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Weil’s Disease dengan Gagal Ginjal Akut Amelia, Rizki; Fadrian, Fadrian
Jurnal Kesehatan Andalas Vol. 13 No. 3 (2024): November 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i3.2431

Weil's disease is a severe leptospirosis characterized by multiorgan failure with symptoms of high fever, jaundice, kidney failure, liver necrosis, lung abnormalities, cardiovascular collapse, neurological changes, and bleeding. Acute kidney injury may occur in 20% to 85% of patients during the second phase of leptospirosis disease. It has been reported a 31-year-old male patient had a persistent high fever, pain in the muscles and joints throughout the body, especially in the muscles of both calves, headache, eyes and the whole body looked yellow, urinating like dark tea. The patient once fished in the river barefoot. Physical examination showed icteric sclera, ciliary injection, and temperature 38.9ºC. Laboratory examination of leukocytes 16,880/mm3, platelets 26,000/mm3, ureum 152 mg/dl, creatinine 6.8 mg/dl, direct bilirubin 15 mg/dl, indirect bilirubin 7.2 mg/dl, SGOT 192 U/L, SGPT 71 U/L. Urinalysis showed hematuria and proteinuria. Anti-leptospira IgM serology showed reactive results. On direct dark field microscopic examination of urine samples, fine spiral-shaped Leptospira bacteria were found. On ultrasound examination of the kidneys, the impression of both kidneys showed acute nephritis. The Modified Faine Criteria Score was 39, which suggests presumptive leptospirosis. The patient was treated with intravenous antibiotics Ceftriaxon 2x1 gram and hemodialysis. Keywords: acute kidney injury, hemodialysis, leptospirosis, Weil’s disease

HUBUNGAN INFEKSI PROTOZOA USUS DENGAN KANKER KOLOREKTAL: SEBUAH TINJAUAN SISTEMATIS Rifa, Farras Zahra; Nofita, Eka; Rusjdi, Selfi Renita; Hasmiwati, Hasmiwati; Khambri, Daan; Fadrian, Fadrian
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1844

Colorectal cancer is the third most common malignancy worldwide. Chronic inflammation, including intestinal protozoan infection, is linked to its risk. This systematic review examined the association between protozoan infection and colorectal cancer. Literature was searched in five databases (2014–2024), screened with PRISMA, and assessed using the JBI checklist. Thirty-two studies were reviewed. Protozoan infection incidence was generally higher in colorectal cancer than in non-cancer or other cancer groups. Blastocystis sp. was the most common species. Eighteen of 22 studies showed significant associations, particularly with Blastocystis sp., Cryptosporidium sp., Pentatrichomonas hominis, and Entamoeba histolytica. Factors involved included demographics, biology, environment, lifestyle, clinical history, and cancer stage. Most studies support a significant link. Opportunistic protozoan infections may worsen colorectal cancer progression, and chronic Cryptosporidium infection may induce preneoplastic lesions.

HUBUNGAN STADIUM CHRONIC KIDNEY DISEASE DENGAN HIPERTENSI PADA PASIEN CKD DEWASA DI RSUP DR. M. DJAMIL PADANG TAHUN 2020-2021. Putri, Viona Salsabila; Miro, Saptino; Irawati, Lili; Fadrian, Fadrian; Hamdani, Rita; Rasyid, Rosfita
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1845

Chronic Kidney Disease (CKD) is a condition where there is structural or functional damage to the kidneys for more than 3 months with or without being followed by a decrease in the estimated Glomerular Filtration Rate (eGFR) and is progressive and irreversible. Hypertension is the most common comorbidity found in patients with CKD which can increase the progression of kidney damage. Objective: To determine the relationship between the stage of CKD and hypertension and the distribution of the frequency of patients with CKD based on age, sex, eGFR value, and hypertension. Methods: This research was an observational analytic study with a cross-sectional design. The research was conducted at the Medical Record Installation of RSUP Dr. M. Djamil from December 2022 - March 2023 used a purposive sampling technique and obtained 33 samples. The research data was secondary data in the form of blood pressure and serum creatinine and then analyzed using the Chi-Square test with a degree of confidence of 95% and p-value <0,05. Results: This study showed that most cases of CKD occurred in the age group 41-65 years (54,5%) and mostly found in men (57,6%). In this study, stage 5 CKD was the most common (72,7%) and the majority of patients with CKD suffered from hypertension (69,7%). The results of data analysis obtained p = 0,090 (p> 0.05). Conclusion: There was no significant relationship between the stage of CKD and hypertension (P=0,090) in adult patients at Dr. M. Djamil Padang in 2020–2021.

