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All Journal Jurnal Kedokteran Brawijaya Teosofi: Jurnal Tasawuf dan Pemikiran Islam JAM : Jurnal Aplikasi Manajemen TARBIYA : Journal Education in Muslim Society The International Journal of Accounting and Business Society JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Perspektif : Jurnal Ekonomi dan Manajemen Universitas Bina Sarana Informatika BAREKENG: Jurnal Ilmu Matematika dan Terapan Jurnal Respirologi Indonesia Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Ilmiah Sport Coaching and Education Jurnal Ilmiah Wahana Pendidikan Respiratory Science Jurnal Simki Pedagogia Journal of Education Research KERN : Jurnal Ilmiah Teknik Sipil Berita Kedokteran Masyarakat Buletin Riset Psikologi dan Kesehatan Mental (BRPKM) JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Jurnal Inovasi Global Jurnal Pengabdian Fakultas Pertanian Universitas Lampung Seminar Nasional Riset dan Teknologi (SEMNAS RISTEK) Al-Tadris: Jurnal Pendidikan Bahasa Arab Jurnal Agroindustri Berkelanjutan

Harun Al Rasyid

Faculty Of Medicine, University Of Brawijaya, Malang, East Java

Author-ID : 358171

Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Other

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EKSPRESI BCL-2 PADA NEOPLASMA EPITELIAL OVARIUM JINAK, BORDERLINE, DAN GANAS SERTA KORELASINYA DENGAN DERAJAT HISTOPATOLOGIK Dewi, Rose Khasana; Hardika, Arif Satria; Retnani, Diah Prabawati; Rasyid, Harun Al
Majalah Kesehatan FKUB Vol 7, No 1 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Neoplasma epitelial ovarium diklasifikasikan menjadi 3 kategori yaitu jinak, borderline, dan ganas. Neoplasma ganas ovarium termasuk dalam sepuluh besar penyebab kematian tersering akibat kanker pada perempuan di dunia. Penentuan kategori neoplasma ovarium kadang masih menjadi masalah karena dipengaruhi oleh beberapa faktor, termasuk proliferasi dan apoptosis sel serta invasi stroma. Bcl-2 (B-cell lymphoma 2) merupakan salah satu protein prosurvival yang berfungsi sebagai antiapoptosis dan cukup berperan dalam perkembangan neoplasma. Tujuan penelitian ini adalah untuk mengetahui perbedaan eks-presi Bcl-2 pada neoplasma epitelial ovarium jinak, borderline, ganas serta untuk mengungkap hubungan ekspresi Bcl-2 dengan derajat histopatologik pada neoplasma ganas. Penelitian ini merupakan penelitian analitik cross-sectional. Sampel penelitian berupa 35 blok parafin kasus neoplasma ovarium serosum dan musinosum (13 jinak, 8 borderline, 14 ganas) di RSUD Dr. Saiful Anwar Malang periode 2016-2017. Kelompok neoplasma ganas terdiri dari masing-masing 5 kasus derajat 1 dan 3 (35,7%) serta 4 kasus derajat 2 (28,6%). Perbedaan ekspresi pulasan imunohistokimia Bcl-2 antara neoplasma jinak, borderline, dan ganas dianalisis menggunakan uji Kruskal-Wallis, sedangkan korelasinya dengan derajat histopatologik dianalisis menggunakan uji korelasi Spearman. Hasil penelitian menunjukkan ekspresi Bcl-2 tidak berbeda signifikan antara neoplasma jinak, borderline, dan ganas (p = 0,159). Bcl-2 pada neoplasma ganas menunjukkan eks-presi yang semakin rendah dengan meningkatnya derajat histopatologik (p = 0,021 dan r = -0,608). Ke-simpulannya, tidak terdapat perbedaan ekspresi Bcl-2 yang signifikan antara neoplasma epitelial ovarium jinak, borderline, dan ganas. Ekspresi Bcl-2 berkorelasi negatif yang kuat dengan derajat histopatologik pada neoplasma ganas.Â

PERBEDAAN EKSPRESI PROTEIN CYCLIN D1 ANTARA ADENOMA DAN ADENOKARSINOMA KOLOREKTAL, SERTA KORELASINYA DENGAN GRADING DAN STADIUM TUMOR Rosidah, Aris; Norahmawati, Eviana; Anita, Kenty Wantri; Rasyid, Harun Al
Majalah Kesehatan FKUB Vol 7, No 3 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2020.007.03.1

