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All Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Journal of Pharmaceutical and Medicinal Sciences ad-Dawaa : Journal of Pharmaceutical Sciences Narra J Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Sains dan Kesehatan
Marianti A Manggau
Departemen Farmakologi Dan Toksikologi, Fakultas Farmasi, Universitas Hasanuddin, Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AKTIVITAS ANTI DIABETES MELLITUS TANAMAN DURIAN (Durio zibethinus Murr.) TERHADAP KADAR GLUKOSA DARAH PUASA MENCIT YANG DIINDUKSI ALOKSAN Muh. Nur Amir; Yuyun Sulitiani; Indriani Indriani; Inda Pratiwi; Elly Wahyudin; Marianti A Manggau; Sumarheni Sumarheni; Ismail Ismail
Majalah Farmasi dan Farmakologi Vol. 23 No. 3 (2019): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.092 KB) | DOI: 10.20956/mff.v23i3.9396

Abstract

Durian (Durio zibethinus Murr.) telah lama digunakan sebagai salah satu pengobatan tradisional untuk mengobati berbagai macam penyakit, termasuk untuk penderita diabetes mellitus. Penelitian ini bertujuan untuk menentukan aktivitas ekstrak etanol durian dalam menurunkan kadar glukosa darah pada mencit yang diinduksi aloksan dosis 125 mg / kgBB dan diberi beban glukosa 20%. Sebanyak 36 ekor mencit dibagi menjadi 6 kelompok perlakuan. Kelompok I sebagai kontrol sehat, kelompok II diinduksi dengan aloksan dan diberikan NaCMC 1% (kontrol negatif), kelompok III diinduksi dengan aloksan dan diberikan Acarbose® (kontrol positif), kelompok IV diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 125 mg / kgBB, kelompok V diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 250 mg / kgBB, kelompok VI diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 500 mg / kgBB. Pengukuran kadar glukosa darah dilakukan sebelum induksi alloxan (t-0), 3x24 jam setelah induksi (t-3), dan setiap 30 menit setelah pemberian perlakuan ekstrak dan larutan glukosa hingga menit ke-180 (t30, t60, t90, t120, t150 dan t180), yang dilakukan pengukuran menggunakan alat glukometer (Nesco®). Persen penurunan kadar glukosa darah yang paling tinggi ditunjukkan setelah menit ke-180 pada kelompok EDR dengan dosis 125 mg / kgBB, ESB dosis  250 mg / kgBB dan EDL dosis 500 mg / kgBB yaitu  sebesar 50,60%, 105,62%, dan 62,97%.
STUDI EFEK DISGLIKEMIA PADA PENGGUNAAN INJEKSI CIPROFLOXACIN DAN LEVOFLOXACIN DENGAN KOMBINASI ANTIDIABETIK ORAL DAN INSULIN PADA PASIEN DIABETES MELITUS DI INSTALASI RAWAT INAP RSUD LASINRANG, PINRANG, SULAWESI SELATAN Ririn Sutanti Abdul; Marianti A Manggau; Agus Alim Abdullah
Majalah Farmasi dan Farmakologi Vol. 24 No. 3 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v24i3.11109

Abstract

This study was aimed to determine the dysglycemia effects of fluoroquinolone antibiotics, namely ciprofloxacin or levofloxacin in hospitalized diabetes melitus patients who also taking oral antidiabetic or insulin in Lasinrang Hospital Pinrang by measuring blood glucose levels value before and after using  fluoroquinolon. The research was conducted by a non-experimental observational study with a descriptive-analytic design. Sampling was done by retrospectively method and 49 samples were obtained that met the inclusion and exclusion criteria. The results of this study showed no hypoglycemia effect in hospitalized diabetes melitus patients, who was taking ciprofloxacin or levofloxacin. The percentage effect of hyperglycemia that occurs in patient using ciprofloxacin was 34.78% and levofloxacin was 30.77%. Based on statistical tests, blood glucose levels before and after the patients with diabetes mellitus taking ciprofloxacin or levofloxacin injection showed a significant difference.
EVALUASI PENGGUNAAN TERAPI ANTIBIOTIK EMPIRIS TERHADAP LUARAN KLINIS PASIEN PNEUMONIA KOMUNITAS RAWAT INAP Sukriya AB Pangeran; Marianti A. Manggau; Irawaty Djaharuddin
Majalah Farmasi dan Farmakologi Vol. 26 No. 1 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i1.18888

