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All Journal Jurnal Ilmu Dasar Folia Medica Indonesiana Jurnal NERS UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFM (Jurnal Farmasi Malahayati) Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Inovasi Kesehatan Global Jurnal Sains dan Kesehatan
Widji Soeratri
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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Characterization and Stability Test of Hydrolyzed Collagen Glyserosomes Safiul Fitria, Nur Indah; Erawati, Tristiana; Miatmoko, Andang; Soeratri, Widji
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.71-79

Abstract

Background: Hydrolyzed collagen is a protein obtained from enzymatic denaturation of collagen with a molecular weight of about 10 kDa, and it has been reported to produce anti-aging properties. Delivering hydrolyzed collagen into the dermis becomes a great challenge due to its large molecular weight, so glycerosome, a deformable vesicle containing glycerol as the edge activator, was developed to carry it into the dermis layer. Objective: The study aimed to determine the effect of increasing the concentration of glycerol and hydrolyzed collagen on the characteristics and stability of hydrolyzed collagen glycerosomes. Methods: Glycerosomes were composed of soy lecithin and prepared using a thin film lipid method. The lipid film was hydrated with phosphate-buffered saline pH 5 containing different glycerol concentrations (20% and 40%) and hydrolyzed collagen (2.5% and 5%). Then, characteristic tests and stability tests were carried out. Results: Hydrolyzed collagen glycerosomes had vesicle sizes of 170-180 nm, polydispersity index of 0.253-0.279, zeta potential values of -23.70 to -26.50 mV with deformability indexes of 2.25-3.49. The highest percentage of entrapment efficiency was 85.72%, achieved with a glycerol concentration of 40%. During the stability test at 25°C for 12 weeks, the hydrolyzed collagen glycerosomes did not experience pH and entrapment efficiency changes, but it increased the vesicle size. Conclusion: The use of 40% glycerol produced more deformable vesicles than 20% glycerol in hydrolyzed collagen glycerosomes; however, a formula improvement is required to improve the stability of glycerosomes.
Uji Iritabilitas Sediaan Kombinasi NLC Ekstrak Teh Hijau dan Asam Alfa-Lipoat: Irritability Test of Combination Preparations of NLC Green Tea Extract and Alpha-Lipoic Acid Afra, Fairuz Yaumil; Soeratri, Widji; Purwanto, Djoko Agus
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2425

Abstract

Alpha-lipoic acid as a co-antioxidant can increase the effectiveness of green tea extract as antiaging in the NLC system by increasing stability. This research aims to prove that the preparation of NLC green tea extract with alpha-lipoic acid do not irritate the skin. The method used is making an NLC system using High Shear Homogenization with F1 (without alpha-lipoic acid), F2 (1% alpha-lipoic acid) and F3 (1.5% alpha-lipoic acid) which were tested for irritation in vivo using the back skin of mice. Then observations were made to count the number of inflammatory cells and scoring was carried out. The results obtained were that all formulas had a scoring value of 1 (average number of inflammatory cells 8-15) and were categorized as diffuse inflammatory cells with low density because they were below 50 and the sig value. > 0.05 which means the preparation group is the same as normal. In conclusion, all formulas, both F1, F2 and F3, do not cause irritation. Keywords:          NLC, alpha-lipoic acid, green tea extract, antiaging, irritate   Abstrak Asam alfa-lipoat sebagai ko-antioksidan dapat menambah efektivitas ekstrak teh hijau sebagai antiaging dalam sistem NLC dengan meningkatkan stabilitas. Penelitian ini bertujuan membuktikan sediaan NLC ekstrak teh hijau dengan asam alfa-lipoat tidak iritasi pada kulit. Metode yang digunakan yaitu pembuatan sistem NLC menggunakan High Shear Homogenization dengan F1 (tanpa asam alfa-lipoat) , F2 (1% asam alfa -ipoat) dan F3 ( 1,5% asam alfa-lipoat ) yang diuji iritasi secara in vivo dengan menggunakan kulit punggung mencit. Kemudian dilakukan pengamatan menghitung jumlah sel radang dan dilakukan skoring. Hasil yang didapatkan yaitu pada semua formula memiliki nilai skoring 1 (rata-rata jumlah sel radang 8-15) dan masuk kategori sel radang menyebar dengan kepadatan rendah karena dibawah 50 serta nilai sig. > 0,05 yang berarti kelompok sediaan sama dengan normal. Kesimpulan semua formula baik F1 , F2 dan F3 tidak menimbulkan iritasi. Kata Kunci:         NLC, asam alfa lipoat, ekstrak teh hijau, antiaging, iritasi
Stability and Antiaging Effectiveness Studies of Astaxanthin-Loaded Nanostructured Lipid Carriers Using a Combination of Cetyl Palmitate and Soybean Oil Zhihrotulwida, Dzakiya; Soeratri, Widji; Erawati, Tristiana; Rosita, Noorma
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.473-481

