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All Journal Jurnal Sain Veteriner Jurnal Ilmu dan Kesehatan Hewan Buletin Udayana Mengabdi Jurnal Veteriner Indonesia Medicus Veterinus Jurnal Medik Veteriner Vitek : Bidang Kedokteran Hewan Buletin Veteriner Udayana

I Gusti Ngurah Sudisma

Fakultas Kedokteran Hewan Universitas Udayana Denpasar Bali

Author-ID : 388213

Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Anestesi Infus Gravimetrik Ketamin dan Propofol pada Anjing (THE GRAVIMETRIC INFUSION ANAESTHESIA WITH KETAMINE AND PROPOFOL IN DOGS) I Gusti Ngurah Sudisma; Setyo Widodo; Dondin Sajuthi; Harry Soehartono
Jurnal Veteriner Vol 13 No 2 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.965 KB)

This study aim was to evaluate quality of anaesthesia by using gravimetric infusion anaesthesia withketamine and propofol in dogs. The quality of anaesthesia, duration of actions, and the physiological responsseof anaesthesia were evaluated in twenty domestic dogs. Anaesthesia was induced intramuscularly withatropine (0.03 mg/kg)-xylazine (2 mg/kg) (AX), intravenously ketamine-propofol (KP) (4 mg/kg), andmaintained with continuous intravenous infusion with pre-mixed propofol (P) and normal saline containing2 mg/ml of propofol and 2 mg/ml of ketamine (K). Domestic stray dogs were randomly divided into fivegroups. Groups AXKP-K2P2, AXKP-K4P4, and AXKP-K6P6 were treated with ketamine-propofol the dose0.2 mg/kg/minute, 0.4 and 0.6 mg/kg/minute respectively, while group AXKP-P4 was given propofol 0.4 mg/kg/minute and group AXKP-I was given isoflurane 1-2%. Heart rate (HR), respiratory rate (RR),electrocardiogram (ECG), blood oxygen saturation (SpO2), end tidal CO2 (ET CO2), and capillary refill time(CRT) were measured. No significant difference (P>0.05) found between the groups in anaesthetion times.All groups showed rapid and smooth inductions, prolonged surgical stage, and rapid recovery. Groups AXKPK2P2and AXKP-K4P4 showed minimal physiological effect on the dogs. The HR, RR, ET CO2, SpO2, CRT,and ECG wave were stabl. Combination of AXKP-K6P6 induced SpO2 depression, increased and instabilityof HR, RR and ET CO2. Groups AXKP-P4 showed decreased of HR and respiratory depression. All anaestheticcombinations showed no significant influence (P>0.05) on the electricity of the dog’s heart. The combinationof ketamine-propofol at dose 0.2 and 0.4 mg/kg/minute were found to be better as an application formaintaining anaesthesia by gravimetric continuous intravenous infusion. The method is a suitablealternative for inhalation anaesthesia in dogs.

Anestesi Tetes Infus Gravimetrik Ketapol sebagai Alternatif Bius Umum Secara Inhalasi Guna Menjaga Status Teranestesi pada Babi I Gusti Agung Gde Putra Pemayun; I Gusti Ngurah Sudisma
Jurnal Veteriner Vol 19 No 1 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

This study aim was to evaluate quality and effectiveness of anaesthesia by using gravimetric infusion anaesthesia with ketamine and propofol (ketafol) on pigs. The quality of anesthesia time, the cardiovascular and respiratory response of anaesthesia were evaluated in twelve male pigs with average body weight 35±5 kg. The pigs were divided into four treatments and each treatment consisted of three pigs as repetition. All the experimental animals were premedicated with atropine 0.03 mg/kg mixed with xylazine 2 mg/kg in one syringe injected intramuscularly. Fifteen minutes after premedicated, the pigs was induced intravenously with ketamine 6 mg/kg and propofol 2 mg/kg. Furthermore, the anesthetized state maintaned with gravimetric, each through infusion with propofol (0.1 mg/kg/minute) (PI-P) , ketamine (0.3 mg/kg/ minute) (PIK), combination propofol-ketamin (0.1 and 0.3 mg/kg/minute) (PI-PK), and inhalation with isoflurane 1-2% (PI-I). The heart rate, pulse, respiratory rate, rectal temperature, blood oxygen saturation (SpO2 ), capillary refill time (CRT) were observed before and after treatment of the anesthetic. Premedication combination of atropin 0.03mg/kg mixed with xylazine 2 mg/kg in one syringe and then induced with ketamine 6 mg/kg and propofol 2 mg/kg showed the average length of anesthesia for 32,33 minutes, longer compared to five other treatments with average length of induction three minutes and average recovery time 20.33 minutes. Maintenance of anesthesia with propofol infusion drops (0.1 mg/kg/minute), or propofolketamine infusion drops (0.3 and 0.1 mg/kg/minute) showed safer anesthesia, because they did not make drastic change of heart rate, respiratory rate, rectal temperature, oxygen saturation, pulse, and CRT value in the experimental pigs. The conclusion of this study is the methode of gravimetric intravenous infusion by using ketamine and propofol (ketafol) can be used to maintain anesthesia as an alternative general inhalation anaesthesia in pigs.

