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All Journal JURNAL ILMIAH PLATAX Jurnal Perikanan dan Kelautan Jurnal Penelitian Pendidikan IPA (JPPIPA) Al-Kimia Jurnal Biologi Tropis Jurnal Farmamedika (Pharmamedica Journal) ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sains dan Edukasi Sains Cokroaminoto Journal of Chemical Science PROFICIO: Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Sains Journal of Pharmaceutical Science and Herbal Technology Jurnal Novem Medika Farmasi Bina Bahari : Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Catalyx : Journal of Process Chemistry and Technology
Tahirah Hasan
Universitas Islam Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Uji Kadar Fenolik Total dan Aktivitas Antioksidan Ekstrak Etanol Kunyit Hitam (Curcuma caesia Roxb.) Asal Kabupaten Bone dengan Metode DPPH Wa Yusniawati; Tahirah Hasan; Muhammad Iqbal
Jurnal Novem Medika Farmasi Vol. 3 No. 1: Volume 3 Issue 1
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i1.824

Abstract

kunyit hitam (Curcuma caesia Roxb.) merupakan salah satu tanaman yang mengandung senyawa fenolik dan dapat digunakan untuk mengobati berbagai penyakit. Tujuan penelitian ini untuk menentukan kadar fenolik total dan menentukan nilai IC50 ekstrak etanol rimpang kunyit hitam (Curcuma caesia Roxb.) asal Kabupaten Bone dengan metode DPPH. Metode penelitian meliputi ekstraksi simplisia kunyit hitam dilakukan secara maserasi menggunakan pelarut etanol 70%. Penetapan kadar fenolik total dengan spektrofotometer visibel pada panjang gelombang 764 nm dan uji aktivitas antioksidan dengan metode DPPH, menggunakan spektrofotometer visibel pada panjang gelombang 505 nm. Hasil analisis kadar fenolik total ekstrak etanol kunyit hitam (Curcuma caesia Roxb.) asal Kabupaten Bone diperoleh kadar rata-rata 25,058 mg EAG/g sampel dan hasil uji aktivitas antioksidan ekstrak etanol kunyit hitam (Curcuma caesia Roxb.) diperoleh nilai IC50 sebesar 56,630 + 0,468 μg/mL. Kemampuan aktivitas antioksidan ekstrak etanol kunyit hitam (Curcuma caesia Roxb.) 0,028 kali asam askorbat dengan nilai IC50 sebesar 1,607 + 0,0916 μg/mL.
Skrining Fitokimia Dan Analisis Kadar Fenolik Total Ekstrak Metanol Daun Beligo (Benincasa hispida (Thunb.)Cogn) Asal Mamuju Winda Sri Devi; Tahirah Hasan; Burhanuddin Taebe
Jurnal Novem Medika Farmasi Vol. 3 No. 1: Volume 3 Issue 1
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i1.841

Abstract

Penelitian skrining fitokimia dan fenolik total ekstrak metanol daun beligo Benincasa hispida (Tunb.) Cogn) Asal Mamuju telah dilakukan. Tujuan penelitian adalah untuk mengetahui golongan senyawa yang terkandung pada ekstrak metanol daun beligo dan untuk mengetahui kadar fenolik total ekstrak daun beligo. Ekstraksi secara maserasi dengan pelarut metanol. Skrining fitokimia secara kualitatif untuk golongan senyawa alkaloid, fenolik, tanin, saponin, steroid, dan flavonoid. Analisis fenolik total secara kuantitatif menggunakan spektrofotometer visibel pada panjang gelombang 765nm. Hasil skirining fitokimia ekstrak metanol daun beligo positif mengandung golongan senyawa alkaloid, fenolik, tanin,saponin, steroid, dan flavonoid serta hasil analisis fenolik total dengan kadar 23,9242 mgEAG/g. Kata Kunci: Benincasa hispida (Tunb.)Cogn Fenolik total, Skrining fitokimia,
Analisis kadar omega-3 pada daging udang windu (Penaeus monodon) dan udang putih (Litopenaeus vannamei) asal tarakan provinsi kalimantan utara Ummu Kalsum Wahab; Tahirah Hasan; Tadjuddin Naid
Jurnal Novem Medika Farmasi Vol. 3 No. 1: Volume 3 Issue 1
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i1.846