Sebagian besar karsinoma kolorektal adalah adenokarsinoma, dan lebih dari 95% karsinoma kolorektal diawali oleh lesi prekursor yaitu adenoma. Risiko suatu adenoma berubah menjadi suatu karsinoma akan lebih tinggi pada adenoma dengan ukuran lebih dari 1 cm, tipe villous, dan disertai displasia high grade. Telah diketahui bahwa grading dan stadium merupakan faktor prognostik penting baik pada adenoma maupun adenokarsinoma. Perkembangan adenoma menjadi adenokarsinoma melibatkan peran banyak gen dan protein, salah satunya cyclin D1 yang berperan meningkatkan proliferasi sel, angiogenesis dan invasi sel. Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi cyclin D1 antara adenoma dan adenokarsinoma kolorektal, serta hubungannya dengan grading dan stadium tumor. Lalu, ditentukan 30 sampel untuk masing-masing adenoma dan adenokarsinoma yang diambil dari Instalasi Patologi Anatomi RS. dr. Saiful Anwar Malang. Keseluruhan sampel dilakukan pulasan imunohistokimia dengan antibodi cyclin D1 kemudian dihitung persentase ekspresinya, dan dianalisis hubungan antara cyclin D1 tersebut dengan grading pada adenoma dan grading serta stadium pada adenokarsinoma. Hasil penelitian menunjukkan terdapat perbedaan ekspresi cyclin D1 yang bermaknaÂ antara kelompok adenoma dan adenokarsinoma dengan p < 0,01. Tidak terdapat hubungan yang bermakna antara ekspresi cyclin D1 dengan grading adenoma serta grading dan stadium adenokarsinoma (p > 0,05). Kesimpulan penelitian ini adalah ekspresi cyclin D1 dapat digunakan untuk membedakan antara adenoma dan adenokarsinoma, tetapi ekspresi tersebut tidak berhubungan dengan grading dan stadium tumor.Â

HUBUNGAN EKSPRESI HER2 DENGAN UKURAN TUMOR DAN INVASI KAPSULAR PAPILLARY THYROID CARCINOMA (PTC) Pinahayu, Griesinta Trianty Andria; Retnani, Diah Prabawati; Anita, Kenty Wantri; Rasyid, Harun Al; Susilo, Hery
Majalah Kesehatan FKUB Vol 8, No 1 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.01.3

Papillary thyroid carcinoma (PTC) merupakan karsinoma tersering pada tiroid yang secara klinis dapat menyerupai lesi jinak. PTC subtipe ocult tidak jarang ditemukan bermetastase pada kelenjar getah beningÂ (KGB) atau organ lain. Faktor prognosis pada pasien PTC ditentukan oleh subtipe histologi, ukuran tumor, usia, jenis kelamin, metastase dan invasi kapsular, dengan angka kekambuhan cukup tinggi, yaitu 20%.Â Human Epidermal Growth Factor Receptor 2 (HER2) adalah anggota Epithelial Growth Factor Receptor (EGFR), yang menunjukkan ekspresi kuat pada keganasan sel epitel manusia. Penelitian ini bertujuan untuk melihat hubungan ekspresi HER2 dengan ukuran tumor dan invasi kapsular PTC. Pemeriksaan histopatologi dan imunohistokimia HER2 dilakukan pada 54 sampel, 27 dengan invasi kapsular dan 27 tanpa invasi kapsular, kemudian diukur besar tumor, interpretasi ekspresi HER2, lalu ditabulasi dan dianalisis hubungan ekspresi HER2 dengan ukuran tumor dan invasi kapsular PTC. Ekspresi HER2 pada penelitian ini didapatkan pada 10 sampel HER2 skor 3+,Â 22 sampel skor 2+, 14 sampel skor 1+, danÂ 8 sampel skor 0. Hubungan antara ekspresi HER2 dengan invasi kapsular PTC, dianalisis dengan Mann Whitney test, didapatkan hasil bermakna (p = 0,002). Dengan uji korelasi Spearman, didapatkan korelasi lemah terbalik (koefisien korelasi -.299) tapi bermakna (p = 0,028) antara ekspresi HER2 dengan ukuran tumor PTC. Terdapat hubungan ekspresi HER2 dengan invasi kapsular, dan hubungan lemah berbanding terbalik antara ekspresi HER2 dengan ukuran tumor yaitu semakin besar ukuran tumor semakin rendah skor HER2 dan sebaliknya.Â

