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All Journal Jurnal Ilmu Dasar Jurnal NERS UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFM (Jurnal Farmasi Malahayati) Indian Journal of Forensic Medicine & Toxicology Humanism : Jurnal Pengabdian Masyarakat Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Inovasi Kesehatan Global Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Widji Soeratri
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Stability and Antiaging Effectiveness Studies of Astaxanthin-Loaded Nanostructured Lipid Carriers Using a Combination of Cetyl Palmitate and Soybean Oil Zhihrotulwida, Dzakiya; Soeratri, Widji; Erawati, Tristiana; Rosita, Noorma
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.473-481

Abstract

Astaxanthin is a potent antioxidant belonging to carotenoid compounds that is mainly produced from green microalgae Haematococcus pluvialis. Astaxanthin is beneficial for skin health as antiaging agent, but has limitations in its delivery through the skin. Astaxanthin could be formulated in nanostructured lipid carriers to improve its efficacy. The purpose of this study was to evaluate the stability and antiaging effectiveness of astaxanthin-loaded nanostructured lipid carriers (ASX-NLCs) with cetyl palmitate and soybean oil as lipid combinations at several ratios of 100:0, 90:10, 80:20, and 70:30. ASX-NLCs were synthesized using a high-shear homogenization technique. ASX-NLCs were characterized and stability evaluated after storage for 90 days. The antiaging effectiveness of ASX-NLCs was evaluated by in vitro release test using dialysis bag for 8 hours, as well as collagen density and fibroblast count evaluation on UV-induced skin aging mice for 28 days. After storage, all ASX-NLCs did not change significantly in organoleptic, pH, and particle size. However, other parameters including polydispersity index, viscosity, and entrapment efficiency experienced significant changes in some formulas. The release test showed that F4 (70:30) gave the highest cumulative release and was significantly different from F1 (100:0). The collagen density of the groups treated with ASX-NLC F3 (80:20) and F4 (70:30) increased significantly compared to the UVB control group, while the fibroblast count did not differ significantly in all groups. Overall, ASX-NLCs containing cetyl palmitate and soybean oil at ratios of 80:20 and 70:30 could improve the antiaging effect of astaxanthin which might be influenced by its better stability and release.
Uji Efektivitas Sediaan Nanoparticle Lipid Carrier (NLC) Kombinasi Ekstrak Teh Hijau dan Asam Alfa-Lipoat sebagai Antiaging Abdurrahman, Abdurrahman; Afra, Fairuz Yaumil; Soeratri, Widji; Purwanto , Djoko Agus
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.900

Abstract

Background: Alpha-lipoic acid acts as a co-antioxidant that may enhance the effectiveness of green tea extract as an antiaging agent in a Nanostructured Lipid Carrier (NLC) system by improving its entrapment efficiency. This combination is expected to enhance antiaging benefits through increased collagen density and fibroblast proliferation in the skin. Objective: This study aimed to evaluate the effectiveness of an NLC formulation combining green tea extract and alpha-lipoic acid as an antiaging agent. Methods: The NLC system was prepared using the high-shear homogenization method with three formulations: F1 (without alpha-lipoic acid), F2 (1% alpha-lipoic acid), and F3 (1.5% alpha-lipoic acid). The efficacy test was conducted in vivo using mice, with observed parameters including collagen density and fibroblast count in the dorsal skin over 14 days. Results: The results demonstrated that F2 and F3 exhibited significantly higher collagen density and fibroblast counts compared to F1, indicating that the addition of alpha-lipoic acid enhances antiaging efficacy. Conclusion: This study confirms that the NLC formulation combining green tea extract and alpha-lipoic acid effectively increases collagen density and fibroblast proliferation, suggesting its potential as a superior antiaging agent compared to formulations without the co-antioxidant.
Artikel Review : Regulasi Suplemen Kesehatan Dewi Rahmawati; Widji Soeratri; Dewi Febiyanti; Maulina Apriani; Nabilla Navyani P.A; Nurul Islami Ningtiyas; Zahwa Natasya Novita P.
Inovasi Kesehatan Global Vol. 2 No. 1 (2025): Februari : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i1.1313

Abstract

Supplement is a product that contains additional nutrients to complement food, generally containing one or more nutrients, like vitamins, minerals, amino acids, fiber, and fatty acids, are usually prepared in the form of tablets, capsules, or liquids like syrup. Supplements can help improve nutrition, The purpose of this review is to analyze the effectiveness and safety of using health supplements in preventing and overcoming nutritional deficiencies and improving the quality of life of individuals in this analysis is based on a literature review from the online platform used, namely google scholar and semantic. The results of the journal review in this article show that supplements, such as mangosteen effervescent tablets, vitamin C, and stevia, have significant benefits for health, including improving immunity, managing diabetes, and supporting disease recovery. Education and socialization succeeded in improving people's understanding of the wise use of supplements, with age, knowledge, and socioeconomic conditions influencing consumption behavior.
Implementasi Sustainable Development Goals: Upaya Pemberdayaan Pengrajin Tahu Melalui Pengolahan Limbah Industri Tahu Menjadi Nata De Whey Hardjono, Suko; Ekowati, Juni; Widiandani, Tri; Poernomo, A.Toto; Siswandono; Soeratri, Widji; Agil, Mangestuti; Yuliati, Ninis; Setyo Wiyono, Anang; Suwarno Putra, Adryansyah; Elkania Putri, Safira; Eko Pujiono, Feri
Humanism : Jurnal Pengabdian Masyarakat Vol 6 No 2 (2025): Agustus
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v6i2.24123

