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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Biotechnology MPI (Media Pharmaceutica Indonesiana) The Indonesian Biomedical Journal Science and Technology Indonesia Jurnal Akta Jurnal Fitofarmaka Indonesia JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia JURNAL RECTUM: Tinjauan Yuridis Penanganan Tindak Pidana Devotion: Journal of Research and Community Service Narra J International Journal of Social Service and Research International Journal of Science and Society (IJSOC) MEDICINUS Journal of Law, Poliitic and Humanities The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Al Makki Health Informatics Journal Journal of Food and Pharmaceutical Sciences Asian Journal of Social and Humanities Indonesian Journal of Jamu
Raymond R. Tjandrawinata
Fakultas Bioteknologi, Universitas Katolik Indonesia Atma Jaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Dasar Neurobiologis Akuisisi Bahasa Dini: Mengapa Anak masih Mengungguli Kecerdasan Buatan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qk5jw768

Abstract

Despite remarkable advances in artificial intelligence that have produced large language models (LLMs) capable of mimicking human linguistic behavior with high levels of sophistication, these systems still fall significantly short of the abilities of children in acquiring language rapidly, flexibly, and contextually. This article presents a systematic review from the perspective of cognitive and developmental neuroscience to address the question of why children remain superior in language learning compared to artificial intelligence systems. By examining mechanisms such as neuroplasticity, the involvement of social affective circuits, reward prediction systems, and multimodal sensorimotor functions in child language development, the article argues that human language acquisition is a phenomenon deeply embedded in the body, social relationships, and biological drives-dimensions that artificial systems inherently lack. The implications of this review extend to clinical interventions, education, and the development of AI systems that more closely approximate human neurocognitive architecture.
Menimbang Strategi Penatalaksanaan Deep Vein Thrombosis pada Pasien Strok Hemoragik Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/nca87c96

Abstract

Hemorrhagic stroke is an acute condition with high morbidity and mortality rates, and is frequently accompanied by complications such as deep vein thrombosis (DVT). The main dilemma in managing DVT in this condition is a therapeutic paradox, where anticoagulants use is effective in preventing pulmonary embolism, but carries the risk of worsening intracranial bleeding. International guidelines recommend mechanical prophylaxis, such as intermittent pneumatic compression (IPC), and cautious use of low-dose anticoagulants in stable hematomas, although clinical evidence remains limited. Biological alternatives, such as DLBS1033, derived from Lumbricus rubellus, have shown potential safety and efficacy in case reports from Indonesia. Ethical perspectives, health policy, as well as pharmacological innovations andartificial intelligence, are essential to develop adaptive, equitable, and evidence-based strategies in the management of DVT following hemorrhagic stroke.
Mengembalikan Makna Bernapas Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 11 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/rvt1y058

Abstract

The management of lower respiratory tract diseases, such as bronchitis, chronic obstructive pulmonary disease (COPD), and bronchiectasis, poses a significant challenge, particularly in countries with high levels of air pollution, smoking habits, and high prevalence of infections. Cough, as one of the primary symptoms, serves as a protective mechanism of the body to maintain airway hygiene as well as unobstructed breathing. Therefore, cough should be managed appropriately to ensure efficient mucus expectoration, one way being through the use of mucolytic agents such as bromhexine. Themodern approaches to respiratory infection management emphasize the combination of pharmacological interventions and physiological support. Pharmacological therapy focuses on restoring respiratory function using rational treatment, including control of inflammation, managing mucus drainage, and the rational use of antibiotics. Physiological interventions such as pulmonary rehabilitation and smoking cessation have a substantial long-term impact on improving patients’ quality of life.
T118N Substitution of Hepatitis B X Protein Reduces Colony Formation of HepG2 Cells Artarini, Anita; Nurmalasari, Dewi Riskha; Permanasari, Silmi Citra; Riani, Catur; Tjandrawinata, Raymond Rubianto; Retnoningrum, Debbie Soefie
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2095

