, Saldi Harlyanti Muthma'innah Mashar Hikma, Nurul Irmayani Irmayani Irmayani Irmayani Ismail Ismail Ismail Ismail K, Nurul Alifah Khairi, Nur Khairuddin Khairuddin Laksono Trisnantoro Lukman Muslimin Mangampa, Yunita Mangampa, Yunita Maria Ulfa Maulita Indrisari, Maulita Mirnawati Salampe Muh Anugrawan Nia Rafiana Nuraisyah, Andi Nurfahmi Ruslan Nursamsiar Nursamsiar Nurul Fahimah Radhia R Radhia R, Radhia Radhia Riski Rannu, Sriwanti Lisu Rannu, Sriwanti Lisu Reny Syahruni Risnayanti, Risnayanti Sahibuddin A Gani Sahibuddin A Gani, Sahibuddin A Salampe, Mirnawati Saputri, Nawalu Sitti Rahimah Sitti Rahimah, Sitti Sriwanti Lisu Rannu Sunarti Sunarti Supardi Suwahyuni Mus Suwahyuni Suwahyuni Sweety Dwy Sarty Syamid, Ahmad Gufairil Trisna Junianti Pawarrangan Tuti Handayani Zainal Tuti Handayani Zainal Wahyu Hendrarti Wahyu Hendrarti Waode Syawal Lastri Yunita Mangampa Yuri Pratiwi Yusuf, Nurul Arfiyanti Zainal, Tuti Handayani