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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Science and Technology Indonesia Majalah Kesehatan FKUB Ina Kidney JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Jeumpa Narra J Jurnal Klinik dan Riset Kesehatan Jurnal Penyakit Dalam Indonesia Jurnal Kesehatan Deka in Medicine
Nur Samsu
Brawijaya University, Dr. Saiful Anwar Hospital, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Exploring the efficacy of al-hijamah (wet cupping) in managing hypertension and dyslipidemia among Indonesian population: a meta-analysis Aulya, Justika Usmadhani; Matondang, Asri Rizqi; Farahdina, Farahdina; Rizaliansyah, Ferdian; Samsu, Nur; Fajar, Jonny Karunia
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.8

Abstract

BACKGROUND: In Indonesia, wet cupping therapy has been thoroughly investigated as a treatment for hypertension and dyslipidemia. Nevertheless, the outcomes across these studies are contradictory.OBJECTIVES: To appraise the effectiveness of wet cupping therapy in the management of hypertension and dyslipidemia among the Indonesian population.METHODS: We examined papers sourced from Google Scholar, the Indonesian Scientific Journal Database, and Garba Rujukan Digital until September 5, 2020. These papers investigated blood pressure and lipid profile levels both pre- and post-wet cupping treatment. The collective data underwent Z-test analysis to assess associations.RESULTS: In total, we included 26 papers examining the correlation between wet cupping therapy and blood pressure, as well as 16 papers assessing lipid profile levels. Our combined analysis revealed significantly reduced systolic blood pressure (MD: 13.86; 95% CI: 10.01, 17.71), diastolic blood pressure (MD: 6.31; 95% CI: 3.84, 8.79), and lower total cholesterol levels (MD: 21.56; 95% CI: 10.32, 32.80]) in the post-treatment group compared to the pre-treatment group. However, we were unable to elucidate the impact of wet cupping therapy on the concentrations of low-density lipoprotein and triglyceride.CONCLUSIONS: Wet cupping therapy exhibits potential efficacy in reducing blood pressure and total cholesterol levels among individuals in Indonesia.
Observational Study on How the Frequency of Dialyzer Reuse Impacts Hemodialysis Effectiveness Wicaksono, Ramadi Satryo; Gunawan, Atma; Samsu, Nur; Rifai, Achmad
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.152

Abstract

Background: The increasing practice of dialyzer reuse in hemodialysis raises critical concerns regarding its impact on efficacy, infection risks, and essential metrics such as Urea Reduction Ratio (URR) and Kt/V values. Addressing these concerns is paramount to establishing safe and optimal reuse limits through comprehensive performance assessments. Objective: To evaluate the feasibility of dialyzer reuse by assessing Kt/V and URR measurements. Methods: A prospective cohort study was conducted at RSUD Dr. Saiful Anwar's Hemodialysis Unit from November 2021 to January 2022. Data collection employed a standardized pilot form designed to collate Kt/V and URR data from all participants. Statistical analyses included repeated measures ANOVA to detect temporal changes in average Kt/V and URR, alongside Spearman correlation analysis to explore variable relationships. Results: The study encompassed 15 participants, revealing a statistically significant decline in both Kt/V and URR values across each reuse group (p < 0.05). Specifically, each subsequent reuse of the dialyzer corresponded to a decrement of 0.0469 units in Kt/V and 1.003 units in URR. Notably, by the 7th reuse, hemodialysis adequacy remained satisfactory, achieving an average Kt/V of 1.61. Furthermore, the study indicated that even up to 11 reuses could achieve a Kt/V > 1.4. Similarly, the average URR value for the 7th reuse was 70.207%, with the potential to maintain URR > 65% even after up to 13 reuses. Conclusion: This study unequivocally affirms that hemodialysis adequacy remains satisfactory up to the 7th reuse of dialyzers, despite observed declines in Kt/V and URR values over successive reuses.
Pathogenesis of Immune-Mediated Glomerulonephritis Samsu, Nur
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.158

Abstract

Most forms of glomerulonephritis (GN) are characterized by a pathogenic immune response, which is mediated by the action of various immune system elements, both innate and adaptive. What is clear is that the immunopathogenesis of GN is very broad and complex. Deposits of immune complexes in the glomeruli activate complement and glomerular injury due to the involvement of circulating inflammatory cells and glomerular intrinsic cells, ultimately resulting in a wide variety of clinical manifestations, which depend in part on the location and immunopathology of the patient, including genetic and environmental factors, from asymptomatic to rapidly progressive GN. Most of the treatment strategies for GN are non-specific, consisting of corticosteroids and cytotoxic agents. Thus, an advanced understanding of GN immunopathogenesis may offer many opportunities for future therapeutic interventions on an individual basis. To further facilitate understanding of the pathogenesis of GN, the author also includes a graphical abstract.
Should All Patients with Nephrotic Syndrome Undergo a Renal Biopsy? Samsu, Nur
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.160