Abstract

BACKGROUND: The acute Hepatitis B virus (HBV) infection usually ceases before six months, but chronic infection that lasts for more than six months might develop into liver cirrhosis and hepatocellular carcinoma (HCC). Viral particle load, HBV genotypes and association to the HBV x (HBx) gene mutations are the probable factors related to HCC occurrence. The mutation which leads to HBx T118N was found as the second most common HBx mutation in Indonesia, as compared to the known cancer-related HBx K130M/V131I mutant. However, the effect of T118N mutation and its combination with K130M/V131I on human hepatoma cells has not been elucidated well. Hence, this study was conducted to dissect the role of HBx T118N and its mutant combination in colony formation, as compared to the wild type HBx and cancer-related HBx K130M/V131I.METHODS: In this study, the genes encoding wild type HBx, HBx T118N, and HBx K130M/V131I mutations were obtained as synthetic gene. Meanwhile, the gene encoding HBx T118N/K130M/V131I mutations was successfully generated using site-directed mutagenesis. The optimum condition for colony formation assays was determined through Zeocin sensitivity test of HepG2 cells.RESULTS: Selection of HepG2 cells using Zeocin was determined at 200 µg/mL. Colony formation assays performed upon expression of HBx T118N and HBx T118N/K130M/V131I mutant proteins showed reduced colony numbers as compared to the expression of wild type HBx, similar to the effect from HBx K130M/V131I mutant expression.CONCLUSION: The HBx T118N and HBx T118N/K130M/V131I mutation caused less colony formation of HepG2 cells, similar to the K130/M131I mutation. This indicates a possible role of the T118N mutation in liver cancer development.KEYWORDS: colony formation assay, hepatitis B virus, HBx, T118N, K130M/V131I
National Drug Resilience within the Legal Framework: An Analysis of Regulation and Implementation of Law Number 17 of 2023 Tjandrawinata, Raymond R.; Heliany, Ina
International Journal of Science and Society Vol 6 No 4 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i4.1339

Abstract

National drug resilience is a fundamental pillar for achieving health independence and sovereignty in Indonesia. Strengthening this resilience has become a strategic mandate outlined in Law No. 17 of 2023 on Health, emphasizing the critical role of producing pharmaceuticals, vaccines, medical devices, and natural-based medicines to support the national healthcare system. This article examines the regulatory aspects, implementation, and challenges of realizing national drug resilience through a normative juridical approach. The integration of progressive legal theory, utilitarianism, and the welfare state model is the primary analytical framework for evaluating policy effectiveness. This approach is reinforced by a human rights perspective, particularly the right to health as enshrined in Article 28H of the 1945 Constitution and international frameworks such as ICESCR. The findings highlight that synergy among adaptive legal policies, strengthening biodiversity-based research and innovation, and supporting local industries are key to reducing dependence on imported materials and enhancing global competitiveness. This article contributes to local legal literature by integrating legal theory with human rights frameworks in the context of pharmaceutical policy while offering practical recommendations for supporting sustainable drug resilience policies. It provides a theoretical and strategic foundation for bolstering the national healthcare system through an inclusive and progressive legal approach.
Nutritional composition and action mechanism of Channa striata meat in wound healing: A systematic review Hapsari, Riani; Tjandrawinata, Raymond
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2903

