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UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO Aprilita rina yanti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.
PENGARUH KECERDASAN EMOSIONAL DAN KUALITAS KEHIDUPAN KERJA TERHADAP KOMITMEN ORGANISASIONAL DENGAN BUDAYA ORGANISASI SEBAGAI VARIABEL MODERASI PADA TENAGA KESEHATAN DI RS XYZ RETNA MUTIARA NUDIANTI; APRILITA RINA YANTI EFF; IDRUS JUS'AT
Journal of Nursing and Public Health Vol 13 No 1 (2025)
Publisher : UNIVED Press, Universitas Dehasen Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37676/jnph.v13i1.8498

Abstract

Pendahuluan: Penelitian ini dilandaskan hasil observasi awal yang menginformasikan tingginya tingkat turnover di kalangan tenaga kesehatan yang berdampak pada stabilitas dan kualitas pelayanan kesehatan. Tujuan penelitian ini adalah untuk mengungkap secara empiris pengaruh kecerdasan emosional dan kualitas kehidupan kerja terhadap komitmen organisasional dengan budaya organisasi sebagai variabel moderasi. Metode: Jenis penelitian termasuk dalam kuantitatif dengan desain cross sectional study. Populasi yang digunakan adalah tenaga kesehatan di unit rawat inap. Teknik sampling menggunakan purposive sampling sehingga ditemukan responden sebanyak 77 tenaga kesehatan dengan status karyawan tetap. Teknik pengumpulan data menggunakan kuesioner, dan metode analisa menggunakan analisa three-box method serta PLS-SEM dengan bantuan program Smart-PLS dan SPSS sebagai perbandingan. Hasil dan Pembahasan: Hasil analisa membuktikan bahwa secara simultan dan parsial, kecerdasan emosional, kualitas kehidupan kerja dan budaya organisasi berpengaruh terhadap komitmen organisasional Budaya organisasi mampu memperkuat pengaruh kecerdasan emosional terhadap komitmen organisasional, sedangkan budaya organisasi tidak mampu memoderasi pengaruh kualitas kehidupan kerja terhadap komitmen organisasional. Kesimpulan: Budaya organisasi merupakan variabel dominan yang mampu meningkatkan komitmen organisasional.
Implementation of Lean Hospital and Continuous Improvement in Reducing Outpatient Pharmacy Waiting Time Afrianti Handayani; Aprilita Rina Yanti; Agusdini Banun
International Journal of Economics and Management Sciences Vol. 3 No. 1 (2026): February : International Journal of Economics and Management Sciences
Publisher : Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ijems.v3i1.1178

Abstract

Prescription waiting time is a key indicator of pharmacy service quality that directly influences patient satisfaction and hospital efficiency. Data from the Outpatient Pharmacy Installation of Pelabuhan Jakarta Hospital show average waiting times of 30.49 minutes for non-compounded medications and 35.93 minutes for compounded medications. Although these figures are still within national standards, they have not met the hospital’s internal targets, indicating inefficiencies that require systematic improvement.This study aimed to analyze prescription waiting times and identify waste in outpatient pharmacy services using Lean Hospital and Continuous Improvement approaches. A qualitative analytical method with a case study design was applied. Data collection involved participatory observation, in-depth interviews with key informants (head of pharmacy, pharmacists, and technicians), and document review. Analysis utilized Lean tools such as Value Stream Mapping (VSM), identification of Value Added (VA) and Non-Value Added (NVA) activities, bottleneck analysis, fishbone diagram, and Failure Mode and Effects Analysis (FMEA).The findings revealed that service processes were dominated by non-value-added activities, especially during prescription receipt, verification, packaging, and dispensing. Major wastes included waiting, motion, and overprocessing. Contributing factors were uneven staff distribution, suboptimal e-prescribing systems, incomplete prescriptions, and lack of standardized procedures. The proposed future state VSM demonstrated potential improvements in reducing waiting time and enhancing service efficiency.
Work Discipline Moderates Compliance, Work-Life Quality, and Pharmaceutical Supply Performance Putu Nadya Indra Primardani; Aprilita Rina Yanti; Erry Yudhya Mulyani
International Journal of Nursing and Health Services (IJNHS) Vol. 9 No. 4 (2026): International Journal of Nursing and Health Services
Publisher : Alta Dharma Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35654/ijnhs.v9i4.946

Abstract

Background: Discrepancies between medication records on inventory cards and the actual physical count in the pharmacy department can result in financial losses and reduced reliability of pharmaceutical supply management, disrupting continuity of hospital services. Objective: To analyze the influence of compliance and quality of work life on pharmaceutical supply management performance, with work discipline as a moderating variable. Method: A quantitative cross-sectional study was conducted at the Pharmacy Department of Prima Husada Hospital in Malang. All 32 active pharmacy staff who met the inclusion criteria were included through total sampling. Data were collected using Likert-scale questionnaires and analyzed using the Three-Box Method, multiple linear regression, and Moderated Regression Analysis (MRA) with SPSS. Result: Compliance, quality of work life, and work discipline had significant positive effects on pharmaceutical supply management performance, with high model explanatory power (R²=0.975). The compliance × work-discipline interaction was significantly positive, whereas the quality-of-work-life × work-discipline interaction was significantly negative. Conclusion: Work discipline demonstrated a dual moderating role: it strengthened the relationship between compliance and performance but weakened the relationship between quality of work life and performance. Recommendation: Hospital management should balance supervision, rewards, improvements to record-keeping systems, and resource support to promote accurate and sustainable pharmaceutical inventory management