Article Per Year (5 Year)
p-Index From 2021 - 2026
3.916
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Indonesian Journal of Tropical and Infectious Disease Universa Medicina Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Berita Kedokteran Masyarakat Jurnal Penyakit Dalam Indonesia JUKEJ: Jurnal Kesehatan Jompa Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Fadrian, Fadrian
Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 30 Documents
Search

 1   2   3 
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Successful Management of Panuveitis and Associated Complications in a Patient with Clinical Stage III HIV: A Case Report Putra, Ikhsan Amanda; Fadrian; Rohayat Bilmahdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1144

Abstract

Background: Human immunodeficiency virus (HIV) infection can lead to a myriad of ocular complications, including panuveitis, an inflammatory condition affecting the entire uvea and surrounding structures. The management of panuveitis in HIV patients is complex, often requiring a multidisciplinary approach to address both the underlying immunodeficiency and the ocular inflammation. Case presentation: We present the case of a 37-year-old male patient with clinical stage III HIV who presented with panuveitis in the right eye (OD) secondary to herpes zoster ophthalmicus (HZO). The patient also had post-herpetic neuralgia, oral candidiasis, and malnutrition. He reported a history of unprotected sexual encounters with multiple partners. The patient's CD4 count was critically low at 15 cells/µL, indicating severe immunosuppression. He was initiated on antiretroviral therapy (ART), prophylactic medications to prevent opportunistic infections, and pain management for post-herpetic neuralgia. Conclusion: This case highlights the challenges in managing panuveitis and associated complications in patients with advanced HIV infection. Early diagnosis, prompt initiation of ART, and a multidisciplinary approach are crucial for successful management and improving patient outcomes.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Abstract

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
HUBUNGAN PENERIMAAN DIRI DENGAN KUALITAS HIDUP PASIEN HIV/AIDS DI POLI VCT RSUP DR. M. DJAMIL TAHUN 2023 Bantar, Kevin; Liza, Rini Gusya; Burhan, Ida Rahmah; Yanis, Amel; Firdawati, Firdawati; Fadrian, Fadrian
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 4 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i4.1938

Abstract

HIV/AIDS has been a global health issue for many years. This chronic condition affects multiple aspects of life and acts as a significant stressor that reduces patients’ quality of life. People living with HIV/AIDS (PLWHA) often face limitations in daily activities, making it difficult to accept their identity and life circumstances. This study aimed to analyze the relationship between self-acceptance and quality of life among HIV/AIDS patients at the VCT Clinic of Dr. M. Djamil General Hospital in 2023. An analytical cross-sectional design was used with purposive sampling, involving 84 participants. Data collection took place from November 2022 to November 2023 using the USAQ and WHOQOL HIV-BREF questionnaires. Data were analyzed using Pearson correlation tests. Results showed a positive and significant correlation between self-acceptance and quality of life (p = 0.034; r = 0.231). Significant relationships were also found with the physical (p = 0.012; r = 0.272) and psychological (p = 0.014; r = 0.269) domains. In conclusion, self-acceptance is positively associated with overall quality of life, particularly in physical and psychological aspects, among HIV/AIDS patients.
Korelasi Skor SOFA dengan Kadar Kortisol Darah pada Pasien Sepsis di RSUP Dr. M. Djamil Padang Fahmi, Rahmadina Zesfira; Fadrian, Fadrian; Rikarni, Rikarni; Husni, Husni; Bilmahdi, Rohayat; Irramah, Miftah
Jurnal Kesehatan Andalas Vol. 14 No. 3 (2025): November 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v14i3.2671

Abstract

Sepsis is a life-threatening organ dysfunction due to dysregulation of the body's immune response to infection. The Sequential Organ Failure Assessment score (SOFA score) is a diagnostic tool used to quantitatively and objectively assess the level of organ dysfunction. Sepsis as a stressor of systemic inflammation, causes an increase in cortisol secretion by the adrenals to target tissues, which suppresses inflammation. Objective: To determine the correlation between SOFA score and blood cortisol levels in sepsis patients at RSUP Dr. M. Djamil Padang. Method: Observational analytic study with a cross-sectional method. The sample consisted of 55 patients who had been diagnosed with sepsis. The data used was secondary data from medical records. The data were tested using the Spearman correlation test. Result: A correlation was found between the SOFA score and blood cortisol levels, yielding a correlation coefficient of r = 0.338 and a p-value of 0.012. Conclusion: There is a significant moderate correlation between SOFA scores and blood cortisol levels. Keywords:  blood cortisol, sepsis, SOFA score
CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA LEADING TO LIFE-THREATENING HYPOVOLEMIC SHOCK IN CERVICAL CANCER: A CASE REPORT Nurul Fadila; Raveinal Raveinal; Fadrian Fadrian; Roza Mulyana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.47148

