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All Journal Jurnal Hukum Khaira Ummah Cakrawala Pendidikan Jurnal Kependidikan: Penelitian Inovasi Pembelajaran Jurnal Penelitian dan Evaluasi Pendidikan Pedagogi: Jurnal Ilmu Pendidikan J-Simbol: Jurnal Magister Pendidikan Bahasa dan Sastra Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Kesehatan Information Management For Educators And Professionals (IMBI) Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Lentera: Jurnal Ilmiah Kependidikan KEUDA : JURNAL KAJIAN EKONOMI DAN KEUANGAN DAERAH Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan JURNAL PANGAN Agritech: Jurnal Fakultas Pertanian Universitas Muhammadiyah Purwokerto Faktor Jurnal Ilmiah Kependidikan Jurnal Doktor Manajemen (JDM) BioEksakta : Jurnal Ilmiah Biologi Unsoed Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Triton Borobudur EKONOMIKA45 Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal An-Nufus VIGOR: JURNAL ILMU PERTANIAN TROPIKA DAN SUBTROPIKA Journal of Social Empowerment Widyaparwa Scholarly Journal of Elementary School CKI On Spot Jurnal Teknologi Industri Jurnal Pedagogi Matematika JIIS Journal of Fundamental Management (JFM) International Journal of Education, Vocational and Social Science Jurnal Penelitian Pendidikan

Sugiyono Sugiyono

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Author-ID : 388997

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FORMULASI TABLET HISAP EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz & Pav.) DENGAN PEMANIS SORBITOL-LAKTOSA-ASPARTAM Akhmad Jazuli; Yulias Ninik Windriyati; Sugiyono Sugiyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Sirih merah (Piper crocotum Ruiz & Pav.) adalah salah satu tanaman obat yang biasa digunakan untuk mengobati penyakit diantaranya batuk. Untuk memudahkan penggunaan maka dibuat dalam bentuk sediaan tablet hisap. Penelitian ini bertujuan untuk mengetahui sifat fisik tablet hisap ekstrak etanol daun sirih merah dengan pemanis sorbitol-laktosa-aspartam dan respon rasanya. Ekstrak daun sirih merah diperoleh secara perkolasi dengan penyari etanol 70%. Tablet hisap dibuat dengan metode granulasi basah dengan 5 formula yang mengandung pemanis sorbitol-laktosa sebagai fase internal yakni : FI (0%-82%), F II (20,5%-61,5%), F III (41%-41%), F IV (61,5%-20,5%), F V (82%-0%) dan aspartam sebagai fase eksternal sebanyak 10%. Granul diuji sifat fisiknya meliputi kecepatan alir, sudut diam, dan kompresibilitas. Tablet hisap diuji sifat fisiknya meliputi keseragaman bobot, kekerasan, kerapuhan, waktu melarut dan uji tanggapan rasa. Data tersebut dibandingkan dengan Farmakope Indonesia dan pustaka lainnya. Selain itu data sifat fisik tablet dianalisis secara statistik menggunakan uji Kruskal Wallis, dilanjutkan uji Mann Whitney dengan taraf kepercayaan 95%. Uji tanggapan rasa dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa penggunaan pemanis sorbitol-laktosa-aspartam menghasilkan tablet hisap yang memenuhi persyaratan sifat fisik tablet. Formula V dengan sorbitol-laktosa (82%-0%) dan aspartam 10% dapat diterima oleh 90% responden. Kata kunci : Ekstrak Etanol Daun Sirih Merah, Sorbitol-laktosa-aspartam, Tablet hisap,.

PERBANDINGAN DISOLUSI ASAM MEFENAMAT DALAM SISTEM DISPERSI PADAT DENGAN PEG 6000 DAN PVP yulias ninik; sugiyono sugiyono; widhi astuti; maria faizatul
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Mefenamic acid is an analgetic that insoluble in water, therefore several approaches are required to improve the dissolution and bioavailability. The aim of this research is to know the dissolution of mefenamic acid in solid dispersion system with PEG 6000 and PVP. Solid dispersion of mefenamic acid-PEG 6000 were prepared by fusion method and mefenamic acid-PVP by solvent evaporation method with contain PEG 6000 or PVP for FI (20%), FII (40%), FIII(60%), FIV (80%) and FV (100%) respectively were compared with the weight of mefenamic acid. The powder of solid dispersion systems were investigated for its recovery and dissolution in medium fosfat buffer pH 7.4 until 60 minutes. Pure mefenamic acid and the physical mixture with polimer were used as compared powders. The result of dissolution testing were revealed by Dissolution Efficiency (DE60). The result showed that both PEG 6000 and PVP can increased the dissolution of mefenamic acid from solid dispersion systems. The DE60 of mefenamic acid-PEG 6000 from FI 38,81%; FII 51,05%; FIII 62,87%; FIV 75,63%; FV 87,03%; and the physical mixture of FV 58,84% respectively. Meanwhile the DE60 mefenamic acid-PVP from FI 26,76%; FII 37,78%; FIII 45,23%; FIV 62,41%; FV 82,71%; and the physical mixture of FV 26,44% respectively. Keywords : mefenamic acid, PEG 6000, PVP, solid dispersion, dissolution

