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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Universa Medicina Acta Biochimica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Jurnal Penyakit Dalam Indonesia JUKEJ: Jurnal Kesehatan Jompa Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Fadrian, Fadrian
Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Different Sepsis Patient Outcomes Due to Multidrug-Resistant Organisms (MDRO): A Study of Empirical Antibiotic Sensitivity Test Results Fadrian, Fadrian; Ahmad, Armen; Harvindra, Astrid; Putri, Vidola Yasena
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1740

Abstract

Background: Sepsis, a severe immune response to infection, has a concerning global mortality rate of 85%, predominantly due to Gram-negative bacteria. The rise of antibiotic resistance in these organisms complicates treatment, leading to higher mortality and prolonged hospital stays. Effective empirical antibiotics can mitigate these outcomes. Objective: This study compares outcomes of sepsis patients infected with multidrug-resistant organisms (MDRO) based on empirical antibiotic sensitivity testing, focusing on mortality and length of stay (LOS) within 14 days of sepsis onset. Methods: A prospective cohort observational study at Dr. M. Djamil General Hospital included 94 participants. Patients who died within 14 days were excluded from the LOS analysis to prevent bias. Initial assessments included culture sampling and organ dysfunction. Results: The study revealed no significant difference in mortality based on antibiotic sensitivity (p=0.283), but the LOS was significantly shorter in those treated with sensitive antibiotics (p<0.016). Conclusion: LOS was significantly affected by antibiotic sensitivity, with patients receiving effective antibiotics experiencing shorter stays, though mortality differences were not statistically significant in the 14-day window
Hubungan Indeks Massa Tubuh dengan Kadar Glukosa Darah Puasa dan Tekanan Darah Pada Tenaga Kependidikan Fakultas Kedokteran Universitas Andalas Hasnah, Hidayatul; Yulia, Dwi; desmawati, Desmawati; fadrian, fadrian; alioes, yustini; arisanty, dessy
Majalah Kedokteran Andalas Vol. 47 No. 4 (2024): MKA October 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i4.p371-382.2024

Abstract

Tujuan : mengetahui hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah pada tenaga kependidikan Fakultas Kedokteran Universitas Andalas. Metode : Jenis penelitian ini merupakan penelitian analitik dengan desain penelitian cross-sectional dengan subjek penelitian sebanyak 37 orang yang dilaksanakan di Fakultas Kedokteran Universitas Andalas pada tanggal 08 September 2021. Metode pengambilan sampel ini dengan total sampling, analisis data hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah menggunakan uji korelasi Spearman. Hasil: Nilai median indeks massa tubuh sebesar 24,22 Kg/, nilai rerata 24,94 Kg/, nilai minimum sebesar 16,23 Kg/ dan nilai maksimum 40,15 Kg/. Nilai median kadar glukosa darah puasa 127 mg/dL, nilai rerata 143,65 mg/dL, nilai minimum sebesar 93 mg/dL dan nilai maksimum 399 mg/dL. Nilai median dari tekanan darah 126 mmHg,nilai rerata 128,7 mmHg,  nilai minimum 94 mmHg, dan nilai maksimum 213 mmHg. Tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa (p=0,203) ataupun pada indeks massa tubuh dengan tekanan darah (p= 0,097) pada subjek penelitian. Kesimpulan: tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa dan antara indeks massa tubuh dengan tekanan darah pada tenaga kependidikan pada Fakultas Kedokteran Universitas Andalas.  
Gambaran Dukungan Keluarga Penderita HIV Di Kota Pariaman Oktalina, Dyanti; Astiena, Adila Kasni; Lestari, Yuniar; Hardisman, Hardisman; Triana, Vivi; Fadrian, Fadrian
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 2 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss2.1761

