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Ni Putu Sriwidyani
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Akurasi Pemeriksaan Potong Beku Dibandingkan dengan Histopatologi untuk Mendiagnosis Tumor Ovarium di RSUP Sanglah Denpasar Ida Ayu, Priandini; Dewi, I Gusti Ayu Sri Mahendra; Winarti, Ni Wayan; Sriwidyani, Ni Putu
E-Jurnal Medika Udayana Vol 12 No 11 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i11.P08

Abstract

Ovarian tumors are gynecological tumors that are difficult to detect because of the variety of symptoms and signs that require a precise and accurate diagnosis. Frozen section examination is a histological examination performed rapidly in intraoperative cases in the diagnosis of ovarian tumors with paraffin block examination as the gold standard. This study aims to assess the accuracy of frozen section compared to histopathological examination of paraffin blocks in diagnosing ovarian tumors in RSUP Sanglah Denpasar. This study is a diagnostic test study with a sample of 62 patients selected by consecutive sampling method. Value of sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated from the sample obtained. On paraffin blocks examination, 36 cases of benign ovarian tumors (benign and borderline neoplasms) and 26 cases of malignant ovarian tumors were found. This study obtained a sensitivity value of 88.5%, specificity 100%, positive predictive value 100%, negative predictive value 92.3%, and frozen section accuracy value 95.2%. Therefore, the frozen section examination is a good diagnostic test tool to be used in the diagnosis of ovarian tumors. Keywords : Paraffin Block, Frozen Section, Ovarian Tumor. Tumor ovarium merupakan tumor ginekologi yang sulit dideteksi karena gejala dan tanda yang beragam sehingga memerlukan cara diagnosis yang tepat dan akurat. Pemeriksaan potong beku merupakan pemeriksaan histologi yang dilakukan secara cepat dalam kasus intraoperatif pada diagnosis tumor ovarium dengan pemeriksaan histopatologi blok parafin yang menjadi standar baku emas. Penelitian bertujuan untuk menilai akurasi dari alat uji diagnostik potong beku dengan pemeriksaan histopatologi blok parafin untuk mendiagnosis tumor ovarium di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitian uji diagnostik dengan jumlah sampel 62 pasien yang dipilih dengan metode consecutive sampling. Pada sampel dihitung nilai sensitivitas, spesifisitas, nilai prediksi positif, nilai prediksi negatif, dan akurasi. Pada pemeriksaan histopatologi blok parafin ditemukan 36 kasus tumor ovarium jinak (neoplasma jinak dan borderline) dan 26 kasus tumor ovarium ganas. Penelitian ini mendapatkan nilai sensitivitas 88,5%, spesifisitas 100%, nilai prediksi positif 100%, nilai prediksi negatif 92,3%, dan nilai akurasi potong beku 95,2%. Berdasarkan hal tersebut, pemeriksaan potong beku merupakan alat uji diagnostik yang baik untuk digunakan dalam penegakan diagnosis tumor ovarium. Kata kunci : Blok Parafin, Potong Beku, Tumor Ovarium.
KARAKTERISTIK KLINIKOPATOLOGI DAN MUTASI EGFR PADA PASIEN KARSINOMA PARU DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR TAHUN 2018-2019 Handoko, Jovi Carina; Dewi, I Gusti Ayu Sri Mahendra; Mahastuti, Ni Made; Sriwidyani, Ni Putu
E-Jurnal Medika Udayana Vol 11 No 2 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i02.P11