PENGARUH VARIASI KADAR GETAH SAGU (Metroxylon sagus Rottb) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN PELEPASAN TABLET DEXAMETHASON sugiyono sugiyono; Irawan Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Sago resin is the exudat from the plant sago (Metroxylon sagus Rottb.) from of gels and substances classified as anionic polysaccharides, colloidal nature with consistency and power of adhesive material resembling, it can be used as a binder tablets. This study aims to determine the effect of differences levels of sago resin variation as the ingredient binder dexamethason tablet the physical properties and release. Sago resin comes from the plant of sago then filtered (cleaned of impurities), blended into a fine powder to the next level with mucilago made FI (1%); FII (3%); FIII (5%); FIV (7%) and FV (10%). The sago resin mucilago is used a binder in the manufacture of granule with wet granulation method. The physical properties tested of the granule include flow time, repose of angle and compresibility. Tablets obtained its physical an chemical properties of the tested include uniformity of weight, hardness, friability, disintegration time, disolution and determination of concentration the active substances. The data obtained analyzed by comparing the theoretical approach with the relevant literature and statistically analyzed using corellation regretion alalyzed with a level of 95% The results obtained showed that the granules and tablets of all formulas meet the requirements of physical and chemical properties of a good tablet. The addition concentration of the sago resin as a binder causes the tablet hardness and disintegration time there is a significant difference between the formulas, while the release of the active substance and content uniformity tablets is not influenced by the increase in the concentration of sago resin. Keywords: Sap Sago, Wet Granulation, Dexamethason Tablet

PENGARUH VARIASI KADAR AMILUM GARUT (Maranta arundinaceae Linn) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN KIMIA TABLET PARASETAMOL Sugiyono Sugiyono; Pipit Murdiyani; Yulias Ninik Windriyati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Starch had a characteristic that could be used as a binder. Arrowroot starch containing amylose and amylopectin which could be used as a binder. Paracetamol had the flow properties and compactibility badly, it was necessary to make granules by wet granulation method (Voigt, 1984). This study aimed to determine the influence of variations in levels of arrowroot starch as a binder to the physical and chemical properties of paracetamol tablets. This research was conducted by mixing paracetamol with mucilago amylum arrowroot (FI: 5%, FII: 7.5%, FIII: 10%, FIV: 12.5%, and FV: 15%) and were given lactose, sifted, and dried. Granules sifted back, plus primogel and magnesium stearate. Mixed granules tested flow rate, rupose angle and tapping index . The granules was then into tablet and then their physical properties were observed, including weight uniformity, hardness, brittleness, and dissolving time.The active substance content was decided based on Farmakope Indonesia Edisi III. The data gathered were then analyzed theoretically by comparing then against what were stated in the literature and statistic cally tested by using one way ANAVA with a confidence degree of 95%, which was then furthered by using the Tuckey test. The result that the starch contained in the arrowroot could be used as a paracetamol tablet binder. Tablets of all formulas met the requirements of a good tablet physical properties. Hardness and tablet disintegration time increased with increasing levels of arrowroot starch as binder, while the fragility of the tablet decreased. Key words: arrowroot amylum, binder, Tablet parasetamol