Pemberian Media Photonovela Meningkatkan Pemahaman Isi Informed Consent Pada Pasien Sectio Caesaria di RSIA HST Trenggalek Dewangga Primananda Susanto; Harun Al Rasyid; Lukman Hakim
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol 6, No 2 (2017): August
Publisher : Universitas Muhammadiyah Yogyakarta in Clollaboration with ADMMIRASI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.6132

The aim of this research is to know the effect of traditional comic strip photo novella media on the level of informed understanding of patient of Sectio Caesarea (SC). This research is a quasi-experimental research by dividing the research subjects into two groups namely the treatment group (given photo novella) and control (not given photo novella) each of 30 people in RSIA HST Trenggalek hospital. This study found that group understanding received significantly higher media in terms of explanation of indications, procedures, objectives, alternatives, risks, complications and SC costs compared to patients without photo novella media. There were no significant differences in terms of explanation of action names and SC prognosis in both groups

Differences in the Expression of miRNA-126 and Interleukin (IL)-13 in Fully Controlled and Not Fully Controlled Asthma Patients Yulia Kartina; Susanthy Djajalaksana; Iin Noor Chozin; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.99

Backgrounds: Important finding in the last decades in the field of biology and medicine are micro-RNA (miRNA), including miRNA-126 that are involved in the regulation of interleukin-13 (IL-13) and the T helper 2 cell (Th2) response, the key components of the asthmatic response. The aim of this study is to find the difference in the expression of miRNA-126 and IL-13 serum in fully controlled and not fully controlled groups of stable asthma patients and analyze the relationship between them. Methods: Case-control studies was conducted in 36 stable asthma patients who visited pulmonary outpatient clinic Saiful Anwar Hospital from September 2018 to March 2019. Subjects were divided into 2 groups, each group consisted of 18 fully controlled asthma and 18 not fully controlled asthma patients. The expression of miRNA-126 was measured by the quantitative polymerase chain reaction (q-PCR) and IL-13 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The expression of miRNA-126 was higher in the control group (3.499±2.99) than case group (2.719±2.73), but the difference was not significant (P=0.273). The IL-13 levels were higher in the case group (17.285±9.37) than control group (11.681±5.22), and the difference was significant (P=0.009). However, there was no relationship between the expression of miRNA-126 and IL-13 levels in both groups. Conclusions: There were differences in IL-13 levels, but there were no differences in the expression of miRNA-126 in the two groups. There was no relationship between miRNA-126 expression and IL-13 levels in both groups. (J Respir Indo. 2020; 40(1): 24-32)

The Effect of Pulmonary Rehabilitation on The Duration of Antibiotic Switches, IL-10 Levels and PEFR Values in Hospitalized Community Pneumonia Patients Mariyatul Khiptiyah; Iin Noor Chozin; Suryanti Dwi Pratiwi; Rahmad Rahmad; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.129

Background: Pneumonia is an acute inflammation of the lung parenchyma and ranked third of 30 causes of death in the world. WHO estimates the death caused by pneumonia is 1.6 million per year. Long duration of antibiotic switches is associated with increased morbidity, nosocomial infections and costs of healthcare. This study aims to assess the effect of pulmonary rehabilitation with the duration of antibiotic switches and interleukin-10 (IL-10) levels of pneumonia patients in non-intensive care thus pulmonary rehabilitation can be routinely use as adjuvant therapy. Methods: The study was conducted in May-November 2019 at Saiful Anwar Hospital Malang, with 40 pneumonia patients in the non-intensive care and divided in two groups which contains of 20 patients. This study uses consecutive simple random sampling. In treatment group, pulmonary rehabilitation consists of breathing exercise, effective cough techniques, clapping, postural drainage and breathing muscle exercises with spirometry incentive tools. The pulmonary rehabilitation treatment was done by Medical Rehabilitation Department of Saiful Anwar Malang Hospital. IL-10 levels and PEFR values on the zero and fifth days of treatment were measured. Results: The duration of antibiotic switches received pulmonary rehabilitation was shorter 5.05 days (P

The Effect of Ophiocephalus Striatus Extract on suPAR, Neutrophil Levels and Lung Diffusion Capacity (DLCO) in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients with Muscle Wasting Sasongko Adhi Nugroho; Teguh Rahayu Sartono; Susanthy Djajalaksana; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 39, No 2 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i2.56