Different Sepsis Patient Outcomes Due to Multidrug-Resistant Organisms (MDRO): A Study of Empirical Antibiotic Sensitivity Test Results Fadrian, Fadrian; Ahmad, Armen; Harvindra, Astrid; Putri, Vidola Yasena
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1740

Background: Sepsis, a severe immune response to infection, has a concerning global mortality rate of 85%, predominantly due to Gram-negative bacteria. The rise of antibiotic resistance in these organisms complicates treatment, leading to higher mortality and prolonged hospital stays. Effective empirical antibiotics can mitigate these outcomes. Objective: This study compares outcomes of sepsis patients infected with multidrug-resistant organisms (MDRO) based on empirical antibiotic sensitivity testing, focusing on mortality and length of stay (LOS) within 14 days of sepsis onset. Methods: A prospective cohort observational study at Dr. M. Djamil General Hospital included 94 participants. Patients who died within 14 days were excluded from the LOS analysis to prevent bias. Initial assessments included culture sampling and organ dysfunction. Results: The study revealed no significant difference in mortality based on antibiotic sensitivity (p=0.283), but the LOS was significantly shorter in those treated with sensitive antibiotics (p<0.016). Conclusion: LOS was significantly affected by antibiotic sensitivity, with patients receiving effective antibiotics experiencing shorter stays, though mortality differences were not statistically significant in the 14-day window

Hubungan Indeks Massa Tubuh dengan Kadar Glukosa Darah Puasa dan Tekanan Darah Pada Tenaga Kependidikan Fakultas Kedokteran Universitas Andalas Hasnah, Hidayatul; Yulia, Dwi; desmawati, Desmawati; fadrian, fadrian; alioes, yustini; arisanty, dessy
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i4.p371-382.2024

Tujuan : mengetahui hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah pada tenaga kependidikan Fakultas Kedokteran Universitas Andalas. Metode : Jenis penelitian ini merupakan penelitian analitik dengan desain penelitian cross-sectional dengan subjek penelitian sebanyak 37 orang yang dilaksanakan di Fakultas Kedokteran Universitas Andalas pada tanggal 08 September 2021.Â Metode pengambilan sampel ini dengan total sampling, analisis data hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah menggunakan uji korelasi Spearman. Hasil: Nilai median indeks massa tubuh sebesar 24,22 Kg/, nilai rerata 24,94 Kg/, nilai minimum sebesar 16,23 Kg/Â dan nilai maksimum 40,15 Kg/. Nilai median kadar glukosa darah puasa 127 mg/dL, nilai rerata 143,65 mg/dL, nilai minimum sebesar 93 mg/dL dan nilai maksimum 399 mg/dL. Nilai median dari tekanan darah 126 mmHg,nilai rerata 128,7 mmHg,Â nilai minimum 94 mmHg, dan nilai maksimum 213 mmHg. Tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa (p=0,203) ataupun pada indeks massa tubuh dengan tekanan darah (p= 0,097) pada subjek penelitian. Kesimpulan: tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa dan antara indeks massa tubuh dengan tekanan darah pada tenaga kependidikan pada Fakultas Kedokteran Universitas Andalas.Â Â

Gambaran Dukungan Keluarga Penderita HIV Di Kota Pariaman Oktalina, Dyanti; Astiena, Adila Kasni; Lestari, Yuniar; Hardisman, Hardisman; Triana, Vivi; Fadrian, Fadrian
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 2 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss2.1761

Jumlah penderita HIV di dunia terus meningkat setiap tahunnya. Kondisi ini memerlukan strategi penanggulangan yang tidak hanya berfokus pada pengobatan medis, tetapi juga dukungan dari lingkungan terdekat, khususnya keluarga. Penelitian ini bertujuan untuk mengetahui gambaran peran keluarga dalam mendampingi penderita HIV. Penelitian menggunakan desain observasional dengan pendekatan deskriptif. Populasi adalah penderita HIV di Kota Pariaman dengan sampel 54 orang yang dipilih melalui teknik accidental sampling. Hasil penelitian menunjukkan bahwa sebagian besar penderita berusia ≤ 40 tahun (66,7%), berjenis kelamin laki-laki (77,8%), memiliki pendidikan tinggi (88,9%), bekerja (74,1%), dan tinggal bersama keluarga (85,2%). Bentuk pendampingan keluarga yang ditemukan antara lain dukungan emosional sebagian besar masih kurang (57,4%), sedangkan dukungan informasional (51,9%), instrumental (51,9%), dan penghargaan (57,4%) tergolong baik.Keberadaan keluarga memiliki peran penting dalam meningkatkan motivasi penderita untuk minum obat secara teratur dan menjaga kualitas hidup. Pendampingan yang konsisten dapat memperkuat kepercayaan diri penderita HIV.