Abstract

Karsinoma paru merupakan salah satu jenis karsinoma dengan angka kejadian serta angka kematian cukup tinggi di Indonesia dengan persentase 8,6% dan mortalitas 12,6% dari seluruh kejadian kanker pada tahun 2018. Studi epidemiologi ini dilakukan untuk mempelajari karakteristik pasien kasus karsinoma paru di Rumah Sakit Umum Pusat Sanglah, Denpasar pada tahun 2018-2019. Penelitian ini merupakan penelitian deskriptif observasional dengan desain stufi potong lintang, serta menggunakan data sekunder dari hasil pemeriksaan sitopatologi dan mutasi EGFR pasien karsinoma paru yang terdapat di Laboratorium Patologi Anatomi Rumah Sakit Umum Pusat Sanglah. Variabel yang diteliti adalah usia, jenis kelamin, lateralisasi, tipe sitopatologi, dan mutasi EGFR. Metode total sampling digunakan untuk memperoleh sampel sebanyak 98 sampel. Hasil yang didapatkan berupa kejadian karsinoma paru tertinggi pada rentang usia 50-59 tahun (29,6%), lebih banyak ditemukan pada laki-laki (56,1%), dengan lokasi tersering pada paru dekstra (69,4%). Tipe sitopatologi terbanyak adalah adenokarsinoma (89,8%). Karsinoma paru dengan mutasi EGFR dan tanpa mutasi EGFR ditemukan masing-masing sebanyak 50%. Mutasi EGFR paling sering terjadi pada tipe adenokarsinoma (44,9%). Sementara sisanya terjadi pada tipe karsinoma sel skuamus, adenoskuamus dan NSCLC unclassified yaitu masing-masing sebanyak 1%. Mutasi EGFR paling banyak terjadi pada ekson 19 (31,6%), diikuti oleh ekson 21 (11,2%), ekson 20 (4,1%) dan ekson 18 (3%). Hasil penelitian ini diharapkan dapat digunakan sebagai dasar penelitian dan dikembangkan lebih lanjut untuk membantu mempelajari perkembangan karsinoma paru khususnya di Bali. Kata kunci : Karsinoma Paru, Karakteristik Klinikopatologi, Mutasi EGFR
KARAKTERISTIK KLINIKOPATOLOGI TUMOR SINONASAL DI RSUP SANGLAH PERIODE 2016-2020 Dewi, Ida Ayu Meilasari; Sriwidyani, Ni Putu; Sri Mahendra Dewi, I Gusti Ayu; Winarti, Ni Wayan
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i11.P13

Abstract

Tumor sinonasal merupakan tumor yang melibatkan kavum nasi dan sinus paranasal. Berdasarkan pertumbuhannya dibedakan menjadi tumor jinak dan tumor ganas. Menurut prevalensi, kasus tumor jinak sinonasal jarang terjadi, namun keganasan sinonasal menempati peringkat kedua keganasan kepala leher di Asia. Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi tumor sinonasal di RSUP Sanglah Denpasar pada tahun 2016-2020 berdasarkan usia, jenis kelamin, lokasi tumor, dan tipe histopatologi. Penelitian dilakukan dengan rancangan cross-sectional, menggunakan data sekunder pasien tumor sinonasal yang melakukan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar. Sampel dikumpulkan dengan teknik total sampling, kemudian diolah menggunakan SPSS versi 23. Penelitian mendapatkan 166 kasus tumor sinonasal (jinak dan ganas) yang memenuhi kriteria penelitian. Tumor sinonasal terbanyak terjadi pada rentang usia 51-60 tahun dan 61-70 tahun dengan jumlah masing-masing 41 (24,7%), lebih banyak mengenai laki-laki (65,7%), lokasi tumor tertinggi pada daerah sinonasal (57,2%), dan tipe histopatologi yang paling sering adalah squamous cell carcinoma (22,9%) untuk tumor ganas serta inverted type sinonasal papilloma (18,1%) untuk tumor jinak. Disimpulkan bahwa tumor sinonasal sering terjadi pada usia 51-60 tahun dan 61-70 tahun, jenis kelamin laki-laki, berlokasi di sinonasal, dengan tipe squamous cell carcinoma dan inverted type sinonasal papilloma. Kata kunci : tumor sinonasal, karakteristik klinikopatologi, tipe histopatologi Sinonasal tumours are tumours that occur in the nasal cavity and paranasal sinuses. Based on its growth, classified into benign tumours and malignant tumours. According to prevalence, cases of benign sinonasal tumors are rare, but sinonasal malignancies are the second most common after head and neck malignancy in Asia. The purpose of this study was to determine the clinicopathological characteristics of sinonasal tumors at RSUP Sanglah Denpasar in 2016-2020 based on age, gender, location of the tumour, and histopathological type. The study was conducted with cross-sectional design, using secondary data from sinonasal tumor patients who underwent histopathological examination at the Anatomical Pathology Laboratory, RSUP Sanglah Denpasar Samples were collected by total sampling technique, then processed using SPSS version 23. The study found 166 cases of sinonasal tumours (benign and malignant) that met the research criteria. Sinonasal tumours were most common in the age range of 51-60 years and 61-70 years (24.7%), more common in males (65.7%), the highest tumour location was in the sinonasal (57.2%), and the most common histopathological type was squamous cell carcinoma (22.9%) for malignant tumours and inverted type sinonasal papilloma (18.1%) for benign tumours. It was concluded that most sinonasal tumours occur at the age of 51-60 years and 61-70 years, male gender, located in the sinonasal, with squamous cell carcinoma type and inverted type sinonasal papilloma. Keywords : sinonasal tumour, clinicopathological characteristics, histopathological type
KARAKTERISTIK KLINIKOPATOLOGI PENYAKIT HIRSCHSPRUNG DI RSUP SANGLAH DENPASAR TAHUN 2019-2020 Wilananda, Ida Bagus Ardya Kurnia; Dewi, I Gusti Ayu Sri Mahendra; Winari, Ni Wayan; Sriwidyani, Ni Putu
E-Jurnal Medika Udayana Vol 11 No 11 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i11.P18

