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Journal : Universa Medicina

Risk factors of intracranial stenosis among older adults with acute ischemic stroke Pinzon, Rizaldy; Asanti, Laksmi; Sugianto, Sugianto; Widyo, Kriswanto
Universa Medicina Vol 28, No 1 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.1-7

Abstract

Intracranial large artery atherosclerosis is an important cause of stroke worldwide. Previous studies have shown that it is found more commonly in Asians. However, studies of intracranial stenosis in Indonesian stroke patients have been very few in number. The aim of this cross-sectional study was to determine the frequency and risk factors of intracranial stenosis in acute ischemic stroke. The data were obtained from 234 consecutive patients in the transcranial doppler (TCD) registry. Documentation of risk factors was performed systematically and for TCD sonography TD-DOP 9000 equipment with a 2-MHz probe was used for the examination of the intracranial circulation. The criteria of middle cerebral artery (MCA) stenosis used in this study were a peak systolic velocity (PSV) >140 cm/s or mean systolic velocity (MSV) >80 cm/s. For stenosis of the posterior circulation the criteria were PSV > 90 cm/s or MSV >60 cm/s. The data were obtained from 234 patients, and complete examinations were performed in 182 patients (77.7%). Ischemic stroke is the most common indication for performing TCD sonography. Stenosis was present in 38% of cases, with stenosis iof the anterior circulation being the more common. The most frequent risk factors were hypertension, dyslipidemia, and diabetes. Intracranial stenosis is common in stroke patients, in whom the risk factors are hypertension and diabetes.
Telaah kritis terapi risperidone untuk perbaikan perilaku pada gangguan spectrum autistik Pinzon, Rizaldy; Meliala, Lucas; Sutarni, Sri
Universa Medicina Vol 26, No 1 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.39-45

Abstract

Autisme adalah sindroma klinik yang ditandai oleh gangguan interaksi sosial, hambatan komunikasi verbal, dan keterbatasan aktivitas serta minat. Sampai saat ini, tidak ada terapi untuk autisme. Pengobatan farmakologis terutama ditujukan untuk mengurangi agresivitas, perilaku obsesif kompulsif, dan perilaku melukai diri sendiri. Telaah pustaka ini menunjukkan bahwa risperidone efektif dan aman untuk terapi tantrum, agresivitas, dan perilaku melukai pada anak-anak autistik. Namun risperidon tidak dapat memperbaiki kekurang anak dalam hal interaksi sosial dan komunikasi. Diperlukan penelitian lebih lanjut untuk mengembangkan pengobatan yang efektif untuk memperbaiki gangguan intarksi sosial dan komunikasi pada penderita autistik. Efektifitas yang menjanjikan dari resperidone ini memberikan harapan untuk mengobati anak-anak yang mengalami gangguan perilaku pada autisme.
Combination of five clinical data as prognostic factors of mortality after ischemic stroke Pinzon, Rizaldy Taslim; Babang, Fransiska Theresia Meivy; Pramudita, Esdras Ardi
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.68-76

Abstract

Background The mortality rate after ischemic stoke is influenced by various factors. Prognosis after ischemic stroke can be predicted using a scoring system to help the doctor to evaluate patient’s condition, neurologic deficits, and possible prognosis as well as make appropriate management decisions. The objective of this study was to identify the factors which determine mortality rates in patients after ischemic stroke and to determine the prognosis of ischemic stroke patients using the predictive mortality score.MethodsThis was a nested case control study using data from the stroke registry and medical records of patients at the Neurology Clinic of Bethesda Hospital Yogyakarta between 2011-2015. Data was analysed using simple and multiple logistic regression analysis. The scoring was analyzed using receiver-operating characteristic (ROC) curve and the cut-off point using area under the curve (AUC).ResultsMultiple logistic regression analysis showed a significant association between mortality of ischemic stroke patients and age (OR: 4.539, 95% CI: 1.974-10.439, p<0.001), random blood glucose (OR: 2.692, 95% CI: 1.580-4.588, p<0.001), non-dyslipidemia (OR: 2.313, 95% CI: 1.395-3.833, p=0.001), complications (OR: 1.609, 95% CI: 1.019-2.540, p=0.041), risk of metabolic encephalopathy (OR: 2.499, 95% CI: 1.244-5.021, p=0.010) and use of ventilators (OR: 17.278, 95% CI: 2.015-148.195, p=0.009).ConclusionsAge, high random blood glucose level, complications, metabolic encephalopathy risk and the use of ventilators are associated with mortality after ischemic stroke. The predictive mortality score can be used to assess the prognosis of patients with ischemic stroke.
Complications as important predictors of disability in ischemic stroke Pinzon, Rizaldy Taslim; Sanyasi, Rosa De Lima Renita
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.197-204

