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All Journal Visual Communication Design Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Jurnal Respirasi (JR) Jurnal Akuakultura Universitas Teuku Umar SCRIPTA SCORE Scientific Medical Journal Respiratory Science Narra J International Journal of Health and Pharmaceutical (IJHP) The South East Asian Journal of Management The Journal of Society Medicine (JSOCMED) Jurnal Penyakit Dalam Indonesia
Andika Pradana
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Korelasi Skor Get with The Guidelines-Heart Failure dan Rasio Platelet Limfosit pada Pasien Rawat Inap dengan Gagal Jantung Panjaitan, Samuel Hendryk; Dalimunthe, Naomi Niari; Supriatmo, Supriatmo; Pradana, Andika
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. The Get with the Guidelines-Heart Failure (GWTG-HF) risk score is a widely utilized and validated tool for assessing prognosis in patients with heart failure. Inflammation significantly contributes to the pathophysiology of heart failure, evidenced by platelet activation and a reduction in lymphocyte counts. Consequently, the platelet-to-lymphocyte ratio (PLR) may function as a prognostic biomarker in this population. This study aims to investigate the correlation between the GWTG-HF risk score and PLR as an inflammatory marker in patients hospitalized with heart failure. Methods. This cross-sectional study utilized medical records of heart failure patients admitted to Adam Malik Hospital in Medan from January 2022 to July 2023. Total GWTG-HF scores and PLR values were recorded at the time of patient admission. Correlation analyses were conducted to assess the relationship between the two variables. Results. The study evaluated 106 patient records, with male patients comprising 72.64% and a mean age of 55.84 (SD 14.09) years. The median GWTG-HF score was 37.5, while the median PLR was 137.14. Correlation analysis yielded a coefficient of r = 0.249 (p < 0.05), indicating a statistically significant association.Conclusion. A weak positive correlation exists between the GWTG-HF score and PLR in patients with heart failure, suggesting that PLR may serve as a supplementary inflammatory marker in prognostic assessments.
The Relationship between Malnutrition and Quality of Life in Stable Chronic Obstructive Pulmonary Disease Patients at Prof. Dr. Chairuddin P. Lubis Hospital Field Dalimunthe, Muhammad Bayhaqi; Pradana, Andika; Tarigan, Amira Permatasari; Amelia, Rina
Journal of Society Medicine Vol. 3 No. 9 (2024): September
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i9.164

Abstract

Introduction: Malnutrition is a serious problem in patients with COPD, it interferes with normal skeletal muscle function, with reduced muscle mass and decreased respiratory muscle strength and endurance. It also contributes to respiratory muscle dysfunction, disease severity, and disability progression. Malnutrition is associated with disease severity, associated with more severe exacerbations, and increases the length of hospital stay. Malnutrition in COPD is described with varying prevalence rates ranging from 30-60%. The aim of this study was to analyse the relationship between malnutrition and quality of life in patients with COPD. Method: The research design is an observational analytic conducted from November 2023 to March 2024. The study population was COPD patients who sought treatment at the Pulmonary Polyclinic at RSCPL with a total sample using the consecutive sampling method of 91 people. Manultrition assessment by measuring TB and BW of patients when they arrived and assessing quality of life with the SGRQ questionnaire, Data processing using SPSS by correlating malnutrition with quality of life, degree of shortness of breath, and spirometry. Results: There was a significant positive correlation between malnutrition and quality of life (p=0.001) with the degree of shortness of breath (p=0.014) and spirometry (p=0.001). Conclusion: We found an association between malnutrition and quality of life, degree of breathlessness and spirometry of patients with COPD, further prospective studies in other populations are needed to validate the results of this study.
Comparison of Symptoms and Lung Function in Patients with Chronic Obstructive Pulmonary Disease (COPD) Receiving Monobronchodilators and Dual Bronchodilators Lingga, Elfia Damaiyanti Br; Pandia, Pandiaman; Pradana, Andika
Journal of Society Medicine Vol. 3 No. 11 (2024): November
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i11.169

