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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Primatologi Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Veteriner Jurnal Bios Logos JURNAL KIMIA SAINS DAN APLIKASI Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) IPTEK Journal of Proceedings Series Jurnal Penelitian Hasil Hutan agriTECH Majalah Obat Tradisional JURNAL BIOLOGI INDONESIA Science and Technology Indonesia Al-Kimia Acta Pharmaciae Indonesia : Acta Pharm Indo Indonesian Journal of Chemistry Menara Perkebunan Jurnal Jamu Indonesia Jurnal Penelitian Hasil Hutan ZOOTEC Jurnal Kedokteran Hewan al Kimiya : Jurnal Ilmu Kimia dan Terapan Indonesian Journal of Jamu Jurnal Penelitian Hasil Hutan

Irma Herawati Suparto

Department Of Chemistry FMIPA IPB University, IPB Campus, Dramaga, Bogor, 16680, Indonesia

Author-ID : 393408

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health Veterinary Other

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Potential for Antibacterial Activity of Chitosan-Polyvinyl Alcohol Membrane Loaded with Green Grass Jelly Leaf and Moringa Leaf Extract as a Wound Dressing Nur Inayatullah; Tetty Kemala; Irma Herawati Suparto
Jurnal Kimia Sains dan Aplikasi Vol 25, No 4 (2022): Volume 25 Issue 4 Year 2022
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Chitosan is a natural polymer that can be used as wound dressing material; however, it has rigid and brittle properties. A combination of chitosan and polyvinyl alcohol (PVA) is expected to allow improvement of chitosan’s mechanical properties. Green grass jelly leaf (Cyclea barbarta M.) and moringa leaf (Moringa oleifera L.) have antibacterial compounds that can be added to the chitosan-PVA composite membrane. The purpose of the research was to develop and characterize the chitosan-PVA composite membrane with the addition of green grass jelly leaf and moringa leaf extracts to enhance the antibacterial activity of the membranes that have potential as a wound dressing. Both extracts with various composition volumes (75:25, 50:50, and 25:75) were tested for antibacterial activities against S. aureus and E. coli. Chitosan-PVA composite membrane with the volume ratios of 5:5, 6:4, and 7:3 was added with extract with the highest antibacterial activity. The composites were characterized for density, water vapor permeability, tensile strength, elongation, Fourier Transform Infrared spectroscopy, and Scanning Electron Microscope. The most significant inhibition zone was shown by an extract ratio of 50:50 against S. aureus and E. coli, 13.00±1.17 mm and 7.00±0.17 mm, respectively. Composite membrane with the addition of extract had a larger inhibition zone against S. aureus (9.75±0.75 mm) and E. coli (7.50±0.65 mm) than without extract. Chitosan-PVA(5:5)+extract membrane showed excellent density and water vapor permeability compared to other membrane ratio compositions. Mechanically, the addition of extract decreased the tensile strength and elongation of the membranes; however, it still complied with the medical material standard criteria. The characterization for functional groups showed that chitosan-PVA+extract generated the N-H group peak with two wavenumbers expressed as overlapping amides with amines and protonated amines. The SEM analysis showed that the addition of extract was not distributed homogeneously on the membrane surface.

Cytotoxicity of the Most Active Fraction of the Seeds of Swietenia macrophylla using Human Breast Cancer MCF-7 Cells Dudi Tohir; Fitriah Sari; Irma Herawati Suparto
Jurnal Kimia Sains dan Aplikasi Vol 23, No 7 (2020): Volume 23 Issue 7 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Ethyl acetate fraction from Swietenia macrophylla was reported to have toxicity against the larvae of Artemia salina shrimp larvae. However, there areno reports aboutS. macrophylla, which can inhibit human breast cancer cells MCF-7. Therefore, this study aims to evaluate S. macrophyllaextract's cytotoxicity using human breast cancer MCF-7 cells assay, followed by confirmation of its toxicity using brine shrimp lethality assay. The most active fraction obtained from the ethyl acetate extract of S. macrophylla showed 76.49% inhibition at 50 µg/mL (IC50=34.11 µg/mL). At the same time, the most active fraction may contain a mixture of limonoid compounds after LCMS analysis. The most active fraction obtained from ethyl acetate extract of S. macrophylla showed 76.49%

Synthesis of Carbon Dot Nanoparticles (C-Dot) from Seeds and Seedpods of Kesumba Keling (Bixa orellana) using Hydrothermal and Solvothermal Methods Amrina Rosyada; Sri Sugiarti; Irma Herawati Suparto
Jurnal Kimia Sains dan Aplikasi Vol 26, No 6 (2023): Volume 26 Issue 6 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.6.204-210

