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All Journal VALENSI Farmaka Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Pharmacology and Clinical Pharmacy Research JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Abdi Masyarakat Indonesia JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Abdi Masyarakat Multidisiplin Nanggroe: Journal Of Scholarly Service Journal of Pharmaceutical and Sciences. Nanggroe: Journal of Scholarly Service VIDHEAS: Jurnal Nasional Abdimas Multidisiplin Jurnal Malikussaleh Mengabdi Jurnal Medika: Medika Jurnal Sains dan Kesehatan Taawun: Jurnal Pengabdian kepada Masyarakat
Recky Patala
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Tadulako, Kota Palu, Sulawesi Tengah, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Aktivitas Analgesik dan Antiinflamasi Nanoemulsi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) secara In Vivo Recky Patala; Viani Anggi; Isna Paula; Nur Sakina
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.295

Abstract

Pain and Inflammation are our body's average protective measures. The presence of an inflammatory process is characterised by typical features, namely the appearance of redness, swelling in the area of inflammation, heat, and the onset of pain. One of the traditional plants widely obtained in Indonesia is Curcuma longa L. Curcuma longa L. contains flavonoid and curcumin compounds known to have analgesic and anti-inflammatory effects. The ethanol extract of Curcuma longa L. rhizome is formulated in nanoemulsion dosage form to reduce toxicity, improve drug distribution efficiency, and increase the bioavailability of drugs with low absorption. This study aims to determine the effect of the administration of nanoemulsion of ethanol extract of Curcuma longa L. at doses of 20 and 25 mg/kg bw on analgesic and anti-inflammatory activities carried out on male white rats of Wistar strain induced by 1% acetic acid and 1% carrageenan. Rats were divided into five groups (n=5), namely standard control (nanoemulsion without extract), positive control (mefenamic acid nanoemulsion for analgesic test and diclofenac sodium nanoemulsion for anti-inflammatory test), negative control (1% acetic acid nanoemulsion and 1% carrageenan nanoemulsion), P1 (extract nanoemulsion dose of 20 mg/kg bw), and P2 (extract nanoemulsion dose of 25 mg/kg bw). Furthermore, the number of writhing was measured from 5 to 60 minutes, and the leg volume changed from 1 to 6 hours. The results showed a decrease in the number of writhes with an increase in % Protection and significant inhibition of inflammation (p<0.05) in both doses of 20 mg/kg bw and 25 mg/kg bw with a per cent protection of 35.21% and a decrease in oedema volume by 64.79%. Nanoemulsion of Curcuma longa L. extract at doses of 20 and 25 mg/kg bw has activity as an analgesic and anti-inflammatory induced by 1% acetic acid and 1% carrageenan
The Effect of Binahong Leaves (Anredera cordifolia Steenis) Extract on Blood Urea Nitrogen (BUN) Creatinine Serum and Renal Histopathology of Male White Rats (Rattus norvegicus) with Diabetes Mellitus Tandi, Joni; Patala, Recky; Towulu, Dessy Gracelia; Lidongi, Putri Marcelita; Handayani, Tien Wahyu; Kanan, Maria
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.85034

Abstract

Diabetic nephropathy is one of the complications of diabetes mellitus on the pancreas that can end up in chronic pancreas failure. Various treatment options to repair pancreas damage due to diabetic nephropathy, one of which is by using Anredera cordifolia leaves. This study aims to determine the content of secondary metabolites in Anredera cordifolia leaves ethanol extract, and to determine the effective dose of Anredera cordifolia leaves ethanol extract in regenerating male white rat kidney cells. This study uses a laboratory experimental method. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 25 mg/kg BW, dose 50 mg/kg BW, and dose 100 mg/kg bw. The level of histological damage to the renal tubules was observed with HE staining using an Olympus CX23 microscope. The data from the scoring of the level of renal tubular damage were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test to see the differences between treatments. The results showed that the Anredera cordifolia leaves ethanol extract contained secondary metabolites of alkaloids, flavonoids, saponins, and tannins; Anredera cordifolia leaves ethanol extract has an effect on kidney cell repair; Anredera cordifolia leaves ethanol extract at a dose of 100 mg/kg bw is effective reducing urea and creatinine; with an average decrease of 17.0 and 0.71 mg/dL in repairing kidney cells with an average damage value of 1.
Activity Test of Cassia alata L. Leaf Extract on Kidney Histopathology Damage Score of Diabetes Mellitus Model Patala, Recky; Praypelisa, Ipa; Tandi, Jony; Utami, Indah Kurnia
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86199