Background: Muscle wasting is one of the extrapulmonary manifestation which influence quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. It caused by imbalance of protein metabolism in skeletal muscle. This study aimed to evaluate the effect of Ophiocephalus striatus extract on neutrophil count, soluble urokinase-type plasminogen activator (suPAR) level, diffusion capacity of lung for carbon monoxide (DLCO) and quality of life in stable COPD patients with muscle wasting. Methods: Clinical pre and post quasi experimental study was conducted to 32 stable muscle-wasted COPD patients from Pulmonary Outpatient Clinic Saiful Anwar Hospital Malang, determined by The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016, Bioelectrical impedance analysis (BIA) dengan fat-free mass (FFM)

Impact of Pulmonary Rehabilitation on Hospitalization Duration, IL-6 Levels, and Respiratory Muscle Power in Hospitalized Community-Acquired Pneumonia Patients Santony Santony; Iin Noor Chozin; Teguh Rahayu Sartono; Rahmad Rahmad; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.276

Background: Pneumonia is acute inflammation of the lung parenchyma. The long duration of hospitalization is associated with increased morbidity, nosocomial infections and treatment costs. Methods: The study was conducted from May to November 2019 at Saiful Anwar Hospital, Malang, with 40 pneumonia patients in the non-intensive community inpatient room divided into 2 groups. The treatment group performed pulmonary rehabilitation measures consisting of breathing exercise, effective coughing techniques, clapping, postural drainage and respiratory muscle training using spirometry incentives. Results: The duration of hospitalization for the treatment group was 2.25 days shorter (p<0.001). The average IL-6 level in the 5th day of the treatment group was lower than without treatment, that was 54.43 pg/ml (p=0.221). The mean of pressure threshold loading in the group without treatment was 31.5 cmH2O on first day and 36.35 cmH2O on the 5th day (p <0.001) and on first day treatment group was 32.9 cmH2O and 39.35 cmH2O on the 5th day (p=0.001), and the mean value of the 5th day of the treatment group was higher than without treatment (P=0.015). the mean of the 5th day of the treatment group was higher than without treatment (p=0.06).Conclusion: Pulmonary rehabilitation as adjunctive therapy shortens the duration of hospitalization. In both groups there was a decrease in IL-6 levels on the 5th day compared to zero and the lower IL-6 levels were not significant in the treatment group. There was a significant increase in the value of pressure threshold loading inspiration and expiration day fivecompared to day zero in the two groups and there was a significant increase in the Pressure Threshold Loading Inspiration mean treatment group compared to no treatment on the 5th day, but the Pressure Threshold Loading Expiration rate showed no significant increase.

Differences in Levels of Human 1,3β-D-Glucan from Bronchoalveolar Lavage (BAL) Fluid in The Immunocompromised and Immunocompetent Groups Patients with Suspected Lung Cancer Asih Trimurtini; Ngakan Putu Parsama Putra; Teguh Rahayu Sartono; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 2 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i2.298

Background: Invasive candidiasis occurs in immunocompromised individuals as an opportunistic infection in patients with lung cancer. Although culture and histopathology remain the standard diagnosis of fungal infections, other tests are still needed to provide faster results. Human 1,3-β-D-Glucan (BDG) uses ELISA to detect candidiasis. β D-Glucan level from BAL fluid is positive when the cut-off is p 130 pg / mL. This study aims to determine differences in the levels of Human 1,3β-D-Glucan from Bronchoalveolar Lavage (BAL) fluid between the immunocompromised and immunocompetent groups in patients with suspected lung cancer at RSU Dr. Saiful Anwar Malang.Method: A cross-sectional study was conducted on 33 lung cancer patients who had risk factors for invasive candidiasis in Dr. Saiful Anwar Hospital Malang.Result: 33 study patients had significant differences in BAL levels of Human 1,3β-D-Glucan in the immunocompromised and immunocompetent groups (p = 0.009). In the different tests, there was a slight difference in the levels of BAL Human 1,3β-D-Glucan but it was not statistically significant based on age and sex in the immunocompromised and immunocompetent groups (p = 0.632, p = 0.338, p = 0.472, p = 0.667).Conclusion: Patients suspected of lung cancer have risk factors for invasive candidiasis with higher BDG levels due to immunoparalysis. There were significant differences in the BAL Human levels of 1,3β-D-Glucan in the immunocompromised and immunocompetent groups.

