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All Journal Jurnal Ilmiah Psikologi Terapan Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Journal of Nonformal Education Briliant: Jurnal Riset dan Konseptual Machine : Jurnal Teknik Mesin DIKLUS: Jurnal Pendidikan Luar Sekolah Jurnal Pertanian Agros Journal of Nonformal Education and Community Empowerment JURNAL CRANKSHAFT Jurnal Agroplasma Otopro Jurnal Ilmiah Profesi Pendidikan Jurnal Pendidikan dan Kewirausahaan Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) AGRISAINS: Jurnal Ilmiah Magister Agribisnis Fitrah: Journal of Islamic Education Jurnal Pendidikan dan Pembelajaran Indonesia (JPPI) Dikmas: Jurnal Pendidikan Masyarakat dan Pengabdian Jurnal Rekonstruksi dan Estetik Lifelong Education Journal Jurnal Klinik dan Riset Kesehatan Sinergi Polmed : Jurnal Ilmiah Teknik Mesin eJournal Kedokteran Indonesia Journal of Industrial Community Empowerment Jurnal Ilmu Manajemen Dan Kewirausahaan (JIMK) Jurnal Teknologi Kimia Mineral Journal of Nonformal Education Jurnal Penelitian Pendidikan Joong-Ki Journal of Community Empowerment
Yudi Siswanto
Fakultas Psikologi, Universitas Muhammadiyah Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medical Journal of Indonesia

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Natural remedies in burn care: a systematic review and network meta-analysis Ismail, Muhammad Azri; Tanjaya, Krisanto; Wruhastanti, Gisella Sekar; Siswanto, Yudi
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257608

Abstract

BACKGROUND Burn injuries are a global public health issue that impact healing time and cause complications. While silver sulfadiazine (SSD) cream is commonly used for treatment, research indicates that SSD can hinder the wound healing process. Natural alternatives like Aloe vera, honey, and amniotic membranes have shown promise in promoting wound healing. This study aimed to evaluate their efficacy by their wound healing time and infection rate. METHODS 3 independent reviewers conducted a literature search across 6 databases (Cochrane Central Register of Controlled Trials, PubMed, ScienceDirect, Taylor & Francis, Wiley, and ProQuest). Quality assessment was conducted using the Cochrane Risk of Bias 2 tool, while network meta-analysis was performed using the netmeta package in R. The variable in this study is the average time to burn wound healing and infection occurrence by analyzing MD data or OR of each intervention, with 95% CI to calculate the efficacy. RESULTS A total of 3,434 patients from 37 studies were included. In the analysis of 26 studies comparing the healing time to SSD, A. vera has the best efficacy (MD: −4.75; 95% CI: −8.67 to −0.86), followed by amniotic membrane (MD: −4.71; 95% CI: −7.45 to −1.97), and honey (MD: −4.25; 95% CI: −6.76 to −1.73). Meanwhile, the occurrence of infection analysis in burn wounds across 24 studies highlighted that honey has the lowest infection rate (OR: 0.09; 95% CI: 0.04 to 0.23) and was the only statistically significant finding when compared to SSD. CONCLUSIONS Aloe vera and amniotic membrane are effective for wound healing, while honey is particularly effective in preventing wound infection in patients with burn injuries.
Co-Authors Abdul Malik Abdul Rahmat Agustina, Wilma Akbar, Riven Alfafa, Abduh Malik Aliyah, Khotimatul Amin Yusuf Amiruddin Amiruddin Amiruddin Amrul, Hanifah Mutia Zaida Ningrum Angga Bahri Pratama Ariksa, Jeri Arviansyah, Arviansyah Astuti, Dwi Hari Azizah, Markhamah Watianur Bagus Kisworo, Bagus Cahyani, Arini Dwi Diva Pramesti Putri Dyah Ayu Wulandari Erwin Nyak Akoeb, Erwin Nyak Fadia Talia Salsabila Hervi Fathurrasuli, Fathurrasuli Fikrah Dian Indrawati Sawali Hendi Lilih Wijayanto Hidayah, Sunnatul Hidayat Hidayat Humam, Fachrizal Amirul Hutagalung, Magda Rosalina Ika Nurjannah, Ika Ilyas Ilyas Ilyas, I. Ilyas, I. Imam Shofwan Indarthi, Anifah Widya Indri Lakhsmi Putri, Indri Lakhsmi Irvan, Moh. Farizqo Isa, Abd. Hamid Islahuddin, Islahuddin Ismail, Muhammad Azri Ismaniar Ismaniar Joko Sutarto Jusuf Sjamsudin Kadex Widhy Wirakusuma Kadriadi, Kadriadi Limpat Wihastyoko, Herman Yosef Miftahul Khair Mintarsih Arbarini MITA RAHMAWATI Moh. Azhar Afandy Muhammad Alfian, Muhammad Nurcahyaningsih, Caturinta Nusantara, Bobby Ardhian Perdana, Andika Permadi, Mhd Bambang Prasetyaningtyas, Fitria Dwi Prilianti, Ratna Putra, Eriek Aristya Pradana Riduwan Riduwan, Riduwan Ristiana, Nanda Saputra, Aditiyo Tri Saragi, Jandri Fan HT Setiarto Pratigto Setiawan, Angga Tegar Sintaningrum, Elisabeth Sintaningrum, Elisabeth Prajanti Siswoyo, Devira SRI WARDANI Sungkowo Edy Mulyono Syaifuddin, Muh Tanjaya, Krisanto Tri Joko Raharjo Tri Suminar Urrofik, Safira Arbella Aurell Utsman, U. Utsman, U. Wihastyoko, Herman Wihastyoko, Herman Yosef Limpat Wijayanto, Hendi Lilih Wirakusuma, Kadex Widhy Wruhastanti, Gisella S. Wruhastanti, Gisella Sekar Yoshehira, Orien Yusdianto Yusdianto Zamriyetti, Zamriyetti Zulkarnain Lubis