Abstract

Diabetic nephropathy is a disease experienced by diabetic patients. In this disease, damage to the glomerulus occurs. The administration of antidiabetic drugs tends to cause unwanted side effects, so there is a need for alternative treatment from herbs, one of which is Cassia alata L. Cassia alata L. leaves have chemical content such as flavonoids, alkaloids, tannins, and saponins. Flavonoids reduce blood glucose levels by increasing insulin secretion and mimetic agents, tannins slow carbohydrate digestion and saponins repair pancreatic beta cells and increase glycogen in the liver. This study aims to determine the effect of Cassia alata L. ethanol on the histopathology damage score of male white rat kidney (Rattus norvegicus) induced by streptozotocin. The test animals used were 30 male white rats divided into six treatment groups, each group consisting of five male white rats, namely the normal control group, negative control group, positive control group, treatment group with doses of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The parameters evaluated were kidney tissue damage score and histopathology image analysis. The results showed that the ethanol extract of Cassia alata L. leaves contain alkaloids, flavonoids, saponins, and tannins. The ethanol extract of Cassia alata L. leaves in doses of 500 mg/kg BW, 600 mg/kg BW and 700 mg/kg BW has the activity of reducing the score of kidney tissue damage in male white rats and a dose of 700 mg/kg BW is the best dose in reducing the score of kidney tissue damage in diabetes mellitus models with a score of 2.
PEMANFAATAN TANAMAN DAUN SAMBILOTO (Andrographis paniculata) SECARA ETNOFARMAKOLOGI UNTUK PENYAKIT KOLESTEROL DI DESA MAKU, KECAMATAN DOLO, KABUPATEN SIGI Patala, Recky; I Made Sarwadana; Rianto Tanggo Doko
 Jurnal Abdi Masyarakat Multidisiplin Vol. 2 No. 2 (2023): Agustus: Jurnal Abdi Masyarakat Multidisiplin
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jammu.v2i2.709

Abstract

Penyakit kolesterol merupakan salah satu penyakit yang umum terjadi di masyarakat. Kolesterol merupakan substansi menyerupai lilin yang berwarna putih dan ditemukan dalam tubuh. Kolesterol adalah senyawa lemak kompleks yang 80% dihasilkan dari dalam tubuh (organ hati) dan 20% sisanya dari luar tubuh (zat makanan). Tingginya kolesterol dalam tubuh disebut juga hiperkolesterolemia. Hiperkolesterolemia merupakan kondisi dimana tingginya kadar kolesterol plasma yang dapat meningkatkan resiko ateroskelrosis, suatu kondisi patologis yang menyebabkan penyakitjantung koroner. Sambiloto memiliki kandungan senyawa flavonoid, lakton dan terpenoid. Pada flavonoid memiliki kandungan tertinggi pada bagian akarnya. Flavonoid dapat menghambat Fatty Acid Synthase (FAS) yakni enzim penting dalam metabolisme lemak. Tujuan dalam kegiatan Pengabdian kepada masyarakat ini yaitu untuk memberikan Sosialisasi kepada masyarakat desa Maku tentang pemanfaatan Tanaman daun Sambiloto (Andrographis paniculata) secara Etnofarmakologi untuk Penyakit Kolesterol. Kegiatan Pengabdian kepada Masyarakat ini dilakukan dengan dilakukan dalam bentuk sosialisasi dan edukasi dengan menggunakan metode ceramah dan diskusi. Hasil kegiatan pengabdian masyarakat ini menunjukkan adanya peningkatan pengetahuan dan pemahaman serta perilaku yang baik terhadap pemanfaatan Tanaman daun Sambiloto secara Etnofarmakologi untuk Penyakit Kolesterol.
ANALISIS KADAR PARASETAMOL GENERIK DIBANDINGKAN BERMEREK DAGANG Mariyani; Patala, Recky; Awilia, Nurkhaliza
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 1 (2023): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i1.1483

Abstract

Paracetamol is a substance that can reduce the fever (antipyretic) and relieve the pain (analgesic). Analysis of the levels of generic and branded paracetamol tablets was carried out to determine whether the levels of the active substance in the preparations met the requirements or not by using the High Performance Liquid Chromatography method. The paracetamol quantitative test obtained the results of the levels in sample A = 94.306%, sample B = 99.986%, sample C = 95.296% and sample D = 94.904%. These results indicate that the level of the active substance paracetamol in each sample still meets the requirements of the Indonesian Pharmacopoeia Edition IV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid ChromatographyIV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid Chromatography.
Penyuluhan Pemilihan dan Penggunaan Kosmetik yang Aman Tanpa Bahan Kimia Berbahaya Terhadap Remaja M, Mariyani; Patala, Recky; Pratiwi, Dinda
Jurnal Malikussaleh Mengabdi Vol. 2 No. 1 (2023): Jurnal Malikussaleh Mengabdi, April 2023
Publisher : LPPM Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jmm.v2i1.10662