Abstract

ABSTRACT Hirschsprung's disease is an abnormal condition of the colon with characteristics of the Meissneri submucosus, myenteric plexus and Aurbachi plexus without parasympathetic ganglion cells. Manifestations of Hirschsprung's disease are seen in the discharge of meconium that does not come out within 24 hours. Then there are signs of obstruction to the gastrointestinal tract, vomiting bile, constipation, and irregular bowel movements. In 2017, 2.5 million children died in the first month of life worldwide. 47% of deaths of children under the age of 5 years occur in newborns, which is about 7,000 deaths. Cases of Hirschsprung's disease itself occur in 1:5000-7000 births, with cases in boys 4 times more than girls. This study aims to determine the clinicopathological characteristics of Hirschsprung's disease at Sanglah Hospital Denpasar in 2019-2020 based on clinical symptoms, age, gender, and location of the aganglionic bowel segment. This study was carried out in 2021 at the Sanglah Hospital Denpasar Anatomical Pathology (PA) installation, using data from the years 2019-2020. It was conducted using a cross-sectional method, with secondary data in the form of patient data available at the Sanglah Hospital Denpasar PA Laboratory, and total sampling. SPSS version 26 was used to analyze the data. The results of this study showed that there were 78 patients with Hirschsprung's disease at Sanglah Hospital Denpasar in 2019-2020 and all of them met the criteria of inclusion. Most cases of Hirschsprung's disease in Sanglah Hospital Denpasar experienced the most flatulence, namely 38 cases with a percentage of 36.5%. Cases were dominated by patients within age of 0-12 months with total of 64 people with 82.1% percentage, and dominated by men as many as 50 people with 64.1% percentage. The aganglionic most frequently found in the rectum as many as 49 people with a percentage of 62.8%. It was concluded from the study result that Hirschsprung's disease patients at Sanglah Hospital in 2019-2020 were mostly male, mostly in the age range 0-12 months, with the most clinical symptoms being flatulence, and the most common aganglionic location found in the rectum. This result may then be used as a basis and also study material for further related research and learning Keywords : Hirschsprung's disease, congenital megacolon, aganglionic, clinicopathological characteristics
Association between Ki67 Index and Clinicopathological Parameters in Breast Cancer Patients in Bali Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Tanaka, Tanaka
JBN (Jurnal Bedah Nasional) Vol 8 No 1 (2024): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2024.v08.i01.p03

