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All Journal Jurnal Ilmiah Psikologi Terapan Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Journal of Nonformal Education Briliant: Jurnal Riset dan Konseptual Machine : Jurnal Teknik Mesin DIKLUS: Jurnal Pendidikan Luar Sekolah Jurnal Pertanian Agros Journal of Nonformal Education and Community Empowerment JURNAL CRANKSHAFT Jurnal Agroplasma Otopro Jurnal Ilmiah Profesi Pendidikan Jurnal Pendidikan dan Kewirausahaan Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) AGRISAINS: Jurnal Ilmiah Magister Agribisnis Fitrah: Journal of Islamic Education Jurnal Pendidikan dan Pembelajaran Indonesia (JPPI) Dikmas: Jurnal Pendidikan Masyarakat dan Pengabdian Jurnal Rekonstruksi dan Estetik Lifelong Education Journal Jurnal Klinik dan Riset Kesehatan Sinergi Polmed : Jurnal Ilmiah Teknik Mesin eJournal Kedokteran Indonesia Journal of Industrial Community Empowerment Jurnal Ilmu Manajemen Dan Kewirausahaan (JIMK) Jurnal Teknologi Kimia Mineral Journal of Nonformal Education Jurnal Penelitian Pendidikan Joong-Ki Journal of Community Empowerment
Yudi Siswanto
Fakultas Psikologi, Universitas Muhammadiyah Malang
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Journal : eJournal Kedokteran Indonesia

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The Development of Causative Patterns of Cleft Lip and Palate in Eastern Indonesia Wihastyoko, Herman Yosef Limpat; Arviansyah, Arviansyah; Siswanto, Yudi; Wruhastanti, Gisella S.
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1123.1

Abstract

Cleft lip or cleft palate (CL/P) is a congenital disorder involving genetic and environmental factors. Eastern Indonesia is a region with the fourth-highest incidence of CL/P in Indonesia. Low socioeconomic conditions in this region are thought to contribute to the high prevalence of CL/P, both directly and through maternal health and environmental factors. This study aims to identify and analyze the evolving patterns of causative factors for cleft lip and/or palate (CL/P) in Eastern Indonesia. Conducted between February and October 2024, the research employs a cross-sectional design integrated with a path analysis approach to explore the complex interplay between environmental exposures and genetic predispositions contributing to CL/P in the region. Purposive sampling was used to interview families of CL/P patients to gather samples; the number of respondents was chosen based on the predetermined inclusion criteria. The data obtained were then analyzed using path analysis to examine the relationship between environmental and genetic factors, utilizing the SmartPLS 4.0 software. This study showed that social factors significantly affected CL/P with a t-statistic value of 0.043. Meanwhile, neither economic nor genetic factors had a significant effect. This result may be attributed to limited awareness among families regarding genetic influences, such as those identified through pedigree tracing in individuals with CL/P. Furthermore, as public knowledge has improved, the incidence of consanguineous marriages in Eastern Indonesia has declined, which is one factor that influences CL/P from a genetic perspective. This study highlights the importance of social and economic interventions in reducing the incidence of CL/P. It emphasizes the need for further research employing a genetic analysis approach to obtain more comprehensive results.
Co-Authors Abdul Malik Abdul Rahmat Agustina, Wilma Akbar, Riven Alfafa, Abduh Malik Aliyah, Khotimatul Amin Yusuf Amiruddin Amiruddin Amiruddin Amrul, Hanifah Mutia Zaida Ningrum Angga Bahri Pratama Ariksa, Jeri Arviansyah, Arviansyah Astuti, Dwi Hari Azizah, Markhamah Watianur Bagus Kisworo, Bagus Cahyani, Arini Dwi Diva Pramesti Putri Dyah Ayu Wulandari Erwin Nyak Akoeb, Erwin Nyak Fadia Talia Salsabila Hervi Fathurrasuli, Fathurrasuli Fikrah Dian Indrawati Sawali Hendi Lilih Wijayanto Hidayah, Sunnatul Hidayat Hidayat Humam, Fachrizal Amirul Hutagalung, Magda Rosalina Ika Nurjannah, Ika Ilyas Ilyas Ilyas, I. Ilyas, I. Imam Shofwan Indarthi, Anifah Widya Indri Lakhsmi Putri, Indri Lakhsmi Irvan, Moh. Farizqo Isa, Abd. Hamid Islahuddin, Islahuddin Ismail, Muhammad Azri Ismaniar Ismaniar Joko Sutarto Jusuf Sjamsudin Kadex Widhy Wirakusuma Kadriadi, Kadriadi Limpat Wihastyoko, Herman Yosef Miftahul Khair Mintarsih Arbarini MITA RAHMAWATI Moh. Azhar Afandy Muhammad Alfian, Muhammad Nurcahyaningsih, Caturinta Nusantara, Bobby Ardhian Perdana, Andika Permadi, Mhd Bambang Prasetyaningtyas, Fitria Dwi Prilianti, Ratna Putra, Eriek Aristya Pradana Riduwan Riduwan, Riduwan Ristiana, Nanda Saputra, Aditiyo Tri Saragi, Jandri Fan HT Setiarto Pratigto Setiawan, Angga Tegar Sintaningrum, Elisabeth Sintaningrum, Elisabeth Prajanti Siswoyo, Devira SRI WARDANI Sungkowo Edy Mulyono Syaifuddin, Muh Tanjaya, Krisanto Tri Joko Raharjo Tri Suminar Urrofik, Safira Arbella Aurell Utsman, U. Utsman, U. Wihastyoko, Herman Wihastyoko, Herman Yosef Limpat Wijayanto, Hendi Lilih Wirakusuma, Kadex Widhy Wruhastanti, Gisella S. Wruhastanti, Gisella Sekar Yoshehira, Orien Yusdianto Yusdianto Zamriyetti, Zamriyetti Zulkarnain Lubis