Abstract

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Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis Tamara, Fredo; Fajar, Jonny K.; Gersom, Camoya; Wicaksono, Ramadi S.; Tupamahu, Alvira R.; Huda, Fariz N.; Sari, Fitria R.; Dela, Jamaludin A.; Putri, Irawati E.; Sutrisno, Muhammad A.; Putra, Riyantono; Dwinata, Michael; Friatna, Yudha; Albaar, Thoha M.; Susanto, Agung; Dewi, Ratih TK.; Suseno, Aryo; Samsu, Nur
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1782

Abstract

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.
Strategi Penerapan kebijakan Pengiriman logistik Nol Emisi di Jawa barat Samsu, Nur
Jurnal Kesehatan & Disiplin Ilmu Vol 1 No 03 (2023): Keperawatan & Multidisiplin
Publisher : LPPM Akper Kebonjati

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak Penelitian ini mengkaji penerapan kebijakan pelayaran nol emisi di Indonesiakarena pertumbuhan industri pelayaran di negara itu telah menyebabkan peningkatan emisi kapal, yang berdampak pada kualitas udara dan laut, serta menimbulkan risiko bagi kesehatan manusia, iklim, dan ekosistem. Tujuan dari penelitian ini adalah untuk menentukan dampak kebijakan terhadap industri pelayaran negara jika kebijakan nol emisi berhasil diterapkan. Untuk mengumpulkan data dan wawasan, wawancara dilakukan dengan Departemen Kelautan Indonesia (MDM), dan analisis konten digunakan. Dengan memberikan wawasan tentang implementasi kebijakan nol emisi, penelitian ini membantu mengatasi tantangan keberlanjutan industri pelayaran di Indonesia.
Apakah Perlu Ada Subspesialis Nefro-Kardiologi? Samsu, Nur
Jurnal Klinik dan Riset Kesehatan Vol 4 No 1 (2024): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.1.1

Abstract

Nanoparticle-Enhanced 3D-Connector Microfluidic Paper-Based Analytical Device (3D-µPADs) for Sensitive and Cost-Effective Detection of Albumin-Creatinine Ratio in Urine Sample Sabarudin, Akhmad; Fiddaroini, Saidun; Fahmi, Ahmad Luthfi; Roja’i, Abdul Munir; Salsabila, Isadora Evani; Aulanni’am; Srihardyastutie, Arie; Susanti, Hani; Samsu, Nur
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.504-518

Abstract

Chronic kidney disease (CKD) is a global health challenge affecting over 800 million people worldwide. Early detection is crucial to prevent progression to end-stage renal disease (ESRD), where life-saving interventions like dialysis or transplantation are necessary. Among the markers for early kidney damage, the Albumin Creatinine Ratio (ACR) in urine is one of the most reliable. Conventional methods of ACR detection, such as LC/MS-MS and ELISA, are highly accurate but require expensive equipment and skilled personnel, limiting their accessibility, especially in resource-limited settings. To address this, we developed a 3D-connector microfluidic paperbased analytical device (3D-µPADs) enhanced with gold nanoparticles (AuNPs) for sensitive and low-cost ACR detection. The integration of AuNPs amplifies colorimetric signals, enhancing the visual distinction in albumin detection. Our 3D-µPADs werefabricated using chromatographic paper Whatman No. 1 with hydrophobic barriers created by solid wax printing, followed by reagent immobilization for albumin and creatinine detection. The colorimetric and distance responses, based on reactions with Bromocresol Green (BCG) and Chrome Azurol S-Palladium (CAS-Pd2+), were analyzed using ImageJ software to quantify albumin and creatinine levels. The 3D-µPADs exhibited optimal sensitivity and accuracy, with linear detection ranges for albumin and creatinine of 30–400 mg/g. Validation with human urine samples demonstrated an accuracy of 93.04%, suggesting that 3D-µPADs offer a promising alternative for early nephropathy detection. Our findings provide a cost-effective, accessible tool for CKD screening, potentially transforming diagnostics in low-resource environments.
Serum IL-18 as a predictive biomarker for acute kidney injury in sepsis patients Pratama, Satya; Sutanto, Heri; Samsu, Nur
Deka in Medicine Vol. 2 No. 2 (2025): August 2025
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2025.e643

