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All Journal Jurnal Kesehatan Andalas Universa Medicina Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Berita Kedokteran Masyarakat Jurnal Penyakit Dalam Indonesia JUKEJ: Jurnal Kesehatan Jompa Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Fadrian, Fadrian
Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Warm Autoimmune Hemolytic Anemia with Chronic Hepatitis B Wahyudi, Adefri; Fadrian; Afriant, Rudy
Sumatera Medical Journal Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i1.11836

Abstract

Background: Warm autoimmune hemolytic anemia (wAIHA) is caused by erithrocytes destruction by IgG or IgG plus C3d-mediated autoantibody. Objective: To present a case of warm autoimmune hemolytic anemia (wAIHA) in a patient with chronic hepatitis B infection. Methods: This is a case report that showed a special case. Results: Man, 64 y.o, hospitalized with diagnosis wAIHA and chronic hepatitis B. Diagnosis of wAIHA is built by: severe normocytic normochromic anemia, reticulocytosis 42.29%, increasing lactate dehydrogenase 397 U/L, direct Coombs test (+4), antibody screening IgG (+4). Anothers laboratorium findings: HbsAg (+), albumin 3.5 g/dL, ALT U/L, rapid HIV (-), anti HCV (-). There is no blast found in peripheral blood and bone marrow smear. Patient also diagnosed chronic hepatitis B inactive phase with negative HbeAg, HBV DNA 547 IU/L, normal liver finding in abdominal USG and moderate fibrosis from fibroscan. Washed red cell transfussion was administered, 2 x 125 mg methilprednisolone iv (3 days) tapering off until to 40 mg/day doses. He did not get antiviral prophylaxis and be planned to reevaluate in next 6 months. Conclusion: Steroid is first line therapy in wAIHA. When wAIHA is diagnosed, determination of chronic hepatitis B status should confirmed.  There is a risk of reactivation of chronic hepatitis B infection so monitoring is needed.
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Successful Management of Panuveitis and Associated Complications in a Patient with Clinical Stage III HIV: A Case Report Putra, Ikhsan Amanda; Fadrian; Rohayat Bilmahdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1144

Abstract

Background: Human immunodeficiency virus (HIV) infection can lead to a myriad of ocular complications, including panuveitis, an inflammatory condition affecting the entire uvea and surrounding structures. The management of panuveitis in HIV patients is complex, often requiring a multidisciplinary approach to address both the underlying immunodeficiency and the ocular inflammation. Case presentation: We present the case of a 37-year-old male patient with clinical stage III HIV who presented with panuveitis in the right eye (OD) secondary to herpes zoster ophthalmicus (HZO). The patient also had post-herpetic neuralgia, oral candidiasis, and malnutrition. He reported a history of unprotected sexual encounters with multiple partners. The patient's CD4 count was critically low at 15 cells/µL, indicating severe immunosuppression. He was initiated on antiretroviral therapy (ART), prophylactic medications to prevent opportunistic infections, and pain management for post-herpetic neuralgia. Conclusion: This case highlights the challenges in managing panuveitis and associated complications in patients with advanced HIV infection. Early diagnosis, prompt initiation of ART, and a multidisciplinary approach are crucial for successful management and improving patient outcomes.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Abstract

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
HUBUNGAN PENERIMAAN DIRI DENGAN KUALITAS HIDUP PASIEN HIV/AIDS DI POLI VCT RSUP DR. M. DJAMIL TAHUN 2023 Bantar, Kevin; Liza, Rini Gusya; Burhan, Ida Rahmah; Yanis, Amel; Firdawati, Firdawati; Fadrian, Fadrian
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 4 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i4.1938

Abstract

HIV/AIDS has been a global health issue for many years. This chronic condition affects multiple aspects of life and acts as a significant stressor that reduces patients’ quality of life. People living with HIV/AIDS (PLWHA) often face limitations in daily activities, making it difficult to accept their identity and life circumstances. This study aimed to analyze the relationship between self-acceptance and quality of life among HIV/AIDS patients at the VCT Clinic of Dr. M. Djamil General Hospital in 2023. An analytical cross-sectional design was used with purposive sampling, involving 84 participants. Data collection took place from November 2022 to November 2023 using the USAQ and WHOQOL HIV-BREF questionnaires. Data were analyzed using Pearson correlation tests. Results showed a positive and significant correlation between self-acceptance and quality of life (p = 0.034; r = 0.231). Significant relationships were also found with the physical (p = 0.012; r = 0.272) and psychological (p = 0.014; r = 0.269) domains. In conclusion, self-acceptance is positively associated with overall quality of life, particularly in physical and psychological aspects, among HIV/AIDS patients.
Co-Authors Abdiana Adrial Adrial, Adrial Ahmad, Armen Amel Yanis Amelia F. Dewi Anggrainy, Fenty Arina Widya Murni Armen Ahmad Armen Ahmad Armen Ahmad Asir, Taufik Rizkian Astiena, Adila Kasni Bantar, Kevin Daan Khambri Desmawati Desmawati Desmawati Desmawati Dessy Arisanty Dwi Yulia Dwitya Elvira, Dwitya Dzulkifli, Dzulkifli Elvia Fataya Eva Decroli Fika Tri Anggraini Firdawati, Firdawati Genta Pradana, Genta Hardisman Harun Harnavi Harvindra, Astrid Hasmiwati Hasnah Hasnah Hasnah, Hidayatul Hermalina Sherli Utami Ida Rahmah Burhan Ikhsan Amanda Putra, Ikhsan Amanda Kam, Alexander Khairat, Khairat Lili Irawati Lydia Sarah Shabrina Masnadi, Nice Rachmawati Muhammad Hidayat Muharramah, Disa Hijratul Mustafa Noer Netti Suharti Oktalina, Dyanti Prasetio, Ade Priscilla, Hilary Putri Nirmala Dewi Putri, Vidola Yasena Putri, Viona Salsabila RAVEINAL RAVEINAL Rifa, Farras Zahra Rima Semiarty Rini Gusya Liza, Rini Gusya Rita Hamdani Rizki Amelia Rohayat Bilmahdi Rose Dinda Martini Rosfita Rasyid Roza Mulyana Rudy Afriant Saptino Miro, Saptino Selfi Renita Rusjdi Vitresia, Havriza Vivi Triana Wahyudi, Adefri Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yuniar Lestari Yustini Alioes Zaki Mahmudi Dasril