Abstract

Hypovolemic shock due to acute hemorrhage is a life-threatening condition, particularly in cancer patients undergoing chemotherapy. Although recent studies have established protocols for managing hypovolemic shock in trauma and sepsis, the role of chemotherapy-induced thrombocytopenia in exacerbating post-procedural bleeding risks remains underexplored. This case emphasizes the clinical complexity of managing hemorrhagic shock in advanced-stage cervical cancer patients following percutaneous nephrostomy (PCN). Case Presentation: A 52-year-old female with stage IVB cervical cancer and liver metastasis presented with hypovolemic shock following PCN. She exhibited severe hematuria and chemotherapy-induced thrombocytopenia, leading to prolonged bleeding and subsequent shock. Initial management involved aggressive fluid resuscitation, blood transfusions, and correction of thrombocytopenia. Despite the challenges of managing shock in a patient with concurrent chronic kidney disease (CKD) stage IV, prompt intervention led to significant clinical improvement, stabilization of vital signs, and eventual discharge. Conclusion: This case highlights the importance of early intervention in managing hypovolemic shock in oncology patients with multiple comorbidities, including chemotherapy-induced thrombocytopenia and CKD. A multidisciplinary approach and close monitoring are crucial for improving outcomes in such high-risk patients. Further research is needed to establish tailored management protocols for this patient population.
Perbandingan skor SOFA pada pasien sepsis dengan dan tanpa diabetes melitus tipe 2 Nares Wari, Munsyi; Fadrian; Yerizel , Eti; Reza , Mohamad; Aprilia , Dinda; Nofita , Eka
Jurnal Kesehatan Andalas Vol. 15 No. 1 (2026): March 2026
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v15i1.2672

Abstract

Comparison of SOFA scores in septic patients with and without type 2 diabetes mellitus Sepsis is a life-threatening organ dysfunction.  A dysregulated host response to infection causes it. Organ dysfunction can be represented by an increase in the SOFA score of > 2 points. Every increase in the score reflects worsening of organ dysfunction. Type-2 Diabetes Mellitus (T2DM) is one of the most common comorbidities in sepsis patients. T2DM patients have chronic hyperglycemia. This condition can impair immune function and damage the endothelium.  Objective: To find out the comparison of SOFA scores in sepsis patients with and without T2DM. Methods: This research was an analytical, cross-sectional study using medical record data from RSUP Dr. M. Djamil Padang. The 132 samples comprised 66 sepsis patients with T2DM and 66 without T2DM. Sampling was carried out by using a stratified random sampling technique. Bivariate data analysis used an independent-samples t-tes. The mean of SOFA scores in sepsis patients with T2DM was 8.05 +_ 2.36 and the mean of SOFA scores in sepsis patients 6.38 +_ 2.96. The p-value (<0,05) in both groups was 0.001. Conclusion: There is a significant difference in SOFA scores between sepsis patients with and without T2DM. Keywords: sepsis, SOFA score, T2DM
Comparison of the Diagnostic Value of Presepsin and Procalcitonin as Markers of Bacterial Sepsis Fadrian, Fadrian; Ahmad, Armen; Sadeli, Rezki Pratama; Putri, Vidola Yasena; Agustian, Dede Rahman
Indonesian Journal of Tropical and Infectious Disease Vol. 14 No. 1 (2026): January - April Edition
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v14i1.69526

Abstract

Sepsis is a severe condition caused by an improper immune response during infections. Early diagnosis is challenging due to the low specificity and effectiveness of current diagnostic tools. Procalcitonin is a biomarker with both advantages and limitations. Presepsin has emerged as a potential alternative, offering cost-effectiveness, fewer confounding factors, and a quicker response. This study evaluates the diagnostic capabilities of presepsin and procalcitonin in bacterial sepsis. The study involved patients with sepsis who were treated in the Internal Medicine Department at M. Djamil Hospital, Padang, Indonesia. All participants were adults over 18, excluding those with conditions that could affect the biomarkers. A total of 63 patients were assessed. The mean presepsin level in bacterial sepsis was 205.91 pg/mL (±162.65 SD), while procalcitonin averaged 62.83 ng/mL (±80.48 SD). Blood cultures revealed bacterial infections in 18 patients (28.60%). Among them, eight had Gram-positive (44.40%) and ten had Gram-negative bacteria (55.60%). Presepsin demonstrated variable accuracy in identifying bacterial sepsis and bacteremia. The Area Under the Curve (AUC) for bacterial sepsis was 0.60 (95% CI 0.44-0.75), for Gram-positive bacteremia it was 0.63 (95% CI 0.35-0.90), and for Gram-negative bacteremia it was 0.37 (95% CI 0.10-0.65). In contrast, procalcitonin showed an AUC of 0.51 (95% CI 0.35-0.67) for bacterial sepsis, 0.22 (95% CI 0.01-0.46) for Gram-positive bacteremia, and 0.78 (95% CI 0.54-1.00) for Gram-negative bacteremia. Presepsin has a higher diagnostic value than procalcitonin in detecting bacterial sepsis. Procalcitonin has the highest AUC value in all categories for detecting Gram-negative bacteremia.
Comparison Clinical Outcomes of Sepsis Caused by Multidrug-Resistant (MDR) and Non-MDR Klebsiella pneumoniae Fadrian, Fadrian; Ahmad, Armen; Linosefa, Linosefa; Simanjuntak, Rohayat Bilmahdi; Putri, Vidola Yasena
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.29019

