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Analysis of Potential Antiretroviral Drug Interactions Among HIV Patients at Puskesmas X, Jambi City, in 2025 Junita Anggi Rahmawati; Jelly Permatasari; Nurhayati
Journal of Education Technology Information Social Sciences and Health Vol. 5 No. 2 (2026): September 2026
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/jetish.v5i2.9130

Abstract

Introduction: Human Immunodeficiency Virus (HIV) infection requires continuous antiretroviral (ARV) therapy involving the use of multiple medications. Such combination therapy may increase the risk of drug interactions, which may potentially affect the efficacy and safety of treatment. Methods: This study employed a non-experimental study design with a descriptive approach and retrospective design. The study data were obtained from secondary data in the form of HIV patient visit records. A total of 72 patients were selected using purposive sampling. Potential drug interactions were identified using Drugs.com, Medscape, and DrugBank, and the data were analyzed descriptively using Microsoft Excel 2021. Results: The majority of patients were in the young adult age group (26–35 years), comprising 27 patients (37.50%), and most were male, with 62 patients (86.11%). The most frequently used ARV regimen was a combination of tenofovir disoproxil fumarate (TDF), lamivudine (3TC), and dolutegravir (DTG), used by 63 patients (87.50%). A total of 18 potential drug interactions were identified, predominantly involving pharmacodynamic mechanisms, accounting for 17 cases (94.44%), while pharmacokinetic interactions accounted for 1 case (5.56%). Regarding severity, 17 cases (94.44%) were classified as moderate and 1 case (5.56%) as major, with no minor interactions identified. Conclusion: Potential ARV drug interactions among HIV patients at Puskesmas X, Jambi City, in 2025 were predominantly pharmacodynamic in mechanism and moderate in severity.
Analysis and Management of Potential Drug Interactions in Patients With Diabetes Mellitus and Comorbidities at Hospital X Jelly Permatasari; Indri Meirista; Juwani Legistria
Journal of Education Technology Information Social Sciences and Health Vol. 5 No. 2 (2026): September 2026
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/jetish.v5i2.9241

Abstract

Diabetes mellitus is a chronic metabolic disease that is frequently accompanied by comorbidities, requiring the use of multiple medications (polypharmacy). This increases the risk of potential drug interactions that may reduce therapeutic effectiveness and increase the incidence of adverse drug reactions. This study aimed to analyze potential drug interactions in patients with diabetes mellitus and comorbidities based on severity, interaction mechanisms, and recommended drug interaction management strategies. This descriptive observational study employed a retrospective approach using secondary data obtained from the medical records of patients with diabetes mellitus and comorbidities at Hospital X during the January–December 2025 period. A total of 93 patients who met the inclusion criteria were included in the study. Potential drug interactions were analyzed using the Drugs.com Drug Interaction Checker. The results identified 154 potential drug interactions. Based on severity, moderate interactions were the most common, accounting for 123 cases (80%), followed by minor interactions with 28 cases (18%) and major interactions with 3 cases (2%). Based on interaction mechanisms, pharmacodynamic interactions were more frequent, with 103 cases (67%), than pharmacokinetic interactions, with 51 cases (33%). Recommended drug interaction management strategies included therapeutic monitoring, dose adjustment, modification of drug administration time, and drug substitution when necessary. These findings highlight the importance of identifying and managing potential drug interactions to improve medication safety and therapeutic effectiveness in patients with diabetes mellitus and comorbidities.
Co-Authors Abqori, M. Khautal Amelia, Putri Andriani, Medi Anggita Kresna Wardani Ani Marlina, Ani Anjlyna, Leonyta Annisa Rezi Ritami Ardilla Novianti Armini Hadriyati armini hadriyati, armini Atiqah, Umi Bafadhal, Hamira Barmi Hartesi Deny Sutrisno Devi Orlanda Dewi, Rasmala Dika Febrina Safitri Disty Aldila Wicaksono Etsa, Nadila Permata Fadhilah, Dila Fildzah Luthfia Fitriah Fitriah Fitriah Fitriah Galih Dimas Saputra Gusnawangti Gusnawangti Gusnawangti, Gusnawangti Halimatussa’diyah Halimatussa’diyah HamidatulꞌAliyah, Siti Indri Meirista Indri Meirista Junita Anggi Rahmawati Juwani Legistria Khairunisa, Salwa Khodijah, Siti Ayu Likha Ulandari Lili Andriani Luthfia, Fildzah Magdalena Arifani, Yohana Maratus Sholeha Marisanti, Debi Putri Marta Ariani Mawaddah, Nadiatul Meliani, Meliani Miftahul Ilmi, Miftahul Mitra, Aisa Dinda Muhammad Budi NADIATUL MAWADDAH Nadila Permata Etsa Nilfa Yanti Kartini Tampubolon novrianti, wulan nur Nurhayati Nurhayati, Nurhayati Nurmillah Tul Sa'diah Nurul Atika Orlanda, Devi Prago Kaipur Priska Rahmatillah Putra, Rizky Yulion Putri Amelia Putri Dwi Ramadanti Putry Nelita Manurung Rahadina Rizkika Rahmadha Trifah Rahmawati, Junuta Anggi Raveinal Raveinal Resti Widyastuti Resti Widyastuti Retno Agustia Ningsih Ribka Pangaribuan Riski Herdiyanti Riski Herdiyanti Rizky Yulion Putra Ruri Putri Mariska Ruri Putri Mariska Safitri, Dika Febrina Sanuddin, Mukhlis Secio Lovellya Sela Tresia Sholeha, Maratus Silva Wulan Dari Siti Melvy Susanti Soyata, Amelia Sutrisno , Deny Sutrisno, Denny Uce Lestari Uce Lestari Uce Lestari Ul Husna Aprilia, Annisa Wardani, Anggita Kresna Widyastuti, Resti Yolandari, Dea Yuli Mudia Sari Yulia Putri, Regyna Yulianis Yulianis Yulita, Dea