Abstract

Udang windu (Penaeus monodon) dan udang putih (Litopenaeus vannamei) memilki kandungan omega-3 yang bermanfaat bagi kesehatan, terutama pada perkembangan otak pada anak yang masih dalam taha pertumbuhan, selain itu kandungan omega-3 juga bermanfaat dalam industri obat dan makanan sehingga berpotensi untuk dikembangkan. Penelitian ini bertujuan menentukan kadar asam lemak omega-3 yang terdapat pada daging udang windu (Penaeus monodon) dan udang putih (Litopenaeus vannamei). Metode penelitian meliputi ekstraksi secara sokhletasi dengan pelarut n-heksan, analisis kualitatif dan kuantitatif asam lemak menggunakan GC-MS. Hasil analisis menunjukkan bahwa ekstrak daging udang windu (Penaeus monodon) mengandung asam lemak omega-3 yang terdiri dari EPA 2,64% dan, ekstrak n-heksan udang putih (Litopenaeus vannamei) mengandung asam lemak omega-3 yang terdiri dari EPA 2,16%.
Skrining Fitokimia dan uji Aktivitas Antioksidan Ekstrak Etanol Bawang Putih (Allium sativum L.) dengan Metode ABTS Riska Damayanti; Tahirah Hasan; Muhammad Iqbal
Jurnal Novem Medika Farmasi Vol. 3 No. 1: Volume 3 Issue 1
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i1.869

Abstract

ABSTRAK Bawang putih (Allium sativum L.) diidentifikasi memiliki kandungan senyawa metaboilt sekunder yang dapat dimanfaatkan sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui golongan senyawa dan mentukan nilai IC50 ekstrak etanol bawang putih (Allium sativum L.) dengan metode ABTS. Simplisia bawang putih di ekstraksi dengan cara maserasi menggunakan etanol 96% lalu dilanjutkan skrining fitokimia menggunakan berbagai pereaksi yang spesifik dan uji aktivitas antioksidan dengan metode ABTS. Hasil skrining fitokimia menunjukkan bahwa ekstrak etanol bawang putih mengandung golongan senyawa alkaloid, terpenoid, flavonoid dan saponin. Pengujian aktivitas antioksidan terhadap radikal ABTS menggunakan spektrofotometer visibel pada panjang gelombang 740 nm. Hasil analisis menunjukan bahwa ekstrak etanol bawang putih memiliki aktivitas antioksidan dengan nilai IC50 sebesar 187,682 ± 0.06670 µg/mL. Kemampuan aktivitas antioksidan ekstrak etanol bawang putih (Allium sativum L.) yaitu 0,0129 kali dari aktivitas antioksidan asam askorbat IC50 sebesar 2,427 ± 0,01014 µg/mL Kata Kunci: ABTS, Antioksidan; Asam Askorbat; Bawang Putih (Allium sativum L.); Skrining Fitokimia ABSTRACT Research has shown that secondary metabolic products found in garlic (Allium sativum L.) have potential use as antioxidants. This study uses the ABTS technique to identify the class of chemicals and calculate the IC50 value of an ethanol extract of garlic (Allium sativum L.). After macerating the garlic simplicia in 96% ethanol, the phytochemicals were screened using a variety of specialized reagents, and the antioxidant activity was assessed using the ABTS technique. Garlic ethanol extract includes alkaloid, terpenoid, flavonoid, and saponin components, according to the results of phytochemical screening. ABTS radicals were tested for antioxidant activity using a visible spectrophotometer set to 740 nm. The study findings indicate that the ethanol extract of garlic contains 187.682 ± 0.06670 µg/mL of antioxidant activity. The action of antioxidants Keywords: ABTS, Antioxidant; Ascorbic Acid; Garlic (Allium sativum L.); Phytochemical Screening
Integrating Green Chemistry Metrics with ISO-Compliant Life Cycle Assessment: A Dual-Framework Approach to Sustainable Chemical Manufacturing Tahirah Hasan
Catalyx : Journal of Process Chemistry and Technology Vol. 2 No. 1 (2025): January 2025
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/catalyx.v2i1.1268

Abstract

Integrating waste minimization metrics with Life Cycle Assessment (LCA) enhances sustainability evaluations in chemical manufacturing. This study proposes a hybrid framework combining ISO 14040/14044-compliant LCA with green chemistry indicators such as E-factor, Process Mass Intensity (PMI), and Atom Economy to assess the environmental performance of a chemical process. The methodology employs a cradle-to-gate system boundary and utilizes both primary inventory data and secondary sources including Ecoinvent and EF 3.1 databases. Waste metrics are derived from life cycle inventory data, and environmental impacts are assessed using TRACI 2.1 and EF 3.1 methods. The results demonstrate that integrating waste metrics with LCA offers deeper insights into process sustainability. A process characterized by an E-factor of 2.20, PMI of 5.80, and Atom Economy of 78.0% showed significant material efficiency but also revealed trade-offs between solvent recovery and energy demand. The Life Cycle Impact Assessment (LCIA) reported a Global Warming Potential (GWP) of 2.45 kg CO₂-eq and a water footprint of 2.50 m³ per kg of product, indicating the influence of upstream inputs and energy sources. This dual-framework approach improves decision-making in process design by aligning operational efficiency with environmental outcomes. It facilitates the identification of hotspots, supports targeted optimization, and enhances transparency in sustainability reporting. The findings underscore the value of integrating LCA and green chemistry metrics to advance environmentally responsible chemical manufacturing.
Optimizing Environmental Performance in Chemical Manufacturing: A TRACI and USEtox-Based Life Cycle Approach to Waste Minimization Tahirah Hasan
Catalyx : Journal of Process Chemistry and Technology Vol. 2 No. 2 (2025): April 2025
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/catalyx.v2i2.1277