Abstract

Aim: To assess the association between Ki67 index and various clinicopathological parameters of breast cancer patients in Bali. Methods: This was a cross-sectional study of breast cancer patients at Prof. Dr. I. G. N. G Ngoerah Hospital, a referral hospital in Bali, from 1 January 2021 to 31 December 2021. Clinicopathology data was taken from SIMARS and archives in the Anatomical Pathology Laboratory. Ki67 index was assessed by immunohistochemical examination, categorized into low (Ki67 index <20%) and high (Ki67 index?20%). Association between Ki67 index with clinicopathological parameters was analysis with X2 test with significance level determined at ?=0.05. Results: There were 75 cases of breast cancer patients with a mean age was 50.74 ± 10.05 years old. Low Ki67 index was found in 9 (12%) cases, while high Ki67 index in 66 (88%) cases. There was a significant association between Ki67 index and histological grade of the tumor (p=0.007), nodal status (p=0.014), and molecular subtype of tumor (p=0.007). There was no significant association between Ki67 index and the patient's age (p=0.268), histological subtype (p=0.086), and T stage (p=0.511). Conclusion: Ki67 index has significant association with histological grade of the tumor, nodal status, and the molecular type of the tumor in breast carcinoma patients in Bali.
NF-κB, neutrophil extracellular traps, and microglial in mice with Streptococcus suis serotype 2 meningitis infection Susilawathi, Ni Made; Adi Tarini, Ni Made; Arijana, I Gusti Kamasan Nyoman; Sriwidyani, Ni Putu; Pramitasuri, Tjokorda Istri; Sudewi, Anak Agung Raka; Mahardika, I Gusti Ngurah Kade
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247394

Abstract

BACKGROUND Streptococcus suis is the most frequent etiology of zoonotic bacterial meningitis, potentially initiating an outbreak. Acute bacterial meningitis caused by S. suis has various manifestations, often accompanied by sepsis with multiple organ involvement. This study aimed to evaluate the pattern of S. suis outgrowth in the brain, which is associated with nuclear factor-κappaB (NF-κB) activation, neutrophil extracellular traps (NETs) release (NETosis), and microglial activation as three crucial pathological mechanisms of bacterial meningitis. METHODS This study used 64 female BALB/c mice aged 6 weeks and weighed 18−20 g, grouped into infected and non-infected as the control group. Both groups were administered 1 ml of S. suis serotype 2 suspension (1 × 107 colony forming-unit/ml) and normal saline intraperitoneally. The bacterial colony count of S. suis was evaluated, along with NF-κB and NET levels in blood and brain, as well as meningeal inflammation and microglial activation in the brain at Days 1, 3, 5, and 7 post-infection. RESULTS The invasion of S. suis into the brain slightly induced NF-κB activation, leading to a burst of inflammatory responses, neutrophil infiltration with NET releases, and microglia activation that co-occurred, showing their peaks on Days 3 and 5 after onset. CONCLUSIONS The S. suis invasion into the mice’s brain increased NF-κB activation, NETosis, and microglia activation during S. suis meningitis infection.
GATA3 Expression in Breast Carcinoma: Associations with Clinicopathological Features Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Sinaga, Naomi Juliana; Dewi, Ni Putu Wulan Tantri
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1183