ANALISIS KANDUNGAN BORAKS SEBAGAI BORON PADA GENDAR YANG DIPRODUKSI OLEH INDUSTRI RUMAH TANGGA DI DAERAH AMBARAWA sugiyono sugiyono; siti musinah; rukhanah rukhanah
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTGendar is a type of food produced by adding bleng, which is a chemical compound containing borax asboros. This research was intended to find out (1) the borax contents in the gendar taken from Ambarawa areas and(2) whether there were significant differences in borax levels contained in fresh gendar, dry gendar, gendar fried infresh vegetable oil and gendar fried in used vegetable oil.This was a non-experimental research with the data analyzed descriptively and analytically. The variablesmeasured were borax levels, acting is boros, contained in fresh gendar, dry gendar, gendar fried in fresh vegetableoil and gendar fried in used vegetable oil. The samples for this research were taken randomly from three householdindustried of gendar in Ambarawa areas. The contents of borax were measured using spectrophotometri UV-Vis.The analyses on the borax content in the four types of gendars (fresh gendar, dry gendar, gendar fried in freshvegetable oil and gendar fried in used vegetable oil) used Kruskall-Wallis non-parametric statistical tests followedby Mann-Whitney tests.The analyses showed that all of the four types of gendars really contained borax, as boros, but in diffirentlevels among the diffirent gendars borax contents in the four different gendars taken from Bandungan andSumowono had significant values 0,182 and 0,643 respectively (P > 0,05), contents in the four different gendarstaken from Ambarawa areas also had a significant value of 0,004 (P < 0,05), meaning also that there werestatistically significant differences in the borax contents.Keywords : Borax, Gendar, Spectrophotometri UV-Vis.

PENGARUH PENGGUNAAN AMILUM BIJI DURIAN (Durio Zibethinus L.) SEBAGAI BAHAN PENGHANCUR YANG DITAMBAHKAN SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN KIMIA TABLET IBUPROFEN Sugiyono Sugiyono; Hilda Shofia Afriliana; Yulias Ninik Windriati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keyword : durian seeds amylum, disintegrant, ibuprofen tablets. Amylum is a polysaccharide inside plant that was saved as a food reserves in fruit seed. One of the amylum contents is amylose, essentially insoluble in cold water but can absorb large amount of water and expand, so it can be used as a disintegrant of tablets. The aim of this research is to find out the influence of the used of durian seeds amylum as a disintegrant that be added internally-externally toward the physical and chemical properties of ibuprofen tablets.Ibuprofen tablets were prepared by wet granulation method, with levels of amylum as a disintegrant were 10% which added the intragranular-extragranular with a ratio of FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), FV (0%:100%). Dried granules obtained were then tested its physical properties include flow rate, angle of repose, and compressibility. Tablets were tested in terms of physical and chemical tablets properties include weight uniformity, hardness, friability, disintegration time and active substance content of tablets. Data obtained were analyzed with a theoretical approach that is done by comparing the statistical literature and that is one way ANAVA analysis with 95% confidence level, followed by a Tuckey test.The result obtained shows that all formulation complied with the requirement of good physical and chemical properties of tablet. The added of durian seeds amylum as a tablets disintegrant with internally-externally method causes difference the physical properties of disintegration time ibuprofen tablets in significant, while at hardness and friability there is no difference in significant.

FORMULASI TABLET HISAP EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz & Pav.) DENGAN PEMANIS SUKROSA-LAKTOSA-ASPARTAM M.Fatchur Rochman; Yulias Ninik Windriyati; Sugiyono Sugiyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Sirih merah (Piper crocotum Ruiz & Pav.) merupakan salah satu tanaman yang dapat digunakan sebagai obat batuk, mempunyai rasa yang sangat pahit dan biasa digunakan dalam sediaan rebusan. Tablet hisap ekstrak etanol daun sirih merah merupakan sediaan yang lebih praktis, absorbsinya cepat dan mengandung bahan pemanis untuk menutupi rasa pahit dari sirih merah. Tujuan penelitian ini untuk mengetahui sifat fisik tablet hisap estrak etanol daun sirih merah dengan pemanis sukrosa-laktosa-aspartam dan tanggapan responden pada tablet hisap tersebut. Ekstrak dibuat secara perkolasi dengan etanol 70%. Tablet hisap ekstrak etanol daun sirih merah dibuat dalam 5 formula dengan pemanis sukrosa-laktosa pada fase internal (FI tanpa sukrosa, FII 20,5%, FIII 41%, FIV 61,5%, FV 82%) dan aspartam pada fase eksternal 10% secara granulasi basah. Granul diuji sifat fisiknya meliputi kecepatan alir, sudut diam, dan kompresibilitas. Tablet hisap diuji sifat fisiknya meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu melarut, selain itu dilakukan uji tanggapan rasa. Data yang diperoleh dianalisis dengan persyaratan dalam literatur serta dianalisis secara statistik. Hasil tanggap rasa dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa penggunaan pemanis sukrosa-laktosa-aspartam menghasilkan tablet hisap yang memenuhi persyaratan meliputi kekerasan, kerapuhan dan waktu melarut tablet. Formula IV dengan sukrosa-aspartam(61,5%:20,5%:10%) dapat diterima oleh 85% responden. Kata kunci : ekstrak etanol daun sirih merah, sukrosa-laktosa-aspartam, tablet hisap