Abstract

Introduction: In COPD treatment with a monobronchodilator or dualbronchodilator, can be assessed for the prognosis of therapy outcomes provided to monitor the impact of intervention and recovery of daily activities, prevent acute exacerbations, and improve the productivity of patient’s COPD. To determine the comparison between symptoms and lung function in patients with COPD disease receiving monobronchodilator and dual bronchodilator. Method: This study is a retrospective cohort study. The research sample consists of COPD patients undergoing treatment with monobronchodilator or dualbronchodilator for a minimum of 3 months or 3 treatment visits. Symptoms are measured using mMRC and lung function is measured using spirometry (FEV1). Results: The majority of patients are male (87.1%) and over 60 years old (62.4%), with the majority being smokers (84.7%), and the most common therapy being monobronchodilator (62.4%) and dual bronchodilator (37,6%). There are differences in symptoms and lung function in patients receiving monobronchodilator and dual bronchodilator. Conclusion: The dual bronchodilator is more effective in reducing mMRC values, improving by 96.3%, and increasing spirometry values. The average FEV1 value in spirometry for patients using the dualbronchodilator increased by 13,907%, while for the monobronchodilator, it decreased by 5.589%.
A Study of Relationship Between Asthma Control Test, Lung Function, & Hospitalization Putra, M Yusuf Adira; Tarigan, Amira Permatasari; Pradana, Andika; Resti, Riska; Ramadhani, Adini Arifah; Nasution, Syafiah Amalina
Journal of Society Medicine Vol. 3 No. 12 (2024): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i12.179

Abstract

Introduction: The Asthma Control Test (ACT), developed in 2004, is a crucial tool for assessing asthma control. It facilitates discussions between patients and healthcare providers, guiding treatment decisions based on symptom severity. ACT evaluates symptoms over the past four weeks, while pulmonary function tests like forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) provide objective measures of airway function, offering complementary insights. Method: This cross-sectional study was conducted at Prof. Chairuddin Panusunan Lubis USU Hospital. Asthma patients were recruited, their characteristics documented through interviews, and spirometry was performed to assess lung function. Results: A significant proportion of patients had uncontrolled asthma based on ACT scores, which correlated with decreased lung function and higher risks of exacerbations. The study also explored characteristics of lung adenocarcinoma patients. Most were male (76.4%), heavy smokers (70.6%), and aged over 60 (52.9%). A majority (70.6%) were at Stage IVA, with pleural metastases being the most common. ALK mutations were detected in 5.8% of cases using immunohistochemistry. Conclusion: Achieving optimal asthma control remains a priority to reduce exacerbation risks and improve outcomes. ACT is a practical, patient-centered tool for identifying uncontrolled asthma and guiding management strategies. The adenocarcinoma findings highlight the need for early detection and targeted therapies in lung cancer care. These results reinforce the value of combining patient-reported outcomes and objective tests in disease management.
The Relationship Between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital Deneuve, Olivia Monica; Pradana, Andika; Tarigan, Amira P
Journal of Society Medicine Vol. 3 No. 12 (2024): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i12.180

Abstract

Introduction: Blood eosinophil count may predict treatment response in patients  with chronic obstructive pulmonary disease (COPD) during acute exacerbations. However,  the ability of blood eosinophil counts in stable status to predict eosinophilic. Method: This was a cohort retrospective study performed Juni-August 2022 to Juni-August 2023. Subject were COPD patients who were treated at the outpatient using ICS LABA therapy. Blood samples measured blood eosinophil levels first and control. Results: Based on Wilcoxon test test, there was a significant positive positive correlation of eosinophil counts between ICS LABA  Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital. Conclusion: We demonstrated association between ICS LABA Administration and Blood  Eosinophil Levels in COPD Patient (p value = 0.02).
Probiotics-derived butyric acid may suppress systemic inflammation in a murine model of chronic obstructive pulmonary disease (COPD) Pradana, Andika; Sari, Dina K.; Rusda, Muhammad; Tarigan, Amira P.; Wiyono, Wiwien H.; Soeroso, Noni N.; Eyanoer, Putri C.; Amin, Mustafa M.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1332

Abstract

Systemic inflammation in chronic obstructive pulmonary disease (COPD) contributes to multimorbidity and a diminished quality of life. Probiotics, through the gut-lung axis, have shown potential to mitigate systemic inflammation; however, their specific role in COPD-related inflammation remains unclear. The aim of this study was to evaluate the efficacy of probiotics in reducing serum interleukin-6 (IL-6) levels by enhancing butyric acid production in a murine model of COPD. An in vivo experimental study with a post-test-only control group design was conducted using 30 C57BL/6 mice randomized into five groups: non-COPD healthy control, untreated COPD, COPD treated with bronchodilator, COPD treated with probiotics, and COPD treated with a combination of bronchodilator and probiotics. COPD was induced by six weeks of cigarette smoke exposure, followed by six weeks of treatment while continuing the smoke exposure. Caecal butyric acid and serum IL-6 levels were measured using enzyme-linked immunosorbent assay (ELISA) and gas chromatography, respectively. Caecal butyric acid levels were lowest in untreated COPD mice (1.2±0.28 mmol/L) and significantly increased with probiotic administration (6.6±4.43 mmol/L, p=0.010), exceeding levels observed in healthy controls (3.9±2.05 mmol/L). Serum IL-6 levels were highest in COPD-induced mice (19.4±6.71 pg/mL) and significantly reduced with administration of probiotics (13.5±0.43 pg/mL, p=0.035), approaching levels of healthy controls (13.0±2.24 pg/mL, p=0.847). A negative correlation was observed between butyric acid and serum IL-6 levels (r=-0.420; p=0.021), suggesting that higher butyric acid levels were associated with reduced systemic inflammation. These findings demonstrated that probiotics, via their metabolite butyric acid, effectively reduced systemic inflammation in a COPD mouse model, highlighting their potential as a therapeutic approach for managing COPD-related inflammation.
Relationship Between Asthma Therapy Types, Pulmonary Function, and Asthma Control in Primary Healthcare Facilities in Medan Darmawan, Nengah; Tarigan, Amira Permatasari; Pradana, Andika
Journal of Society Medicine Vol. 4 No. 2 (2025): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.194