Abstract

Kelurahan Tinalan,  Kecamatan Pesantren Kota Kediri, yang menjadi sentra produksi tahu oleh masyarakat. Limbah cair tahu yang selama ini dibuang begitu saja, akan dimanfaatkan untuk pembuatan Nata de Whey yang sehat dan enak dimakan. Upaya pemberdayaan pengrajin tahu serta pemanfaatan dan pengolahan limbah industri tahu telah dilakukan oleh para Apoteker di Tinalan Kediri untuk meningkatkan nilai ekonomis limbah tahu. Pada kegiatan pengabdian kepada masyarakat ini telah dikenalkan varian tahu yang lebih beragan serta variasi kemasan yang semakin menarik. Metode pelaksanaan yang dilakukan terdiri dari 3 tahapan, yaitu:1) pemanfaatan limbah cair tahu dengan memberikan ceramah dan pemutaran video pembuatan Nata de Whey; 2) informasi tentang varian produk tahu, pengemasan dan label yang menarik dilakukan melalaui ceramah dan memberikan contoh pengemasan produk tahu; 3) cara pemasaran online dilakukan melalui ceramah kepada para pengrajin. Outcome yang diharapkan dari kegiatan adalah adanya peningkatan pemahaman para pengrajin yang ditandai dengan rata-rata nilai post test 60,05 %. Sedangkan output kegiatan berupa artikel di media massa, foto dan video dokumentasi, modul materi edukasi, serta artikel ilmiah yang terbit di jurnal nasional terindeks ISSN. Dengan meningkatnya pemahaman para pengrajin tahu tentang pemanfaatan dan pengolahan limbah cair tahu menjadi pangan sehat, maka diharapkan Sustainable Development Goals dapat tercapai khususnya kondisi good health and well-being serta partnership for goals di masyarakat.
Effect of Combination Soy Bean Oil and Oleic Acid to Characteristic, Penetration, Physical Stability of Nanostructure Lipid Carrier Resveratrol Soeratri, Widji; Hidayah, Rohmawati; Rosita, Noorma
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Resveratrol is an antioxidant that can be used as anti-aging. Topical use has several problems because solubility in water is low and unstable to light. This study aimed to evaluate the effect of the combination of soy bean oil and oleic acid liquid lipids on the characteristics, penetration, and stability of resveratrol nanostructured lipid carriers (NLC). Nanostructured lipid carriers (NLC) were made with high shear homogeneous technique. To determine the characterization of NLC, diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry were used. Examination of the morphological form was carried out with a transmission electron microscope. The particle size and polydispersity index examination were measured by the Delsa Nanoâ„¢ particle size analyzer, while the efficiency of trapping resveratrol in the NLC system was measured by the dialysis membrane method. Furthermore, the penetration depth test on the skin of mice was done by fluorescence microscope method using rhodamine B markers. Physical stability test was performed by examination of particle size and index polydispersity for 30 days. The formula with liquid soy bean oil and oleic acid liquid lipids improved the characteristics including the effectiveness of entrapment and colloidal stability. However, the formula with soy bean oil and oleic acid combination liquid lipids did not provide better penetration into the skin than the use of single liquid lipids. While the formula with soy bean oil and oleic acid liquid lipids proved to improve the physical stability for 30 days.
Co-Authors Abdurahman Abdurrahman Afra, Fairuz Yaumil Anita Natalia Suryawijaya Bambang Widjaja Cita Rosita Sigit Prakoeswa Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Dewi Febiyanti Dewi Isadiartuti DEWI RAHMAWATI Diana Fitrianingrum Djoko Agus Purwanto Dwi Setyawan Dyah Rahmasari Eko Pujiono, Feri Elkania Putri, Safira Epipit Eryka A. Novarinandha Fairuz Yaumil Afra Fedik Abdul Rantam Fransisca Dita Mayangsari Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni Isnaeni Juni Ekowati Luky Hayuning Les Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Maulina Apriani Nabilla Navyani P.A Ninis Yuliati, Ninis Nisa Qurrota Ayun Noor Ifansyah Noor Ifansyah Noorma Rosita Nuruddin, Mahrus Naufal Nurul Islami Ningtiyas Paramanandana, Abhimata Paramita, Diajeng Putri Pawahid Pawahid Poernomo, A.Toto Retno Sari Ria Hanistya Rina Mutya Suzliana Rohmawati Hidayah Rufaidah Azzahrah Setyo Wiyono, Anang Siswandono Soemiyati Srinalesti Mahanani, Srinalesti Suko Hardjono Suwarno Putra, Adryansyah Tri Widiandani Tristiana Erawati Munandar Tutiek Purwanti Virnanda Syafira Hartatiningrum Yulis Setiya Dewi Zahwa Natasya Novita P. Zhihrotulwida, Dzakiya