DISOLUSI ASAM MEFENAMAT DALAM SISTEM DISPERSI PADAT DENGAN PEG 4000 Yulias Ninik Windriyati; Sugiyono Sugiyono; Lies Sunarliawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTMefenamic acid is an analgetic that insoluble in water and classified into class II in theBiopharmaceutic Classification System (BCS), therefore the dissolution become the rate limitingstep of absorption process and bioavailability. Several approaches are required to improve thedissolution like preparation of solid dispersion. The aim of this research is to know the dissolutionof mefenamic acid in solid dispersion system with PEG 4000.Solid dispersion of mefenamic acid-PEG 4000 were prepared by fusion method withcontain PEG 4000 for FI (20%), FII (40%), FIII(60%), FIV (80%) and FV (100%) respectivelywere compared with the weight of mefenamic acid. The powder of solid dispersion systems wereinvestigated for its recovery and dissolution in medium fosfat buffer pH 7.4 until 60 minutes. Puremefenamic acid and the physical mixture with polimer were used as compared powders. Theresult of dissolution testing were revealed by Dissolution Efficiency (DE60)The result showed that PEG 4000 can increased the dissolution of mefenamic acid fromsolid dispersion systems. The DE60 of mefenamic acid-PEG 4000 from FI 30,41%; FII 30,60%;FIII 36,19%; FIV 36,42%; FV 41,92%; and the physical mixture of FV 23,63% respectively. Thevariations of concentration of PEG 4000 in this solid dispersion not influence the dissolution ofmefenamic acidKeywords : Mefenamic acid, PEG 6000, PVP, solid dispersion, dissolution

Co-Authors Abdul Rokhman Abdul Rolhim Achmad Noe'man Adolf Z. D. Siahay Afid Burhanuddin Agoes Hendriyanto Agustin Hanivia Cindy Akhmad Jazuli Alifya Asmiasti Anggun Novita Sihite Ani Kusniawati Areha Binar Febrinesa Arief Prabowo Brainadi Widjojo Arpi Pratama Bambang Hariyanto Bambang Haryanto Diah Hapsari Widyarini Diini Fitriani Doni Ahmad Saefuddin Dwi Susilo Rini Eka Danik Prahastiwi Eko Hari Purnomo Elvira Syamsir Endang Mulyati Ningsih Endang Prangdimurti Eny Ariyanto Etrya Narawati Fashihullisan M. Fitriani Fitriani Ghosa Kurnia Fistika Hadi Nugroho Hidayatul Istiqomah Hilda Shofia Afriliana Hoerip Satyagraha Husaini Usman I Gusti Putu Adi Palguna Irawan Sukma Ismiarti Ismiarti Isnaeni, Diyan Johan Oscar Ong Joko Sutrisno Kamsinah Kamsinah Khaerul Wahidin Khoirul Qudsiyah Kristiyanto, Yogi Lia Yulianasari Lies Sunarliawati Lina Erviana Lucky Prayoga Lutfia Afifatul Ainiyah Lutfia Afifatul Ainiyah M Fashihullisan M Fatchur Rochman maria faizatul Masyudzulhak Djamil MZ Mira Suminar Muhamad Solkhan Muhammad Gustriama MUHAMMAD ILHAM Muhammad Solehfuddin Mukodi Mukodi Mukodi Mukodi Mulyanto Widodo Muryan Awaludin Ngabdul Munif Niken Larasati Niva Argista Niva Argista Nurman Susilo Pipit Murdiyani Ramlan Asbar Rendie Prasetyo Retno Andhita Ananda Rio Octogi Siregar Rokhani Hasbullah rukhanah rukhanah Sari Rudijati Simson Werimon Siti Musinah Siti Samiyarsih Sri Amini SUMPENA SUMPENA Teguh Dwi Putra Tri Wahyuningsih triani hardiyati Umar Ma’ruf Vit Ardhyantama Widhi Astuti Windi Asterini Wisnu Sasangka Wiwiek Joelijani Wiwik Joelijani Yulias Ninik Windriati

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Journal : Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)