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All Journal Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Universa Medicina Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Biomedika Jurnal Respirasi (JR) Jurnal Peduli Masyarakat Respiratory Science Cermin Dunia Kedokteran International Journal of Public Health Excellence (IJPHE) Smart Society Empowerment Journal Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Cermin Dunia Kedokteran
Yusup Subagio Sutanto
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : respiratory science

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New GOLD COPD Guideline 2019: How We Deal with It? (Inhaled Corticosteroid Use and Blood Eosinophil Count) Ari Julian Saputra; Kiki Widyastuti; Yusup Subagio Sutanto
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.13

Abstract

Background: Blood eosinophils may predict response to inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), where ICS is recommended in patients at high risk of exacerbations by the Global Initiative for COPD (GOLD) strategy. It can help clinicians to estimate the likelihood of beneficial preventive responses to the addition ICS to regular bronchodilator treatment, and thus can be used as a biomarker in conjunction with clinical assessment when making decisions regarding ICS use. This study aims to compare therapeutic data with blood eosinophil count in COPD patients. Methods: Data were collected from consecutive COPD outpatients in Bukit Asam Medika Hospital starting from March 1st, 2019 until June 30th, 2019 and dr. H. Mohamad Rabain Hospital starting from Oct 1st, 2019 until Dec 27th, 2019. We collected demographics, anthropometrics, smoking history, therapy, dynamic lung volumes, the Medical Research Council scale (MRC), CAT score, and blood eosinophil count. Results: From 57 data collected, 24 (42,1%) patients were having blood eosinophil count ≥300. Patients who have more exacerbation in COPD Group C were 33,3% and 63,2% in COPD Group D. The proportions of ICS-treated COPD Group D patients and blood eosinophil count of <300 and ≥300 was 63,9% and 36,1%, respectively. Conclusion: This study may provide information and characteristic of COPD patient in Indonesia rural area and showed who may have benefit to ICS therapy based on recommendation GOLD COPD 2019. Blood eosinophils counts is a low-cost biomarker and may help clinicians to made decision therapy.
Aromatherapy Effectivity in Controlling Anxiety, Respiration Rate, Pulse Rate, and Pain in Bronchoscopy Nur Amalia Santang; Yusup Subagio Sutanto; Debree Septiawan
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.116

Abstract

ackground: Bronchoscopy is a relatively safe diagnostic and therapeutic procedure, but it is often reported as an uncomfortable experience and causes acute procedural anxiety that affects the procedure and the patient and operator's comfort. Anti-anxiety drugs have the risk of causing mild to severe side effects. Therefore, we need premedication with potent anxiolytics with minimal side effects, such as the use of aromatherapy. This study aims to analyze the effectiveness of aromatherapy as an additional premedication to reduce anxiety, respiratory rate, pulse rate, and pain in patients undergoing bronchoscopy. Method: A clinical study with experimental quasi pre-post test control group design using consecutive sampling was performed in pulmonary patients undergoing bronchoscopy in dr. Moewardi Hospital from February to March 2020. The study subjects were randomized into three groups: lavender aromatherapy, orange aromatherapy, and control. Hospital anxiety and depression scale (HADS) score, respiratory rate, pulse, and visual analogue scale (VAS) pain score were measured before and after bronchoscopy.  Results: A total of 45 subjects of lung patients undergoing bronchoscopy participated in this study. Post hoc test differences in the HADS anxiety score of lavender and orange groups showed a significant decrease (P=0.011); (P=0.083), respectively. The decrease in the control group was not significant (P=0.622). There was a significant decrease in the respiratory rate of lavender (P≤0.0001), and orange groups (P=0.001), while the control group did not decrease (P=0.515). There was a significant decrease in pulse rate in the lavender (P=0.004) and orange (P=0.011) groups. The decrease in the control group was not significant (P=0.900). There was a significant decrease in VAS pain scores in the lavender and orange groups with each (P<0.001), whereas, in the control group, there was an increase in VAS pain scores. Conclusion: Aromatherapy effectively controls anxiety, respiration rate, pulse, and pain in bronchoscopy patients.  
Carcinoembryonic Antigen (CEA) and Cancer Antigen 125 (CA-125) as Diagnostic Biomarkers for Malignant Pleural Effusion Harsini, Harsini; Kurniawan, Yoseph Dwi; Sutanto, Yusup Subagio
Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i3.142

Abstract

Background: The etiology of pleural effusion is very important in malignant pleural effusion management and prognosis. Pleural fluid cytology examination is a simple diagnostic tool and has been widely used to differentiate the etiology of pleural fluid with high specificity albeit its relatively low sensitivity. The use of tumor markers for malignant pleural effusion in Indonesia is still sparse. This study was intended to determine the sensitivity and specificity of CEA and CA-125 examinations in diagnosing malignant pleural effusion. Method: This was an observational analytic study with a cross-sectional approach to find the diagnostic value of CA-125 and CEA of pleural fluid in malignant pleural effusion. Subjects were patients with suspicion of malignant pleural effusion who underwent treatment in the emergency room, polyclinic, and inpatient ward at RSDM from October - November 2022. Results: CEA value with a cutoff of ≥32.00 had a sensitivity of 83.3%; specificity of 87.8%; PPV of 90.9%; NPV of 77.8% with an accuracy of 85.0% (P=0.001), a CA-125 value with a cutoff of >152.40 had a sensitivity of 83.3%; specificity 81.3%; PPV 87.0%; NPV 76.5%; with an accuracy of 82.5% (P=0.001). An increase in CEA and CA-125 signified a significant risk of malignant pleural effusion (P<0.05). Patients with increased CEA and CA-125 had 105 times the risk of developing malignant pleural effusion. Conclusion: CEA ≥32.00 and CA-125 >152.40 are potential biomarkers to predict malignant pleural effusion with CEA having better specificity than CA-125.
Analysis of Risk Factors for Antimicrobial Resistance in Nosocomial Pneumonia Larissa Amanda; Jatu Aphridasari; Yusup Subagio Sutanto
Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i2.179

