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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Indonesian Journal of Biotechnology The Indonesian Biomedical Journal Science and Technology Indonesia Jurnal Akta Jurnal Fitofarmaka Indonesia Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia JURNAL RECTUM: Tinjauan Yuridis Penanganan Tindak Pidana Devotion: Journal of Research and Community Service Narra J International Journal of Social Service and Research Jurnal Impresi Indonesia International Journal of Science and Society (IJSOC) Journal of Social Research Journal Of World Science MEDICINUS Journal of Law, Poliitic and Humanities The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy INJURITY: Journal of Interdisciplinary Studies Eduvest - Journal of Universal Studies Journal of Social Science Influence: International Journal of Science Review Al Makki Health Informatics Journal Journal of Food and Pharmaceutical Sciences Asian Journal of Social and Humanities Indonesian Journal of Jamu
Raymond R. Tjandrawinata
Fakultas Bioteknologi, Universitas Katolik Indonesia Atma Jaya
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Preeklamsia dan Dampaknya dalam Perspektif Psikologi, Sosiologi, dan Medis Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/wbqkwr31

Abstract

Preeklamsia merupakan komplikasi kehamilan serius yang berdampak multidimensional terhadap kesehatan ibu dan janin. Secara medis, kondisi ini ditandai oleh hipertensi pascausia kehamilan 20 minggu serta temuan proteinuria atau gangguan organ lain, dan dapat menyebabkan komplikasi seperti gagal organ, kelahiran prematur, hingga kematian maternal dan neonatal. Di sisi psikologis, diagnosis preeklamsia sering memicu kecemasan, depresi, dan stres mendalam akibat ketidakpastian terhadap kondisi kehamilan, yang memperburuk kualitas hidup ibu. Sementara itu, dari perspektif sosiologis, preeklamsia mencerminkan ketimpangan sosioekonomi, terutama di negara berkembang, di mana akses terhadap perawatan kesehatan yang memadai masih terbatas. Kurangnya edukasi, ketidakmerataan distribusi fasilitas medis, serta beban sosial terhadap keluarga semakin memperparah dampak kondisi ini. Oleh karena itu, pendekatan interdisipliner yang mencakup intervensi medis, dukungan psikososial, dan kebijakan publik yang progresif sangat penting untuk pencegahan dan penanganan preeklamsia secara komprehensif.
Kalsium, Vitamin D, dan Farmakoterapi Masa Depan dalam Pencegahan Preeklamsia: Tinjauan Komprehensif dari Perspektif Klinis dan Molekuler Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/38v6gh35

Abstract

Preeklamsia tetap menjadi penyebab utama morbiditas dan mortalitas maternal serta neonatal di seluruh dunia. Meskipun telah banyak diteliti, patofisiologi preeklamsia masih belum sepenuhnya dipahami, melibatkan interaksi kompleks antara ketidakseimbangan angiogenik, disregulasi imun, stres oksidatif, dan gangguan plasentasi. Intervensi nutrisi, khususnya suplementasi kalsium dan vitamin D, telah mendapatkan perhatian luas sebagai strategi preventif berbasis bukti. Suplementasi kalsium dosis tinggi terbukti menurunkan insiden preeklamsia, terutama pada populasi dengan asupan kalsium rendah, melalui mekanisme yang melibatkan penghambatan parathyroid hormone (PTH) dan peningkatan vasodilatasi arteriol uterus. Sementara itu, vitamin D memiliki efek imunomodulator dan angiogenik, serta berperan penting dalam menstabilkan fungsi endotel dan menekan ekspresi faktor antiangiogenik seperti soluble fms-like tyrosine kinase-1 (sFlt-1). Artikel ini meninjau secara sistematis bukti-bukti klinis dan molekuler terkini mengenai peran kalsium dan vitamin D dalam pencegahan preeklamsia, serta mengeksplorasi potensi agen farmakologis masa depan, seperti pravastatin, esomeprazole, dan pendekatan berbasis nanopartikel. Selain itu, dibahas pula formulasi nutraseutikal menggunakan Formical-B, yang menunjukkan hasil awal yang menjanjikan dalam menurunkan risiko preeklamsia melalui jalur antioksidan dan modulasi tekanan darah. Tinjauan ini menawarkan perspektif integratif yang menggabungkan intervensi nutrisi dan terapi molekuler sebagai kerangka masa depan pencegahan preeklamsia berbasis personalisasi.
Jejak Memori dalam Jaringan Fasia Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/83wqt329

