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All Journal HAYATI Journal of Biosciences Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Microbiology Indonesia Majalah Kedokteran Bandung BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Biosains Pascasarjana Jurnal Perikanan dan Kelautan Jurnal Riset Industri Jurnal Ilmiah Arena Tekstil The Indonesian Biomedical Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Ilmu dan Teknologi Kayu Tropis Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) International Journal of Health Science and Technology Sciences of Pharmacy Jurnal Kajian Budaya dan Humaniora (JKBH)

Ratu Safitri

Faculty Of Mathematics And Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia

Author-ID : 358699

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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UTILIZATION OF SAGO DREGS AS RUMINANT FEED BY USING THE FERMENTATION METHOD: LITERATURE REVIEW Titi Lahanda Susanti; Ratu Safitri; Abun Hasbuna Padmadijaya
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 9 No. 2 (2022): December 2022
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

ABSTRACT Every year there is a change in the stock of ruminant feed that occurs in the rainy season and water shortages in the dry season. Utilization of agricultural waste as an alternative feed is one way to overcome these problems. One of the wastes that have the potential to be used as feed ingredients is sago waste. Sago pulp is a waste that is rich in lignocellulose, namely cellulose. Several biotechnology applications in ruminant feed fermentation can improve properties such as taste, aroma, shelf life, texture and nutritional value of food. Fermentation using mold or yeast, as well as bacteria or a mixture of various microorganisms can increase the nutrients in the feed needed by ruminant feed. Processing of lignocellulosic materials is required to obtain optimal degradation results. The degradation process will convert lignocellulosic material into raw materials that are easily digested by the ruminant. Enzymes produced by microorganisms can increase crude protein, crude fat, carbohydrates, crude fiber, vitamins and minerals. Thus, the fermentation method of sago dregs and its use as feed can increase the nutritional value, so that productivity can be increased when given as feed. ABSTRAK Setiap tahun terjadi perubahan stok pakan ternak ruminansia yaitu pada musim hujan dan kekurangan air pada musim kemarau. Pemanfaatan limbah pertanian sebagai pakan alternatif merupakan salah satu cara untuk mengatasi permasalahan tersebut. Salah satu limbah yang berpotensi untuk dimanfaatkan sebagai bahan pakan adalah limbah sagu. Ampas sagu merupakan limbah yang kaya akan lignoselulosa yaitu selulosa. Beberapa aplikasi bioteknologi dalam fermentasi pakan ternak ruminansia dapat meningkatkan sifat-sifat seperti rasa, aroma, umur simpan, tekstur dan nilai gizi makanan. Fermentasi menggunakan kapang atau khamir, serta bakteri atau campuran berbagai mikroorganisme dapat meningkatkan nutrisi dalam pakan yang dibutuhkan pakan ruminansia. Pengolahan bahan lignoselulosa diperlukan untuk mendapatkan hasil degradasi yang optimal. Proses degradasi akan mengubah bahan lignoselulosa menjadi bahan baku yang mudah dicerna oleh ruminansia. Enzim yang dihasilkan oleh mikroorganisme dapat meningkatkan protein kasar, lemak kasar, karbohidrat, serat kasar, vitamin dan mineral. Dengan demikian, metode fermentasi ampas sagu dan pemanfaatannya sebagai pakan dapat meningkatkan nilai gizi, sehingga produktivitas dapat meningkat bila diberikan sebagai pakan.

Assessment of Teratogenic Effects of Sappan Wood (Caesalpinia Sappan L.) Extract In Rats (Rattus novergicus) Jeri Nobia Purnama; Erick Khristian; Mas Rizky A.A Syamsunarno; Yusof Kamisah; Ratu Safitri
HAYATI Journal of Biosciences Vol. 30 No. 6 (2023): November 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.6.1036-1042

Treatment using plant materials has been widely researched and observed to assist in curing a disease. Medicinal products derived from herbal plants are proven useful as drugs must follow guidelines not to cause acute or chronic toxicity. The purpose of this study was to investigate the teratogenic potential of an ethanolic sappan wood extract on the growth of unborn rats. Six groups of pregnant rats are created: Aquadest was administered to the Control group, whereas the Treatment groups received 100, 200, 300, 400, or 500 mg.kg-1 BW of an ethanolic extract of Sappan wood. On the twenty-first day of gestation, pregnant rats were CO2-euthanized and delivered vaginally. Rats' body weight during pregnancy was observed, along with fetal growth measurements, viscoelastic examination, and skeletal development. Wistar rats' reproductive systems, fetal body weight, body length, and tail length were all unaffected by ethanol extract of Sappan wood at doses from 100 mg/kg to 500 mg/kg. In fetuse rat from the control group and the five dosage groups, no skeletal development had taken place and there were no obvious external abnormalities. Even at the maximum dose of 500 mg, sappan wood extract demonstrated no teratogenic effects on the development of fetal rats.kg-1 BW.