Abstract

Wound healing is a complex biological process requiring adequate nutritional support, particularly proteins, amino acids, fatty acids, and essential minerals. Snakehead fish (Channa striata) has been traditionally consumed in Southeast Asia to accelerate recovery after surgery and childbirth. Emerging evidence suggests that its nutritional composition plays a pivotal role in tissue repair. The aim of this systematic review was to consolidate evidence on the nutritional composition of C. striata and elucidate its mechanisms of action in wound healing based on preclinical and clinical studies. A systematic search was conducted across PubMed, ScienceDirect, ProQuest, and Google Scholar for studies published between 2000 and 2023, following PRISMA 2020 guidelines. Eligible studies included biochemical analyses, in vitro and in vivo preclinical studies, and clinical trials assessing the wound-healing effects of C. striata. Data extraction covered nutrient composition, study design, wound-healing parameters, and mechanistic pathways. Out of 2898 identified studies, 22 of them met the inclusion criteria: ten biochemical composition studies, nine preclinical investigations, and four clinical trials. C. striata extract demonstrated high levels of albumin (0.76–10.73 g/100 g), essential and non-essential amino acids (notably glutamic acid, arginine, and glycine), fatty acids (palmitic, arachidonic, linoleic), and minerals such as zinc and copper. Preclinical models consistently showed enhanced fibroblast proliferation, epithelialization, tensile strength, and collagen deposition. Clinical studies in post-cesarean patients reported significant improvements in wound healing scores, uterine involution, pain reduction, and biomarker modulation (VEGF, IL-6, MMP-9). In conclusion, C. striata exhibits promising wound-healing potential attributable to its rich nutrient profile and multi-pathway mechanisms involving collagen synthesis, angiogenesis, and immunomodulation. However, the limited number of clinical trials underscores the need for larger, well-designed studies to confirm its translational efficacy in human wound care.
The Evolving Brain: Unraveling the Forces Shaping Human Cognition R. Tjandrawinata, Raymond
Asian Journal of Social and Humanities Vol. 3 No. 4 (2025): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v3i4.475

Abstract

This interdisciplinary study explores the evolution of the human brain by integrating perspectives from anthropology, neuroscience, evolutionary biology, and technology studies. It delves into the factors driving brain expansion over time, including social complexity, dietary transitions, tool use, and the development of language. By synthesizing primary and secondary data, the research highlights the interplay between cognitive development and environmental pressures, showcasing how human neural architecture was shaped by adaptive responses to changing conditions. The findings reveal that evolutionary adaptations not only influenced brain size and structure but also laid the groundwork for cognitive resilience, particularly in the face of aging and modern technological advancements. This study underscores the profound impact of social and environmental challenges on brain evolution and its ongoing plasticity. Furthermore, it addresses critical questions about how rapid technological shifts are shaping cognitive functions and neural pathways today. By examining the past, present, and future trajectories of the human brain, this research provides a comprehensive framework for understanding its evolutionary processes and offers insights into navigating the challenges of an increasingly complex and technology-driven world.
Ethics and Intellectual Property Rights in Genetic Therapy R. Tjandrawinata, Raymond; Heliany, Ina; Soelistyo Budi, Henry
Asian Journal of Social and Humanities Vol. 3 No. 5 (2025): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v3i5.500

Abstract

Genetic technology, particularly CRISPR-Cas9, has transformed the paradigm of treating genetic diseases by offering new hope for more effective and precise therapies. However, this advancement also presents significant ethical and intellectual property rights (IPR) challenges. This article explores the impact of patents on the development and accessibility of genetic therapy, as well as the ethical issues arising from human genetic modification, especially at the germline level. Using a qualitative analytical approach that combines literature reviews and case studies, the article examines patent disputes that have emerged in the development of CRISPR and how applied patent policies can exacerbate inequities in access to critically needed medical therapies. Furthermore, the article discusses ethical concerns regarding the misuse of genetic technology and its potential impact on future generations. In conclusion, the article proposes the need for more inclusive and balanced policies that prioritize both innovation and accessibility, as well as strict regulations to ensure the safe and ethical application of genetic technology, while considering broader social and cultural impacts.
The Intersection of Max Planck’s Metaphysical Assertion and Christian Theology: A Pragmatic Review of Consciousness and Creation R. Tjandrawinata, Raymond; B. Atawolo, Andreas
Devotion : Journal of Research and Community Service Vol. 5 No. 12 (2024): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v5i12.25389