Abstract

Chemical manufacturing is under increasing pressure to reduce its environmental footprint. Life Cycle Assessment (LCA), as defined by ISO 14040/14044, is an established method for evaluating such impacts. This study aims to integrate LCA with quantitative waste minimization metrics Process Mass Intensity (PMI) and E-Factor to evaluate the environmental benefits of process redesign. Two chemical process scenarios (baseline and improved) were assessed using a cradle-to-gate LCA approach. TRACI 2.1 and USEtox were employed to evaluate environmental impacts across categories such as climate change, human toxicity, and water use. PMI and E-Factor were calculated from foreground process data, and background inventory was sourced from the ecoinvent database. Allocation was based on mass, and uncertainty was assessed via Monte Carlo simulations and sensitivity analysis. The improved process demonstrated a 33% reduction in PMI and a 50% decrease in E-Factor, driven by solvent recovery and energy optimization strategies. Climate change impact dropped from 15.0 to 10.2 kg CO2-eq, while human toxicity and water footprint also saw substantial improvements. LCA findings provided actionable insights for process redesign, revealing that targeted waste minimization enhances overall environmental performance. While energy demands initially rose, optimization and heat integration neutralized trade-offs, supporting more sustainable operations. Integrating LCA with PMI and E-Factor offers a robust, standardized framework for evaluating waste minimization in chemical processes. This approach supports environmentally sound decision-making and can guide future innovations in green chemistry and sustainable manufacturing.
Dynamic Sustainability Modeling under Energy and Emission Uncertainty: Tools for Resilient Policy and Industrial Decision-Making Tahirah Hasan
Catalyx : Journal of Process Chemistry and Technology Vol. 2 No. 4 (2025): October 2025
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/catalyx.v2i4.1328

Abstract

Uncertainty in energy markets and emission factors presents a significant challenge to sustainable manufacturing. This study aims to develop a simulation-based sensitivity framework to assess how variability in fossil fuel prices and emission coefficients impacts sustainability outcomes. Using One-At-a-Time (OAT), Tornado analysis, and Monte Carlo simulations, the study evaluates the influence of energy prices (oil, coal, natural gas) and emission factors (CO₂ per GJ for various fuels) on manufacturing sustainability. The framework incorporates real-world parameter ranges and applies probabilistic modeling to capture compound uncertainties. Sensitivity analysis reveals that coal and oil prices are the most influential variables in cost-driven assessments, while emission factor variation particularly for coal and diesel introduces significant uncertainty in carbon accounting. Monte Carlo simulations, run over 10,000 iterations, show wide variability in sustainability scores, underscoring the need for risk-informed planning. Tornado diagrams visually rank variable importance, facilitating policy and operational prioritization. Contextual influences, such as national energy mixes and regulatory environments, further shape parameter sensitivity. Findings demonstrate the strategic value of compound modeling in subsidy targeting, supply chain planning, and compliance forecasting. This study contributes a practical, adaptable framework for sustainability modeling under uncertainty. By quantifying the probabilistic impact of volatile energy and emissions data, it enhances the credibility and utility of manufacturing assessments. The framework supports policymakers and industry leaders in designing robust, context-specific strategies for sustainable transitions.
Co-Authors . Apriansyah Abd. Rauf Patong Abd. Wahid Wahab Abdul Wahid Suleman Abidin, Araf Asraf Andhika Pratama Tulak Ardiansyah Habar Ardillah Ardillah Arfiani Arifin Besse Yuliana Burhanuddin Taebe Desriani Lestari Endah Dwijayanti Endah Dwijayanti Evianti Evianti Hasanuddin, Rusman Hasri Hasri Hasri Helena, Shifa Ikha Safitri Ikha Safitri Irfayanti, Nur Alfiah Irwan Jasmiadi Jasmiadi Lucky Hartanti Lucky Hartanti, Lucky M. Natsir Djide Mazriatii Mega Fatimah Rosana Mega Sari Juane Sofiana Mega Sari Juane Sofiana Muh. Agung Irawan Muh. Resky Pratama Muhammad Iqbal Muhammad Jusman Risaldi Muhammad Rusdi Nur Alim Nur Atika Aqila Nur Ida Nur Ida Nurdiansyah, Syarif Irwan Nurdin, Syamsidar Putri Indah Sari Rachmin Munadi Riska Damayanti Riska Ninsi Riza Linda Syarif Irwan Nurdiansyah Tadjuddin Naid Titi Firdha Ummu Kalsum Wahab Wa Yusniawati Warsidah, Warsidah Winda Sri Devi yasnidar yasir Yasnidar Yasnidar Zulfitri Zulfitri