Article Per Year (5 Year)
p-Index From 2021 - 2026
4.955
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Tropical and Infectious Disease JURNAL PENGABDIAN KEPADA MASYARAKAT QUANTUM: Jurnal Inovasi Pendidikan Sains JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA J-PEK (JURNAL PEMBELAJARAN KIMIA) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Orbital: Jurnal Pendidikan Kimia Indonesian Journal of Chemistry Jurnal Kiprah Psychology, Evaluation, and Technology in Educational Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Riset Pendidikan Kimia (JRPK) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Pembelajaran Sains Jurnal Abdi: Media Pengabdian Kepada Masyarakat BIO-EDU: Jurnal Pendidikan Biologi Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat Asia Humanism : Jurnal Pengabdian Masyarakat Hydrogen: Jurnal Kependidikan Kimia Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Bakti Nusa Linggau UNESA Journal of Chemical Education Borneo Journal of Pharmacy Jurnal Pengabdian Farmasi dan Sains Khidmah Nusantara JURNAL KEBIDANAN
Tutik Sri Wahyuni
UIN Sayyid Ali Rahmatullah Tulungagung
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
In Vitro Study of Garcinia dulcis (Roxb.) Kurz Leaves Extract against Hepatitis C Virus: Garcinia dulcis Leaves Extract against Hepatitis C Virus Apriyanto, Dadan Ramadhan; Hartati, Sri; Sri Wahyuni, Tutik; Inge Lusida, Maria
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.20

Abstract

Garcinia dulcis is a plant commonly used in traditional medicine in tropical regions. It has anti-bacterial, anti-inflammatory, anti-tumor, and anti-malaria properties. Despite its potential benefits, studies on its effectiveness as an antiviral are limited. This study investigated the antiviral properties of G. dulcis leaf extract against the JFH-1 strain genotype 2a as a treatment for Hepatitis C Virus (HCV). Huh7it-1 cells infected with the HCV genotype 2a strain JFH-1 were used to determine the antiviral effect of methanol extracts of G. dulcis leaves (GD-LE). GD-LE antiviral activity was investigated using a focus-forming assay for anti-HCV and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay for cytotoxicity. A time-of-addition study of anti-HCV was also performed to determine the mode of action of GD-LE. The results showed that GD-LE inhibited HCV replication with an IC50 of 17.06 µg/mL without giving any toxicity to the cells. The mode-of-action of GD-LE was found to inhibit HCV replication in the co-addition and post-infection stages. These findings suggest that GD-LE could be a promising candidate for anti-HCV treatment. However, further study regarding GD-LE bioactive compound isolation needs to be done to prepare an effective antiviral.
In Vitro Study of Garcinia dulcis (Roxb.) Kurz Leaves Extract against Hepatitis C Virus: Garcinia dulcis Leaves Extract against Hepatitis C Virus Apriyanto, Dadan Ramadhan; Hartati, Sri; Sri Wahyuni, Tutik; Inge Lusida, Maria
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.20

Abstract

Garcinia dulcis is a plant commonly used in traditional medicine in tropical regions. It has anti-bacterial, anti-inflammatory, anti-tumor, and anti-malaria properties. Despite its potential benefits, studies on its effectiveness as an antiviral are limited. This study investigated the antiviral properties of G. dulcis leaf extract against the JFH-1 strain genotype 2a as a treatment for Hepatitis C Virus (HCV). Huh7it-1 cells infected with the HCV genotype 2a strain JFH-1 were used to determine the antiviral effect of methanol extracts of G. dulcis leaves (GD-LE). GD-LE antiviral activity was investigated using a focus-forming assay for anti-HCV and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay for cytotoxicity. A time-of-addition study of anti-HCV was also performed to determine the mode of action of GD-LE. The results showed that GD-LE inhibited HCV replication with an IC50 of 17.06 µg/mL without giving any toxicity to the cells. The mode-of-action of GD-LE was found to inhibit HCV replication in the co-addition and post-infection stages. These findings suggest that GD-LE could be a promising candidate for anti-HCV treatment. However, further study regarding GD-LE bioactive compound isolation needs to be done to prepare an effective antiviral.
Co-Authors , Idha Kusumawati Abdul Rahem Achmad Fuad ACHMAD FUAD Achmad Fuad Hafid Adita Ayu Permanasari, Adita Ayu Adita Ayu Permatasari Adyana, Hendar Dio AGUS HARIANTO Andang Miatmoko Annisa Nayla Ichyaiddina Apriyanto, Dadan Ramadhan Ario Imandiri, Ario Aty Widyawaruyanti Chie Aoki-Utsubo Dahri, Baso Desi Kartikasari Dewi Isadiartuti Dewi Melani Hariyadi Dewi Melani Hariyati Dinda Monika Nusantara Ratri Dini Retnowati Fadlan, Arif Fahimah Martak Fahmi Dimas Abdul Azis Farida Ifadotunnikmah Firdaus, Mochamad Abdi Rohman Hadi Poerwono Halim, Moh. Kamal Handayani, Rosita Hanifah Khairun Nisa Harnanik Nawangsar Heny Arwaty Herra Studiawan Hidayatus, Laila Nur Hilkatul Ilmi Idha Kusumawati Inge Lusida, Maria Kholis Amalia Nofianti Lidya Tumewu Linda Yuli Revyanti M. Agus Syamsur Rijal Mangestuti Agil Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Muhammad Agus Syamsur Rijal Mumtazah, Ziyana Myrna Adianti Neni Purwitasari Nindya Tresiana Noorma Rosita Nur Rahmayanti Afifah Nur Rahmiati, Nur Nuril Huda Nurina Febriyanti Ayuningtyas Nuzul Wahyuning Diyah Pratiwi Pudjiastuti Pratiwi Soesilawati Prof. Dr. Retno Sari, M.Sc., Apt. Purwitasari, Neni Purwitasari, Neny Rafinda Herina Suci Rakhmawati Rakhmawati Rakhmawati, Alfiana Eka Ratna Kartika Irawati Retno Sari Retno Widyowati Retno Widyowati Rice Disi Oktarina Rina Puspitasari Risqi, Sitna Windia Saipul Maulana Silfianah, Ifah Sri Hartati Subhan Rullyansyah Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sukardiman Syahrur Marta Dwi Susilo Syaiful Amfri Syaiful Amri Syamsiar, Syamsiar Syamsur Rizal, Agus Tahta Zilli Arsyka, Azzilani Tri Widiandani Utami Islamiati Wahyuni, Riza Putri Widyowati, Rr. Retno Wiwied Ekasari Wiwied Ekasari Yusuf Syaril Alam Yusuf, Helmy Zeni Aprilia, Lovty