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Journal : Research Journal of Life Science

α-Amylase and α-Glucosidase Inhibition by Brown Seaweed (Sargassum sp) Extracts Muhammad Firdaus; Asep Awaludin Prihanto
Research Journal of Life Science Vol 1, No 1 (2014)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.827 KB) | DOI: 10.21776/ub.rjls.2014.001.01.2

Abstract

Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to control post-prandial hyperglycemia associated with diabetes mellitus. In vitro inhibitory effects of crude extracts of seaweed against α-amylase and α-glucosidase were studied. Crude ethyl acetate extracts of Sargassum aquifolium were the stronger inhibitor to α-amylase and α-glucosidase than others. Furthermore, Sargassum aquifolium ethyl acetate extract significantly suppressed the rise in postprandial glucose level after oral administration of glucose in normal rats. The results of this study suggest that the crude Sargassum aquifolium extract may suppress the rise in postprandial hyperglycemia in vivo in part, through inhibition of alpha amylase and glucosidase.
Prebiotics Activity of Laminaran Derived From Sargassum crassifolium Anies Chamidah; Hardoko Hardoko; Asep Awaludin Prihanto
Research Journal of Life Science Vol 3, No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.58 KB) | DOI: 10.21776/ub.rjls.2016.003.03.4

Abstract

The objectives of this study were to evaluate the prebiotic activity based on the change in cell biomass of the probiotic strain after 24-h growth in the presence of Laminaran from Sargassum crassifolium with the methods of laminaran acid extract (LAE) and laminaran modified extract (LME), inulin, or glucose-relative against the change in cell biomass of Escherichia coli FNCC 0091 grown under the same condition. Prebiotic activity was calculated for L. plantarum FNCC 0051 and Bifidobacterium longum FNCC 1081. The results showed that the increasing cell number of L. plantarum was higher in both substrates LAE and LME (0,58 and 2,03log cycle), whereas that of B. longum was lower. The higher prebiotic activity score obtained for L. plantarum and B. longum grown on LME were positive (0,26 and 0,96 log cycle), whereas the lowest score was for L. plantarum and B. longum grown on LAE, which were negative (-0,35 and -0,31 log cycle), but the higher prebiotic activity score was obtained for inulin (4,08 and 4,78 log cycle). It could be concluded that Laminaran Modified Extract (LME) has potential as prebiotic source, but its potential was lower than inulin.
Co-Authors Abdul Aziz Jaziri Abu Bakar Sambah Abu Bakar Sambah Aditia Gustiana Gunawan Affan Gaffar Agus Susilo Akhiroh, Puji Alifatul Fatchiyah Andi Kurniawan Andi Kurniawan Angga Wira Perdana Anies Chamidah Anies Chamidah Anif Fatwa Chawa Anisa Millah Taqiyyah Anisa Millah Taqiyyah Ardiansyah Kurniawan Beauty Suestining Diyah Dewanti Choiriyatun Hanifah Dedes Amertaningtyas Djamaludin, Heder Dodyk Pranowo Dwi Febrianti Eddy Suprayitno Euis Asriani Euis Asriani Euis Asriani faidzil Ikram Farida Isroani Farikh Assafri Firman Jaya Gandhatyasri Rohmah, Wendra Gilang Drajat Maulana Guntur Guntur Hanan Dwi Laksono Timur Happy Nursyam Hardoko Hardoko Hardoko Hardoko Hariati, Anik Martinah Herly Evanuarini Hidayatun Muyasharoh Hidayatun Muyasyaroh Hidayatun Muyasyaroh Hidayatun Muyasyaroh Jauharotul Afifah Karimah Karimah Kartika D. Aninta Kartikaningsih, Hartati Ken Audia Pradarameswari Ken Audia Pradarameswari Ken Audia Pradarameswari Khotibul Umam Al Awwaly Linggar Rucitra, Andan M. Aris Munandar Maftuch Maftuch Marlinda Elvina Susanti Masyithoh, Dewi Melianti, Rika Gian Miftakhul Cahyati MOHAMAD FADJAR Mohammad Fadjar Morita Ikasari, Dhita Muhamad Firdaus Muhammad Firdaus Muyasyaroh, Hidayatun Nada Itorul Umam Nurjannah Nurjannah Premy Puspitawati Rahayu Putra, Prily Lovian Rahmi Nurdiani Randy Fahrudin Ardiansyah Ria Dewi Andriani Rina Rifqie Mariana Riska Septifani Soffi Trisnaningrum Suci Puspita Sari Suci Puspita Sari Suci Puspita Sari Suci Puspitasari Sukoso Sukoso Suprayogi Suprayogi Tambunan, Jenny Ernawati Titis Sari Kusuma Tri Widayanti, Vindhya Umam, Nada Itorul Wenny Bekti Sunarharum Yanuhar, Uun Yenny Risjani YOGA DWI JATMIKO Yoga Dwi Jatmiko Yunita Eka Puspitasari