Abstract

Pneumonia komunitas merupakan penyakit infeksi pada parenkim paru-paru yang mengancam jiwa sehingga dapat diberikan terapi antibiotik empiris. Penelitian ini bertujuan mengetahui nilai DDD dan kualitas penggunaan terapi antibiotik empiris menggunakan metode Gyssens pada pasien pneumonia komunitas rawat inap serta hubungannya terhadap luaran klinis pasien di RSUD Kota Makassar. Penelitian ini bersifat observasional dengan pengambilan data dilakukan secara retrospektif dari rekam medis pasien usia >19 tahun yang memenuhi kriteria inklusi periode Januari 2018-Desember 2019. Dikumpulkan data karakterisik pasien, pengobatan dan luaran klinis pasien setelah pemberian antibiotik. Analisis data dilakukan secara deskriptif dan dilanjutkan uji Chi square  untuk menganalisis hubungan penggunaan antibiotik dengan luaran klinis pasien. Karakteristik pasien yang beresiko yaitu usia, jenis kelamin, jumlah obat dan komorbid turut dianalisis. Hasil evaluasi kuantitatif antibiotik bahwa seftriakson memiliki DDD  tertinggi yaitu 44,9 DDD/100 patient-days, pada evaluasi kualitatif dari 74 sampel sebanyak 14 pasien (18,9%) memenuhi kategori ketepatan pemberian antibiotik (kategori 0) dan ketidaktepatan pemberian antibiotik pada kategori IVa sebanyak 50 pasien (67,6%), kategori IVb sebanyak 9 pasien (12,2%) dan kategori IIa sebanyak 1 pasien (1,4%). Uji chi-square menunjukkan tidak ada hubungan bermakna antara jumlah dan ketepatan penggunaan terapi antibiotik empiris terhadap luaran klinis pasien pneumonia komunitas pada periode Januari 2018-Desember 2019. Pasien yang memiliki komorbid baik yang berkategori infeksi maupun kategori infeksi dan non infeksi merupakan faktor resiko yang memiliki hubungan yang bermakna dengan luaran klinis pasien pada periode tersebut.
Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review Doloking, Haeria; Lallo, Subehan; Manggau, Marianti A; Rifai, Yusnita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.39968

Abstract

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Efek penggunaan Antihipertensi Kombinasi Amlodipin dan Valsartan Pasien Stroke Iskemik di RSUP Dr. Wahidin Sudirohusodo Makassar: Effect of the Use of Combination Antihypertensive Amlodipine and Valsartan with Ischemic Stroke Patients at RSUP Dr. Wahidin Sudirohusodo Makassar Mirfaidah Nadjamuddin; Marianti A Manggau; Cahyono Kaelan
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.358

Abstract

Telah dilakukan penelitian efek penggunaan Antihipertensi dengan pasien stroke iskemik di RSUP Dr. Wahidin Sudirohusodo Makassar. Stroke dapat disebabkan oleh beberapa kondisi medis, diantaranya tekanan darah tinggi, diabetes, kelainan pembuluh darah atau jantung, dan migrain, serta faktor gaya hidup yang tidak sehat, seperti konsumsi rokok dan alkohol. Penelitian dilakukan dengan metode Kohort, dimana bersifat prospektif karena data yang diambil merupakan data assesmen dari pasien di Rumah Sakit Umum Pusat (RSUP) Dr. Wahidin Sudirohusodo Makassar. Data diperoleh dianalisis terhadap hubungan antara obat Amlodipin 5 mg + Valsartan 80 mg dan Amlodipin 10 mg + Valsartan 80 mg. Pemberian obat Antihipertensi di RSUP Dr.Wahidin Sudirohusodo pada pasien Stroke Iskemik terbanyak dari golongan Amlodipin 5 mg + Valsartan 80 mg Efek penggunaan obat Antihipertensi pada uji Mann-whitney diperoleh nilai p>0,05 yang menunjukkan bahwa tidak terdapat perbedaan penurunan tekanan darah yang signifikan antara pemakaian obat Amlodipin 5 mg + Valsartan dengan Amlodipin 10 mg + Valsartan 80 mg
Chemical fingerprinting and antioxidant properties of Glochidion philippicum Khairuddin, Khairuddin; Manggau, Marianti A.; Rante, Herlina; Hardiyanti, Widya; Latada, Nadila P.; Umar, Abdul H.; Nur, Syamsu; Wahyudin, Elly; Rahman, Latifah; Yulianty, Risfah; Nainu, Firzan
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1886