Pengalaman ibu menyusui di RSIA X kota Malang Fiella Rachmatika; Harun Al Rasyid; Lilik Zuhriyah
Berita Kedokteran Masyarakat (BKM) Vol 35, No 8 (2019)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

The experience of breastfeeding mothers in RSIA X MalangPurpose: Several factors cause a low level of exclusive breastfeeding in Indonesia. One of them is breastfeeding, which is not immediately resolved by health workers in the hospital. Mothers who have just given birth in an MCH hospital expect help and assistance from health professionals to not have difficulty breastfeeding. This study is to uncover the experience of nursing mothers in an MCH hospital. Method: This phenomenology research took place in a hospital in Malang in April-May 2019 with five informants by purposive sampling. Data were from in-depth interviews and analyzed using an interpretive phenomenology analysis. Results: There were seven themes: satisfied and comfortable giving birth, health workers in hospitals did not deliver breastfeeding information and assistance, more comfortable breastfeeding because it was practical and economical, grateful to have struggled to provide breastfeeding so that children were healthy, disappointed and worried about breastfeeding, pain, and tiredness of breastfeeding, the desire to obtain breastfeeding support and information from the hospital. The mother expects to obtain breastfeeding support in the form of information and assisting breastfeeding so that the mother understands how to breastfeed and does not experience breastfeeding problems when returning home. Conclusion: Our study hospital did not consistently serve as a friendly environment for breastfeeding mothers.

Co-Authors Achmad Chusairi Agus Tri Indah K agus tri indah, agus tri Amalia , Rizky Tri Anisa Ramadhani Kusumastiti Annisa Nurul Arofah Anungputri, Pramita Sari Aris Rosidah Armanu Thoyib Asih Trimurtini Asrul Asrul Azwa, Nor Azzahra, Azimah Badrul Munir, Badrul Baradatu, Karen Syafiyah Citra Cicilia Lihawa, Cicilia Dewangga Primananda Susanto Dewi Retno Sari Saputro, Dewi Retno DEWI SARTIKA Dewi, Rose Khasana Eky Indyanty Wuryaning Lestari Erdi Suroso Esa Ghanim Fadhallah Eviana Norahmawati Fiella Rachmatika Gede Sasmika Suwandi Hakim, Lukman Hani, Miftahul Khairunnisa Harahap, Nur Azizah Hardika, Arif Satria Herdiana, Novita Iin Noor Chozin Irwan Irwan Iskandar, Ferdi Ja'far, Ja'far Jamil, Ahmad Kenty Wantri Anita, Kenty Wantri Khaled, Naswan Abdo Kusumastiti, Anisa Ramadhani Lilik Zuhriyah Lukman Hakim Lukman Hakim lumban gaol, andy Luqiana, Jihan Nabila Machlusil Husna, Machlusil Marani, Ika Novitaria Mariyatul Khiptiyah Masruroh Rahayu, Masruroh Nadiya Elfira Bilqis, Nadiya Elfira Ngakan Putu Parsama Putra Ningsih, Agustin Setia Noermijati, Noermijati Nurul Fadhilah Otik Nawansih Panjaitan, Nurul Aisyah Salsabila Pinahayu, Griesinta Trianty Andria Prabowo, Edwin Damar Pratama, Arista Pratama, Erlan Anugrah Pratiwi, Suryanti Dwi Putra, Ngakan Putu Putri Dina Mardika Rahmad Rahmad Retnani, Diah Prabawati retnaningtyas, sri Rezkiah, Fahmy Riskawati, Yhusi Karina Rizky Rosita, Rizky Santony Santony Sasongko Adhi Nugroho Shahdevi Nandar Kurniawan, Shahdevi Nandar Siahaan, Sylvia Sagita Sidiq, Krisna Sri Budhi Rianawati, Sri Budhi Sriyanti, Rini Subeki Subeki Sugiri, Yani Jane Supiyan, Arif Dwi Suryanti Dwi Pratiwi Susanthy Djajalaksana Susanto, Dewangga Primananda Susilo, Hery Sutanto Sutanto Sutrasno Sutrasno Tae, Vidria Handayani Tanto Pratondo Utomo Teguh Rahayu Sartono Teguh Rahayu Sartono Tita Hariyanti Triwahju Astuti Umar Muhammad Noor Windasari, Eka Yani Jane Sugiri Yasep Setiakarnawijaya Yudha Rose Satiti, Yudha Rose Yulia Kartina Yuliandari, Puspita Zanemi, Fani

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