Abstract

Kosmetik digunakan dengan tujuan memperbaiki maupun merawat kecantikan untuk menunjang penampilan  menjadi suatu kebutuhan primer untuk saat ini khususnya di kalangan remaja. Perkembangan trend kosmetik saat ini menjadi beberapa ancaman dikarenakan ada beberapa produsen yang menambahkan zat yang dilarang dalam penambahan kosmetik demi memperoleh hasil yang instan tanpa memikirkan efeknya, sehingga dilakukan pendampingan agar masyarakat memahai tentang cara pemilihan dan  penggunaan kosmetik yang aman serta dampak akibat penggunaan kosmetik dengan bahan kimia berbahaya. Kegiatan ini menggunakan metode penyuluhan dan  media leaflet, hkegiatan ini menghasilkan pemahaman masyarakat menjadi meningkat mengenai kosmetik. Diharapkan masyarakat remaja Desa Lampo Kabupaten Donggala memiliki pengetahuan dan bijak dalam memilih dan menggunakan kosmetik. 
Efektivitas Ekstrak Etanol Kulit Buah Pepaya (Carica papaya L.) terhadap Kadar Kreatinin dan Ureum Tikus Putih Jantan (Rattus norvegicus) yang Diinduksi Streptozotocin: Effectiveness of Ethanol Extract of Papaya Peel (Carica papaya L.) on Creatinine and Ureum Levels of Male White Rats (Rattus norvegicus) Induced by Streptozotocin Recky Patala; Yunlis Silintowe Kenta; Irnawati Irnawati
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.661

Abstract

Salah satu faktor yang paling mempengaruhi penyakit ginjal adalah Diabetes Melitus. Diabetes Melitus yang tidak terkendali dapat menyebabkan komplikasi mikrovaskuler yang disebut dengan nefropati diabetik. Gangguan fungsi ginjal tersebut diukur dengan Glomerular Filtration Rate (GFR). Dimana penurunan GFR diikuti dengan kenaikan kadar kreatinin dan ureum darah. Penelitian ini bertujuan untuk mengetahui apakah senyawa metabolit sekunder yang terkandung dalam ekstrak kulit buah pepaya (Carica papaya L.) serta dosis berapakah ekstrak kulit buah pepaya memberikan pengaruh terhadap kadar kreatinin dan ureum tikus putih jantan. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 5 kelompok perlakuan yang terdiri dari 5 ekor hewan uji. Kelompok I kontrol normal (suspensi Na CMC 0,5%). Kelompok II kontrol negatif (streptozotocin 40 mg/kg BB). Kelompok III diberikan ekstrak etanol kulit buah pepaya 100 mg/kg BB. Kelompok IV diberikan ekstrak etanol kulit buah pepaya 200 mg/kg BB dan kelompok V diberikan ekstrak etanol kulit buah pepaya 400 mg/kg BB. Perlakuan diberikan selama 28 hari dan dilakukan pengukuran kadar kreatinin dan ureum pada hari ke- 14, 21 dan 28. Analisis data yang digunakan yaitu One Way Anova dan uji lanjut LSD menggunakan program SPSS 24. Hasil penelitian ini menunjukkan bahwa ekstrak etanol kulit buah pepaya mengandung senyawa metabolit sekunder flavonoid, alkaloid dan saponin serta ekstrak etanol kulit buah pepaya menunjukkan adanya efek penurunan kadar kreatinin dan ureum tikus putih jantan pada dosis 400 mg/kg BB.
Penguatan Peran Masyarakat Menuju Kemandirian Kesehatan Melalui Pemanfaatan Tanaman Obat Keluarga (Toga) dalam Pengendalian Penyakit Kolesterol Recky Patala; I Made Sarwadana; Tri Olan Palumpun; Ayu Wulandari
TAAWUN Vol. 4 No. 01 (2024): TA'AWUN FEBRUARY 2024
Publisher : Pusat Penelitian Pengabdian Pada Masyarakat Sekolah Tinggi Ilmu Tarbiyah Al-Fattah Siman Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37850/taawun.v4i01.618

Abstract

Efforts towards the independence of health human resources are a concrete manifestation of community participation in health development as a trigger for community empowerment activities, one of which is Family Medicinal Plants (FMP). FMP is a selection of medicinal plants that can be planted in the home yard. The utilization of Family Medicinal Plants in controlling Cholesterol Disease in the home environment is very important, especially for families who do not have access to health services. Therefore, this activity aims to help and strengthen the role of the community, especially the Prosperous Village community in utilizing FMP around as an alternative medicine for controlling Cholesterol Disease. The methods used in the implementation of this service are observation, preparation and design, socialization, lectures, discussions, and training and mentoring. The results achieved from this activity are an increased understanding of the types of FMP, their classification, processing methods, utilization of FMP, and the importance of FMP for cholesterol treatment and getting FMP cultivation skills by utilizing the yard and garden around the house to be used as a place for FMP cultivation. The existence of a FMP garden which is the output of this service is then expected to be used for treatment or can be used to improve the economy by selling FMP products.
Uji Toksisitas Akut Oral Ekstrak Etanol Akar Tanaman Bungkus (Smilax rotundifolia L.) pada Tikus Putih Jantan (Rattus nervegicus) Wulandari, Ayu; Patala , Recky; Mariyani , Mariyani; Prinasari , Rezan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.605