The Diagnostic Accuracy of IgG Avidity Testing for Differentiating Acute from Chronic Toxoplasmosis in Pregnant Women: A Meta-Analysis Hermalina Sherli Utami; Rohayat Bilmahdi; Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1467

Background: Differentiating acute from chronic Toxoplasma gondii infection during pregnancy is a critical diagnostic challenge. Persistent Immunoglobulin M (IgM) antibodies create ambiguity, complicating clinical management. The IgG avidity test serves as a key tool to estimate infection timing. This meta-analysis aimed to systematically evaluate and quantify the diagnostic accuracy of the IgG avidity test for identifying acute toxoplasmosis in pregnant women. Methods: A systematic literature search was conducted across PubMed, Scopus, Web of Science, EMBASE, and LILACS for studies published between January 2015 and December 2025 evaluating the IgG avidity test's diagnostic accuracy in pregnant women. Included studies required data for a 2x2 contingency table. The QUADAS-2 tool was used for bias assessment. A bivariate random-effects model was used to pool sensitivity, specificity, likelihood ratios (PLR, NLR), and the diagnostic odds ratio (DOR). Results: Seven studies, comprising 1,250 pregnant women, were included. The pooled sensitivity was 0.96 (95% Confidence Interval [CI]: 0.92–0.98), and the pooled specificity was 0.97 (95% CI: 0.94–0.99). The pooled PLR was 32.5 (95% CI: 15.1–69.8), the NLR was 0.04 (95% CI: 0.02–0.08), and the DOR was 785 (95% CI: 289–2134). The area under the SROC curve was 0.99 (95% CI: 0.97–1.00). Substantial heterogeneity was observed across studies. A sensitivity analysis excluding one study with a high risk of bias did not significantly alter the results, and Deeks' test showed no evidence of publication bias (p=0.21). Conclusion: The IgG avidity test demonstrated excellent pooled diagnostic accuracy for differentiating acute from chronic toxoplasmosis in pregnancy. However, significant heterogeneity across studies underscores that a single performance estimate is not universally applicable. The test is a powerful tool for resolving diagnostic uncertainty, but results must be interpreted based on assay-specific performance and in the context of the complete clinical picture.

The Diagnostic Accuracy of IgG Avidity Testing for Differentiating Acute from Chronic Toxoplasmosis in Pregnant Women: A Meta-Analysis Hermalina Sherli Utami; Rohayat Bilmahdi; Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1467

Background: Differentiating acute from chronic Toxoplasma gondii infection during pregnancy is a critical diagnostic challenge. Persistent Immunoglobulin M (IgM) antibodies create ambiguity, complicating clinical management. The IgG avidity test serves as a key tool to estimate infection timing. This meta-analysis aimed to systematically evaluate and quantify the diagnostic accuracy of the IgG avidity test for identifying acute toxoplasmosis in pregnant women. Methods: A systematic literature search was conducted across PubMed, Scopus, Web of Science, EMBASE, and LILACS for studies published between January 2015 and December 2025 evaluating the IgG avidity test's diagnostic accuracy in pregnant women. Included studies required data for a 2x2 contingency table. The QUADAS-2 tool was used for bias assessment. A bivariate random-effects model was used to pool sensitivity, specificity, likelihood ratios (PLR, NLR), and the diagnostic odds ratio (DOR). Results: Seven studies, comprising 1,250 pregnant women, were included. The pooled sensitivity was 0.96 (95% Confidence Interval [CI]: 0.92–0.98), and the pooled specificity was 0.97 (95% CI: 0.94–0.99). The pooled PLR was 32.5 (95% CI: 15.1–69.8), the NLR was 0.04 (95% CI: 0.02–0.08), and the DOR was 785 (95% CI: 289–2134). The area under the SROC curve was 0.99 (95% CI: 0.97–1.00). Substantial heterogeneity was observed across studies. A sensitivity analysis excluding one study with a high risk of bias did not significantly alter the results, and Deeks' test showed no evidence of publication bias (p=0.21). Conclusion: The IgG avidity test demonstrated excellent pooled diagnostic accuracy for differentiating acute from chronic toxoplasmosis in pregnancy. However, significant heterogeneity across studies underscores that a single performance estimate is not universally applicable. The test is a powerful tool for resolving diagnostic uncertainty, but results must be interpreted based on assay-specific performance and in the context of the complete clinical picture.