C-dot is a 0-dimensional nanoparticle with photoluminescence properties and can be synthesized from plants, such as the Kesumba Keling plant. Kesumba Keling contains a red pigment sourced from the bixin and norbixin dyes containing functional groups like ‒COOH and ‒COO‒. These functional groups are anticipated to enhance the luminescence intensity produced by C-dot. This research focuses on synthesizing C-dots from Kesumba Keling seeds and seedpods using hydrothermal and solvothermal methods. It also involves an analysis of how different solvents and passivation agents affect the luminescence of C-dots, along with a comparison of the resulting fluorescent colors. The highest yield, at 73.26%, was achieved when using Kesumba Keling seedpods and ethanol as the solvent without adding urea. Furthermore, C-dots synthesized using ethanol as the solvent display a stronger luminescent glow compared to those produced using double-distilled water as the solvent. Additionally, all C-dots synthesized in this study emit a blue luminescence. Characterizing C-dots using a UV-Vis spectrophotometer reveals absorption peaks at two different wavelengths: 260‒280 nm and 320‒340 nm. These absorption peak results align with C-dot characteristics, as confirmed by Fourier transform infrared spectrophotometry. When comparing the intensity of C-dots, those derived from Kesumba Keling peel using the double-distilled water solvent with the addition of urea exhibit a higher intensity (measuring at 0.99) than C-dots obtained from Kesumba Keling peel using ethanol as a solvent with added urea. The solvothermal method is deemed the most effective for C-dot synthesis, as it yields the highest luminescence intensity, accompanied by an emission wavelength shift to 491.65 nm.

Antioxidant, Cytotoxic, and Insulinotropic Activities of Several Leaves Extracts of Medicinal Plants Amelia Marzanti; Riska Widya Aprianti; Silmi Mariya; Rachmitasari Noviana; Eti Rohaeti; Irma Herawati Suparto
Jurnal Kimia Sains dan Aplikasi Vol 26, No 1 (2023): Volume 26 Issue 1 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.1.34-38

The prevalence of diabetes mellitus and cancer is increasing; thus, research into efficient treatments utilizing active compounds derived from medicinal plants has focused on these diseases. Through the agro maritime 4.0 approach, medicinal plants are explored in the archipelago of Indonesia, particularly on Tinjil Island, Banten Province. The medicinal plants identified on the island include Morinda citrifolia, Terminalia catappa, and Gnetum gnemon. Therefore, this study aimed to evaluate the in vitro of aqueous extracts of leaves of those three plant species. All aqueous extracts were analyzed for total phenolic content and further tested for antioxidant activity using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), MTT cytotoxic activity (3-[4,5-dimethylthiazole-2-yl]-2- 5-diphenyl-tetrazolium-bromide) in MCF-7- (ATCC HTB 22) and Burkitt’s Lymphoma Raji (ATCC CCL 86) cells, and insulinotropic activity in pancreatic BRIN BD11 cells. The results showed that the total phenolic content of T. catappa was significantly higher (9.21 ± 2.49 mg GAE/g extract sample) compared to M. citrifolia (3.00 ± 0.35 mg GAE/g) and G. gnemon (7.47 ± 0.33 mg GAE/g). Compared to the other two extracts, T. catappa extract has the best DPPH antioxidant activity of IC50 7.44 ± 0.77 µg/mL (p<0.05). MTT cytotoxic activity in all samples did not inhibit the proliferation of Raji cells but did the proliferation of MCF-7 cells. The IC50 for the best cytotoxic activity was shown in M. citrifolia (8.06 µg/mL). T. catappa triggered insulin secretion at 62.5 µg/mL with the highest insulin concentration (54.55 mg/mL). The aqueous extract of T. catappa leaves shows potential as an antioxidant and insulinotropic agent, while M. citrifolia leaves have a cytotoxic effect with anticancer potential.