Abstract

Astaxanthin is a potent antioxidant belonging to carotenoid compounds that is mainly produced from green microalgae Haematococcus pluvialis. Astaxanthin is beneficial for skin health as antiaging agent, but has limitations in its delivery through the skin. Astaxanthin could be formulated in nanostructured lipid carriers to improve its efficacy. The purpose of this study was to evaluate the stability and antiaging effectiveness of astaxanthin-loaded nanostructured lipid carriers (ASX-NLCs) with cetyl palmitate and soybean oil as lipid combinations at several ratios of 100:0, 90:10, 80:20, and 70:30. ASX-NLCs were synthesized using a high-shear homogenization technique. ASX-NLCs were characterized and stability evaluated after storage for 90 days. The antiaging effectiveness of ASX-NLCs was evaluated by in vitro release test using dialysis bag for 8 hours, as well as collagen density and fibroblast count evaluation on UV-induced skin aging mice for 28 days. After storage, all ASX-NLCs did not change significantly in organoleptic, pH, and particle size. However, other parameters including polydispersity index, viscosity, and entrapment efficiency experienced significant changes in some formulas. The release test showed that F4 (70:30) gave the highest cumulative release and was significantly different from F1 (100:0). The collagen density of the groups treated with ASX-NLC F3 (80:20) and F4 (70:30) increased significantly compared to the UVB control group, while the fibroblast count did not differ significantly in all groups. Overall, ASX-NLCs containing cetyl palmitate and soybean oil at ratios of 80:20 and 70:30 could improve the antiaging effect of astaxanthin which might be influenced by its better stability and release.
Optimization Using D-Optimal Design of Nanostructured Lipid Carrier (NLC) with Variation of Surfactants and Co-surfactant Athiyyah, Wafa'ul; Soeratri, Widji; Rosita, Noorma; Siti Hartini Hamdan
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.1-14

Abstract

Background: Nanostructured lipid carriers (NLC) are topical delivery systems designed to address the challenges associated with active ingredients, such as poor solubility and limited skin penetration. NLCs incorporate surfactants, such as sorbitan monooleate and lauryl glucoside, to stabilize the system, while the addition of soy lecithin as a co-surfactant further enhances NLC stability. A D-optimal design was employed to optimize the NLC components, ensuring that the formulation achieved the desired characteristics. Objective: To determine the optimal NLC formulation. Method: Optimization was conducted using the D-optimal design method. The NLCs were prepared using the high-shear homogenization method with an Ultra-Turrax device. Characterization included measuring the particle size, polydispersity index (PDI), pH, and creaming index. Results: All formulations resulted in homogeneous emulsions with a white color, slight aroma of castor oil, smooth texture, and thick consistency. The particle sizes ranged from 200 to 500 nm, although the polydispersity index was not significantly influenced by surfactants or co-surfactants. All the formulations maintained an appropriate pH range for skin compatibility and product stability. The %creaming index demonstrated that the co-surfactant effectively reduced creaming in the NLCs. Conclusion: The optimal formulation consisted of 0.284% sorbitan monooleate, 3.429% lauryl glucoside, and 0.287% soy lecithin.
Design and Optimization of Nanostructured Lipid Carriers for Quercetin in Skin Lightening Applications Ressa Marisa; Widji Soeratri; Tristiana Erawati Munandar
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.15-25

Abstract

Background: Quercetin, a potential skin-lightening agent, reduces intracellular and fungal tyrosinase activities. However, its poor water solubility and limited skin permeability hinder its applications. Nanostructured lipid carriers (NLCs), which are composed of biocompatible and biodegradable lipids, enhance drug stability and skin penetration. The lipid type, surfactant concentration, and formulation parameters influence NLC stability. Objective: This study aimed to optimize NLC formulations for quercetin delivery by evaluating their organoleptic properties, particle size, polydispersity index (PDI), and pH.  Methods: NLCs were prepared using 10% total lipids (4% solid and 6% liquid lipids) and surfactant mixtures at varying concentrations via High Shear Homogenization. Initial formulations using myristic acid and castor oil were unstable and underwent phase separation within five days. Results: Substituting the solid lipid with a 1:3 combination of beeswax and cocoa butter produced a stable formulation during storage at room temperature. The lipid and surfactant compositions significantly influenced the particle size and PDI. While the pH remained stable, statistical analysis revealed significant changes in particle size and PDI across the formulations. Conclusion: Optimized NLC formulations for quercetin delivery demonstrated improved stability and potential for effective skin lightening. Further research is warranted to evaluate the in vivo efficacy and scalability of this approach.
Potensi Jintan Hitam (Nigella sativa) sebagai Agen Antibakteri terhadap Bakteri Patogen Klinis Allyssia Salma; Kadeq Novita Prajawanti; Bella Fevi Aristia; Khoirun Nisyak; Widji Soeratri
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.757

