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All Journal Jurnal Ilmu Dasar Jurnal NERS UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFM (Jurnal Farmasi Malahayati) Indian Journal of Forensic Medicine & Toxicology Humanism : Jurnal Pengabdian Masyarakat Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Inovasi Kesehatan Global Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Widji Soeratri
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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PENENTUAN STABILITAS SEDIAAN KRIM TABIR SURYA DARI BAHAN EKSTRAK RIMPANG KENCUR (Kaempferia galanga L.) Widji Soeratri; Noor Ifansyah; Diana Fitrianingrum
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 10 No 2 (2005): June 2005
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/441

Abstract

The objective of this research was to know the chemical stability of the etil para-metoksi sinamat (EPMS) formulated in sunscreen cream of oil in water base. The EPMS was isolated from Kaempferia galanga L. tuber pulvis with maceration-percolation method using ethanol 96%. The chemical stability of the EPMS formulated in sunscreen cream of the oil in water base was investigated by keeping the cream at room temperature. At appropriate interval the concentration of EPMS in cream was measured. The results showed that the EPMS formulated in sunscreen cream of oil in water base was unstable at room temperature for 70 days. The concentration of EPMS in cream significantly decreased after 70 days (p = 0,01) during keeping at room temperature with the coefficient degradation value (k)= 4.4.10-3/day.
PENENTUAN PERSENTASE TRANSMISI ERITEMA DAN PIGMENTASI BEBERAPA MINYAK ATSIRI Widji Soeratri; Noor Ifansyah; Soemiyati; Epipit
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 10 No 2 (2005): June 2005
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/444

Abstract

Prolonged and repetitive skin exposure to the sunlight can cause several disadvantageous effects. The harmful UV radiation of sunlight includes UV-A, which is implicated in tanning, photo aging and UV-B, which is especially responsible for erythema. For protecting the skin against UV light, the pharmaceutical sunscreen products with several active ingredients include natural product-essential oils are used. In this experiment we have investigated the effect of several essential oils as protection of the skin against UV light. The essential oil that used in this experiment were Lavender oil, Kenanga oil, Nilam oil, Geranium oil, Rosemary oil, Neroli oil, and Rose Moroccan oil. The sunscreen effectiveness determination was performed in vitro by determine their percentage of erythema transmission and percentage of pigmentation transmission employed spectrophotometer at wavelength 292.5–372.5 nm. The results showed only lavender oil was effective as sunscreen with the percentage of erythema transmission and percentage of pigmentation transmission was 9.94% and 80.15%, respectively. It was categories as suntan.
Formulasi Krim Antioksidan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas (L.) Lamk) Sebagai Anti Aging Dipahayu, Damaranie; Soeratri, Widji; Agil, Mangestuti
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

The Effect of Decyl Glucoside on Stability and Irritability of Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations Rufaidah Azzahrah; Noorma Rosita; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.220-228

Abstract

Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLC-GTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HET-CAM test.
Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid Anita Natalia Suryawijaya; Tutiek Purwanti; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.115-124

Abstract

Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 "‹"‹before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.
Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract Fairuz Yaumil Afra; Widji Soeratri; Djoko Agus Purwanto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.229-234

Abstract

Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations. It happened because alpha-lipoic acid can increase stability and antioxidant activity. Objective: Comparing the physical characteristics and stability of NLC-GTE with or without alpha-lipoic acid. Methods: NLC-GTE manufactured using the High Shear Homogenization method. NLC-GTE was divided into two formulas, without the addition of alpha-lipoic acid for F1 and with the addition of alpha-lipoic acid for F2. The characteristics and physical stability were tested, including organoleptic, pH, particle size, and polydispersity index. Stability test was held using the thermal cycling method. Results: Based on characteristic test, it was found that F2 had larger particle size value than F1. The average particle size value of F1 is 313.9 ± 0.76 nm and 423.4 ± 0.75 nm for F2. The F1 and F2 preparations had a polydispersity index value below 0.3, so they were homogeneous. The average pH value of F1 is 5.998 ± 0.01, and F2 is 4.798 ± 0.004. The physical stability test showed a difference before and after the sixth day in particle size and pH, but it was still in the range, so it was safe. However, there was a separation in F1 after day 6. Conclusion: Based on the characteristics and physical stability tests, F1 (without alpha-lipoic acid) and F2 (with alpha-lipoic acid) had differences in particle size and pH. From the physical stability test, it can be concluded that F2 is more stable than F1.
WEBINAR UPAYA HILIRISASI PRODUK KOSMETIKA PADA SISWA SMK FARMASI DI SURABAYA Dewi Isadiartuti; Widji Soeratri; Noorma Rosita; I Gusti Ayu Adhi Aryapatni; Suko Hardjono; Tristiana Erawati; Herra Studiawan; Maria Lucia Ardhani Dwi Lestari; Virnanda Syafira Hartatiningrum
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 7 No. 1 (2023): Jurnal Panrita Abdi - Januari 2023
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v7i1.18675