Abstract

Background: Breast carcinoma is a heterogeneous disease, morphologically and molecularly. GATA binding protein 3 (GATA3) is an important marker in breast cancer origin. GATA3 expression and its prognostic value in breast carcinoma are inconsistent. Tumor budding is a small cluster of malignant cells in the invasive edge of the tumor. Breast carcinoma with highgrade tumor budding has an unfavorable prognosis. The objective of this study was to determine whether there is a relationship between GATA3 expression and clinicopathological parameters in breast carcinoma including with tumor budding grade. Another objective of this study was to determine the association between GATA3 expression and other clinicopathological factors with nodal status. Methods: This was a cross-sectional study involving breast carcinoma patients at Prof. Dr. I.G.N.G Ngoerah Hospital during the year 2022 who underwent mastectomy and axillary node dissection. GATA3 expression was determined by immunohistochemistry and categorized into weak and strong expression. Tumor budding was evaluated in Hematoxylin Eosin slides and categorized into low and high grades. The association between GATA3 expressions and clinicopathological parameters, and the association between GATA3 expression and clinicopathological parameters with nodal status, were assessed with a chi-square test with a significance level determined at p 0.05. Results: There were 61 breast carcinoma patients with mastectomy and axillary node dissection that fulfilled inclusion and exclusion criteria. GATA3 expression was significantly associated with the histological type (p = 0.012) and molecular subtype (p 0.001) of the tumor. There was an association between nodal status and molecular subtype of tumor (p = 0.012), tumor stage (p = 0.005), and tumor budding grade (p = 0.024), but there was no association between GATA3 expression and nodal status (p = 0.066). Conclusion: GATA3 expression is associated with the histological type and molecular subtype of tumor in breast carcinoma, but not with nodal status. Nodal status was associated with molecular subtype, T stage, and tumor budding grade of tumor.
Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Yasa, I Nyoman Wawan Tirtha; Sudarsa, I Wayan; Niryana, I Wayan; Sriwidyani, Ni Putu; Jawi, I Made; Yasa, I Wayan Putu Sutirta; Manuaba, Ida Bagus Tjakra Wibawa; Suryawisesa, Ida Bagus Made
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3680

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
Imunohistokimia S100 Dapat Mengidentifikasi Pola Kerusakan Saraf Tepi Pada Morbus Hansen Tipe Pausibasiler dan Multibasiler Citra, Dandy; Sriwidyani, Ni Putu; Saputra, Herman
Majalah Patologi Indonesia Vol. 34 No. 2 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.605

Abstract

Background Morbus Hansen (MH) is a granulomatous infectious disease of the skin caused by Mycobacterium leprae, which induces skin lesions and peripheral nerve injuries that can cause physical disabilities. The basis of the diagnosis of MH is based on classic clinical signs, characteristic histopathological findings and demonstration of acid-fast bacilli in skin biopsies. However, determining neurovascular involvement in a granulomatous reaction is challenging in pathologic diagnosis. S100, a marker of pheripheral nerve, may aid MH diagnosis. The aim of this study to determine different pattern of S100 immunostaining in paucibacillary and multibacillary type MH. Methods This research was an analytic cross-sectional study. Sample was MH patients who underwent a skin biopsy and was examined for histopathology by routine H&E staining and Ziehl Neelsen (ZN) staining at the Anatomical Pathology Laboratory, Faculty of Medicine, Udayana University/Prof.Dr. I.G.N.G Ngoerah hospital, Denpasar from 2017 to 2022. Clinical information, histopathological examination results and ZN stain data were obtained. Pattern of neurovascular damage was determined by S100 immunohistochemistry and catagorized into intact infiltrated pattern and reduced/fragmented infiltrated patterns. The association between MH type and S100 staining pattern was analyzed by Chi-square test with a significance value of p<0.05. Results The results showed that the staining pattern in paucibaciler type MH was mostly reduced/fragmented infiltrated pattern, meanwhile in multibacillary type MH was mostly intact infiltrated pattern. There was a significant different S100 immunostaining pattern in Paucibaciler and Multibaciler MH (p=0.001). Conclusion S100 immunostaining can identify differences in staining patterns in cases of paucibacillary and multibacillary MH types. S100 may used as aditional testing to determine neurovascular involvement.
High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Wetan, Ni Gusti Ayu Agung Manik Yuniawaty
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1085

