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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Universa Medicina Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Biomedika Jurnal Peduli Masyarakat Respiratory Science Cermin Dunia Kedokteran International Journal of Public Health Excellence (IJPHE) Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan
Yusup Subagio Sutanto
Faculty of Medicine, Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Respiratory Science

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Carcinoembryonic Antigen (CEA) and Cancer Antigen 125 (CA-125) as Diagnostic Biomarkers for Malignant Pleural Effusion Harsini, Harsini; Kurniawan, Yoseph Dwi; Sutanto, Yusup Subagio
Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i3.142

Abstract

Background: The etiology of pleural effusion is very important in malignant pleural effusion management and prognosis. Pleural fluid cytology examination is a simple diagnostic tool and has been widely used to differentiate the etiology of pleural fluid with high specificity albeit its relatively low sensitivity. The use of tumor markers for malignant pleural effusion in Indonesia is still sparse. This study was intended to determine the sensitivity and specificity of CEA and CA-125 examinations in diagnosing malignant pleural effusion. Method: This was an observational analytic study with a cross-sectional approach to find the diagnostic value of CA-125 and CEA of pleural fluid in malignant pleural effusion. Subjects were patients with suspicion of malignant pleural effusion who underwent treatment in the emergency room, polyclinic, and inpatient ward at RSDM from October - November 2022. Results: CEA value with a cutoff of ≥32.00 had a sensitivity of 83.3%; specificity of 87.8%; PPV of 90.9%; NPV of 77.8% with an accuracy of 85.0% (P=0.001), a CA-125 value with a cutoff of >152.40 had a sensitivity of 83.3%; specificity 81.3%; PPV 87.0%; NPV 76.5%; with an accuracy of 82.5% (P=0.001). An increase in CEA and CA-125 signified a significant risk of malignant pleural effusion (P<0.05). Patients with increased CEA and CA-125 had 105 times the risk of developing malignant pleural effusion. Conclusion: CEA ≥32.00 and CA-125 >152.40 are potential biomarkers to predict malignant pleural effusion with CEA having better specificity than CA-125.
Analysis of Risk Factors for Antimicrobial Resistance in Nosocomial Pneumonia Amanda, Larissa; Aphridasari, Jatu; Sutanto, Yusup Subagio
Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i2.179

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Background: Antibiotic resistance is often linked to nosocomial pneumonia, one of the most prevalent hospital-acquired illnesses. Determining risk factors is crucial for management and preventative plans. To develop preventative and control measures, this research was conductedto identify the variables linked to antibiotic resistance in nosocomial pneumonia patients. Method: In this retrospective cohort analysis, 237 individuals with nosocomial pneumonia were included. Odds Ratios (OR) were computed for relevant factors after data were evaluated using the chi-square or Fisher’s exact test to find significant relationships between patient characteristics and antibiotic resistance. Results: Of the 237 patients, 58.2% exhibited antibiotic resistance. Several variables were found to be significantly associated with antibiotic resistance: age >59 years (OR=1.68; P=0.049), intensive care unit (ICU) admission (OR=2.65; P=0.002), high care unit (HCU) admission (OR=2.16; P=0.028), history of prior antibiotic use (OR=2.42; P=0.004), and endotracheal tube (ETT) use (OR=2.04; P=0.024). Patients older than 59 years had a 1.68-fold higher risk. Those admitted to the ICU and HCU had 2.65-fold and 2.16-fold higher risks, respectively. Patients with a history of prior antibiotic use had a 2.42-fold increased risk, and those with ETT use had a 2.04-fold increased risk. Conclusion: Older age, admission to intensive care units (ICU/HCU), previous antibiotic use, and endotracheal tube use are significant factors associated with antibiotic resistance in nosocomial pneumonia. These findings highlight key areas for targeted interventions to mitigate resistance.
Co-Authors -, Harsini -, Reviono . Reviono Adhiputri, Artrien Agnes Sri Harti Agnes Sri Harti Akhmad Syaikhu Ana Rima Ana Rima Setijadi Apridasari, Jatu Apriningsih, Hendrastutik Ari Natalia Probandari Arwin Muhlishoh Atmojo, Anang Purwoko Avamira Rosita Pranoto Bambang Abdul Syukur Bhisma Murti Brian Wasita Caesaria Sarah Selleca Dhani Redhono, Dhani Harsini , Harsini Harsini Harsini Jatu Aphridasari Kurniawan, Yoseph Dwi Larissa Amanda Leli Saptawati Lestari, Anggraini Dwi Liana Herlina Maria Dewi Caetline marwoto marwoto Mellia Silvy Irdianty, Mellia Silvy Mochammad Imron Awalludin Murti, Paulus Wisnu Kuncoro Nony Puspawati Nugroho, I.G.B Indro Nurul Devi Ardiani, Nurul Devi Putranto, Wachid R, Sari Apriliana Rahajeng Putriningrum Raharjo, A. Farih Reviono Reviono Saelan, Saelan Samuel - Santi, Nur Sebayang, Pribadi M Septiawan, Debree Sibarani, Lia Priscilia Sigit, Indarto Siregar, Sihsusetyaningtyas Tiominar Soetejo, FX Sri Haryati Subandrio, Subandrio SURYAWATI, BETTY Sutanto, Magdalena Sutanto, Magdalena Sutanto Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Wati, Martha Ratna Widyasanti, Diana Windu Prasetya Yogie Irawan Yundari, Yundari