Abstract

Background: Antibiotic resistance is often linked to nosocomial pneumonia, one of the most prevalent hospital-acquired illnesses. Determining risk factors is crucial for management and preventative plans. To develop preventative and control measures, this research was conductedto identify the variables linked to antibiotic resistance in nosocomial pneumonia patients. Method: In this retrospective cohort analysis, 237 individuals with nosocomial pneumonia were included. Odds Ratios (OR) were computed for relevant factors after data were evaluated using the chi-square or Fisher’s exact test to find significant relationships between patient characteristics and antibiotic resistance. Results: Of the 237 patients, 58.2% exhibited antibiotic resistance. Several variables were found to be significantly associated with antibiotic resistance: age >59 years (OR=1.68; P=0.049), intensive care unit (ICU) admission (OR=2.65; P=0.002), high care unit (HCU) admission (OR=2.16; P=0.028), history of prior antibiotic use (OR=2.42; P=0.004), and endotracheal tube (ETT) use (OR=2.04; P=0.024). Patients older than 59 years had a 1.68-fold higher risk. Those admitted to the ICU and HCU had 2.65-fold and 2.16-fold higher risks, respectively. Patients with a history of prior antibiotic use had a 2.42-fold increased risk, and those with ETT use had a 2.04-fold increased risk. Conclusion: Older age, admission to intensive care units (ICU/HCU), previous antibiotic use, and endotracheal tube use are significant factors associated with antibiotic resistance in nosocomial pneumonia. These findings highlight key areas for targeted interventions to mitigate resistance.
Co-Authors -, Harsini -, Reviono . Reviono Adam Prabata Adhiputri, Artrien Agnes Sri Harti Agnes Sri Harti Agnes Sri Harti Agnes Sri Harti Akhmad Syaikhu Ana Rima Ana Rima Setijadi Ana Rima Setijadi Ana Rima Setijadi Anindita Hapsari, Brigitta Devi Aphridasari, Jatu Apridasari, Jatu Apriningsih, Hendrastutik Ari Julian Saputra Ari Natalia Probandari Artrien Adhiputri Arwin Muhlishoh Atmojo, Anang Purwoko Avamira Rosita Pranoto Bambang Abdul Syukur Bambang Abdul Syukur Bhisma Murti Brian Wasita Brian Wasita Caesaria Sarah Selleca Debree Septiawan Debree Septiawan Dhani Redhono, Dhani Diana Kurniasari Sagita Fahlevie Fahlevie Farih Raharjo Fitrotin Aziza Hari Wujoso Harsini Harsini , Harsini Harsini Harsini Hendra - Kurniawan Hendra Kurniawan Hendra Kurniawan Hendrastutik Apriningsih Hendrastutik Apriningsih Hermiana Ernastin Tobi Heru Sigit Pramono Ita Haryatie Jatu Aphridasari Jatu Apridasari Jatu Apridasari Jatu Aviani Jerry Indra Setiawan Kiki Widyastuti Kurniawan, Yoseph Dwi Larissa Amanda Leli Saptawati Lestari, Anggraini Dwi Liana Herlina Linda Soebroto Luths Maharina Magdalena - Sutanto Magdalena Sutanto Maria Dewi Caetline Maria Dewi Caetline marwoto marwoto Mellia Silvy Irdianty Mia Herdiyani Achmad Mochammad Imron Awalludin Muhammad Addinul Huda Murti, Paulus Wisnu Kuncoro Muttaqin Huda Nony Puspawati Nony Puspawati Nugroho, I.G.B Indro Nur Amalia Santang Nurul Devi Ardiani Nurul Devi Ardiani, Nurul Devi Paulus Arka Triyoga Putranto, Wachid R, Sari Apriliana Rahajeng Putriningrum Raharjo, A. Farih Ratna Adhika Reviono Reviono - Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Roman Diaz Rullyano Hardian Saelan, Saelan Safina Mutmainnah Samuel Samuel - Samuel - Samuel Samuel Santi, Nur Satria Maulana EH Sebayang, Pribadi M Septiawan, Debree Sibarani, Lia Priscilia Sigit, Indarto Siregar, Sihsusetyaningtyas Tiominar Soetejo, FX Sri Haryati Subandrio, Subandrio Sulistyani Kusumaningrum Suradi Suradi Suradi Suradi Suradi Suradi SURYAWATI, BETTY Sutanto, Magdalena Sutanto, Magdalena Sutanto Teguh Budi Santosa Vita Ovaria Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Wati, Martha Ratna Widiastuti Widiastuti Widyasanti, Diana Windu Prasetya Windu Prasetya Windu Prasetyo Yanny Octavia Sally Ride Yogie Irawan Yundari, Yundari