Abstract

BACKGROUND: Sepsis is a syndrome that can result in multiorgan dysfunction, including acute kidney injury (AKI). AKI is a serious complication of sepsis, and its incidence ranges from 30% to 50%. Newer predictive biomarkers such as serum interleukin-18 (IL-18) are being evaluated as early diagnostic markers with potentially greater sensitivity than serum creatinine. OBJECTIVES: To evaluate the usefulness of serum IL-18 levels as a predictive biomarker for AKI in patients with sepsis. METHODS: The cross-sectional study was conducted at Dr. Saiful Anwar General Hospital and included 68 sepsis patients, 34 with AKI and 34 without AKI. The serum level of IL-18 was measured using the ELISA method. AKI diagnosis was made according to the KDIGO criteria. The Mann-Whitney test, Spearman correlation, and receiver operating characteristic (ROC) curve analysis were included in the statistical analysis. RESULTS: The results showed that serum IL-18 levels were significantly greater in the AKI group compared with the non-AKI group (49.88 ± 50.87 vs. 19.89 ± 10.40; p < 0.001). A significant positive correlation was observed between serum IL-18 levels and the risk of AKI (r = 0.505; p < 0.001). ROC analysis revealed an area under the curve (AUC) of 0.792 with 82.4% sensitivity and 64.7% specificity at a cut-off value of 23.81 pg/mL. Logistic regression revealed that with each 1-unit increase in serum IL-18, a 7.3% increase in the risk of developing AKI was observed. CONCLUSION: Serum IL-18 has good potential to serve as a predictive biomarker for AKI in sepsis patients, with reasonable diagnostic accuracy.
Effect of Combination of Rosmarinic Acid with Valsartan and Irbesartan on NO and ADMA Levels in Diabetic Nephropathy Model Rats Tidel, Caesar; Samsu, Nur; Rifai, Achmad
Clinical and Research Journal in Internal Medicine Vol. 6 No. 1 (2025): Volume 6 No 1, May 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.01.04

Abstract

Background: Diabetic nephropathy (DN) is a complication that often occurs in diabetes mellitus, in which the kidneys are damaged. Nitric oxide (NO) and Asymmetric Dimethylarginine (ADMA) are mediators that play a role in the pathophysiology of DN. Rosmarinic acid (AR) is an antioxidant compound that has the potential to be an alternative treatment for diabetic nephropathy. Valsartan and Irbesartan are antihypertensive drugs that have a nephroprotective effect. However, no studies have studied the concomitant use of AR with these two antihypertensive drugs. Aim: To identify the effect of the combination of AR and Valsartan and Irbesartan on NO and ADMA levels in DN rat models.. Methods: True experimental laboratory design and a randomized posttest only controlled group design method. The rats were divided into four groups, namely the negative control group, positive control (diabetic rats without therapy), group 3 (AR) 75 mg/kgBW/day with Irbesartab 1.5 mg/kg BW/day) and group 4 (AR) 75 mg/kgBW /day with Valsartan 1 mg/kg/day). Data were analyzed using One-way ANOVA with a significance level of p<0.05. Results: Administration of Valsartan (79.42±13.95 µmol/L) and Irbesartan (84.62±18.59 µmol/L) significantly increased NO levels compared to the positive control (61.49±8.03 µmol/L) (p< 0.05). Administration of Valsartan (57.87 ± 9.29 ng/mL) and Irbesartan (53.77 ± 9.42 ng/mL) did not decrease NO levels compared to control (50.46 ± 8.52 ng/mL) (p> 0.05 ). Conclusion: Administration of valsartan and irbesartan increased NO levels in DN rats exposed to rosmarinic acid. However, administration of valsartan and irbesartan did not affect ADMA levels in DN rats exposed to rosmarinic acid.
Co-Authors ACHMAD RIFAI Achmad Rudijanto Akhmad Sabarudin Albaar, Thoha M. Arie Srihardyastutie asihanti rosita ferdiana Atma Gunawan Aulanni’am Aulya, Justika Usmadhani Baridwan, Fakhri Camoya Gersom Dela, Jamaludin A. Dewi, Ratih TK. Diana Lyrawati Didi Candradikusuma Dwinata, Michael Fachrureza, Mochamad Fahmi, Ahmad Luthfi Fajar, Jonny Karunia Farahdina, Farahdina Fatimatuz Zahroh, Fatimatuz Fiddaroini, Saidun Fredo Tamara, Fredo Friatna, Yudha Gandung Satriyono, Gandung Hani Susanti, Hani Heri Sutanto Huda, Fariz N. Ida Wahyuni Indiastari, Dewi Jack Roebijoso Jonny K. Fajar Kosasih, Angelia Kusuma, Yeziga Enggar Matondang, Asri Rizqi Mutia, Tari Ni Luh Tantri Niniek Budiarti B Novitasari, Adinda Dian Nurike S Mudjari, Nurike S Oktavia Rahayu Adianingsih Pratama, Satya Putra, Riyantono Putri, Irawati E. Rifa'i, Achmad Rizaliansyah, Ferdian Roja’i, Abdul Munir Rosandy, Kharisma Ogit Rudy Salam, Rudy Salsabila, Isadora Evani Saraswati, Dara Sari, Fitria R. Susanto, Agung Suseno, Aryo Sutrisno, Muhammad A. Tidel, Caesar Tupamahu, Alvira R. Waafi, Affa Kiysa Wicaksono, Ramadi S. Wicaksono, Ramadi Satryo Winoto, Eden Winoto, Eden Suryoiman Wursito, Wursito Zuhri, Mohammad harisudin