Abstract

Antibacterial substances such as thymoquinone, carvacrol, thymol, and p-cymene are found in black cumin (Nigella sativa), a type of herb. This study reviewed 12 recent scientific publications to assess the antibacterial efficacy of N. sativa against clinical pathogenic microorganisms. A comprehensive literature review of in vitro, in silico studies, and applications was conducted. The study found that black cumin extract and oil were more efficient against Gram-positive bacteria such as Staphylococcus aureus than Gram-negative bacteria such as Escherichia coli and Salmonella typhi. The antibacterial activity increased with the concentration of the extract, especially in the polar form (ethanol). Active compounds such as thymoquinone also showed high binding affinity to MRSA bacterial proteins molecularly. The application of N. sativa in the form of ointments, antibacterial textiles, and dental health products also showed good effectiveness. Based on these findings, Nigella sativa has great potential as a safe and environmentally friendly natural antibacterial alternative, although further clinical studies are needed to validate its efficacy and safety.
Uji Efektivitas Sediaan Nanoparticle Lipid Carrier (NLC) Kombinasi Ekstrak Teh Hijau dan Asam Alfa-Lipoat sebagai Antiaging Abdurrahman, Abdurrahman; Afra, Fairuz Yaumil; Soeratri, Widji; Purwanto , Djoko Agus
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.900

Abstract

Background: Alpha-lipoic acid acts as a co-antioxidant that may enhance the effectiveness of green tea extract as an antiaging agent in a Nanostructured Lipid Carrier (NLC) system by improving its entrapment efficiency. This combination is expected to enhance antiaging benefits through increased collagen density and fibroblast proliferation in the skin. Objective: This study aimed to evaluate the effectiveness of an NLC formulation combining green tea extract and alpha-lipoic acid as an antiaging agent. Methods: The NLC system was prepared using the high-shear homogenization method with three formulations: F1 (without alpha-lipoic acid), F2 (1% alpha-lipoic acid), and F3 (1.5% alpha-lipoic acid). The efficacy test was conducted in vivo using mice, with observed parameters including collagen density and fibroblast count in the dorsal skin over 14 days. Results: The results demonstrated that F2 and F3 exhibited significantly higher collagen density and fibroblast counts compared to F1, indicating that the addition of alpha-lipoic acid enhances antiaging efficacy. Conclusion: This study confirms that the NLC formulation combining green tea extract and alpha-lipoic acid effectively increases collagen density and fibroblast proliferation, suggesting its potential as a superior antiaging agent compared to formulations without the co-antioxidant.
Artikel Review : Regulasi Suplemen Kesehatan Dewi Rahmawati; Widji Soeratri; Dewi Febiyanti; Maulina Apriani; Nabilla Navyani P.A; Nurul Islami Ningtiyas; Zahwa Natasya Novita P.
Inovasi Kesehatan Global Vol. 2 No. 1 (2025): Februari : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i1.1313

Abstract

Supplement is a product that contains additional nutrients to complement food, generally containing one or more nutrients, like vitamins, minerals, amino acids, fiber, and fatty acids, are usually prepared in the form of tablets, capsules, or liquids like syrup. Supplements can help improve nutrition, The purpose of this review is to analyze the effectiveness and safety of using health supplements in preventing and overcoming nutritional deficiencies and improving the quality of life of individuals in this analysis is based on a literature review from the online platform used, namely google scholar and semantic. The results of the journal review in this article show that supplements, such as mangosteen effervescent tablets, vitamin C, and stevia, have significant benefits for health, including improving immunity, managing diabetes, and supporting disease recovery. Education and socialization succeeded in improving people's understanding of the wise use of supplements, with age, knowledge, and socioeconomic conditions influencing consumption behavior.
Co-Authors Abdurahman Abdurrahman Abhimata Paramanandana Afra, Fairuz Yaumil Allyssia Salma Anita Natalia Suryawijaya Athiyyah, Wafa'ul Bambang Widjaja Bella Fevi Aristia Cita Rosita Sigit Prakoeswa Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Dewi Febiyanti Dewi Isadiartuti DEWI RAHMAWATI Diana Fitrianingrum Djoko Agus Purwanto Dwi Setyawan Dyah Rahmasari Epipit Eryka A. Novarinandha Fairuz Yaumil Afra Fedik Abdul Rantam Fransisca Dita Mayangsari Herra Studiawan I Gusti Ayu Adhi Aryapatni Isnaeni Kadeq Novita Prajawanti Khoirun Nisyak Luky Hayuning Les Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Maulina Apriani Miatmoko, Andang Nabilla Navyani P.A Nisa Qurrota Ayun Noor Ifansyah Noor Ifansyah Noorma Rosita Nuruddin, Mahrus Naufal Nurul Islami Ningtiyas Paramita, Diajeng Putri Pawahid Pawahid Purwanto , Djoko Agus Ressa Marisa Retno Sari Ria Hanistya Rina Mutya Suzliana Rohmawati Hidayah Rufaidah Azzahrah Safiul Fitria, Nur Indah Siti Hartini Hamdan Soemiyati Srinalesti Mahanani, Srinalesti Suko Hardjono Tristiana Erawati Tristiana Erawati Tristiana Erawati Munandar Tutiek Purwanti Virnanda Syafira Hartatiningrum Yulis Setiya Dewi Zahwa Natasya Novita P. Zhihrotulwida, Dzakiya