Kuning Telur Ayam Kampung Dapat Digunakan Sebagai Emulsifier Minyak Cengkeh untuk Bahan Anestetik pada Ikan Komet Deo Lauda Putra; I Gusti Ngurah Sudisma; I Wayan Wirata
Jurnal Veteriner Vol 22 No 4 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Penelitian ini bertujuan untuk mengetahui efektivitas campuran minyak cengkeh dengan kuning telur ayam kampung sebagai anestetik pada ikan komet (Carassius auratus auratus). Objek penelitian yang digunakan adalah 36 ekor ikan komet, berukuran 10 ± 5 cm, bobot badan 15-25 g, dan diberi pakan pellet. Data pada penelitian ini diperoleh dengan mencatat lama waktu teranestesinya ikan. Hewan coba dibagi menjadi sembilan kelompok perlakuan yaitu: perlakuan I (minyak cengkeh 100 ppm), perlakuan II (minyak cengkeh 100 ppm + etanol 96% 1 mL/L), perlakuan III (minyak cengkeh 100 ppm + kuning telur 0,4 mL/L), perlakuan IV (minyak cengkeh 100 ppm + kuning telur 0,6 mL/L), perlakuan V (minyak cengkeh 100 ppm + kuning telur 0,8 mL/L), perlakuan VI (minyak cengkeh 100 ppm + kuning telur 1 mL/L), perlakuan VII (minyak cengkeh 100 ppm + kuning telur 1,2 mL/L), perlakuan VIII (minyak cengkeh 100 ppm + kuning telur 1,4 mL/L), perlakuan IX (minyak cengkeh 100 ppm + kuning telur 1,6 mL/L). Masing-masing perlakukan dilakukan pengulangan sebanyak empat kali. Data yang diperoleh dianalisis dengan sidik ragam dan dilanjutkan dengan uji jarak berganda Duncan. Berdasarkan hasil penelitian diperoleh bahwa masing-masing kelompok perlakuan menunjukkan waktu induksi berbeda nyata (P<0,05) sedangkan waktu durasi dan waktu pemulihan tidak berbeda nyata (P>0,05). Induksi anestesi pada ikan komet dengan waktu induksi tercepat adalah 3,05 ± 0,32 menit menggunakan kombinasi minyak cengkeh 100 ppm + kuning telur 1,6 mL/L.

Respons Fisiologis Babi Bali Terhadap Anestetik Ketamin dan Propofol I Gusti Agung Gde Putra Pemayun; I Gusti Ngurah Sudisma
Jurnal Veteriner Vol 23 No 1 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