Abstract

BackgroundStroke is the main cause of disability and death in many countries. The high incidence of disability in stroke survivors requires special attention to determine various predictive factors of disability. This study aimed to identify the various predictive factors of disability in ischemic stroke.MethodsThis study was a cross sectional study on 4510 ischemic stroke patients. Each patient’s data had been recorded in the electronic stroke registry of Bethesda Hospital. Ischemic stroke diagnosis was confirmed by brain CT scan, which was interpreted by a neurologist and a radiologist. Disability was assessed using the modified Rankin scale. Predictors of disability were assessed. Multiple logistic regression analysis was used to analyse the data. ResultsThe subjects were predominantly males, >60 years of age, and suffered stroke for the first time. The incidence of disability was 31.5% (1420/4510). Multiple logistic regression analysis showed that the presence of complications (OR: 6.43; 95% CI: 4.74-8.73; p<0.001), decreased level of consciousness (OR: 4.82; 95% CI: 3.95-5.90; p <0.001), onset ³3 hours (OR: 1.93; 95% CI: 1.52-2.45; p<0.001), recurrent stroke (OR: 1.63; 95% CI: 1.39-1.90; p<0.001), and age >60 years (OR: 1.55; 95% CI: 1.35-1.79; p<0.001) were independent predictive factors of disability.ConclusionWe demonstrated that a substantial proportion of patients with ischemic stroke become disabled. And the presence of complications was the most predictive factor of disability in ischemic stroke.
Co-Authors Adnyana, Kadek Sinthia Grahita Agung Endro Nugroho Agung Wiwiek Indrayani Agustinus Rudolf Phyma, Agustinus Rudolf Al Jody, Abraham Al Jody, Abraham Alexxander Alexxander, Alexxander Alfi Yasmina Alfi Yasmina Amboro, Wisnu Anak Agung Gede Sugianthara Angela, Angela Ardiani, Birgitta Lisbethiara Bagaskara, Arya T Basuki, Mudjiani Bisay, Vallentino Ardine Prasetya Budi Harsana, Mary Rose Angelina Bustami, Mursyid Ciptasari, Debora Purwasista Daniel Mahendra Krisna, Daniel Mahendra Desyandri Desyandri Digdoyo, Ananda Dodik Tugasworo Erna Kristin Esdras Ardi Pramudita, Esdras Ardi Fedora, Gusti Ayu Jacinda Amanda Ferdy Firmansyah Firdaus Hafidz As Shidieq Fithrie, Aida Fransiska Theresia Meivy Babang, Fransiska Theresia Meivy Gelgel, Putu Clara Shinta Hakim, Manfaluthy Hardi Astuti Witasari Hariatmoko Hariatmoko, Hariatmoko Hidayat, Muh. Faris I Putu Eka Widyadharma Ida Safitri Laksanawati Ika Puspitasari Iwan Dwiprahasto Jarir At Thobari Jesisca, Jesisca Johan Budiman Kadex Reisya Sita Damayanti Kriswanto Widyo, Kriswanto Kushartanti, Bernadeta Margareta Wara Lailla Affianti Fauzi Laksmi Asanti, Laksmi Lestari, MMA Dewi Lucas Meliala Maharani, Anyelir Dewi Maharani, Regina Vika Marpaung, Refianda Olivia Febrianti Mitasari, Pradita S Mugiono, Iroen Muhammad Hasnawi Haddani Muktiarini, Bernadetha Muslimah Muslimah Nani Kurniani Nathanael, Hanshel Everad Novita Intan Arovah Nugraha, Boya Padma, Radha Govinda Pagan Pambudi Pandita, Felicia Dara Puspitaning Paramitha, Dessy Pratiwi, Woro Rukmi Priskila, Loury Priskila, Loury Purwaka, Barlaam Bagus Purwaka Purwandityo, Ayuningtyas Galuh Purwantiningsih, Purwantiningsih Putra, I Dewa Gde Rainey Chrisananta Ratih Puspita Febrinasari Rendra, Andreas K. Renita Sanyasi, Rosa De Lima Renita Sanyasi, Rosa De Lima Renita, Rosa De Lima Rosa De Lima Renita Sanyasi, Rosa De Lima Renita Setyawan, Irfanianta Arif Sinaga, Ruth Vanessa Gloria Sinulingga, Zenine Charolin Siti Nurhayati Sudharmadji Sugianto Sugianto s Sugianto Sugianto Susanto, Agnes Susi Susanti Sutejo, Mianti Nurrizky Thomas Eko Purwata Tri Murti Andayani Trijayanti, Christiana Vania Rau, Chiquita Putri Veronica, Vanessa Vidyatama, Veren Amoreta Widyantanti, Maria Atika Sukmana Wijaya, Vincent Ongko Wijono, Andre Dharmawan Wuysang, Audry Devisanty Y, Yudiyanta Yacobus Christian Prasetyo Yolanda Dyah Kartika Zalukhu, Marta Lisnawati