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All Journal Jurnal Ilmu Dasar Folia Medica Indonesiana Jurnal NERS UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFM (Jurnal Farmasi Malahayati) Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Inovasi Kesehatan Global Jurnal Sains dan Kesehatan
Widji Soeratri
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : UNEJ e-Proceeding

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CHARACTERIZATION AND THE RELEASE TEST OF ANTI-AGING TRETINOIN IN NANOEMULSION USING OLIVE OIL Tristiana Erawati M.; Widji Soeratri
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

People are more and more desire a youthful andattractive appearance. Aging of the skin can be theresult of a normal process that involves a lowerrate of metabolic activities and is calledchronologic aging. Photoaging is the consequenceof chronic sun exposure and manifests clinicallywith fine and coarse wrinkling, roughness, dryness,laxity, shallowness, pigmentary mottling,telangiectasia, and in some cases withpreneoplastic and neoplastic changes (Stefanaki etal., 2005). Tretinoin is a compound that is able toshow an effect of prevention and treatment ofwrinkles due to photo aging, acne, andinflammation of the skin. It is all-trans retinol isoxidized through retinal to its most activemetabolite (Kligman et. al, 1986). The effectivity ofan active ingredient is determined among othersby the ability to reach the site of action. To reachthe site of action the active ingredients used orallyor topically must first dissolve, release thenabsorbed or penetrates through the membraneand then diffuses into the site of action. Tretinoinpractically insoluble to increase it usednanoemulsion delivery as a vehicle. Solubility isone of the factors of drug absorption. Highersolubility of drug caused higher amount of drug toabsorb. Smaller droplet of emulsion caused rapiddrug release. In this study tretinoin loaded innanoemulsion using olive oil than it characterizedand test of tretinoin release compared withtretinoin in emulsion. Olive oil used as oil phase innanoemulsion as known it widely used in cosmetic.MATERIAL AND METHODSResearch MaterialsTretinoin (PT. Cortico Mulia), olive oil , Tween 80(Sigma Aldrich), Span 80 (Sigma Aldrich), ethanol96 % (E-Merck), NaH2PO4 (E-Merck) and Na2HPO4(E-Merck), aquademineralisata (PT Brataco).Research InstrumentsStirrer plate (Dragon Lab MS-Pro), ultrasonic(Branson 3510), shaker machine (Wine shake), pHmeter (Eutech Instruments pH 700), particleanalyzer (Delsa Nano C), Franz diffusion cell withcellophane membranes, spectrophotometer(Shimadzu UV-1800), Transmission ElectronMicroscopy (TEM-type JOEL JEM-1400), lightmicroscope.
Co-Authors Abdurahman Abdurrahman Abhimata Paramanandana Afra, Fairuz Yaumil Allyssia Salma Anita Natalia Suryawijaya Athiyyah, Wafa'ul Bambang Widjaja Bella Fevi Aristia Cita Rosita Sigit Prakoeswa Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Dewi Febiyanti Dewi Isadiartuti DEWI RAHMAWATI Diana Fitrianingrum Djoko Agus Purwanto Dwi Setyawan Dyah Rahmasari Epipit Eryka A. Novarinandha Fairuz Yaumil Afra Fedik Abdul Rantam Fransisca Dita Mayangsari Herra Studiawan I Gusti Ayu Adhi Aryapatni Isnaeni Kadeq Novita Prajawanti Khoirun Nisyak Luky Hayuning Les Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Maulina Apriani Miatmoko, Andang Nabilla Navyani P.A Nisa Qurrota Ayun Noor Ifansyah Noor Ifansyah Noorma Rosita Nuruddin, Mahrus Naufal Nurul Islami Ningtiyas Paramita, Diajeng Putri Pawahid Pawahid Purwanto , Djoko Agus Ressa Marisa Retno Sari Ria Hanistya Rina Mutya Suzliana Rohmawati Hidayah Rufaidah Azzahrah Safiul Fitria, Nur Indah Siti Hartini Hamdan Soemiyati Srinalesti Mahanani, Srinalesti Suko Hardjono Tristiana Erawati Tristiana Erawati Tristiana Erawati Munandar Tutiek Purwanti Virnanda Syafira Hartatiningrum Yulis Setiya Dewi Zahwa Natasya Novita P. Zhihrotulwida, Dzakiya