Abstract

Pharmacy Vocational High School (SMK) students are prepared to work immediately after finishing school. Students receive lessons on the basics of pharmaceutical preparation and entrepreneurship. Cosmetics are a pharmaceutical dosage form widely used by the broader community for personal hygiene, appearance improvement, and health functions. The Minister of Health of the Republic of Indonesia No. 1175/Menkes/Per/VIII/2010 concerning cosmetic production permits provides an opportunity for cosmetic products to be produced with simple technology. During the COVID-19 pandemic, which results in a heavy economic burden for the government and society, there are business opportunities for Pharmacy Vocational School students. Community service aims to increase students' knowledge and insight and encourage students in class XI and XII of the Sekesal Pharmacy Vocational School in Surabaya and Kapasari Pharmacy Vocational School in Surabaya to become entrepreneurs in the cosmetics sector. The implementation method is through a webinar that provides material covering products, formulations, stability, and licensing of cosmetic products. Participants had the opportunity to discuss the material provided, fill out evaluations in the form of pre/post-test and make E-posters about cosmetic products. The evaluation results show an increase in participants' knowledge and insight, and participants are interested in producing cosmetic preparations, which are expected to become new business fields that can improve their welfare. --- Siswa Sekolah Menengah Kejuruan (SMK) Farmasi dipersiapkan untuk segera bekerja setelah menamatkan sekolah. Siswa memperoleh pelajaran tentang dasar-dasar pembuatan sediaan farmasi dan kewirausahaan. Kosmetika merupakan salah satu bentuk sediaan farmasi yang banyak digunakan oleh masyarakat luas untuk tujuan kebersihan diri, peningkatan penampilan, dan memiliki fungsi kesehatan. Permenkes RI No 1175/Menkes/Per/VIII/2010 tentang izin produksi kosmetika memberikan peluang produk kosmetika diproduksi dengan teknologi sederhana.  Dalam  masa pandemi covid 19, yang mengakibatkan beban ekonomi berat bagi pemerintah dan masyarakat, terdapat peluang usaha bagi siswa SMK Farmasi. Pengabdian masyarakat bertujuan untuk meningkatkan pengetahuan dan wawasan siswa serta mendorong siswa  kelas XI dan XII SMK Farmasi Sekesal Surabaya dan SMK Farmasi Kapasari Surabaya untuk berwirausaha di bidang kosmetika. Metode pelaksanaan melalui webinar dengan  pemberian materi meliputi produk, formulasi, stabilitas dan perizinan produk kosmetika. Peserta mendapatkan kesempatan berdiskusi tentang materi yang diberikan,  mengerjakan pre/post test, mengisi evaluasi, dan membuat E-poster tentang produk kosmetika. Dari hasil evaluasi diketahui terdapat peningkatan pengetahuan dan wawasan peserta dan peserta tertarik untuk memproduksi sediaan kosmetika yang diharapkan dapat menjadi lahan usaha baru yang dapat meningkatkan kesejahteraannya.
EFEK ASAM ALFA-LIPOAT TERHADAP AKTIVITAS ANTIOKSIDAN NLC EKSTRAK TEH HIJAU DENGAN METODE DPPH Afra, Fairuz Yaumil; Soeratri, Widji; Purwanto, Djoko Agus
JFM (Jurnal Farmasi Malahayati) Vol 7, No 2 (2024)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v7i2.15920