ABSTRAKAnestesi merupakan tahapan yang sangat penting sebelum dilakukan tindakan pembedahan. Anestesi ketamin dan propofol sering digunakan sebagai agen induksi pada manusia maupun hewan kesayangan. Tujuan penelitian ini adalah untuk mengetahui waktu induksi, durasi anestesi, waktu pemulihan dan respons fisiologis babi bali terhadap anestesi ketamin, propofol dan kombinasi ketamin-propofol (ketafol). Digunakan 12 ekor babi bali, bobot 22-27 kg, umur 2,5-3,0 bulan, dan jenis kelamin jantan. Alat fisiograf digunakan untuk pemantauan perubahan fisiologis pada sistem kardiovaskuler, respirasi dan suhu tubuh. Babi dipremedikasi dengan atropin sulfat (0,02 mg/kg bb) dan xilazin (2 mg/kg bb) secara intramuskuler, 20 menit kemudian diinduksi dengan ketamin (4 mg/kg bb), propofol (1,5 mg/ kg bb) dan kombinasi ketamin- propofol (2 dan 0,75 mg/kg bb) secara intravena. Babi yang diinduksi ketamin menghasilkan waktu induksi 1,87±0,41 menit, durasi anestesi 13,00±2,55 menit, dan waktu pemulihan 14,25±3,77 menit, yang diinduksi propofol menghasilkan waktu induksi 2,75±0,56 menit, durasi anestesi 19,25±3,77 menit dan waktu pemulihan 7,50±1,80 menit, sedangkan yang diinduksi ketafol menghasilkan waktu induksi 2,25±0,56 menit, durasi anestesi 25,50±3,64 menit dan waktu pemulihan 8,50±1,66 menit. Babi yang diinduksi ketamin, propofol dan ketafol menunjukkan waktu induksi yang tidak berbeda nyata, tetapi durasi anestesi dengan ketapol nyata lebih lama dibandingkan dengan ketamin atau propofol dan waktu pemulihan tidak berbeda nyata dengan propofol tetapi sangat nyata lebih singkat dibandingkan dengan ketamin. Anestesi dengan ketafol menghasilkan durasi anestesi yang nyata lebih lama dan waktu pemulihan yang sangat nyata lebih cepat, tidak ditemukan perubahan yang ekstrim terhadap respon fisiologis pada sistem kardiovaskuler dan respirasi selama babi bali teranestesi.

Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats Saputra, Made Gede Adi Surya; Sudira, I Wayan; Samsuri, Samsuri; Merdana, I Made; Dharmayudha, Anak Agung Gde Oka; Sudisma, I Gusti Ngurah
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.216-229

Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fixed Doses Procedure. Based on the Globally Harmonized System compared to this study reported that acute dermal median lethal dose (LD50) was > 2000 mg/kg. It can be concluded that hibiscus leaves simplicial ointment 40% has safe to apply topically and doesn't produce acute skin toxicity.

Uji Fitokimia Terhadap Ekstrak Etanol 70% Dan Ekstrak Air Bunga Kecubung (Datura metel L.) Yang Berpotensi Sebagai Bahan Anestesi Sudira, I Wayan; Samsuri, Samsuri Samsuri; Sudisma, I Gusti Ngurah; Diana, Kadek Leni Martha
Jurnal Sain Veteriner Vol 42, No 3 (2024): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.74161

Anestesi umum dapat didefinisikan sebagai suatu depresi dari sistem saraf pusat (SSP) yang menyeluruh akan tetapi bersifat reversible, yang mengakibatkan hilangnya respon dan persepsi terhadap semua rangsang dari luar. Salah satu agen baru yang berpotensi sebagai bahan anestesi adalah tumbuhan kecubung (Datura metel L.). Penelitian ini bertujuan untuk mengetahui kandungan senyawa kimia yang terkandung dalam ekstrak etanol 70% dan ekstrak air bunga kecubung (Datura metel L.) melalui uji fitokimia dan mengetahui kandungan senyawa kimia yang berpotensi sebagai bahan anestesi. Sampel penelitian berupa bunga kecubung didapat dari daerah Danau Tamblingan, Munduk, Kabupaten Buleleng, Bali yang diekstraksi menggunakan pelarut etanol 70% dan pelarut air dengan menggunakan metode maserasi. Hasil penelitian menunjukkan ekstrak etanol 70% dan ekstrak air bunga kecubung (Datura metel L.) dengan uji fitokimia positif mengandung senyawa alkaloid, saponin, tanin, fenolat, dan flavonoid namun negatif mengandung triterpenoid/steroid serta mengandung senyawa kimia yang berpotensi sebagai bahan anestesi yaitu alkaloid, saponin, tanin, fenolat, dan flavonoid

LAPORAN KASUS: CUTANEOUS LIPOMA PADA ANJING RAS LOKAL Prasetyo, Catur; Gorda, I Wayan; Sudisma, I Gusti Ngurah
VITEK : Bidang Kedokteran Hewan Vol. 15 No. 1 (2025): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v15i1.304

Cutaneous lipoma is a benign tumor of fatty tissue, whose presence is generally not dangerous but can cause discomfort or be aesthetically disturbing. The purpose of this case report is to outline how to diagnose and treat cases of cutaneous lipoma in dogs. The case presented involves an 8-month-old female local dog with predominantly black fur and white markings, which was diagnosed with a cutaneous lipoma. The chosen treatment method was surgery to remove the fatty mass from the cutaneous tissue of the caudal abdominal region. Before surgery, the dog received premedication with atropine sulfate subcutaneously, and anesthesia was administered using xylazine and ketamine intramuscularly, given separately. The operation to remove the tumor involved making incisions through the skin and subcutaneous tissue. The wound was closed using a continuous suture pattern with absorbable PGA 3.0 sutures for both the subcutaneous layer and the skin. Post-operative treatment included regular cleaning of the wound area with 0.9% NaCl, application of antibiotic powder, and oral administration of cefixime trihydrate and meloxicam for five days. A week after surgery, the dog showed signs of recovery based on physical and clinical evaluations.