Abstract

This systematic review explores the intersection of Max Planck's assertion that "matter is a derivative of consciousness" with key concepts in Christian theology, particularly creation, existence, and the imago Dei. The study aims to investigate how Planck's views align with and enrich theological doctrines, fostering dialogue between science and faith. The objective is to analyze interdisciplinary literature to uncover complementary understandings of the cosmos' origin and nature, drawing from scientific insights and Christian theological frameworks. A qualitative methodology is employed, comprising a systematic analysis of scholarly articles, theological texts, and scientific literature that address consciousness, metaphysics, and divine creation. The findings reveal significant alignment between Planck's concept of consciousness as foundational to matter and Christian beliefs about God’s creative agency and humans as bearers of the imago Dei. This synthesis enhances comprehension of the cosmos as a creation sustained by an underlying consciousness, aligning with the theological principle of divine intentionality. In conclusion, this review highlights the potential for meaningful dialogue between scientific and theological perspectives, offering a unified understanding of existence that bridges the material and metaphysical realms.
COMPARATIVE COMPETITION LAW IN HEALTHCARE: A REVIEW OF U.S. AND INDONESIAN REGULATORY APPROACHES Tjandrawinata, Raymond R.
International Journal of Social Service and Research Vol. 5 No. 3 (2025): International Journal of Social Service and Research
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v5i3.1210

Abstract

The rapid expansion of digital health services and telemedicine introduces new dimensions to competition law enforcement in healthcare. This paper explores strategic recommendations to enhance Indonesia's competition law in healthcare by focusing on strengthening regulatory institutions, improving judicial consistency, fostering private enforcement mechanisms, and developing targeted policies for emerging digital health markets. This study employs a comparative legal analysis approach, integrating qualitative and normative research methods, to examine the effectiveness of existing competition law frameworks governing healthcare in the United States and Indonesia, identifying best practices, challenges, and opportunities for improvement. The findings reveal stark contrasts in competition law enforced between the two countries, particularly in market concentration, regulatory oversight, judicial intervention, and private litigation mechanisms. By adopting a framework that fosters industry sustainability while preventing anti-competitive behavior, Indonesia can create a more competitive, innovative, and accessible healthcare system that benefits both pharmaceutical companies and consumers alike.
Co-Authors . Anindyajati Achmad K. Harzif Agung Endro Nugroho Agung Endro Nugroho Andon Hestiantoro Andreas Bernadinus Atawolo Andri Prasetiyo Anindini Winda Amalia Anita Artarini Armini Syamsidi ARTARINI, ANITA Babu, Murali Mohan Budi Wiweko Caroline G. Puspita CATUR RIANI Danang Agung Yunaidi Dayana, Hepy Debbie S. Retnoningrum Debbie S. Retroningrum DEBBIE SOEFIE RETNONINGRUM DERMAWAN, DONI Dewi Riskha Nurmalasari Diana Nur Afifah Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Gayatri, Anggi Gita Pratama Hapsari, Riani Harry Martha Wijaya Hartati Tuna, Hartati Heliany, Ina Henry Soelistyo Budi Henry Soelistyo Budi, Henry Soelistyo Herbert Situmorang Herbert Situmorang Hiendrawan, Stevanus Huda Shalahudin Darusman Indriawati, Iin Irsan Hasan Ismaya, Wangsa T. Kaka Renaldi Kanadi Sumapradja Krisnayanti, Ni Putu Eka Kristiana, Hery Kristiana, Hery Laurentia Stephani Liana W. Susanto Lilik Sulastri Luh Putu Nurshanti, Ni Maggy T. Suhartono Maggy T. Suhartono Maggy Thenawidjaja Suhartono Marcellus Simadibrata Martha Wijaya, Harry Melva Louisa Murali Mohan Babu Murdani Abdullah Nafrialdi Nafrialdi Nailufar, Florensia Nailufar, Florensia Ni Luh Putu Nurshanti Novia Tri Astuti Novia Tri Astuti Novitasari, Putri Rachma Permanasari, Silmi Citra Rachman, Andika Raden Muharam Natadisastra Retroningrum, Debbie S. Santi Tan Saut Horas Hatoguan Nababan Setiabudy, Rahajuningsih D Shirly Kumala SILMI MARIYA Simatupang, Stefeny Theresia Sinaga, Wenny S.L. Soelistyo Budi, Henry Steven Susanto, Liana W Suwijiyo Pramono Suwijiyo Pramono Tan, Santi Viedya Novalinda Said Wangsa T. Ismaya Wangsa Tirta Ismaya Widjaja, Nadia Winoto, Imelda L Winoto, Imelda L Yanti Lim Zaelani, Bella Fatima Dora