Abstract

Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is that they resemble stem cells which are capable of self-renewal, resistance to chemotherapy and radiation, and metastasis. CD90 is a stem cell marker found in several malignancies, including breast carcinoma. The objective of this study was to prove that CD90 can predict the occurrence of axillary nodal metastasis in breast carcinoma. Methods: The study design was a case-control study. The subjects of this study were breast cancer patients at Prof. Dr. I. G. N. G. Ngoerah Hospital who underwent mastectomy and axillary lymphadenectomy in the year 2019. CD90 immunohistochemistry was performed and its association with metastasis, along with various clinicopathological markers, was assessed with chi-square and logistic regression tests with a significance level determined at α=0.05. Results: There were 25 cases of breast carcinoma with axillary nodal metastasis and 25 cases without metastasis. There was a significant relationship between high CD90 expression and the occurrence of nodal metastasis (p=0.010). There was no relationship between patient age, histologic grade, histologic subtype, molecular subtype, and T-stage with axillary nodal metastasis. Breast carcinoma patients with high CD90 expression have a 7.25 times higher nodal metastasis risk compared to patients with low CD90 expression. Conclusion: High CD90 expression could predict axillary nodal metastasis in breast carcinoma.
Co-Authors Anak Agung Ayu Ngurah Susraini Angelia Ongko Prabowo annie minerva datui Astuti, Ida Ayu Jelantik Bintang Dwi Oktaviani Cahyani, Kadek Cindy Dwi Citra, Dandy Damayanti, Ni Kadek Ayu Maya Desak Made Cittarasmi Saraswati Seputra Dewi, Ida Ayu Krisna Cantika Dewi, Ida Ayu Meilasari Dewi, Ni Putu Wulan Tantri Diahningrum, Sylvi Handoko, Jovi Carina Henky, . Herlina Eka Shinta Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Dewa Ayu Inten Primayanti I Gde Raka Widiana I Gede Indradika Pratama Putra I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Sri Mahendra Dewi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Made Cesar Vajrashrava Sunantara I Gusti Ngurah Mayun I Gusti Ngurah Pratama Yuda Atmaja I Gusti Nyoman Sri Wiryawan I Kadek Yana Parastuta I Ketut Bawantika Adi Putra I Made Gotra I Made Jawi I Made Muliarta I MADE MULIARTA . I W. Sudarsa I Wayan Juli Sumadi I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Sugiritama Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu, Priandini Iin Indrayani Maker, Luh Putu Ivana Juliarty Sitanggang Kadek Dwi Pradnyawati Kandy Rosa Ismalia Katrin Rotua Simbolon Ketut Mulyadi Komang Chandra Surya Dika Limantoro, Joshua Lisanthoni, Johnathan Luh Ayu Widayanti Luh Ayu Widayanti Luh Komang Ayu Widhiaty Karang Luh Putu Iin Indrayani Maker Luh Yeni Laksmini M. Arif Perdana Ariyansyah Made Agus Cahya Nugraha Koriawan Maker, Luh Putu Iin Indrayani Manuaba, Ida Bagus Tjakra Wibawa Moestikaningsih . Nariswari, Ida Ayu Ista Nathaniela, Jocelin Ni Gusti Ayu Agung Manik Yuniawaty Wetan Ni Kadek Ayu Maya Damayanti Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Adi Tarini Ni Made Mahastuti Ni Putu Ekawati Ni Wayan Candrawati Ni Wayan Winarti Nornazirah Binti Azizan Popi Imelda Margareth Sitompul Pramitasuri, Tjokorda Istri Putra, Putu Krishna B. S. Putri, Kadek Sri Adi Putu Ayu Widya Pramesti Putu Erika Paskarani Putu Febry Krisna Pertiwi Putu Julia Chandra Devi Raka-Sudewi A. A. Sang Ayu Putu Yuliantini Setiawan, I Gede Budhi Silvia Nuhyil Indriani Sinaga, Naomi Juliana Sri Mahendra Dewi, I Gusti Ayu Suastini, Kadek Denik Sumadi, I Wayan J. Suryawisesa, Ida Bagus Made Susilawathi, Ni Made tanaka, Tanaka Tjandra Kristiana Volman Tampubolon Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wilananda, Ida Bagus Ardya Kurnia Wimpie I Pangkahila Winari, Ni Wayan Yasa, I Nyoman Wawan Tirtha