Compliance in medication control of hypertension patients during the transition period of the COVID-19 pandemic Priscilla, Hilary; Semiarty, Rima; Masnadi, Nice Rachmawati; Abdiana; Fadrian
BKM Public Health and Community Medicine Vol 39 No 10 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i10.9850

Purpose: This study aims to determine the relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto, during the transition period of the COVID-19 pandemic. Methods: This observational analytic study with a cross-sectional design was conducted from May to June 2023 at the Talawi Public Health Center, Sawahlunto, with 83 research subjects. The research instrument used primary data from the MMAS-8 questionnaire with short interviews and secondary data in medical records of hypertension patients at the Talawi Public Health Center, Sawahlunto, in 2021–2023. The research results were analyzed by chi-square test. Results: The results of this study were that the majority of hypertensive patients were not compliant in controlling their medication (65.1%), and the majority of hypertensive patients had uncontrolled blood pressure (61.4%). Conclusion: This study concludes a significant relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto (p=0.041).

Gambaran Kelainan Refraksi di Poliklinik Mata RSUP Dr. M. Djamil Padang Tahun 2021 Dzulkifli, Dzulkifli; Hidayat, Muhammad; Liza, Rini Gusya; Vitresia, Havriza; Adrial, Adrial; Fadrian, Fadrian
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1207

Latar belakang: Kelainan refraksi merupakan tidak tepatnya cahaya jatuh di retina yang diakibatkan panjang aksial mata serta kekuatan optik yang terganggu. Ametropia adalah kondisi cahaya tidak dapat difokuskan di retina tanpa bantuan akomodasi karena adanya kelainan refraksi pada mata. Terdapat tiga jenis kelainan refraksi, yaitu miopia, hipermetropia, serta astigmatisme. Objektif: Tujuan penelitian ini adalah untuk mengetahui gambaran kelainan refraksi di Poli Mata RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif observasional melalui studi kasus dengan mengumpulkan data rekam medis pasien kelainan refraksi di Poliklinik Mata RSUP Dr. M. Djamil Padang periode 1 Januari 2021 – 31 Desember 2021 dengan mata yang didiagnosis kelainan refraksi yang memenuhi kriteria inklusi dan ekslusi sebanyak 110 pasien. Seluruh variabel dianalisis dengan analisis univariat. Hasil: Hasil penelitian menunjukkan 85 pasien didiagnosis astigmatisme, dengan 50 pasien didiagnosis miopia, serta 8 pasien didiagnosis hipermetropia. Pasien kelainan refraksi dengan kelompok usia terbanyak adalah pada rentang 10-19 tahun (31.82%) dengan mayoritas perempuan (67.27%). Gejala klinis terbanyak adalah pandangan kabur (100%). Berdasarkan tingkatannya pasien miopia terbanyak adalah miopia tinggi (70.73%), hipermetropia terbanyak adalah hipermetropia rendah (76.92%), lalu astigmatisme miopia kompositus merupakan jenis astigmatisme terbanyak (83.01%). Visus pasien kelainan refraksi sebelum dan sesudah dikoreksi terbanyak adalah kelompok mild – no visual impairment (39.54%) & (94.09%). Kesimpulan: Gambaran dari pasien kelainan refraksi pada penelitian ini rentang usia 10-19 tahun merupakan kelompok usia terbanyak serta perempuan mengalami kelainan refraksi lebih banyak dari laki-laki. Dengan miopia derajat tinggi merupakan miopia terbanyak. Hipermetropia derajat rendah merupakan yang terbanyak. Serta astigmatisme miopia kompositus merupakan kelompok astigmatisme terbanyak. Keluhan umum terbanyak adalah pandangan kabur. Kategori visus terbanyak sebelum dan sesudah dikoreksi adalah kategori mild – no visual impairment. Kata kunci: miopia, hipermetropia, astigmatisme

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