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All Journal The Indonesian Biomedical Journal Universa Medicina Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JURNAL ETIKA KEDOKTERAN INDONESIA The Indonesian Journal of Community and Occupational Medicine Pharmaceutical Sciences and Research (PSR) Magna Neurologica
Pukovisa Prawiroharjo
Departemen Neurologi Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Association of Hydration Status and Other Occupational Factors with Attention, Concentration, and Working Memory among Mine Workers Adrian Cristianto Yusuf; Dewi Friska; Yetty Ramli; Pukovisa Prawiroharjo; Agus Sugiharto
The Indonesian Journal of Community and Occupational Medicine Vol. 5 No. 3 (2026): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v5i3.204.94-103

Abstract

Background: Hot work environments and poor hydration status may impair workers’ cognitive functions, particularly attention, concentration, and working memory, increasing the risks of operational errors and unsafe behaviors. In open-pit coal mining, heat exposure, high workload, and operational demands contribute to elevated incident rates.Objective: This study aimed to examine the association between hydration status and occupational factors with attention, concentration, and working memory among mine workers at PT. X.Methods: This analytic observational study employed a cross-sectional design among 90 morning-shift coal miners at PT. X, East Kalimantan, recruited using convenience sampling. Cognitive function was assessed using the Digit Span Test, with the Forward Digit Span (FDS) subtest assessing attention and concentration and Backward Digit Span (BDS) subtest assessing working memory. Hydration status was assessed using Urine Specific Gravity (USG) to determine hydration trends over three consecutive days, and perceived stress was measured using the Perceived Stress Scale-10 (PSS-10).Results: The result showed significant associations between hydration status and attention and concentration (p=0.023), as well as working memory (p=0.019). Job type, workload, and work climate were also significantly associated with attention, concentration, and working memory. No change in hydration status trends were observed during the three-day measurement period, with a consistent median USG value of 1,018, indicating mild dehydration. Conclusion: Hydration status, job type, workload, and hot work climate were significantly associated with attention, concentration, and working memory, whereas age, sex, health status, and perceived stress did not show consistent associations with cognitive outcomes.
BLOOD-BASED BIOMARKERS FOR PREDICTING POST-STROKE PROGNOSIS: A SCOPING REVIEW OF PENTRAXIN-3, NEUROPENTRAXIN-1, AND NEUROPENTRAXIN-2 Elizabeth Divina; Siti Alyaa Salma Ghozali; Pukovisa Prawiroharjo
Magna Neurologica Vol. 4 No. 2 (2026): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i2.3308

Abstract

Background: Stroke remains a major global health challenge, with substantial losses in disability-adjusted life-years, particularly in low-middle-income countries. Predicting post-stroke outcomes remains challenging because outcomes are driven by complex and overlapping processes, including inflammation, vascular injury, and neurodegeneration. Consequently, blood-based biomarkers, such as the pentraxin group that reflect underlying pathophysiology, have gained attention. However, existing evidence is fragmented and heterogeneous, underscoring the need for systematic mapping of the pentraxin group as biologically informed prognostic tools. Objective: This systematic scoping review aims to map and synthesize existing evidence on the prognostic value of blood-based biomarkers Pentraxin-3 (PTX3), Neuropentraxin-1 (NPTX1), and Neuropentraxin-2 (NPTX2) in predicting clinical outcomes after stroke. Methods: This PRISMA-ScR–guided scoping review systematically mapped evidence on blood-based biomarkers: PTX3, NPTX1, and NPTX2, for post-stroke prognosis from 6 databases and used NOS for quality assessment. Results: A total of 18 studies were included in the final scoping review. Lower serum NPTX2 levels were significantly associated with post-stroke cognitive impairment. Studies investigating PTX3 demonstrated substantial heterogeneity in sampling timing, cutoff definitions, and follow-up duration. Across studies, higher PTX3 concentrations were independently associated with increased mortality (AUC ~0.73–0.81, P value <0.0001), greater baseline neurological severity as measured by the National Institutes of Health Stroke Scale (NIHSS), and poorer functional outcomes assessed by the modified Rankin Scale (mRS). Conclusion: Despite the large heterogeneity of studies, the overall evidence supports PTX3, NPTX1, and NPTX2 as less-invasive prognostic blood-based biomarkers for post-stroke outcomes. However, studies on NPTX1 and NPTX2 are still very limited.
Co-Authors Abu Rachman Adre Mayza Adrian Cristianto Yusuf Agus Purwadianto Agus Sugiharto Agustin, Rulliana Ali Sulaiman Anna Rozaliyani Broto Wasisto Budi Utomo Chandrika Najwa Malufti Dewi Friska Dewi Sumaryani Soemarko Elizabeth Divina Fadlika Harinda Faisal, Hana Khairina Putri Febriani Endiyarti Ferry Sandra Finna Fitriana Fitriana Nur Rahmawati Frans Santosa Gadistya Novitri Adinda Ghina Faradisa Hatta Hadjat S Digdowirogo Hansel Tengara Widjaja Herqutanto - Hindun Wilda Risni Huda Shalahuddin Darusman Iffa Mutmainah Indah Aprianti Putri Jonathan Hartanto Julitasari Soendoro Julitasari Sundoro Jusak Nugraha Lastri, Diatri Nari Librianty, Nurfanida Mahrani Martiem Mawi Mohammad Baharuddin Mohammad Baharuddin Muhammad Baharudin Muhammad Hamdan Nadia Farhanah Syafhan Nuri Purwito Adi Nurrani Mustika Dewi Paramita Khairan Peter Pratama Prijo Sidipratomo Prijo Sidipratomo Prijo Sidipratomo Putri Dianita Ika Meilia R Sjamsuhidajat Radi Muharris Mulyana Ramdinal Aviesena Zairinal Rani Sauriasari, Rani Reggy Lefrandt Rianto Setiabudi Rianto Setiabudy Risni, Hindun Wilda Rizky Rafiqoh Afdin Sarah Shafa Marwadhani Setyanto, Darmawan Budi Siti Alyaa Salma Ghozali Soetedjo Soraya, Indana Ayu Uti Sari Wawang Sukarya Wawang Sukarya Wiji Lestari Yadi Permana Yetty Ramli Yohanna Kusuma Yudhisman Imran, Yudhisman Yuli Budiningsih Zubairi Djoerban