Optimized Novel Antibacterial Production from Geobacillus kaustophilus Tm6T2 (a) as Treatment for Salmonella typhimurium Akeyla Tabina Tawangalun; Ani Melani Maskoen; Emma Rachmawati; Candra Arumimaniyah; Shinta Asarina; Ratu Safitri; Tri Yuliana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2202

Geobacillus sp. is recognized for its potential to produce bacteriocins, antibacterial substances that hold promise in addressing gastrointestinal illnesses. This study aimed to optimize the medium and pH conditions for producing antibacterial substances by Geobacillus kaustophilus Tm6T2 (a). The research employed a descriptive and experimental methodology. Growth studies were conducted in Mueller Hinton Broth with CaCl2 and MgSO4 and Nutrient Broth with KCl and MgCl2 across 6, 7, and 8 pH values. Subsequently, antibacterial substance production was achieved at the late logarithmic phase and was assessed against the gastrointestinal pathogen Salmonella typhimurium. Interestingly, findings indicated that antibacterial substance production might not solely correlate with bacterial cell count. Despite a lower bacterial cell count, the highest inhibition zone against S.typhimurium was observed at 13.11 mm in NB salt at pH 8. Analytical results show that the variation of pH and both mediums significantly affects the presence of the inhibition zone (p < 0.10). This finding suggests the complexity of factors influencing antibacterial activity. Overall, the optimum condition for antibacterial production in G.kaustophilus Tm6T2(a) was identified at pH 8 using NB salt. These findings have potential implications for developing antibacterial solutions targeting gastrointestinal pathogens.

HISTOPATHOLOGICAL STRUCTURE OF THE RAT KIDNEY AFTER ADMINISTRATION OF SAPPAN WOOD EXTRACT (Caesalpinia sappan L.) IN IRON OVERLOAD CONDITION Jeri Nobia Purnama; Firdawati, Nurul; Khristian, Erick; Safitri, Ratu; Utama, Gemilang Lara; Fakhira, Anisa Muthia
Jurnal Biosains Pascasarjana Vol. 26 No. 2 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i2.2024.87-98

Excessive amounts of iron in the body can lead to damage to various organs, including the kidneys. Iron chelators have been demonstrated to effectively reduce the accumulation of this excess iron. This study aims to investigate the impact of administering sappan wood extract (Caesalpinia sappan) as an adjuvant to iron chelators on the structure and function of kidneys in a rat model of iron overload. The experimental research, spanning 28 days, employed a Completely Randomized Design (CRD) involving 30 male Wistar rats (Rattus norvegicus) distributed across 6 test groups. Iron dextran at 60 mg/kg bb induced iron overload, while a comparative iron chelator, deferiprone, was given at 1.35 mg/kg bb. Various doses of Sappan wood extract (SWE) 100, 150, and 200 mg/kg bb were administered to separate test groups. The parameters that are being observed include the distribution of iron and the structure of kidney injury. At a 95% confidence level, the acquired data were examined using analysis of variance (ANOVA), and the Duncan test was used to see whether there were any differences. The study's findings demonstrated that each treatment group's kidney iron levels differed from the excess iron-containing control group (p <0.05). The histological investigation results demonstrated a significant difference in damage scores (p <0.05) between the groups administered secang wood extract and the excess besei control group. Adminstered of 100 mg/kgbw dose of EKS might lower their organ iron levels and lessen the harm that the iron did to their kidneys. Keyword: Sappan Wood (Caesalpinia sappan L.), Iron Overload, Kidney

Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model Khristian, Erick; Ghozali, Mohammad; Bashari, Muhammad H.; Purnama, Jeri N.; Irianto, Gunawan; Panigoro, Ramdan; Safitri, Ratu
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1003

Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis. An experimental design with a post-test-only control group method was conducted using animal models. Fifty rats were used and divided into ten groups, nine received different intravenous doses of iron dextran: 10, 20, 30, 40, 50, 60, 80, 100, and 120 mg/kg body weight (BW) and a control group received no treatment. The results showed that intravenous iron dextran starting at a dose of 10 mg/kg BW caused significant changes in liver iron concentration while starting at 20 mg/kg BW significantly affected hepatocyte morphology, transferrin levels, unsaturated iron binding capacity, serum iron levels, and transferrin saturation. Intravenous iron dextran starting at 40 mg/kg BW resulted significant changes in the level of total iron binding capacity compared to control group. In conclusion, intravenous iron dextran significantly altered hepatocyte morphology, increased liver iron concentration, and modified the serum iron profile, reflecting changes that might be observed in patients with transfusion-dependent thalassemia.

In Silico Study of Brazilin from Secang Wood (Caesalpinia Sappan L) as a Candidate for Splenomegaly Therapy Youngest, Racy; Rusdianto, Rusdianto; Kamisah, Yusof; Maskoen, Ani Melani; Safitri, Ratu
International Journal of Health Science and Technology Vol. 6 No. 3 (2025): April
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/ijhst.v6i3.4032

Brazilin is a flavonoid found in secang (sappan) wood extract (Caesalpinia sappan L) currently undergoing clinical trials in phase 2 for the treatment of thalassemia patients. It is recognized for its antioxidant effects and its efficacy as a strong iron chelator, facilitating the binding and excretion of excess iron in the bloodstream of patients with thalassemia. This flavonoid compound may serve as a Janus kinase 2 (JAK2) inhibitor through the EPO/EPOR/JAK2/STAT5 pathway, which is responsible for splenomegaly (enlarged spleen). This study aims to investigate the mechanism by which sappan wood metabolite chemicals (brazilin) inhibit JAK2 in silico. This inhibition is expected to reduce splenomegaly in thalassemia patients and serve as an alternative to ruxolitinib (conventional medications). The pharmacokinetic profile of the ligand is predicted according to Lipinski's rule, while the binding energy (ΔG), initiation constant, and chemical bonds are examined using molecular docking with AutoDock v.4.25. This study successfully determined that brazilin, with a binding energy of -8.37 kcal/mol, is comparable to ruxolitinib, which has a binding energy of -8.71 kcal/mol. This finding shows that brazilin derived from sappan wood contains bioactive chemicals with potential JAK2 inhibitory activities. This finding establishes a foundation for further research aimed at developing new therapeutic agents for the treatment of splenomegaly in β-thalassemia and associated disorders.

Aplikasi Helicoverpa Armigera Nuclear Polyhedrosis Virus Subkultur (Hanpv1) pada Ectropis Burmitra Miranti, Mia; Safitri, Ratu; Melanie, M; Fitriani, Nurullia
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (477.241 KB)

Helicoverpa armigera Nuclear Polyhedrosis Virus (HaNPV) telah diproduksi pada larva Spodoptera litura. Virus hasil produksi tersebut adalah Helicoverpa armígera Nuclear Polyhedrosis Virus Subkultur atau HaNPV1. Penelitian dilakukan menggunakan metode deskriptif eksplorasi dengan menginfeksikan larva instar dua, tiga dan empat Ectropis burmitra (ulat jengkal daun teh) dengan sediaan HaNPV1 yang dioleskan pada pakan larva dengan konsentrasi virus yang digunakan sebesar 4 x 102, 4 x 104 dan 4 x 106 polihedra/ml. Hasil penelitian menunjukkan bahwa tingkat kematian larva instar dua, tiga dan empat Ectropis burmitra yangdiinfeksi virus dengan konsentrasi 4 x 102, 4 x 104 dan 4 x 106 polihedra/ml antara 80%-100%. Efektivitas infeksi HaNPV1 hingga 100% pada larva E. burmitra instar dua untuk semua konsentrasi infeksi. Akan tetapi semakin tua instar larva, tingkat kematian turun menjadi 80% pada larva instar tiga dan empat yang diinfeksi HaNPV1 dengan konsentrasi sebesar 4 x 102 polihedra/ml. Pada konsentrasi virus sebesar 4 x 106 polihedra/ml seluruh larva instar dua, tiga dan empat mencapai tingkat kematian 100%. Tingkat kematian yang tinggi terjadi pada larva ini karena E. burmitra masih satu ordo dengan H. armigera (sebagai inang utama HaNPV) dan S. litura yaitu Ordo Lepidoptera