Abstract

Konsep bahwa fasia dapat menyimpan memori emosional atau somatik telah memicu perdebatan dalam bidang terapi manual, neurobiologi, dan biofisika. Artikel ini menyelidiki landasan ilmiah di balik hipotesis tersebut dengan meninjau literatur primer dan sekunder dari dua dekade terakhir. Melalui pendekatan multidisipliner yang mencakup neuroanatomi, epigenetik, mekanobiologi, dan biokomunikasi, artikel ini mengusulkan model teoretis yang menjelaskan kemungkinan keterlibatan fasia sebagai penyimpan informasi. Dengan mengintegrasikan konsep neurofascial plasticity, resonansi morfik, dan tensegritas, disertai evaluasi kritis terhadap data empiris, disarankan bahwa meskipun belum ada bukti definitif, kemungkinan adanya sistem penyimpanan memori dalam fasia patut dijelajahi lebih lanjut secara sistematik dan eksperimental.
Di Balik Peradangan: Tinjauan tentang Peran Antinosiseptif Sel Imun dalam Modulasi Nyeri Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/zxrk2y26

Abstract

Immune cells have long been considered antagonists in pain physiology, as they have largely been viewed primarily through the lens of inflammation and nociceptive amplification. However, emerging research is reshaping this narrative. This article describes the evolving role of immune cells — not merely as proinflammatory molecules, but also as agents involved in pain modulation and suppression. Recent findings in neuroimmunology reveal a complex molecular dialogue between immune mediators and nociceptive pathways, particularly highlighting the contributions of regulatory T cells, macrophage subtypes, and glial cells in reducing nociceptive signals. Antinociceptive mechanisms mediated by cytokines, lipid-derived mediators, and immune-to neuronal communication are reviewed along with their translational potential in chronic pain therapy. By redefining the role of immune cells into central figures in the analgesic process, a paradigm shift is emerging, which requires an integrative approach in pain research and therapy.
Uji Klinik Terdesentralisasi: Mendefinisikan Ulang Partisipasi, Kuasa, dan Presisi dalam Riset Kesehatan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/trzykz54

Abstract

Decentralized clinical trials (DCTs) have emerged as a transformative force in biomedical research, breaking down traditional boundaries and reshaping how evidence is generated, validated, and applied. By leveraging digital health technologies, real-world data, and remote engagement infrastructures, DCTs have the potential to democratize clinical research by improving inclusivity and accessibility. However, these opportunities come with challenges related to regulatory governance, technological ethics, and socio-political representation. This brief article explores both the conceptual and empirical foundations of DCTs, drawing from recent studies, international policy documents (such as white papers), regulatory initiatives, and global practice surveys. It examines the epistemological, operational, and normative shifts introduced by DCTs and proposes a framework for understanding their impact on three core dimensions of clinical science: participation, power, and precision. Ultimately, this article argues that DCTs are not merely a digital enhancement, but rather a fundamental reconfiguration of how health knowledge is generated and governed.
Epigenom yang Berkembang: Fungsi dan Aplikasinya Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/1cyz2p11

Abstract

Epigenome is a set of reversible modifications that synergistically regulate gene expression without altering the DNA sequence. The epigenome serves as a functional bridge between the genome and the environment, enabling precise spatiotemporal regulation of gene expression, which is crucial for cellular identity and development of organisms. Unlike the static genome, the epigenome is dynamic and responsive to endogenous and exogenous signals, including developmental, metabolic, environmental stress, and pathological conditions. This paper comprehensively reviews the fundamental mechanisms of epigenetic dynamics, its role in phenotype formation, and its implications in disease etiology and therapeutic innovation. By integrating cutting-edge findings from developmental biology, oncology, neurobiology, and regenerative medicine, the epigenome can be understood as a multidimensional lens for interpreting biological memory, developmental plasticity, and potential molecular engineering.
The Effect of Phaleria macrocarpa Bioactive Fraction (Proliverenol) Supplementation on Liver Damage in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) Irsan Hasan; Saut Horas Hatoguan Nababan; Raymond R. Tjandrawinata; Danang Agung Yunaidi; Liana W. Susanto
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/a4ba3z37