Abstract

Jumlah penderita HIV di dunia terus meningkat setiap tahunnya. Kondisi ini memerlukan strategi penanggulangan yang tidak hanya berfokus pada pengobatan medis, tetapi juga dukungan dari lingkungan terdekat, khususnya keluarga. Penelitian ini bertujuan untuk mengetahui gambaran peran keluarga dalam mendampingi penderita HIV. Penelitian menggunakan desain observasional dengan pendekatan deskriptif. Populasi adalah penderita HIV di Kota Pariaman dengan sampel 54 orang yang dipilih melalui teknik accidental sampling. Hasil penelitian menunjukkan bahwa sebagian besar penderita berusia ≤ 40 tahun (66,7%), berjenis kelamin laki-laki (77,8%), memiliki pendidikan tinggi (88,9%), bekerja (74,1%), dan tinggal bersama keluarga (85,2%). Bentuk pendampingan keluarga yang ditemukan antara lain dukungan emosional sebagian besar masih kurang (57,4%), sedangkan dukungan informasional (51,9%), instrumental (51,9%), dan penghargaan (57,4%) tergolong baik.Keberadaan keluarga memiliki peran penting dalam meningkatkan motivasi penderita untuk minum obat secara teratur dan menjaga kualitas hidup. Pendampingan yang konsisten dapat memperkuat kepercayaan diri penderita HIV.
The Diagnostic Accuracy of IgG Avidity Testing for Differentiating Acute from Chronic Toxoplasmosis in Pregnant Women: A Meta-Analysis Hermalina Sherli Utami; Rohayat Bilmahdi; Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1467

Abstract

Background: Differentiating acute from chronic Toxoplasma gondii infection during pregnancy is a critical diagnostic challenge. Persistent Immunoglobulin M (IgM) antibodies create ambiguity, complicating clinical management. The IgG avidity test serves as a key tool to estimate infection timing. This meta-analysis aimed to systematically evaluate and quantify the diagnostic accuracy of the IgG avidity test for identifying acute toxoplasmosis in pregnant women. Methods: A systematic literature search was conducted across PubMed, Scopus, Web of Science, EMBASE, and LILACS for studies published between January 2015 and December 2025 evaluating the IgG avidity test's diagnostic accuracy in pregnant women. Included studies required data for a 2x2 contingency table. The QUADAS-2 tool was used for bias assessment. A bivariate random-effects model was used to pool sensitivity, specificity, likelihood ratios (PLR, NLR), and the diagnostic odds ratio (DOR). Results: Seven studies, comprising 1,250 pregnant women, were included. The pooled sensitivity was 0.96 (95% Confidence Interval [CI]: 0.92–0.98), and the pooled specificity was 0.97 (95% CI: 0.94–0.99). The pooled PLR was 32.5 (95% CI: 15.1–69.8), the NLR was 0.04 (95% CI: 0.02–0.08), and the DOR was 785 (95% CI: 289–2134). The area under the SROC curve was 0.99 (95% CI: 0.97–1.00). Substantial heterogeneity was observed across studies. A sensitivity analysis excluding one study with a high risk of bias did not significantly alter the results, and Deeks' test showed no evidence of publication bias (p=0.21). Conclusion: The IgG avidity test demonstrated excellent pooled diagnostic accuracy for differentiating acute from chronic toxoplasmosis in pregnancy. However, significant heterogeneity across studies underscores that a single performance estimate is not universally applicable. The test is a powerful tool for resolving diagnostic uncertainty, but results must be interpreted based on assay-specific performance and in the context of the complete clinical picture.
Compliance in medication control of hypertension patients during the transition period of the COVID-19 pandemic Priscilla, Hilary; Semiarty, Rima; Masnadi, Nice Rachmawati; Abdiana; Fadrian
BKM Public Health and Community Medicine Vol 39 No 10 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i10.9850