Abstract

Glochidion philippicum has been suggested to exhibit considerable pharmacological potential, yet its chemical composition and bioactivity remain inadequately explored. The aim of this study was to investigate the chemical fingerprint and antioxidant properties of G. philippicum leaf extracts using Fourier-transform infrared spectroscopy (FTIR) with chemometric analyses, and in vitro and in vivo evaluations. Four extraction methods (maceration, reflux, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE)) were optimized with water, 70% ethanol, ethyl acetate, and n-hexane as solvents. FTIR profiles were analyzed with principal component analysis (PCA), hierarchical cluster analysis, and orthogonal partial least squares discriminant analysis. An in vitro study assessing the free radical scavenging capacity was conducted using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) methods, while in vivo evaluations were conducted using Drosophila melanogaster to measure antioxidant enzyme activity and expression of endogenous antioxidant-related genes. FTIR profiles identified functional groups contributing to antioxidant activity. In vitro assays using ABTS and FRAP methods revealed that extracts obtained with 70% ethanol and water exhibited the highest antioxidant activity, attributed to key functional groups such as C=C (aromatic), O−H (acidic), N=O (nitro), and C−O (ester). In vivo studies showed that ethanol-based MAE extracts (MAEEO) significantly improved the survival of autoinflammatory PGRP-LBΔ mutant larvae exposed to heat-killed Escherichia coli. Real-time quantitative PCR analysis indicated this effect was dependent on endogenous antioxidant gene activation. The study highlights that G. philippicum leaf extracts as a natural source of bioactive compounds with exogenous antioxidant properties, offering potential for therapeutic applications.
Utilization of Fucoidan Based on Nanodelivery in Health Promotion Perspective, Molecular Mechanism, and Community Empowerment: A Scoping Review Alexandraa, Francisca Diana; Massi, Muh. Nassrum; Leman, Yanti; Manggau, Marianti A.; Frethernety, Agnes; Jayanti, Ira
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.9131

Abstract

Introduction: Fucoidan is a sulfated polysaccharide derived from brown algae with proven anticancer, antioxidant, and immunomodulatory properties. However, its clinical utilization remains limited due to high molecular weight and low bioavailability. Recent advances in nanodelivery systems provide promising strategies to overcome these limitations and align with community-based health promotion initiatives. Methods: This scoping review adopted the PEOS framework (Population, Exposure, Outcome, Study Design) and PRISMA flow to map current evidence on fucoidan’s molecular mechanisms, nanocarrier innovations, and community empowerment perspectives. Literature searches were conducted in PubMed, ScienceDirect, EBSCO, and Google Scholar from 2015–2023 using keywords “fucoidan,” “nanoparticle,” “nanocarrier,” “molecular mechanism,” and “health promotion.” Twenty-three eligible articles were critically appraised using Hawker’s Quality Assessment Tool. Results: Fucoidan exhibits anticancer effects through upregulation of Bax, downregulation of Bcl-2, activation of caspases, and inhibition of angiogenesis via NF-?B, MAPK, and Nrf2 signaling pathways. Nanodelivery systems including chitosan fucoidan nanoparticles, PEGylated PLGA, hydrogels, and microneedle patches enhanced stability, absorption, and targeted efficacy. Preclinical studies demonstrated tumor inhibition, wound healing, and immunomodulatory benefits. From a public health perspective, fucoidan-based nanotechnology supports health promotion through increased scientific literacy, integration into Health Promoting Hospitals, and economic empowerment of coastal communities producing brown algae. Conclusion:Fucoidan represents a multifunctional bioactive compound whose efficacy is strengthened by nanodelivery innovation. Integrating molecular insights with health promotion and community empowerment creates a sustainable model linking biotechnology, preventive health, and local economic development. This review emphasizes the importance of interdisciplinary collaboration in translating marine biopolymers into accessible, evidence-based complementary therapies.
Co-Authors . Lukman . Mufidah . Subehan A Rufaidah Hashary Agus Alim Abdullah Aisyah Fatmawaty Alexandraa, Francisca Diana Cahyani Purnasari Cahyono Kaelan Doloking, Haeria Elly Wahyudin Firzan Nainu Frethernety, Agnes Gatot S Lawrence Gemini Alam Hardiyanti, Widya Herlina Rante Inda Pratiwi Indriani Indriani Irawaty Djaharuddin Ismail Ismail Jayanti, Ira Kasim, Hasyim Khairuddin - Lallo, Subehan Latada, Nadila P. Latifah Rahman Leman, Yanti M Natsir Djide M Rusdi Magfirah Magfirah Massi, Muh. Nassrum Matias N Kolobani Mirfaidah Nadjamuddin Muhammad Aswad Muhammad Yunus Amran,*,** Seung Pil Ban,** Ashari Bahar,* O-Ki Kwon** Nasruddin AM Nurul Inayah Nurul Insani Restuyani Paranoan Reymon Reymon Ririn Sutanti Abdul Risfah Yulianty Riska Damayanty Riska Purnamasari Subehan Lallo Suhartina Hamzah Sukriya AB Pangeran Sumarheni Sumarheni Syamsu Nur, Syamsu Umar, Abdul H. Yulia Yusrini Djabir Yunus Amran Yusnita Rifai, Yusnita Yuyun Sulitiani