Abstract

Introduction: Asthma is a chronic respiratory disease that affects millions globally. Effective asthma therapy is essential for improving pulmonary function and achieving asthma control. However, many patients remain uncontrolled despite treatment. This study aims to evaluate the relationship between asthma therapy types, pulmonary function, and asthma control in primary healthcare facilities in Medan. Method: This retrospective descriptive study utilized medical records of asthma patients from May 2022 to May 2023 at several primary healthcare centers in Medan. Data collected included demographic characteristics, asthma therapy types (inhaler vs. inhaler + oral), pulmonary function (APE prediction), and asthma control levels. Chi-Square tests were performed to assess statistical associations. Results: The study found that most asthma patients were female (83.3%) and over 50 years old (62.5%). Regarding pulmonary function, 73.0% of patients had an APE prediction of ≥60%, indicating relatively good lung function. However, asthma control remained poor, with 68.8% of patients classified as uncontrolled. The majority of patients (68.8%) used inhalers as their primary therapy, while 31.2% received a combination of inhaler and oral medication. Statistical analysis showed no significant relationship between the type of asthma therapy and pulmonary function (p = 1.000), nor between the type of therapy and asthma control level (p = 0.067). Conclusion: The study found no significant relationship between asthma therapy type, pulmonary function, and asthma control level. These findings suggest that other factors, such as therapy adherence, proper inhaler technique, and medication adjustments, may contribute to asthma control.
Blood Eosinophil Count as a Predictor of Asthma Exacerbation Damanik, Rizki amaliah; Pradana, Andika; Pandia, Pandiaman
Journal of Society Medicine Vol. 4 No. 2 (2025): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.197

Abstract

Introduction: Asthma is a heterogeneous disease characterized by chronic airway inflammation, where eosinophils play a crucial role. Eosinophil levels are often considered a biomarker for asthma severity and treatment response. However, their relationship with asthma exacerbation severity remains unclear. This study aimed to evaluate the relationship between blood eosinophil levels and the severity of asthma exacerbations in patients at Prof. Dr. Chairuddin P. Lubis USU Hospital. Method: This study employed an analytic observational design with a retrospective cohort approach. Data were collected from 25 asthma patients through medical records, including demographic characteristics, blood eosinophil levels, and asthma exacerbation severity. The relationship between eosinophil levels and exacerbation severity was analyzed using the Whitney test. Results: The majority of asthma patients were in the 26-50 age group (44%) and predominantly female (80%). Most patients had blood eosinophil levels <100 (84%), and severe exacerbations were the most common (72%). Statistical analysis showed no significant relationship between blood eosinophil levels and asthma exacerbation severity (p = 0.976). Conclusion: This study found no significant correlation between blood eosinophil levels and asthma exacerbation severity. Other factors, such as corticosteroid use, delayed immune response, and non-eosinophilic asthma, may influence exacerbation severity. These findings emphasize the importance of a multidimensional evaluation in asthma management, including the identification of different asthma phenotypes to guide more precise treatment strategies.
Analysis of Blood Eosinophil Levels as an Indicator of Controlled Asthma Classification at the University of Sumatra Utara Hospital Damanik, Rizki Amaliah; Pradana, Andika; Pandia, Pandiaman
Journal of Society Medicine Vol. 4 No. 3 (2025): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i3.198