Synthesis and Characterization of Fluorapatite-Copper(II) Oxide with Sol-Gel Method as an Antibacterial Biomaterial Manasye Erlangga; Charlena Charlena; Irma Herawati Suparto
Jurnal Kimia Sains dan Aplikasi Vol 27, No 4 (2024): Volume 27 Issue 4 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.4.174-181

One of the calcium phosphate compounds that can be used as an antibacterial material for coating dental implants is fluorapatite (FAp). This research aims to synthesize FAp at three different sintering temperatures (600, 800, and 1000°C), copper(II) oxide (CuO), and fluorapatite-copper(II) oxide (FAp-CuO) using the sol-gel method, and test the antibacterial properties of the synthesized products. The sol-gel technique proved successful in synthesizing FAp, with optimal results observed at a sintering temperature of 1000°C, achieving a crystallinity level of 90%. Analyses conducted using X-ray diffractometer, Fourier-transform infrared spectrometer, and scanning electron microscope-energy dispersive X-ray spectrometer revealed FAp as the dominating phase, exhibiting Ca/P and P/F ratios of 1.84 and 4.67, respectively. In FAp-CuO, replacing Ca2+ with Cu2+ ions lowered the average crystallite size, crystallinity, and Ca/P ratio. FAp, CuO, and FAp-CuO all displayed antibacterial activities against S. aureus and E. coli, with FAp-CuO having the maximum average inhibitory zone diameters of 0.243 and 1.397 mm, respectively.

Co-Authors . NURHAIMI-HARIS . Permanawati Adi Winarto Agus Harsoyo Agus Malik Ibrahim Alfa A Perdana Alzamori, Winda Amalia Yunita Amelia Marzanti Amrina Rosyada Andi Nursanti Ani Suryani Suryani Annisa Dewi, Fitriya Nur Arief Boediono Auliatifani, Reza Auliya Ilmiawati Baiq NM Utami Bella Fitri Rahmantika Cece Sumantri Cecep Abdurohman Putra Charlena Chonny Damayanti Chusnul Choliq Chusnul Choliq Daniel Putra Oktavianus Laia Dede R. Adawiyah Dedy Duryadi Solihin DEWI APRI ASTUTI Dewi, Fitriya Nur Annisa Dewi, Tri Isyani Tungga Diah Iskandriati Dondin Sajuthi Dudi Tohir Dwi Ramadhani Ekowati Handharyani Era Rahmi Eti Rohaeti Ferian A Setiyoko Fiqa Annisa Rakhmatika Fitriah Sari Fransiska Rungkat Zakaria Gina, Safira Gregory K. Wilkerson Gustan Pari Gustan Pari Harrold Halilintar MR Subu Taopan Huda Shalahudin Darusman I Nengah Budiarsa I NENGAH BUDIARSA Ibrahim, Agus Malik Ida Ayu Putu Sri Widnyani Iin Indriawati Iin Kurnia Hasan Basri Irmanida Batubara J. Mark Cline Khaydanur Khaydanur Khaydanur, Khaydanur Laela Wulansari Latifah Kosim Darusman Lilis Nurhadijah Lis Rosmanah Luthfiana, Widya M. Rafi Manasye Erlangga Mohamad Rafi Mohamad Rafi Mohamad Rafi Munawaroh, Fauziyatul Nengsih, Nunuk Kurniati Noviyan Darmawan Nunuk Kurniati Nengsih Nur Inayatullah Nurhadijah, Lilis Nurul Siti AYUNINGTIAS PAMUNGKAS, DIAH DARU Perdana, Alfa A Permanawati Permanawati PERMANAWATI, PERMANAWATI Pijoh, Deyv Purnomo, Tsania Firqin Rachmitasari Noviana Rachmitasari Noviana Rahmagiarti, Cintera Rakhmatika, Fiqa Annisa Reno Fitri Hasrini Retno Wulansari Reza Auliatifani Ria Oktarina Riska Widya Aprianti Rizki Aulia Ansari Rudi Heryanto SATRIYAS ILYAS Sela Septima Mariya Septaningsih, Dewi Anggraini Septi Iriani Setiyoko, Ferian A Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya SILMI MARIYA Sri Rahmatul Laila Sri Supraptini Mansjoer Subu Taopan, Harrold Halilintar MR Sulistiyani Sulistiyani, Sulistiyani SUMINAR SETIATI ACHMADI Teja Kisnanto Tetty Kemala Tri Isyani Tungga Dewi Tsania Firqin Purnomo Ummah, Isna Mustafiatul Utami, Baiq NM Uus Saepuloh Uus Saepuloh Veby Tri Yani Veby Tri Yani Wasmen Manalu Widyawati Widyawati Widyawati Widyawati Wildayati, Wildayati Wina Yulianti Wisaeni Intannia Wisnu Ananta Kusuma Wulan Tri Wahyuni Wulansari, Laela Yessie Widya Sari Yoga Yuniadi Yuliana Yuni Cahya Endrawati Yusuf Ryadi Zuraida Zuraida Zuraida

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