MACROSCOPIC ANALYSIS OF INCISION WOUND HEALING IN WHITE RATS TREATED WITH PLATELET-RICH PLASMA DERIVED FROM PORCINE BLOOD Made Sandy Widhi Raharja; I Wayan Wirata; Anak Agung Sagung Kendran; I Gusti Ngurah Sudisma; I Wayan Gorda; I Ketut Berata
Buletin Veteriner Udayana Bul. Vet. Udayana. April 2025 Vol. 17 No. 2
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i02.p10

Platelet-rich plasma (PRP) has been identified as a potential therapeutic agent to mitigate factors that impede healing. PRP, which is enriched with growth factors, plays a critical role in accelerating tissue regeneration across various stages of wound repair. This study aimed to investigate the effects of PRP derived from porcine blood on the healing of incisional wounds in white rats (Rattus norvegicus). Macroscopic parameters, including wound length, wound color, moisture levels, and crust formation, were evaluated. The study employed an experimental design, utilizing a split-time completely randomized design (CRD) with statistical analysis. The results demonstrated significant improvements in wound closure, as evidenced by reduced wound length, accelerated changes in wound color, maintained wound moisture leading to faster drying, and enhanced crust formation, all of which contributed to a reduction in wound size (P < 0.05). These findings indicate that PRP derived from porcine blood significantly accelerates the healing process of incisional wounds in white rats, as reflected by macroscopic healing indicators. Further research is recommended to determine the optimal shelf life of PRP to ensure its efficacy and stability during prolonged storage, thereby supporting its sustainable clinical application.

Co-Authors A.A.G.J. Wardita Aida Lousie Tenden Rompis An'nisafitri Lutviana Anak Agung Gde Jaya Wardhita, Anak Agung Gde Jaya Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Anak Agung Sagung Kendran Bendelin Melda Loekali Deo Lauda Putra Diana, Kadek Leni Martha Dondin Sajuthi DWI SURYANTO Erika Erika Grace Tabitha Tenggi Olihta Simatupang Gunanti . I Gede Soma I Gusti Agung Arta Putra I Gusti Agung Ayu Suartini I Gusti Agung Gede Putra Pemayun I Gusti Made Krisna Erawan I K. SUATHA I Ketut Anom Dada I Ketut Berata I Ketut Suada I Made Agus Adnyana I Made Merdana I Made Sukada i Nengah Wandia I NYOMAN MANTIK ASTAWA I Nyoman Suarsana I Nyoman Suartha I Nyoman Sulabda I Putu Gede Yudhi Arjentinia I Putu Juli Sukariada I Wayan Gorda I Wayan Gorda I Wayan Suardana I Wayan Sudira I Wayan Wirata I Wayan Wirata I.G.A.G.P. Pemayun I.H. Utama I.K.A. Dada I.W. Batan I.W. Gorda Ida Bagus Komang Ardana Ida Bagus Ngurah Swacita Kadek Karang Agustina Luh Dewi Anggreni Luh Komang Ayu Puteri Priharyanthi Luh Made Sudimartini M.D. Rudyanto Made Gede Adi Surya Saputra Made Sandy Widhi Raharja Marliani, Ni Kadek Mokhamad Fakhrul Ulum, Mokhamad Monica, Mia Nur Liliana Putri Prihatiningsih Prasetyo, Catur Putra, I Gede Putu Alit Anggara Putu Ayu Sisyawati Putriningsih Rahmiati, Nur Ilmi Riki Siswandi Rosita, Indah Rosni Lumban Gaol Rozalina, Irma Samsuri Samsuri Samsuri, Samsuri Samsuri Samuel, Josia Sasmita, Debbie Aprillia Yona Setyo Widodo Sholichah, Sholichah Sukma, Ni Ketut Ayu Mega Sultan, Nurul Fadillah T. Sari Nindia Tjokorda Sari Nindhia Vivi Indrawati

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