Abstract

Ekstrak teh hijau senyawa yang berperan sebagai antiaging namun memiliki kelarutan yang sangat rendah dalam lipid sehingga dibuat sistem pembawa Nanoparticle Lipid Carrier (NLC). NLC ekstrak teh hijau mengalami fotodegradasi sehingga dilakukan penambahan ko-antioksidan yaitu asam alfa-lipoat. Penelitian ini bertujuan untuk membandingkan efek asam alfa-lipoat terhadap aktivitas antioksidan. Penelitian menggunakan metode eksperimental dengan F1 (tanpa asam alfa-lipoat) , F2 (1%) dan F3 (1,5%). Penelitian dilakukan dengan mengukur nilai penghambatan menggunakan metode DPPH dengan melakukan penyinaran UV sebelum dan sesudah 21 jam. Dari uji analisis statistik didapatkan hasil tidak ada perbedaan bermakna sebelum dan sesudah penyinaran UV selama 21 jam. Nilai persen penghambatan DPPH pada F2 dan F3 lebih tinggi dibandingkan F1. Penambahan asam alfa-lipoat memberikan aktivitas antioksidan lebih tinggi dibandingkan tidak menggunakan asam alfa-lipoat
Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design Setyawan, Dwi; Soeratri, Widji; Nuruddin, Mahrus Naufal; Paramita, Diajeng Putri; Widjaja, Bambang
Jurnal ILMU DASAR Vol 21 No 1 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.483 KB) | DOI: 10.19184/jid.v21i1.10220

Abstract

The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using Minitab® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate. Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.
Characterization and Stability Test of Hydrolyzed Collagen Glyserosomes Safiul Fitria, Nur Indah; Erawati, Tristiana; Miatmoko, Andang; Soeratri, Widji
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.71-79

Abstract

Background: Hydrolyzed collagen is a protein obtained from enzymatic denaturation of collagen with a molecular weight of about 10 kDa, and it has been reported to produce anti-aging properties. Delivering hydrolyzed collagen into the dermis becomes a great challenge due to its large molecular weight, so glycerosome, a deformable vesicle containing glycerol as the edge activator, was developed to carry it into the dermis layer. Objective: The study aimed to determine the effect of increasing the concentration of glycerol and hydrolyzed collagen on the characteristics and stability of hydrolyzed collagen glycerosomes. Methods: Glycerosomes were composed of soy lecithin and prepared using a thin film lipid method. The lipid film was hydrated with phosphate-buffered saline pH 5 containing different glycerol concentrations (20% and 40%) and hydrolyzed collagen (2.5% and 5%). Then, characteristic tests and stability tests were carried out. Results: Hydrolyzed collagen glycerosomes had vesicle sizes of 170-180 nm, polydispersity index of 0.253-0.279, zeta potential values of -23.70 to -26.50 mV with deformability indexes of 2.25-3.49. The highest percentage of entrapment efficiency was 85.72%, achieved with a glycerol concentration of 40%. During the stability test at 25°C for 12 weeks, the hydrolyzed collagen glycerosomes did not experience pH and entrapment efficiency changes, but it increased the vesicle size. Conclusion: The use of 40% glycerol produced more deformable vesicles than 20% glycerol in hydrolyzed collagen glycerosomes; however, a formula improvement is required to improve the stability of glycerosomes.
Co-Authors A'liyatur Rosyidah, M.Si., Ph.D Abdurahman Abdurrahman Abhimata Paramanandana Afra, Fairuz Yaumil Allyssia Salma Anita Natalia Suryawijaya Athiyyah, Wafa'ul Bambang Widjaja Bella Fevi Aristia Cindi Dia Annisa Cita Rosita Sigit Prakoeswa Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Dewi Febiyanti Dewi Isadiartuti DEWI RAHMAWATI Diana Fitrianingrum Djoko Agus Purwanto Dwi Setyawan Dyah Rahmasari Eko Pujiono, Feri Elkania Putri, Safira Epipit Eryka A. Novarinandha Fairuz Yaumil Afra Fedik Abdul Rantam Fransisca Dita Mayangsari Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni Isnaeni Juni Ekowati Kadeq Novita Prajawanti Khoirun Nisyak Luky Hayuning Les Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Maulina Apriani Miatmoko, Andang Nabilla Navyani P.A Ninis Yuliati, Ninis Nisa Qurrota Ayun Noor Ifansyah Noor Ifansyah Noorma Rosita Nugroho, Nadia Paramitha Nuruddin, Mahrus Naufal Nurul Islami Ningtiyas Paramita, Diajeng Putri Pawahid Pawahid Poernomo, A.Toto Purwanto , Djoko Agus Ressa Marisa Retno Sari Ria Hanistya Rina Mutya Suzliana Rohmawati Hidayah Rufaidah Azzahrah Safiul Fitria, Nur Indah Setyo Wiyono, Anang Siswandono Siti Hartini Hamdan Soemiyati Srinalesti Mahanani, Srinalesti Suko Hardjono Suwarno Putra, Adryansyah Tri Widiandani Tristiana Erawati Tristiana Erawati Tristiana Erawati Munandar Tutiek Purwanti Virnanda Syafira Hartatiningrum Yulis Setiya Dewi Zahwa Natasya Novita P. Zhihrotulwida, Dzakiya