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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Simetris Indonesian Journal of Cancer Emerging Science Journal Civil Engineering Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JURNAL ILMIAH MAKSITEK Abdi Masya Jurnal Abdikarya : Jurnal Karya Pengabdian Dosen dan Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer IJRETINA - International Journal of Retina Engagement: Jurnal Pengabdian Kepada Masyarakat
Teguh Triyono
Department Of Clinical Pathology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia
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Journal : Indonesian Journal of Cancer

 1 
Faktor yang Memengaruhi Episode Transfusi Packed Red Cell (PRC) pada Anak dengan Keganasan PURWANTO, DIAN A.P; MULATSIH, SRI; TRIYONO, TEGUH
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTPRC transfusion is an adjuvant therapy frequently used in children with malignancy. There are some factors affecting transfusion episodes. For rational use of PRC must consider these factors. Objective: To find factors affecting transfusion episodes in children with malignancy. This retrospective cohort study evaluated children with malignancy between January 1 and December 31, 2015 who were admitted to Sardjito hospital. Patients were receiving therapy dan PRC transfusion during the four months following cancer diagnosis. Those with incomplete data or renal failure were excluded. The influence of these factors were analyzed with Chi-square or Fisher’s exact and Kolmogorov-Smirnov when iligible, and the most influential factor were analyzed by logistic regression. Out of 123 subjects receiving a PRC transfusion, 56 (45,5%) subjects received a PRC transfusion more than one times episodes. Higher episodes of transfusion were observed for patients whose bleeding (RR 6.940 (95%CI 2.563 to 18.790). Lower episodes of transfusion were observed for patients receiving transfusion previously and hematological malignancies, but the result were not significant (RR 0,524 (IK95% 0,057 – 4,852) and 0,464 (IK 95% 0,140 – 1,540) respectively). Bleeding is factor affecting transfusion episodes of PRC in children with malignancy.ABSTRAKTransfusi PRC merupakan terapi adjuvant yang sering digunakan pada anak dengan keganasan. Terdapat beberapa faktor yang memengaruhi episode transfusi sehingga penggunaan PRC rasional harus mempertimbangkan faktor tersebut. Penelitian ini bertujuan mengetahui faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. Penelitian kohort retrospektif pada anak (0 –18 tahun) yang dirawat di RSUP Dr. Sardjito dengan penyakit keganasan yang telah terdiagnosis selama empat bulan dan mendapat terapi serta transfusi PRC sejak 1 Januari – 31 Desember 2015. Register tidak lengkap atau dengan gagal ginjal dieksklusi. Pengaruh faktor– faktor tersebut dianalisis dengan uji Chi-square atau uji Fisher serta Kolmogorov-Smirnov bila tidak memenuhi syarat, dan faktor yang paling berpengaruh dianalisis dengan uji logistic regression. Dari 123 subjek, 56 subjek dengan episode transfusi PRC > 1 kali. Keganasan hematologi, riwayat transfusi, dan perdarahan memengaruhi episode transfusi PRC > 1 kali. Analisis multivariat didapatkan perdarahan memengaruhi episode transfusi PRC > 1 kali (RR 6,940 (IK95% 2,563 – 18,790), namun riwayat transfusi dan keganasan hematologi tidak bermakna dengan nilai RR secara berturut-turut 0,524 (IK95% 0,057 – 4,852) dan 0,464 (IK 95% 0,140 – 1,540). Penelitian ini menyimpulkan bahwa perdarahan merupakan faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. 
Co-Authors Abdul Salam Sofro Adie, Prayoga Wira Aditya Rio Prabowo Aditya Wicaksana Aflifia Birruni Sabila Agiel, Raiddin Muhamad Agni, Angela Nurini Akbar, Hammar Ilham Anak Agung Wiradewi Lestari Andri Christianalusi Arta Farmawati Asysyifa, Azzahra Bambang Margono Budi Mulyono Budi Mulyono Caesar Haryo Bimoseno Carvalho, Hermes Chamim, Moch. David Dwi Putera DIAN A.P PURWANTO Dicky Moch Rizal Dicky Moch Rizal Djordjevic, Branislav Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari E. Elsa Herdiana Murhandarwati Eko Surojo Endang Yuniastuti Eti Nurwening Sholikhah Fridawati, Veronica Fuad Anshori Hanggoro Tri Rinonce Hanifah, Shabrina Hans Vrielink Harjo Seputro, Harjo Harsito, Catur Ilham Habibi, Ilham Indra Tri Mahayana Jarir At Thobari Jaya, Sudi Indra Johan Kurnianda Jonliberti Purba Kaslam, Surawijaya Bakhtiar Majid, Faishal M. Mardiah Suci Hardianti Muhammad Luthfi Neti Nurani Ni Kadek Mulyantari Nurrahma, Bira Arumndari Nurul Muhayat Pramudi, Ganjar PRITA MURANI NUGRAHETI PURWANTO, DIAN A.P Raehanul Bahraen Raharjo, Wijang W. Rina Susilowati Sholehuddin, Muhammad Ilham Singgih Dwi Prasetyo Sri Mulatsih Sri Mulatsih Sri Mulatsih Suhardjo Suhardjo Sukmaji Indro Cahyono, Sukmaji Indro Surawijaya Bakhtiar Kaslam Sutaryo Sutaryo Syahru Agung Setiawan Syarifa, Cut Alima Titik Nuryastuti Tri Ratnaningsih Tri Ratnaningsih Triyono Triyono Triyono Ubaidillah Ubaidillah Umi Solekhah Intansari Usi Sukorini Veronica Fridawati Widodo, Irianiwati Wijang Wisnu Raharjo Zainal Arifin