Abstract

Purpose: This study aims to determine the relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto, during the transition period of the COVID-19 pandemic. Methods: This observational analytic study with a cross-sectional design was conducted from May to June 2023 at the Talawi Public Health Center, Sawahlunto, with 83 research subjects. The research instrument used primary data from the MMAS-8 questionnaire with short interviews and secondary data in medical records of hypertension patients at the Talawi Public Health Center, Sawahlunto, in 2021–2023. The research results were analyzed by chi-square test. Results: The results of this study were that the majority of hypertensive patients were not compliant in controlling their medication (65.1%), and the majority of hypertensive patients had uncontrolled blood pressure (61.4%). Conclusion: This study concludes a significant relationship between adherence to medication control and blood pressure in hypertensive patients at the Talawi Public Health Center, Sawahlunto (p=0.041).
Gambaran Kelainan Refraksi di Poliklinik Mata RSUP Dr. M. Djamil Padang Tahun 2021 Dzulkifli, Dzulkifli; Hidayat, Muhammad; Liza, Rini Gusya; Vitresia, Havriza; Adrial, Adrial; Fadrian, Fadrian
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1207

Abstract

Latar belakang: Kelainan refraksi merupakan tidak tepatnya cahaya jatuh di retina yang diakibatkan panjang aksial mata serta kekuatan optik yang terganggu. Ametropia adalah kondisi cahaya tidak dapat difokuskan di retina tanpa bantuan akomodasi karena adanya kelainan refraksi pada mata. Terdapat tiga jenis kelainan refraksi, yaitu miopia, hipermetropia, serta astigmatisme. Objektif: Tujuan penelitian ini adalah untuk mengetahui gambaran kelainan refraksi di Poli Mata RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif observasional melalui studi kasus dengan mengumpulkan data rekam medis pasien kelainan refraksi di Poliklinik Mata RSUP Dr. M. Djamil Padang periode 1 Januari 2021 – 31 Desember 2021 dengan mata yang didiagnosis kelainan refraksi yang memenuhi kriteria inklusi dan ekslusi sebanyak 110 pasien. Seluruh variabel dianalisis dengan analisis univariat. Hasil: Hasil penelitian menunjukkan 85 pasien didiagnosis astigmatisme, dengan 50 pasien didiagnosis miopia, serta 8 pasien didiagnosis hipermetropia. Pasien kelainan refraksi dengan kelompok usia terbanyak adalah pada rentang 10-19 tahun (31.82%) dengan mayoritas perempuan (67.27%). Gejala klinis terbanyak adalah pandangan kabur (100%). Berdasarkan tingkatannya pasien miopia terbanyak adalah miopia tinggi (70.73%), hipermetropia terbanyak adalah hipermetropia rendah (76.92%), lalu astigmatisme miopia kompositus merupakan jenis astigmatisme terbanyak (83.01%). Visus pasien kelainan refraksi sebelum dan sesudah dikoreksi terbanyak adalah kelompok mild – no visual impairment (39.54%) & (94.09%). Kesimpulan: Gambaran dari pasien kelainan refraksi pada penelitian ini rentang usia 10-19 tahun merupakan kelompok usia terbanyak serta perempuan mengalami kelainan refraksi lebih banyak dari laki-laki. Dengan miopia derajat tinggi merupakan miopia terbanyak. Hipermetropia derajat rendah merupakan yang terbanyak. Serta astigmatisme miopia kompositus merupakan kelompok astigmatisme terbanyak. Keluhan umum terbanyak adalah pandangan kabur. Kategori visus terbanyak sebelum dan sesudah dikoreksi adalah kategori mild – no visual impairment. Kata kunci: miopia, hipermetropia, astigmatisme
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Successful Management of Panuveitis and Associated Complications in a Patient with Clinical Stage III HIV: A Case Report Putra, Ikhsan Amanda; Fadrian; Rohayat Bilmahdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1144

Abstract

Background: Human immunodeficiency virus (HIV) infection can lead to a myriad of ocular complications, including panuveitis, an inflammatory condition affecting the entire uvea and surrounding structures. The management of panuveitis in HIV patients is complex, often requiring a multidisciplinary approach to address both the underlying immunodeficiency and the ocular inflammation. Case presentation: We present the case of a 37-year-old male patient with clinical stage III HIV who presented with panuveitis in the right eye (OD) secondary to herpes zoster ophthalmicus (HZO). The patient also had post-herpetic neuralgia, oral candidiasis, and malnutrition. He reported a history of unprotected sexual encounters with multiple partners. The patient's CD4 count was critically low at 15 cells/µL, indicating severe immunosuppression. He was initiated on antiretroviral therapy (ART), prophylactic medications to prevent opportunistic infections, and pain management for post-herpetic neuralgia. Conclusion: This case highlights the challenges in managing panuveitis and associated complications in patients with advanced HIV infection. Early diagnosis, prompt initiation of ART, and a multidisciplinary approach are crucial for successful management and improving patient outcomes.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Abstract