Abstract

Liver is considered one of the most vital organs, acting as the center of metabolism of nutrients and excretion of waste products. Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of chronic liver disease. The management of NAFLD continues to evolve, and clinicians are currently faced with a variety of alternative options, both nonpharmacotherapeutic and pharmacotherapy, to avoid more severe liver disease. Phaleria macrocarpa (Scheff.) Boerl., namely, mahkota dewa in Indonesia, has been used empirically to treat cancer, allergy, and diabetes mellitus. Proliverenolis a proprietary bioactive fraction derived from the dried fruit of Phaleria macrocarpa (Scheff.) Boerl. Proliverenol was reported to have hepatoprotective, anti-inflammatory, antioxidant, and antifibrotic effects. The study found that Proliverenol bioactive fraction, at a dosage of 1000 mg twice daily for at least 4 weeks of treatment, is effective in improving liver damage with a good safety profile.
Tinjauan Terpadu terhadap Terapi Presisi dan Standardized Herbal Drug untuk Non-Alcoholic Fatty Liver Disease (NAFLD): Kemajuan Molekuler, BuktiKlinis, serta Implikasi Integratif Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/mh4ry926

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a progressive hepatic disorder that has become a central component of the global metabolic syndrome spectrum. Its complex pathogenesis involves insulin resistance, chronic inflammation,oxidative stress, and activation of fibrogenic pathways. Along with the deepening understanding of molecular mechanisms,precision therapies targeting farnesoid X receptor (FXR) agonists, peroxisome proliferator-activated receptor (PPAR) modulators, incretin mimetics, and RNA-based technologies are being developed, although challenges remain concerningside effects and accessibility. In this context, Veprolin containing Proliverenol, a bioactive fraction of Phaleria macrocarpa, offers potential as an adjuvant standardized herbal drug with anti-inflammatory, antifibrotic, and reparative effects, as demonstrated in preclinical studies. This review highlights the importance of integrative, precision-oriented, and sustainable multimodal therapeutic strategies.
Clinical Study of DLBS2411, a Mucoprotector and Proton Pump Inhibitor Bioactive Fraction Derived From Cinnamomum burmanii, on the Intragastric Acidity Tjandrawinata, Raymond Rubianto; Abdullah, Murdani; Simadibrata, Marcellus; Susanto, Liana W; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202543-54

Abstract

Background: DLBS2411, A bioactive fraction derived from the bark of Cinnamomum burmanii has been developed to address acid-related gastrointestinal disorders. This study evaluated the pharmacodynamic effect of DLBS2411 on the 24-hour intragastric acidity in healthy adults.  Methods: In a 3-arm, parallel, double-blind, randomized, placebo-controlled clinical trial, healthy subjects received a single dose of DLBS2411 (250 mg or 500 mg) or placebo. Gastric pH was monitored, analyzed and profiled over 24 hours. Results: Of a total of 54 enrolled male subjects, 47 subjects (87.04%) were eligible for the analysis. The mean 24-hour intragastric pH for DLBS2411 250 mg and 500 mg was 2.29 ± 0.42 and 2.13 ± 0.50, respectively, both higher than placebo (1.93 ± 0.70). Differences were more pronounced during the first 12 hours (daytime). DLBS2411 250 mg and 500 mg reached a gastric pH 4 significantly faster (129.9 ± 128.2 and 92.9 ± 106.8 minutes) compared to placebo (196.9 ± 99.7 minutes). No serious adverse events occurred. All adverse events were mild and had been resolved by the end of study, confirming the safety and tolerability of DLBS2411 at the dose of 250 and 500 mg. Conclusion: DLBS2411 effectively suppressed the intragastric acidity and demonstrated a good safety profile in healthy adults. These findings warrant further studies of DLBS2411 in patients with gastric acid-related disorders. Keywords: Alternative medicine, DLBS2411 cinnamomum burmanii, healthy volunteers, intragastric-acidity, proton pump inhibitors
Harnessing Artificial Intelligence in Generic Formulation Development and Life Cycle Management - A Comprehensive Review Babu, Murali Mohan; Luh Putu Nurshanti, Ni; Martha Wijaya, Harry; R. Tjandrawinata, Raymond
Al Makki Health Informatics Journal Vol. 3 No. 1 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i1.45