Abstract

Background: Klebsiella pneumoniae is a common pathogen causing sepsis and is associated with high morbidity and mortality. The emergence of multidrug-resistant organisms (MDROs), particularly extended-spectrum β-lactamase-producing K. pneumoniae (ESBL-KP) and carbapenem-resistant K. pneumoniae (CRKP), has limited antimicrobial therapy options and may worsen clinical outcomes such as mortality and length of hospital stay (LOS). Objective: This study aims to compare the clinical characteristics and outcomes of sepsis caused by multidrug-resistant K. pneumoniae and non-resistant strains, focusing on mortality and LOS.Methods: An observational analytical study with a cohort design was conducted at Dr. M. Djamil General Hospital in Padang from October 2024 to January 2025. Subjects diagnosed with sepsis due to pneumonia and confirmed positive for K. pneumoniae through blood or respiratory cultures were included using consecutive sampling. Isolates were categorized into MDR (ESBL-KP and CRKP) and non-MDR. Clinical data were analyzed descriptively to described subject characteristics, while bivariate analysis (chi-square and independent t-test) evaluated associations between resistance profiles and outcomes, focusing on mortality and LOS (p < 0.05). Results: Of the 70 subjects, 39 (55.7%) had confirmed infection with MDR strains and 31 (44.3%) with non-MDR.Mortality was highest in the CRKP (56.5%), followed by non-MDR (38.7%) and ESBL-KP (25.0%). Statistical analysis revealed a notable association between the resistance profiles of K. pneumoniae and mortality (p < 0.001 for both CRKP and ESBL-KP vs non-MDR). However, there were no statistically significant differences in mean hospital LOS across the groups (CRKP: 16.30 ± 9.81 days; ESBL-KP: 13.63 ± 9.77 days; non-MDR: 16.06 ± 9.49 days; all p > 0.05). Conclusion: Sepsis caused by multidrug-resistant K. pneumoniae, including both ESBL and CRKP, is significantly associated with increased mortality. Early identification and appropriate antimicrobial management are essential to improve subject outcomes. 
Co-Authors Abdiana Adrial Adrial, Adrial Agustian, Dede Rahman Ahmad, Armen Amel Yanis Amelia F. Dewi Anggrainy, Fenty Aprilia , Dinda Arina Widya Murni Armen Ahmad Armen Ahmad Armen Ahmad Asir, Taufik Rizkian Astiena, Adila Kasni Bantar, Kevin Bilmahdi, Rohayat Daan Khambri Desmawati Desmawati Dessy Arisanty Dwi Yulia Dwitya Elvira, Dwitya Dzulkifli, Dzulkifli Elvia Fataya Eva Decroli Fahmi, Rahmadina Zesfira Fika Tri Anggraini Firdawati, Firdawati Genta Pradana, Genta Hardisman Harun Harnavi Harvindra, Astrid Hasmiwati Hasnah Hasnah Hasnah, Hidayatul Hermalina Sherli Utami Husni Husni Ida Rahmah Burhan Ikhsan Amanda Putra, Ikhsan Amanda Kam, Alexander Khairat, Khairat Lili Irawati Linosefa Linosefa Lydia Sarah Shabrina Masnadi, Nice Rachmawati Miftah Irramah Muhammad Hidayat Muharramah, Disa Hijratul Mustafa Noer Nares Wari, Munsyi Netti Suharti Nofita , Eka Nurul Fadila Oktalina, Dyanti Prasetio, Ade Priscilla, Hilary Putri Nirmala Dewi Putri, Vidola Yasena Putri, Viona Salsabila Raveinal Raveinal RAVEINAL RAVEINAL Reza , Mohamad Rifa, Farras Zahra Rikarni Rikarni Rima Semiarty Rini Gusya Liza, Rini Gusya Rita Hamdani Rizki Amelia Rohayat Bilmahdi Rose Dinda Martini Rosfita Rasyid Roza Mulyana Sadeli, Rezki Pratama Saptino Miro, Saptino Selfi Renita Rusjdi Simanjuntak, Rohayat Bilmahdi Vitresia, Havriza Vivi Triana Yerizel , Eti Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yuniar Lestari Yustini Alioes Zaki Mahmudi Dasril