Abstract

Background: Smilax rotundifolia, commonly known as "bungkus" plant, is an indigenous species from Papua recognized for its potential as an aphrodisiac agent. Traditionally, the local population applies parts of the plant directly to the male genital area, a method that causes itching and highlights the need for development into a safer and more user-friendly formulation. Objective: This study aimed to evaluate the safety of the ethanol extract of Smilax rotundifolia roots through acute toxicity testing, with observation parameters including signs of toxicity, body weight changes, and LD₅₀ value. Methods: Acute toxicity testing was conducted on male white rats (Rattus norvegicus) divided into five groups: normal control and treatment groups receiving extract doses of 5, 50, 300, and 2000 mg/kg body weight. Toxic signs were observed at 0; 0.5; 1; 2; 4; 6; and 24 hours post-administration, while body weight was monitored over a 14-day period. Results: No mortality was observed in any of the treatment groups up to day 14. The rats’ body weights did not show significant changes, and no notable macroscopic organ abnormalities were found, even in the group receiving the highest dose (2000 mg/kgBW). Conclusion: Based on these findings, the ethanol extract of Smilax rotundifolia root is classified as low toxicity (Category 5) or practically non-toxic.
Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan (Rattus Novergicus) Model Hiperkolesterolemia-Diabetes: Effectiveness of Ethanol Extract of Avocado Seeds (Persea americana mill.) on Blood Glucose Levels of Male White Rat (Rattus novergicus) Hipercolesterolemia-diabetes Model Patala, Recky; Dewi, Niluh Puspita; Pasaribu, Meilinda Handayani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.087 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13929

Abstract

Diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to a deficiency of insulin secretion or when insulin resistance occurs. Herbal medicine is one alternative method that can be used to control blood glucose levels and prevent complications of diabetes mellitus. One of the medicinal plants is avocado seeds (Persea americana Mill.) The active compounds contained in avocado seeds that have antidiabetic activity are flavonoids, alkaloids, tannins and saponins. This study aims to determine the content of secondary metabolites in the extract of avocado seed, the effect of extract of avocado seed and the dose of extract of avocado seed that is effective in lowering blood glucose levels. This research was a laboratory experiment using a modified randomized controlled pretest and posttest group design. Test animals used were 30 rats which were divided into six treatment groups, namely normal control, negative control, positive control, a dose of 250, 300 and 350 mg/kg groups. The results showed that extract of avocado seed contained secondary metabolites: flavonoids, alkaloids, saponins, and tanins;extract of avocado seed gave effect to decrease blood glucose levels; extract of avocado seed with a dose of 350 mg/kg was effective in lowering blood glucose levelswith an avarage decrease of 99,8 mg/dL.
Co-Authors A, Faidil Afdal Akhmad Khumaidi Arfiah, Arfiah Awilia, Nurkhaliza Ayu Wulandari Ayu Wulandari Ayu Wulandari Fahri, Mohammad Fahruddin Fahruddin Fatma, Nurul Gunawan Pamudji Widodo Handayani , Tien Wahyu Handayani, Tien Wahyu Hardani, Muhammad Fakhrul I Made Sarwadana I Made Sarwadana Irnawati Irnawati Islamiati , Utami Isna Paula Joni Tandi, Joni Khildah Khaerati Kiki Rizki Handayani Lidongi, Putri Marcelita M, Mariyani Magfiroh Magfiroh Maramis M Maria Kanan Mariyani Mariyani Mariyani , Mariyani Masyita, Andi Atirah Megawati Megawati Monica Sandra Makatang Monica Sandra Makatang Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Nugroho , Agung Endro Nur Ikhwan Nur Sakina Nurlina Ibrahim Nurul Ulzmi Palumpun, Tri Olan Pasaribu, Meilinda Handayani Pratiwi, Dinda Praypelisa, Ipa Prinasari , Rezan Rianto Tanggo Doko Ririen Hardani Risnawati Risnawati Salsabila, Unik Hanifah Sarwadana, I Made Sri Hudayah Sri Mulyani Sugeng Santoso Tandi, Jony Tien Wahyu Handayani Toding, Ficanata Adhiguna Towulu, Dessy Gracelia Tri Olan Palumpun Utami, Indah Kurnia Viani Anggi Vidya Christin Wulandari , Ayu Yanuarty , Rezky Yanuarty, Rezky Yuliet Yuliet Yunlis Silintowe Kenta