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
HUBUNGAN PENERIMAAN DIRI DENGAN KUALITAS HIDUP PASIEN HIV/AIDS DI POLI VCT RSUP DR. M. DJAMIL TAHUN 2023 Bantar, Kevin; Liza, Rini Gusya; Burhan, Ida Rahmah; Yanis, Amel; Firdawati, Firdawati; Fadrian, Fadrian
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 4 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i4.1938

Abstract

HIV/AIDS has been a global health issue for many years. This chronic condition affects multiple aspects of life and acts as a significant stressor that reduces patients’ quality of life. People living with HIV/AIDS (PLWHA) often face limitations in daily activities, making it difficult to accept their identity and life circumstances. This study aimed to analyze the relationship between self-acceptance and quality of life among HIV/AIDS patients at the VCT Clinic of Dr. M. Djamil General Hospital in 2023. An analytical cross-sectional design was used with purposive sampling, involving 84 participants. Data collection took place from November 2022 to November 2023 using the USAQ and WHOQOL HIV-BREF questionnaires. Data were analyzed using Pearson correlation tests. Results showed a positive and significant correlation between self-acceptance and quality of life (p = 0.034; r = 0.231). Significant relationships were also found with the physical (p = 0.012; r = 0.272) and psychological (p = 0.014; r = 0.269) domains. In conclusion, self-acceptance is positively associated with overall quality of life, particularly in physical and psychological aspects, among HIV/AIDS patients.
Co-Authors Abdiana Adrial Adrial, Adrial Ahmad, Armen Amel Yanis Amelia F. Dewi Anggrainy, Fenty Arina Widya Murni Armen Ahmad Armen Ahmad Armen Ahmad Asir, Taufik Rizkian Astiena, Adila Kasni Bantar, Kevin Bilmahdi, Rohayat Daan Khambri Desmawati Desmawati Dessy Arisanty Dinda Aprilia Dwi Yulia Dwitya Elvira, Dwitya Dzulkifli Elvia Fataya Eti Yerizel Eva Decroli Fahmi, Rahmadina Zesfira Fasril, Thira Fika Tri Anggraini Firdawati Firdawati Genta Pradana, Genta Hardisman Harun Harnavi Harvindra, Astrid Hasmiwati Hasnah Hasnah Hasnah, Hidayatul Hermalina Sherli Utami Husna Yetti Husni Husni Ida Rahmah Burhan Ikhsan Amanda Putra, Ikhsan Amanda Kam, Alexander Khairat, Khairat Lili Irawati Linosefa Linosefa Lydia Sarah Shabrina Masnadi, Nice Rachmawati Miftah Irramah Muhammad Hidayat Muharramah, Disa Hijratul Mustafa Noer Netti Suharti Nurul Fadila Oktalina, Dyanti Prasetio, Ade Priscilla, Hilary Putri Nirmala Dewi Putri, Vidola Yasena Putri, Viona Salsabila RAVEINAL RAVEINAL Raveinal Raveinal Rifa, Farras Zahra Rikarni Rikarni Rima Semiarty Rini Gusya Liza, Rini Gusya Rita Hamdani Rizki Amelia Rohayat Bilmahdi Rose Dinda Martini Rosfita Rasyid Roza Mulyana Rozi Abdullah Saptino Miro, Saptino Selfi Renita Rusjdi Simanjuntak, Rohayat Bilmahdi Ulvyana, Vyora Vitresia, Havriza Vivi Triana Wati, Westi Permata Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yuniar Lestari Yustini Alioes Zaki Mahmudi Dasril Zhira Shada Athaya