PENGOLAHAN LIMBAH INDUSTRI ACI AREN UNTUK MENINGKATKAN NILAI TAMBAH INDUSTRI DAN KESEJAHTERAAN MASYARAKAT: PENGOLAHAN LIMBAH INDUSTRI ACI AREN UNTUK MENINGKATKAN NILAI TAMBAH INDUSTRI DAN KESEJAHTERAAN MASYARAKAT Safitri, Ratu; Yulia, Tri; Kuntana, Yasmi P.
Jurnal Kajian Budaya dan Humaniora Vol 4 No 2 (2022): Jurnal Kajian Budaya dan Humaniora (JKBH), Juni 2022
Publisher : PT. RANESS MEDIA RANCAGE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61296/jkbh.v4i2.20

Kegiatan pengabdian masyarakat di Desa Sukamaju, Kecamatan Rancakalong, Kabupaten Sumedang ini bertujuan untuk mengolah limbah Pati Aren (Arenga Pinnata). Dengan demikian limbah industri pati Aren akan memberi nilai tambah ekonomi bagi pemilik industi dan sekaligus meningkatkan kesehatan lingkungan masyarakat. Pelatihan pengolahan limbah pati Aren diperlukan untuk memberi pengetahuan dan keterampilan bagi pengusaha lokal dan pemerintahan desa untuk tidak membuang limbah cair atau pun padat sebelum di olah ke lingkungan. Pelatihan fermentasi limbah cair industri pati aren menjadi pupuk organik cair. Limbah cair pati aren memiliki kandungan karbohidrat yang tinggi dengan kadar BOD5 2985 mg/L dan COD 8740 mg/L sangat potensial untuk di ubah menjadi pupuk cair. Proses pembuatan pupuk organik cair ini adalah fermentasi limbah cair oleh mikroorganisme fungsional untuk menghilangkan bau dan untuk produksi biofertilizer lengkap yang mengandung hormon tumbuhan, unsur hara dan biomasa sel miroorganisme fungsional. Program pengabdian kepada masyarakat meliputi observasi lapangan, penyuluhan dan pelatihan.

Differential Regulation of Slc40a1, Fth1, and Hmox1 by Deferasirox in Splenic Iron Overload Wibowo, Annisa Maharani; Kuntana, Yasmi Purnamasari; Arrizqiani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404386

Iron overload, often arising from repeated transfusions in thalassemia major, disrupts iron homeostasis and induces oxidative stress. Deferasirox is a widely used oral chelator, yet its effects on splenic iron-regulatory gene expression remain unclear. This study investigated the impact of deferasirox on ferritin heavy chain (Fth1), ferroportin (Slc40a1), and heme oxygenase-1 (Hmox1) expression in a rat model of splenic iron overload. Eighteen male Wistar rats were randomly assigned into three groups (n = 6 each): normal (N), iron dextran-induced overload without treatment (KN), and iron overload treated with deferasirox (KP). Gene expression was quantified by real-time PCR using the 2−ΔΔCT (Livak) method, with statistical analysis performed via one-way ANOVA and Tukey’s post hoc test. Iron overload significantly upregulated Fth1 (2.26-fold) and Slc40a1 (1.72-fold) versus controls (p < 0.05). Deferasirox treatment reduced Fth1 (3.28-fold decrease) and Slc40a1 (1.15-fold reduction) relative to untreated overload, though not significantly (p > 0.05). In contrast, Hmox1 expression markedly increased (55.25-fold, p < 0.05) following deferasirox administration. These results indicate that deferasirox selectively modulates splenic iron-regulatory genes, suggesting both chelation and adaptive stress-response mechanisms, thereby supporting its therapeutic role in managing iron overload.

