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All Journal HAYATI Journal of Biosciences Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Microbiology Indonesia Majalah Kedokteran Bandung BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Biosains Pascasarjana Jurnal Perikanan dan Kelautan Jurnal Riset Industri Jurnal Ilmiah Arena Tekstil The Indonesian Biomedical Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Ilmu dan Teknologi Kayu Tropis Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) International Journal of Health Science and Technology Sciences of Pharmacy Jurnal Kajian Budaya dan Humaniora (JKBH)
Ratu Safitri
Faculty Of Mathematics And Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effect of Deferiprone on Hepatic Expression of Hamp, Ftl, and Tfr1 Genes in an Iron-Overloaded Rat (Rattus norvegicus) Model Salsabila, Nadhila Hasna; Kuntana, Yasmi Purnamasari; Arrizqiyani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404387

Abstract

Iron overload is linked to progressive impairment of organ function, with the liver being the primary site of deposition due to the lack of a physiological route for iron elimination. The maintenance of systemic iron balance depends on key regulatory proteins, including hepcidin (Hamp gene), ferritin light chain (Ftl gene), and transferrin receptor 1 (Tfr1 gene). This study tested the hypothesis that Deferiprone (DFP), an oral iron chelator, modulates the hepatic expression of Hamp, Ftl, and Tfr1 genes in an iron-overloaded rat model. Eighteen male Wistar rats (150-200 g) were randomly assigned into three groups: Normal (N), Negative Control (NC; induced with Iron Dextran), and Treatment (T; Iron Dextran + DFP). Iron overload was induced via intravenous injection of Iron Dextran (120 mg/kg BW) over 15 days at 3-day intervals, while DFP was administered orally (100 mg/kg BW) in three divided doses for 28 consecutive days. Gene expression was assessed using RT-PCR, and relative quantification was performed using the Livak method. The iron-overloaded rats showed marked upregulation of Hamp and Ftl and downregulation of Tfr1. Administration of DFP significantly reversed these alterations, decreasing Hamp and Ftl levels while restoring Tfr1 expression to levels comparable to normal controls. These results highlight the potential role of DFP in modulating hepatic iron-regulatory genes under iron overload conditions. 
Co-Authors Abun Abun Abun Hasbuna Padmadijaya Ahmad Yani Nelly Wahyuni Lia Destiarti Akeyla Tabina Tawangalun Alif Bagus Rakhimullah Ani Melani Maskoen Ani Melani Maskoen Ari Widiyantoro Arrizqiani, Tanendri Aufa Aulia Kanza Bambang Priadie Bashari, Muhammad H. Bashari, Muhammad Hasan BERTI HARIASIH HANDAYANI Candra Arumimaniyah Diana Indah Permatasari E. M. Soekartadiredja Edhyana Sahiratmadja Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Emma Rachmawati Erick Khristian Erick Khristian Erick Khristian Fakhira, Anisa Muthia Febby Hauwita Firdawati, Nurul Fitri Rahmi Fadhilah Gemilang Lara Utama Harlia Harlia Herman Susanto Ibnu Dwi Buwono Irianto, Gunawan Iskandar Iskandar Jeri Nobia Purnama Jeri Nobia Purnama Jeri Nobia Purnama Joko Kusmoro Kamisah, Yusof Kartiawati Alipin Khristian, Erick Marlinda Siahaan Maryati Maryati Mas Rizky A.A Syamsunarno Mas Rizky A.A. Syamsunarno Masahiko Kurabayasi Melanie, M Mia Miranti Mia Miranti Rustama Mohammad Ghozali Mohammad Ghozali Mohammad Ghozali, Mohammad Mutia, Theresia Nia Rossiana Nurullia Fitriani Poniah Andayaningsih Purnama, Jeri N. R. Ninda Naufal Utami Ramdan Panigoro Rifaida Eriningsih Rifaida Eriningsih Rifaida Eriningsih, Rifaida Rika Pura Berliyani ROFIQ SUNARYANTO Ruhyat Kartasudjana Rusdianto Rusdianto, Rusdianto Rymond Jusuf Rumampuk Salsabila, Nadhila Hasna Shinta Asarina Sri Rejeki Rahayuningsih Sukaya Sastrawibawa Sunendi, Sunendi Tanendri Arrizqiyani, Tanendri Tatsuya Iso Theresia Mutia Theresia Mutia Theresia Mutia, Theresia Titi Lahanda Susanti Tri Yuliana Unang Supratman Uni Gamayani Wibowo, Annisa Maharani Yasmi P. Kuntana, Yasmi P. Yasmi Purnamasari Kuntana Youngest, Racy Yuli Andriani Yuli Andriani Yulia, Tri Yusof Kamisah