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All Journal Journal of Educational, Health and Community Psychology Journal of Biomedicine and Translational Research AlphaMath: Journal of Mathematics Education Biomedical Journal of Indonesia Manuju : Malahayati Nursing Journal Majalah Patologi Indonesia JURNAL AKUNTANSI KEUANGAN DAN MANAJEMEN Jurnal Ilmiah Wahana Pendidikan Journal of Community Development Jurnal Abdi Masyarakat Indonesia GANESHA MEDICINA Makara Journal of Science Jurnal Pijar : Studi Manajemen dan Bisnis Jurnal Fisioterapi dan Kesehatan Indonesia Innovative: Journal Of Social Science Research Riset Informasi Kesehatan Jurnal Penyakit Dalam Indonesia Indonesian Journal of Agricultural, Resource and Environmental Economics Metathesis: Journal of English Language, Literature, and Teaching Policy Brief Pertanian, Kelautan, dan Biosains Tropika Journal of Business Application Observasi: Jurnal Publikasi Ilmu Psikologi Journal of Career and Entrepreneurship International Health Sciences Journal Afeksi: Jurnal Psikologi Kajian Ilmiah Mahasiswa Administrasi Publik (KIMAP) CJPP
Dewi Sukmawati
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Biomedical Journal of Indonesia

 1 
Innate and Adaptive Immune Components in Human Breast Milk and Their Role in Early-Life Immunity Salsabila, Hanum; Sukmawati, Dewi; Iswanti, Febriana Catur
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.272

Abstract

Human breast milk is a uniquely complex biological fluid renowned for delivering essential nutrients to newborns. Beyond its nutritional value, it also contains important immunological components that play a fundamental role in infant health and development. This review explores the immunological characteristics of breast milk, highlighting its diverse array of immune cells and bioactive molecules, including secretory IgA, cytokines, and chemokines. These components actively contribute to the maturation of the infant’s immune system, strengthen defenses against infections, and facilitate the development of a balanced gut microbiome. This discussion also explores how the immune components in breast milk function to benefit infants, examining their protective mechanisms and developmental impacts. Additionally, it addresses how storage conditions—such as freezing, refrigeration, or pasteurization—may alter the integrity and effectiveness of these vital immune factors. Furthermore, the influence of external environmental factors, including maternal diet, stress, and exposure to pollutants, is considered for their potential effects on the immunological quality of breast milk. For this literature review, relevant studies were systematically searched across multiple academic databases, including PubMed, ScienceDirect, Google Scholar, ResearchGate, and Elsevier. The search was limited to publications from the past ten years. Emerging research underscores the adaptive nature of breast milk and its profound impact on early-life immunity, offering valuable insights for optimizing infant feeding practices and potential clinical applications.
Co-Authors Afina Aurellya Kamal Aqilah, Nayra Ardiansyah, Rangga Arizal Hamizar Arleni Bustami Aulya, Yenny Ayu Made Ratna Dewi, Ida Ayun, Tresya Hesi Qurrata Azwar, Herlyssa Barasila, Atikah Chalida Biantara, I Dewa Gede Bagus Cecilia Syifa Citra Shabira Davi Abdulloh Haidzam Dwi Anita Suryandari Erbi, Mesa Taja Izza Jannati Fadhillah, Muhamad Rizqy Falatehan, Citra Shabira Farlikhatun, Lili Febriana Catur Iswanti Gani, Adamas Rizky Ghaniyyatul Khudri Gumelar Adhimandala, Dwiki Cacala Hanifah Harita, Adiwignya Nugraha Widhi Hartanti, Retno Heri Wibowo Indrawanto, Mochammad Fahrin Izzati, Indah Nur Jaelan Usman, Jaelan Jeanne A. Pawitan Junaidi Junaidi Khatimah, Mutiara Khusnul Khatimah, Nurul Gusti Kusmardi Kusmardi Kusnanda, Raniah Ratna Brillianti Laila Hayati, Laila Lindawati Kartika Luh Komang Widnyani Wulan Laksmi Luluk Yunaini Maharani, Cynthia Wulan Maharani, Sofya Devi Mega Sylvia Dewi Meita Santi Budiani, Meita Santi Mone, Ansyari Muhammad Luthfi Multazam, Arvy Yanasta Mulyana, Phonny Aditiawan Nindyantoro Nurhidayati, Asti OKTAVIANA, MIMBAR Olievia Prabandini Mulyana, Olievia Prabandini Pajar Pratama, Galuh Putri, Ellyana Ilsan Eka Rahayu Puji Haryanti Raniswati, Sholekhania Novita Ria Kodariah Safrudin Safrudin Salsabila, Hanum Santosa, Rizky Putra Shabira, Citra Siauta, Jenny Anna Sri Mulyeni Sri Sukamti, Sri Sukmawati, Rizda Yuli Suprapto, Mariana Nadhira Yuli Syah, Onke Alvin Syahroni, Vika Yulian Tangke, Diar Muzna Trian Maulana, Trian Triana, Novi Ubaydillah, Haliza Ihza Umi Anugerah Izzati, Umi Anugerah Wanasurya , Deasy Febriyanti Wardhana, Diva Ayu Wawaimuli Arozal Widyastutik Yuda Nabella Prameswari Yuni Putri Yustisi Yunia Dwie Nurchayanie Yunus Indra Purnama, Yunus Indra Zaskiyanti, Alifah Anggellia