Abstract

Artificial intelligence (AI) is revolutionizing the pharmaceutical industry by enhancing efficiency, precision, and cost-effectiveness in drug development. This study explores the application of AI in the lifecycle management of generic drugs, focusing on key stages such as active pharmaceutical ingredient (API) synthesis, excipient selection, pre-formulation studies, bioequivalence testing, and regulatory compliance. By leveraging machine learning algorithms, AI facilitates predictive modeling, risk assessment, and optimization of drug formulation processes, reducing time-to-market and improving scalability. Despite significant advancements, challenges such as data quality, algorithm transparency, and infrastructure limitations persist, particularly in resource-constrained settings. This review highlights case studies and emerging technologies that address these challenges, providing actionable insights for pharmaceutical stakeholders. The study also discusses AI's potential to streamline supply chain logistics, enhance accessibility, and ensure regulatory adherence. By integrating AI across all stages of generic drug development, this research underscores its transformative potential in improving drug affordability, accessibility, and patient outcomes globally.
Co-Authors Achmad K. Harzif Agung Endro Nugroho Agung Endro Nugroho Andon Hestiantoro Andri Prasetiyo Anindini Winda Amalia Anindyajati Anindyajati Anita Artarini Armini Syamsidi ARTARINI, ANITA B. Atawolo, Andreas Babu, Murali Mohan Budi Wiweko Caroline G. Puspita CATUR RIANI Danang Agung Yunaidi Dayana, Hepy Debbie S. Retnoningrum Debbie S. Retroningrum DEBBIE SOEFIE RETNONINGRUM Dewi Riskha Nurmalasari Diana Nur Afifah Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Gayatri, Anggi Gita Pratama Hapsari, Riani Hartati Tuna, Hartati Heliany, Ina Henry Soelistyo Budi Henry Soelistyo Budi, Henry Soelistyo Herbert Situmorang Herbert Situmorang Huda Shalahudin Darusman Indriawati, Iin Irsan Hasan Ismaya, Wangsa T. Kaka Renaldi Kanadi Sumapradja Krisnayanti, Ni Putu Eka Kristiana, Hery Kristiana, Hery Laurentia Stephani Liana W. Susanto Lilik Sulastri Luh Putu Nurshanti, Ni Maggy T. Suhartono Maggy T. Suhartono Maggy Thenawidjaja Suhartono Marcellus Simadibrata Martha Wijaya, Harry Melva Louisa Murdani Abdullah Nafrialdi Nafrialdi Nailufar, Florensia Nailufar, Florensia Novia Tri Astuti Novia Tri Astuti Novitasari, Putri Rachma Permanasari, Silmi Citra Rachman, Andika Raden Muharam Natadisastra Retroningrum, Debbie S. Santi Tan Saut Horas Hatoguan Nababan Setiabudy, Rahajuningsih D Shirly Kumala SILMI MARIYA Simatupang, Stefeny Theresia Sinaga, Wenny S.L. Soelistyo Budi, Henry Susanto, Liana W Suwijiyo Pramono Suwijiyo Pramono Tan, Santi Viedya Novalinda Said Wangsa T. Ismaya Wangsa Tirta Ismaya Widjaja, Nadia Winoto, Imelda L Winoto, Imelda L Yanti Lim Zaelani, Bella Fatima Dora