Abstract

Introduction: Asthma is a chronic inflammatory disease of the airways characterized by variable airflow obstruction. Eosinophils play a crucial role in airway inflammation and may serve as a biomarker for asthma control classification. This study aims to analyze the relationship between blood eosinophil levels and asthma control classification in patients at the University of Sumatra Utara Hospital. Methods: This was an analytical observational study with a retrospective cohort approach based on medical records. A total of 25 stable asthma patients who had been receiving inhaled corticosteroid-long-acting beta-agonist (ICS-LABA) therapy for at least one year were included. Data were analyzed using SPSS version 26, and the Kruskal-Wallis test was performed to assess the relationship between eosinophil levels and asthma control classification. Results: The majority of patients were aged 26-50 years (44%) and female (80%). Most patients had eosinophil levels <100 (84%), while 8% had levels between 100-300 and another 8% had levels >300. Regarding asthma control, 46.7% of patients were fully controlled, 43.3% were partially controlled, and 10% were uncontrolled. Statistical analysis showed a significant relationship between eosinophil levels and asthma control classification (p = 0.009), indicating that lower eosinophil levels are associated with better asthma control. Conclusion: The study found that lower eosinophil levels were associated with better asthma control. These findings suggest that blood eosinophil levels may serve as an indicator for assessing asthma control, though further research is needed to confirm this relationship.
Profil Tatalaksana ICS/LABA pada Pasien Asma Persisten Sedang di Poliklinik Paru RS Prof. Chairuddin Panusunan Lubis Universitas Sumatera Utara Resti, Riska; Tarigan, Amira Permatasari; Pradana, Andika; Wahyuni, Arlinda Sari
ANATOMICA MEDICAL JOURNAL | AMJ Vol 8, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v8i2.23821

Abstract

Asma adalah penyakit heterogen kronis yang paling umum pada saluran pernapasan di wilayah Asia-Pasifik dengan tingkat kontrol asma tertinggi adalah asma yang terkontrol sebagian yaitu 63%, diikuti oleh asma yang tidak terkontrol sebesar 30% dan asma yang terkontrol penuh sebesar 7%. Tujuan penelitian adalah untuk mengetahui profil penggunaan ICS/LABA berdasarkan tingkat kontrol asma. Penelitian dilakukan dengan metode retrospektif kohort analitik menggunakan 61 rekam medis dari 1 Januari 2017 hingga 31 Desember 2019. Subjek penelitian adalah pasien dengan asma persisten sedang yang menerima terapi ICS/LABA selama minimal 3 bulan. Analisis statistik deskriptif digunakan untuk menilai profil pengobatan ICS/LABA pada hasil klinis. Jenis kelamin didominasi oleh perempuan sebanyak 48 orang (78,7%), rentang usia 41-50 tahun sebanyak 20 orang (32,8%). Pada karakteristik pengobatan didominasi oleh ICS/LABA jenis Diskus Salmeterol/Fluticason propionat dosis 50/250 mcg sebanyak 33 orang (54,1%) dan ICS/LABA jenis Turbuhaler Formoterol Fumarat/Budesonide dosis 4,5/160 mcg sebanyak 28 orang (45,9%). Proporsi tingkat kontrol asma tertinggi adalah asma terkontrol sebagian sebanyak 44 orang (70,5%). Profil penatalaksanaan yang bervariasi didapatkan dengan mayoritas penggunaan ICS/LABA adalah jenis Diskus Salmeterol/Fluticason propionat dengan dosis 50/250 mcg.Kata Kunci : asma persisten sedang, ics/laba, profil tatalaksana
Co-Authors Abdullah, Muntasir Adida, Fiony Amin, Mona N. Amin, Mustafa M. Anhar, Taufik Aritonang, Minarni ES. Dalimunthe, Muhammad Bayhaqi Dalimunthe, Naomi Niari Damanik, Rizki amaliah Dangana, Amos Darmawan, Nengah Deneuve, Olivia Monica Erna Mutiara Eyanoer, Putri C. Febrina, Citra Dina Firdaus, Ruby Hutabarat, Eva Susanti Debora Imam Salehudin Iman Sudjudi Lingga, Elfia Damaiyanti Br Listyoko, Aditya S. Listyoko, Aditya Sri Mahendra, Mahendra Maryaningsih, Maryaningsih Monica, Nanda S. Monica, Nanda Soraya Nasution, Syafiah Amalina Osareniro, Osakue E. Pandia, Pandiaman Panjaitan, Samuel Hendryk Putra, M Yusuf Adira Putri Chairani Eyanoer, Putri Chairani Ramadhani, Adini Arifah Resti, Riska Rhinsilva, Ella Rina Amelia Rusda, Muhammad Sari, Dina K. Sebayang, Risa RB. Sihombing, Benny Simbolon, Novery Sinaga, Bintang YM. Sinaga, Sudirman P. Sinaga, Sudirman Parningotan Soeroso, Noni N. Supriatmo Supriatmo, Supriatmo Tarigan, Amira P. Tarigan, Amira Permatasari Taufik Ashar Triwahyudi, Bibit Vera, Yeni Wahyuni, Arlinda S. Wahyuni, Arlinda Sari Wijanarko, Wahyu Wiwien H. Wiyono Yusran Ibrahim Zulkarnain Zulkarnain