EFFECT OF POWDER AND LIQUID PREPARATIONS OF PROBIOTICS ON WHITE SHRIMP (Litopenaeus vannamei) GROWTH PERFORMANCE Safitri, Ratu; Andriani, Yuli; Sunendi, Sunendi; Iskandar, Iskandar; Buwono, Ibnu Dwi
BIOTROPIA Vol. 27 No. 3 (2020): BIOTROPIA Vol. 27 No. 3 December 2020
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.0.0.0.1124

Indonesia is the second largest supplier of white shrimp (Litopenaeus vannamei, Boone 1931) in the USA market. Hence, the need for its sustainable production and improved growth. Probiotics, among others, are known for their growth enhancing attributes. Therefore, this study was conducted to determine the effects of powder and liquid probiotics on the growth of white shrimps at the Minaloka Jaya shrimp ponds, Grabag District, Purwerojo Regency, Central Java. The shrimps were cultivated for 60 days and applied with three probiotic treatments, namely commercial liquid probiotics with dosage of 10 mL/kg feed, powder probiotics with dosage of 10 g/kg feed and liquid probiotic with dosage of 10 mL/kg feed. Each probiotic preparation was administered four times a day to over 150,000 vannamei shrimps which were cultured in a semi-intensive system. Probiotics in powder and liquid forms contain Lactobacillus fermentum, L acidophilus, L. plantarum, L, curvatus, Bacillus licheniformis, B. subtilis, and B. polimyxa. B. megaterium, B. coagulans, Pseudomonasputida, Nitrosomonas sp. and Nitrobacter sp. Using the Randomized Block Design (RBD), the three treatments were replicated five times. The application of probiotics in both powder and liquid forms had increased the growth yield of the vannamei shrimp. However, the powder probiotic had shown better growth performance than the commercial liquid probiotics and liquid preparation of probiotics. Probiotic powder form provides a specific growth rate (SGR) of 8.18%, absolute body length of 9.68 cm, absolute biomass of 6.78 g, and feed conversion ratio (FCR) of 1.93.

Co-Authors Abun Abun Abun Hasbuna Padmadijaya Ahmad Yani Nelly Wahyuni Lia Destiarti Akeyla Tabina Tawangalun Alif Bagus Rakhimullah Ani Melani Maskoen Ani Melani Maskoen Ari Widiyantoro Arrizqiani, Tanendri Aufa Aulia Kanza Bambang Priadie Bashari, Muhammad H. Bashari, Muhammad Hasan BERTI HARIASIH HANDAYANI Candra Arumimaniyah Diana Indah Permatasari E. M. Soekartadiredja Edhyana Sahiratmadja Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Emma Rachmawati Erick Khristian Erick Khristian Erick Khristian Fakhira, Anisa Muthia Febby Hauwita Firdawati, Nurul Fitri Rahmi Fadhilah Gemilang Lara Utama Harlia Harlia Herman Susanto Ibnu Dwi Buwono Irianto, Gunawan Iskandar Iskandar Jeri Nobia Purnama Jeri Nobia Purnama Jeri Nobia Purnama Joko Kusmoro Kamisah, Yusof Kartiawati Alipin Khristian, Erick Marlinda Siahaan Maryati Maryati Mas Rizky A.A Syamsunarno Mas Rizky A.A. Syamsunarno Masahiko Kurabayasi Melanie, M Mia Miranti Mia Miranti Rustama Mohammad Ghozali Mohammad Ghozali Mohammad Ghozali, Mohammad Mutia, Theresia Nia Rossiana Nurullia Fitriani Poniah Andayaningsih Purnama, Jeri N. R. Ninda Naufal Utami Ramdan Panigoro Rifaida Eriningsih Rifaida Eriningsih Rifaida Eriningsih, Rifaida Rika Pura Berliyani ROFIQ SUNARYANTO Ruhyat Kartasudjana Rusdianto Rusdianto, Rusdianto Rymond Jusuf Rumampuk Salsabila, Nadhila Hasna Shinta Asarina Sri Rejeki Rahayuningsih Sukaya Sastrawibawa Sunendi, Sunendi Tanendri Arrizqiyani, Tanendri Tatsuya Iso Theresia Mutia Theresia Mutia Theresia Mutia, Theresia Titi Lahanda Susanti Tri Yuliana Unang Supratman Uni Gamayani Wibowo, Annisa Maharani Yasmi P. Kuntana, Yasmi P. Yasmi Purnamasari Kuntana Youngest, Racy Yuli Andriani Yuli Andriani Yulia, Tri Yusof Kamisah

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